---
title: "Joint governance for embryo editing and embryo selection in reproductive genomics"
id: "nature-1-embryo-editing-and-embryo-selection-need-joint-governance"
canonical_url: "https://medichelpline.com/clinical-feed/nature-1-embryo-editing-and-embryo-selection-need-joint-governance"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "Nature Medicine"
source_url: "https://www.nature.com/articles/s41591-026-04669-z"
published_at: "2026-09-23T10:34:20.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Joint governance for embryo editing and embryo selection in reproductive genomics
## Provenance & Clinical Metadata
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- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** Nature Medicine
- **Source URL:** [Original Journal Publication](https://www.nature.com/articles/s41591-026-04669-z)
- **Published At:** 2026-09-23T10:34:20.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- Recent reports of **base editing** in early human embryos represent a significant scientific advance but do not establish clinical indications for **heritable genome editing**. - Jerabek et al. reported adenine base editing at two targets without the major chromosomal abnormalities seen in some earlier CRISPR–Cas9 experiments. - Bower et al. used base editing to create a functional knockout of a developmental regulator in early human embryogenesis. - These studies suggest reduced toxicity compared with some prior approaches and potentially higher efficacy, but they are experimental and do not justify clinical use. - A parallel and rapidly developing market for reproductive genomics is expanding the scope of embryo testing beyond chromosomal abnormalities and serious monogenic variants to whole-genome profiling and **polygenic ranking** for common diseases and non-clinical traits. - Commercialization of expanded embryo profiling and ranking is progressing faster than professional consensus and regulatory clarity. - The American Society for Reproductive Medicine’s recent opinion states that **preimplantation genetic testing for polygenic disorders (PGT-P)** is not ready for clinical use, citing uncertain predictive value and ethical concerns. - The convergence of improved embryo-editing techniques and an expanding embryo-selection market raises urgent governance questions; editing and selection technologies should be considered together rather than separately. - Existing national and international reports and recommendations on heritable human genome editing (for example, documents from major academies and WHO) are relevant context but the source did not detail specific governance proposals in this correspondence. - The correspondence emphasizes the need for oversight that accounts for both technological advances in editing and the commercialization of selection tools to prevent premature or inappropriate clinical application.
## Clinical Analysis & Structured Key Points
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[correspondences](https://www.nature.com/nm/articles?type=correspondence) 4. article * Correspondence * Published: 23 September 2026 # Embryo editing and embryo selection need joint governance * [Hervé Chneiweiss](https://www.nature.com/articles/s41591-026-04669-z#auth-Herv_-Chneiweiss-Aff1-Aff2) [ORCID: orcid.org/0000-0001-7675-5061](https://orcid.org/0000-0001-7675-5061)[1](https://www.nature.com/articles/s41591-026-04669-z#Aff1),[2](https://www.nature.com/articles/s41591-026-04669-z#Aff2), * [François Hirsch](https://www.nature.com/articles/s41591-026-04669-z#auth-Fran_ois-Hirsch-Aff1) [ORCID: orcid.org/0000-0002-1314-6717](https://orcid.org/0000-0002-1314-6717)[1](https://www.nature.com/articles/s41591-026-04669-z#Aff1) & * [Catherine Bourgain](https://www.nature.com/articles/s41591-026-04669-z#auth-Catherine-Bourgain-Aff1-Aff3) [ORCID: orcid.org/0000-0002-6761-0140](https://orcid.org/0000-0002-6761-0140)[1](https://www.nature.com/articles/s41591-026-04669-z#Aff1),[3](https://www.nature.com/articles/s41591-026-04669-z#Aff3) * [on behalf of the INSERM Ethics Committee](https://www.nature.com/articles/s41591-026-04669-z#group-1) Show authors [_Nature Medicine_](https://www.nature.com/nm) (2026) [Cite this article](https://www.nature.com/articles/s41591-026-04669-z#citeas) [ Save article ](https://www.nature.com/articles/s41591-026-04669-z/save-research?_csrf=paRizRC12x5QAC3UI6H6GrDGPUynlWwO) [ View saved research ](https://www.nature.com/saved-research) Recent reports on base editing in early human embryos mark an important scientific moment. They also risk being misread and therefore deserve attention because they suggest that some of the toxicity associated with earlier CRISPR–Cas9 approaches might be reduced while efficacy might be drastically increased. Jerabek et al.[1](https://www.nature.com/articles/s41591-026-04669-z#ref-CR1 "Jerabek, S. et al. Preprint at bioRxiv https://doi.org/10.64898/2026.05.30.728989 \(2026\).") reported adenine base editing at two targets without the major chromosomal abnormalities seen in some earlier experiments, whereas Bower et al.[2](https://www.nature.com/articles/s41591-026-04669-z#ref-CR2 "Bower, O. J. et al. Nature https://doi.org/10.1038/s41586-026-10792-1 \(2026\).") used base editing to establish a functional knockout of a developmental regulator in early human embryogenesis. These are important advances in embryo research. They do not establish a clinical indication for heritable genome editing. The more immediate issue is how improved editing could intersect with a rapidly developing market for reproductive genomics. Preimplantation genetic testing was developed to detect chromosomal abnormalities and pathogenic variants associated with serious monogenic disorders. Commercial providers now go further, offering whole-genome embryo profiling and polygenic ranking for common diseases and, in some cases, non-clinical traits[3](https://www.nature.com/articles/s41591-026-04669-z#ref-CR3 "Ethics Committee of the American Society for Reproductive Medicine & Practice Committee of the American Society for Reproductive Medicine. Fertil. Steril.125, 24–30 \(2026\)."),[4](https://www.nature.com/articles/s41591-026-04669-z#ref-CR4 "Grebe, T. A. et al. Genet. Med. 26, 101052 \(2024\)."),[5](https://www.nature.com/articles/s41591-026-04669-z#ref-CR5 "Raz, A., Halsband, A., Langner, R. & Shkedi-Rafid, S. EMBO Rep. 27, 265–268 \(2026\)."). A recent American Society for Reproductive Medicine opinion concludes that preimplantation genetic testing for polygenic disorders (PGT-P) is not ready for clinical use, citing uncertain predictive value and substantial ethical concerns[3](https://www.nature.com/articles/s41591-026-04669-z#ref-CR3 "Ethics Committee of the American Society for Reproductive Medicine & Practice Committee of the American Society for Reproductive Medicine. Fertil. Steril.125, 24–30 \(2026\)."). Yet commercialization is proceeding faster than professional consensus. 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Jerabek, S. et al. Preprint at _bioRxiv_ (2026). 2. Bower, O. J. et al. _Nature_ (2026). 3. Ethics Committee of the American Society for Reproductive Medicine & Practice Committee of the American Society for Reproductive Medicine. _Fertil. Steril._**125** , 24–30 (2026). 4. Grebe, T. A. et al. _Genet. Med._ **26** , 101052 (2024). [Article](https://doi.org/10.1016%2Fj.gim.2023.101052) [CAS](https://www.nature.com/articles/cas-redirect/1:CAS:528:DC%2BB2cXktlCrsro%3D) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=38393332) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=&journal=Genet.%20Med.&doi=10.1016%2Fj.gim.2023.101052&volume=26&publication_year=2024&author=Grebe%2CTA) 5. Raz, A., Halsband, A., Langner, R. & Shkedi-Rafid, S. _EMBO Rep._ **27** , 265–268 (2026). 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[Download references](https://citation-needed.springer.com/v2/references/10.1038/s41591-026-04669-z?format=refman&flavour=references) ## Author information ### Authors and Affiliations 1. INSERM Ethics Committee, Paris, France Hervé Chneiweiss, François Hirsch, Catherine Bourgain, Tal Anahory, Bertrand Bed’Hom, François Bompart, Céline Bourzac, Frédérique Claudot, Frédérique Lesaulnier, Séverine Mathieu, Jennifer Merchant, Jean-Noël Missa, Israël Nisand, Isabelle Rémy-Jouet & Corinne Sébastiani 2. Sorbonne University, CNRS, INSERM, Center for Neuroscience at Sorbonne University (NeuroSU), Paris, France Hervé Chneiweiss 3. INSERM, CERMES3, Villejuif, France Catherine Bourgain 4. Centre de Médecine et Biologie de la Reproduction, CHU Montpellier, Montpellier, France Tal Anahory 5. Muséum national d’Histoire naturelle, Paris, France Bertrand Bed’Hom 6. VOLRETHICS Association, Paris, France François Bompart 7. École nationale vétérinaire d’Alfort, Maisons-Alfort, France Céline Bourzac 8. Université de Lorraine, Nancy, France Frédérique Claudot 9. Institut du Cerveau, Paris, France Frédérique Lesaulnier 10. École Pratique des Hautes Études (EPHE), PSL University, Paris, France Séverine Mathieu 11. Université Paris-Panthéon-Assas, Paris, France Jennifer Merchant 12. Université libre de Bruxelles, Brussels, Belgium Jean-Noël Missa 13. Université de Strasbourg, Strasbourg, France Israël Nisand 14. Institut de Biologie en Santé, Inserm, Angers, France Isabelle Rémy-Jouet Authors 1. Hervé Chneiweiss [View author publications](https://www.nature.com/search?author=Herv%C3%A9%20Chneiweiss) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Herv%C3%A9%20Chneiweiss)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Herv%C3%A9%20Chneiweiss%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 2. François Hirsch [View author publications](https://www.nature.com/search?author=Fran%C3%A7ois%20Hirsch) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Fran%C3%A7ois%20Hirsch)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Fran%C3%A7ois%20Hirsch%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) 3. Catherine Bourgain [View author publications](https://www.nature.com/search?author=Catherine%20Bourgain) Search author on:[PubMed](https://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=search&term=Catherine%20Bourgain)[Google Scholar](https://scholar.google.co.uk/scholar?as_q=&num=10&btnG=Search+Scholar&as_epq=&as_oq=&as_eq=&as_occt=any&as_sauthors=%22Catherine%20Bourgain%22&as_publication=&as_ylo=&as_yhi=&as_allsubj=all&hl=en) ### Consortia ### on behalf of the INSERM Ethics Committee * Tal Anahory * , Bertrand Bed’Hom * , François Bompart * , Catherine Bourgain * , Céline Bourzac * , Hervé Chneiweiss * , Frédérique Claudot * , François Hirsch * , Frédérique Lesaulnier * , Séverine Mathieu * , Jennifer Merchant * , Jean-Noël Missa * , Israël Nisand * , Isabelle Rémy-Jouet * & Corinne Sébastiani ### Corresponding author Correspondence to Hervé Chneiweiss. ## Ethics declarations ### Competing interests The authors declare no competing interests. ## Rights and permissions [Reprints and permissions](https://s100.copyright.com/AppDispatchServlet?title=Embryo%20editing%20and%20embryo%20selection%20need%20joint%20governance&author=Herv%C3%A9%20Chneiweiss%20Tal%20Anahory%20et%20al&contentID=10.1038%2Fs41591-026-04669-z&copyright=The%20Author%28s%29%2C%20under%20exclusive%20licence%20to%20Springer%20Nature%20America%2C%20Inc.&publication=1078-8956&publicationDate=2026-09-23&publisherName=SpringerNature&orderBeanReset=true) ## About this article [![Check for updates. 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Jerabek, S. et al. Preprint at _bioRxiv_ (2026). 2. Bower, O. J. et al. _Nature_ (2026). 3. Ethics Committee of the American Society for Reproductive Medicine & Practice Committee of the American Society for Reproductive Medicine. _Fertil. Steril._**125** , 24–30 (2026). 4. Grebe, T. A. et al. _Genet. Med._ **26** , 101052 (2024). [Article](https://doi.org/10.1016%2Fj.gim.2023.101052) [CAS](https://www.nature.com/articles/cas-redirect/1:CAS:528:DC%2BB2cXktlCrsro%3D) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=38393332) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=&journal=Genet.%20Med.&doi=10.1016%2Fj.gim.2023.101052&volume=26&publication_year=2024&author=Grebe%2CTA) 5. Raz, A., Halsband, A., Langner, R. & Shkedi-Rafid, S. _EMBO Rep._ **27** , 265–268 (2026). [Article](https://doi.org/10.1038%2Fs44319-025-00668-2) [CAS](https://www.nature.com/articles/cas-redirect/1:CAS:528:DC%2BB2MXjtVGnurnL) [PubMed](http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=41372635) [ Google Scholar](http://scholar.google.com/scholar_lookup?&title=&journal=EMBO%20Rep.&doi=10.1038%2Fs44319-025-00668-2&volume=27&pages=265-268&publication_year=2026&author=Raz%2CA&author=Halsband%2CA&author=Langner%2CR&author=Shkedi-Rafid%2CS) 6. Karavani, E. et al. _Cell_ **179** , 1424–1435.e8 (2019). [Article](https://doi.org/10.1016%2Fj.cell.2019.10.033) [CAS](https://www.nature.com/articles/cas-redirec
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