---
title: "Guselkumab for Moderate-to-Severe Plaque Psoriasis in Chinese Patients: Randomized Double-Blind Tr"
id: "pubmed-40921728"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-40921728"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/40921728/"
doi: "10.1097/CM9.0000000000003771"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Guselkumab for Moderate-to-Severe Plaque Psoriasis in Chinese Patients: Randomized Double-Blind Tr
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-40921728
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/40921728/)
- **DOI:** [10.1097/CM9.0000000000003771](https://doi.org/10.1097%2FCM9.0000000000003771)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This article reports a multicenter, randomized, double-blind, placebo-controlled clinical trial of **guselkumab** in Chinese patients with **moderate-to-severe plaque psoriasis** published in Chinese Medical Journal (Engl). - The trial is identified as a Clinical Trial with PMID 40921728 and DOI 10.1097/CM9.0000000000003771 and appears in the 2026 Sep 5 issue (Vol. 139, No. 17, pp. 2587–2596); electronic publication noted as Epub 2025 Sep 8. - The publication lists a large collaborative author group from multiple dermatology departments across China and employees/affiliates of Johnson & Johnson; lead author is Kun Huang. - Study design is explicitly described in the title as **randomized, double-blind, placebo-controlled**, indicating allocation concealment and blinding procedures at minimum in the trial methodology. - The source excerpt provides author names, affiliations, publication metadata, and links to full-text resources but does not include trial enrollment numbers, baseline characteristics, dosing regimen, primary or secondary endpoint definitions, efficacy outcomes (such as PASI responses), or safety/adverse-event data in the provided abstract excerpt. - Full efficacy and safety results, statistical analyses, and detailed methods were not reported in the PubMed page excerpt included here; readers are referred to the full-text source (link provided on PubMed) for those data. - The trial was conducted across many tertiary dermatology centers in China; sponsors/industry collaborators include Johnson & Johnson personnel listed among affiliations. - Key clinical terms from the source: **guselkumab**, **plaque psoriasis**, **randomized**, **double-blind**, **placebo-controlled**.
## Clinical Analysis & Structured Key Points
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Epub 2025 Sep 8. # Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial [Kun Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+K&cauthor_id=40921728)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-1 "Department of Dermatology , The First Affiliated Hospital of Chongqing Medical University , Chongqing400016 , China."), [Songmei Geng](https://pubmed.ncbi.nlm.nih.gov/?term=Geng+S&cauthor_id=40921728)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-2 "Department of Dermatology , The Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine , Xi'an , Shaanxi710114 , China."), [Xiaohua Tao](https://pubmed.ncbi.nlm.nih.gov/?term=Tao+X&cauthor_id=40921728)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-3 "Department of Dermatology , Zhejiang Provincial People's Hospital , Hangzhou , Zhejiang310011 , China."), [Liangdan Sun](https://pubmed.ncbi.nlm.nih.gov/?term=Sun+L&cauthor_id=40921728)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-4 "Department of Dermatology , The Affiliated Hospital of Anhui Medical University School of Medicine , Hefei , Anhui230022 , China."), [Chao Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+C&cauthor_id=40921728)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-5 "Department of Dermatology , The First Affiliated Hospital of Fujian Medical University , Fuzhou , Fujian350005 , China."), [Bin Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+B&cauthor_id=40921728)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-6 "Dermatology Hospital of Southern Medical University \(Guangdong Provincial Dermatology Hospital\) , Guangzhou , Guangdong510665 , China."), [Yan Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+Y&cauthor_id=40921728)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-7 "Department of Dermatology , Jiangsu Provincial People's Hospital , Nanjing , Jiangsu210029 , China."), [Rong Xiao](https://pubmed.ncbi.nlm.nih.gov/?term=Xiao+R&cauthor_id=40921728)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-8 "Department of Dermatology , The Second Xiangya Hospital of Central South University , Changsha , Hunan410013 , China."), [Chunlei Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+C&cauthor_id=40921728)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-9 "Department of Dermatology , The Third Hospital of Peking University , Beijing100191 , China."), [Furen Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+F&cauthor_id=40921728)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-10 "Shandong Dermatological Hospital , Jinan , Shandong250022 , China."), [Qianjin Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+Q&cauthor_id=40921728)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-11 "Hospital for Skin Diseases , Chinese Academy of Medical Sciences , Nanjing , Jiangsu210042 , China."), [Jie Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+J&cauthor_id=40921728)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-12 "Department of Dermatology , Ruijin Hospital of Shanghai Jiaotong University School of Medicine , Shanghai200025 , China."), [Huiping Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=40921728)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-13 "Department of Dermatology , Tianjin Medical University General Hospital , Tianjin300050 , China."), [Yuling Shi](https://pubmed.ncbi.nlm.nih.gov/?term=Shi+Y&cauthor_id=40921728)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-14 "Shanghai Skin Disease Hospital , Shanghai200040 , China."), [Zhiming Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Z&cauthor_id=40921728)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-15 "Department of Dermatology , First Affiliated Hospital of Wenzhou Medical University , Wenzhou , Zhejiang325000 , China."), [Wei Yan](https://pubmed.ncbi.nlm.nih.gov/?term=Yan+W&cauthor_id=40921728)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-16 "Department of Dermatology , West China Hospital , Sichuan University , Chengdu , Sichuan610041 , China."), [Litao Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+L&cauthor_id=40921728)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-17 "Department of Dermatology , Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital , Tianjin300120 , China."), [Juan Tao](https://pubmed.ncbi.nlm.nih.gov/?term=Tao+J&cauthor_id=40921728)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-18 "Department of Dermatology , Union Hospital , Tongji Medical College of Huazhong University of Science & Technology , Wuhan , Hubei430030 , China."), [Shoumin Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=40921728)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-19 "Department of Dermatology , Henan Provincial People's Hospital , Zhengzhou , Henan450003 , China."), [Xiumin Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+X&cauthor_id=40921728)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-20 "Department of Dermatology , Beijing Tongren Hospital , Capital Medical University , Beijing100730 , China."), [Hao Cheng](https://pubmed.ncbi.nlm.nih.gov/?term=Cheng+H&cauthor_id=40921728)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-21 "Department of Dermatology , Sir Run Run Shaw Hospital , Zhejiang University School of Medicine , Hangzhou , Zhejiang310016 , China."), [Jinhua Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+J&cauthor_id=40921728)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-22 "Department of Dermatology , Huashan Hospital , Fudan University , Shanghai200040 , China."), [Juan Su](https://pubmed.ncbi.nlm.nih.gov/?term=Su+J&cauthor_id=40921728)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-23 "Department of Dermatology , Xiangya Hospital , Central South University , Changsha , Hunan410008 , China."), [Zhenying Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+Z&cauthor_id=40921728)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-24 "Department of Dermatology , The University of Hong Kong-Shenzhen Hospital , Shenzhen , Guangdong518053 , China."), [Zhiqiang Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+Z&cauthor_id=40921728)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-25 "Department of Dermatology , The First Hospital Affiliated to AMU \(Southwest Hospital\) , Chongqing400038 , China."), [Lu Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+L&cauthor_id=40921728)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-26 "Johnson & Johnson , Beijing100000 , China."), [Rui Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+R&cauthor_id=40921728)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-26 "Johnson & Johnson , Beijing100000 , China."), [Tong Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+T&cauthor_id=40921728)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-27 "Johnson & Johnson , Shanghai200233 , China."), [Weilong Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+W&cauthor_id=40921728)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-27 "Johnson & Johnson , Shanghai200233 , China."), [Yuhan Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+Y&cauthor_id=40921728)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-27 "Johnson & Johnson , Shanghai200233 , China."), [Ming Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+M&cauthor_id=40921728)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-27 "Johnson & Johnson , Shanghai200233 , China."), [Zhongqi Dong](https://pubmed.ncbi.nlm.nih.gov/?term=Dong+Z&cauthor_id=40921728)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-27 "Johnson & Johnson , Shanghai200233 , China."), [Shu Lyu](https://pubmed.ncbi.nlm.nih.gov/?term=Lyu+S&cauthor_id=40921728)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-27 "Johnson & Johnson , Shanghai200233 , China."), [Min Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+M&cauthor_id=40921728)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#full-view-affiliation-28 "Department of Dermatology , Second Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , Zhejiang310006 , China.") Affiliations Expand ### Affiliations * 1 Department of Dermatology , The First Affiliated Hospital of Chongqing Medical University , Chongqing400016 , China. * 2 Department of Dermatology , The Second Affiliated Hospital of Xi'an Jiaotong University School of Medicine , Xi'an , Shaanxi710114 , China. * 3 Department of Dermatology , Zhejiang Provincial People's Hospital , Hangzhou , Zhejiang310011 , China. * 4 Department of Dermatology , The Affiliated Hospital of Anhui Medical University School of Medicine , Hefei , Anhui230022 , China. * 5 Department of Dermatology , The First Affiliated Hospital of Fujian Medical University , Fuzhou , Fujian350005 , China. * 6 Dermatology Hospital of Southern Medical University (Guangdong Provincial Dermatology Hospital) , Guangzhou , Guangdong510665 , China. * 7 Department of Dermatology , Jiangsu Provincial People's Hospital , Nanjing , Jiangsu210029 , China. * 8 Department of Dermatology , The Second Xiangya Hospital of Central South University , Changsha , Hunan410013 , China. * 9 Department of Dermatology , The Third Hospital of Peking University , Beijing100191 , China. * 10 Shandong Dermatological Hospital , Jinan , Shandong250022 , China. * 11 Hospital for Skin Diseases , Chinese Academy of Medical Sciences , Nanjing , Jiangsu210042 , China. * 12 Department of Dermatology , Ruijin Hospital of Shanghai Jiaotong University School of Medicine , Shanghai200025 , China. * 13 Department of Dermatology , Tianjin Medical University General Hospital , Tianjin300050 , China. * 14 Shanghai Skin Disease Hospital , Shanghai200040 , China. * 15 Department of Dermatology , First Affiliated Hospital of Wenzhou Medical University , Wenzhou , Zhejiang325000 , China. * 16 Department of Dermatology , West China Hospital , Sichuan University , Chengdu , Sichuan610041 , China. * 17 Department of Dermatology , Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital , Tianjin300120 , China. * 18 Department of Dermatology , Union Hospital , Tongji Medical College of Huazhong University of Science & Technology , Wuhan , Hubei430030 , China. * 19 Department of Dermatology , Henan Provincial People's Hospital , Zhengzhou , Henan450003 , China. * 20 Department of Dermatology , Beijing Tongren Hospital , Capital Medical University , Beijing100730 , China. * 21 Department of Dermatology , Sir Run Run Shaw Hospital , Zhejiang University School of Medicine , Hangzhou , Zhejiang310016 , China. * 22 Department of Dermatology , Huashan Hospital , Fudan University , Shanghai200040 , China. * 23 Department of Dermatology , Xiangya Hospital , Central South University , Changsha , Hunan410008 , China. * 24 Department of Dermatology , The University of Hong Kong-Shenzhen Hospital , Shenzhen , Guangdong518053 , China. * 25 Department of Dermatology , The First Hospital Affiliated to AMU (Southwest Hospital) , Chongqing400038 , China. * 26 Johnson & Johnson , Beijing100000 , China. * 27 Johnson & Johnson , Shanghai200233 , China. * 28 Department of Dermatology , Second Affiliated Hospital , Zhejiang University School of Medicine , Hangzhou , Zhejiang310006 , China. * PMID: **40921728** * DOI: [ 10.1097/CM9.0000000000003771 ](https://doi.org/10.1097/cm9.0000000000003771) Item in Clipboard Clinical Trial # Efficacy and safety of guselkumab in Chinese patients with moderate-to-severe plaque psoriasis: A randomized, double-blind, placebo-controlled trial Kun Huang et al. Chin Med J (Engl). 2026. Show details Display options Display options Format Abstract PubMed PMID Chin Med J (Engl) Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chin+Med+J+%28Engl%29%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Chin+Med+J+%28Engl%29%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40921728/) . 2026 Sep 5;139(17):2587-2596. doi: 10.1097/CM9.0000000000003771. Epub 2025 Sep 8. ### Authors [Kun Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+K&cauthor_id=40921728)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40921728/#short-view-affiliation-1 "Department of Dermatology , The First Affiliated Hospital of Chongqing Medical University , Chongqing400016 , China."), [Songmei Geng](https://pubmed.ncbi.nlm.nih.gov/?term=Geng+S&cauthor_id=40921728)[ 2 ](https://pubmed
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