---
title: "High metabolic rate selection dampens gut microbiota response to dietary restriction in bank voles"
id: "biorxiv-4-selection-for-high-metabolic-rate-reduces-gut-microbiota-responsiveness-to"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-4-selection-for-high-metabolic-rate-reduces-gut-microbiota-responsiveness-to"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1?rss=1"
published_at: "2026-09-22T08:47:28.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# High metabolic rate selection dampens gut microbiota response to dietary restriction in bank voles
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-4-selection-for-high-metabolic-rate-reduces-gut-microbiota-responsiveness-to
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1?rss=1)
- **Published At:** 2026-09-22T08:47:28.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Researchers tested whether hosts and their gut microbiota show coordinated, reversible plasticity to short-term **dietary restriction** using bank voles (Clethrionomys glareolus) from long-term artificial selection lines. - Two experimental groups were compared: lines selected for **high aerobic metabolism** (A-lines) and unselected control lines (C-lines). - Dietary restriction was implemented by diluting food with insoluble fiber; measurements were taken at baseline, after dietary restriction, and after a recovery period. - Measured traits included food consumption, body mass, resting metabolic rate (RMR), and fecal microbiota composition. - Dietary restriction produced a temporary increase in food consumption and decreases in body mass and **resting metabolic rate**, indicating physiological impacts of transient energy limitation. - Gut microbiota composition shifted significantly following dietary restriction, but these changes largely reverted toward baseline during recovery, showing reversible microbiota plasticity. - Contrary to the authors’ prediction, bacterial diversity changes in response to dietary restriction were stronger in C-lines than in A-lines, indicating reduced microbiota responsiveness in A-line voles. - The authors interpret the weaker microbiota response in A-lines as possible increased host control over microbial communities associated with directional selection for high metabolic capacity. - Overall, the study highlights substantial capacity for reversible plasticity in both host physiology and **gut microbiota** under fluctuating energy availability, and suggests that selection on host metabolic traits can alter microbiota responsiveness. - Funding sources and declarations were reported; no competing interests were declared by the authors.
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Joanna K Baran 1 Jagiellonian University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Joanna%2BK%2BBaran%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Baran%20JK&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJoanna%2BK%2BBaran%2B) * [ORCID record for Joanna K Baran](http://orcid.org/0000-0002-2688-5287 "Open in new tab") Paweł M Koteja 2 Jagiellonian University in Krakow: Uniwersytet Jagiellonski w Krakowie; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Pawe%C5%82%2BM%2BKoteja%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Koteja%20PM&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3APawe%25C5%2582%2BM%2BKoteja%2B) * [ORCID record for Paweł M Koteja](http://orcid.org/0000-0003-0077-4957 "Open in new tab") Tea Ivancic 1 Jagiellonian University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Tea%2BIvancic%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ivancic%20T&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ATea%2BIvancic%2B) Kunika 1 Jagiellonian University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=%2BKunika%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kunika&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3A%2BKunika%2B) Małgorzata Lipowska 1 Jagiellonian University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Ma%C5%82gorzata%2BLipowska%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Lipowska%20M&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMa%25C5%2582gorzata%2BLipowska%2B) * [ORCID record for Małgorzata Lipowska](http://orcid.org/0000-0003-3550-4105 "Open in new tab") Piotr Łukasik 1 Jagiellonian University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Piotr%2B%C5%81ukasik%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=%C5%81ukasik%20P&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3APiotr%2B%25C5%2581ukasik%2B) * [ORCID record for Piotr Łukasik](http://orcid.org/0000-0002-4164-6487 "Open in new tab") Edyta T Sadowska 2 Jagiellonian University in Krakow: Uniwersytet Jagiellonski w Krakowie; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Edyta%2BT%2BSadowska%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Sadowska%20ET&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AEdyta%2BT%2BSadowska%2B) * [ORCID record for Edyta T Sadowska](http://orcid.org/0000-0003-1240-4814 "Open in new tab") Phillip C Watts 3 University of Jyväskylä; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Phillip%2BC%2BWatts%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Watts%20PC&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3APhillip%2BC%2BWatts%2B) * [ORCID record for Phillip C Watts](http://orcid.org/0000-0001-7755-187X "Open in new tab") Anni M Hämäläinen 4 University of Turku * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Anni%2BM%2BH%C3%A4m%C3%A4l%C3%A4inen%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=H%C3%A4m%C3%A4l%C3%A4inen%20AM&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAnni%2BM%2BH%25C3%25A4m%25C3%25A4l%25C3%25A4inen%2B) * [ORCID record for Anni M Hämäläinen](http://orcid.org/0000-0001-9260-8299 "Open in new tab") * For correspondence: anni.hamalainen@utu.fi * [Abstract](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5799449/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5799449/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5799449/1) * [Supplementary material](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1.supplementary-material)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_data/node:5799449/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5799449/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Host-microbiota interactions are crucial in adapting to environmental changes, such as fluctuating energy availability. Yet, the extent to which hosts and their microbiota exhibit coordinated plasticity in response to transient energy limitation remains unclear. Here, we examined the capacity for parallel reversible plasticity in hosts and gut microbiota to temporary dietary restriction in hosts with differing energy needs. We subjected bank voles (Clethrionomys glareolus) from a long-term artificial selection experiment for high aerobic metabolism (A-lines) and control lines (C-lines) to dietary restriction (food dilution with insoluble fiber) followed by a recovery period. We measured traits relevant for vole energy consumption and fecal microbiota composition at baseline, after dietary restriction, and after recovery. We hypothesized that A-line voles would experience more severe and prolonged physiological effects of dietary restriction than C-line voles, which might be counteracted by higher microbiota responsiveness. Dietary restriction caused a temporary increase in food consumption, decrease in body mass and resting metabolic rate, and significant shifts in gut microbiota composition, all of which returned to near baseline levels during the recovery period. These effects were largely similar for the selection lines, but contrary to our prediction, the effect of dietary restriction on bacterial diversity was stronger in C-lines. This suggests higher resistance of the A-line microbiota to dietary changes, perhaps resulting from increased host control over microbial communities due to the directional selection for high metabolic capacity. Overall, our findings highlight a substantial capacity for reversible plasticity in host physiology and gut microbiota in fluctuating environments. ### Competing Interest Statement The authors have declared no competing interest. ## Funder Information Declared National Science Centre, https://ror.org/03ha2q922, 2018/29/B/NZ8/01924, 2016/23/B/NZ8/00888 Jagiellonian University, https://ror.org/03bqmcz70, DS/WBINOZ/INOS/757 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC 4.0 International license](http://creativecommons.org/licenses/by-nc/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. 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[ Download PDF](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/09/22/2026.09.18.752420.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [Supplementary Material ](https://www.biorxiv.org/content/10.64898/2026.09.18.752420v1.supplementary-material) [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) Selection for high metabolic rate reduces gut microbiota responsiveness to dietary restriction in bank voles Joanna K Baran, Paweł M Koteja, Tea Ivancic, Kunika, Małgorzata Lipowska, Piotr Łukasik, Edyta T Sadowska, Phillip C Watts, Anni M Hämäläinen bioRxiv 2026.09.18.752420; doi: https://doi.org/10.64898/2026.09.18.752420 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. 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