---
title: "Light-regulated GATA25 activates TCP4 to drive petiole and hypocotyl elongation in Arabidopsis"
id: "biorxiv-1-light-dependent-activation-of-tcp4-by-the-gata25-transcription-factor-promotes"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-1-light-dependent-activation-of-tcp4-by-the-gata25-transcription-factor-promotes"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1?rss=1"
published_at: "2026-10-22T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Light-regulated GATA25 activates TCP4 to drive petiole and hypocotyl elongation in Arabidopsis
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-1-light-dependent-activation-of-tcp4-by-the-gata25-transcription-factor-promotes
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1?rss=1)
- **Published At:** 2026-10-22T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The authors identified **GATA25** as a light- and photoperiod-responsive transcription factor that modulates petiole and hypocotyl elongation in Arabidopsis thaliana. - Overexpression of GATA25 increased petiole and hypocotyl lengths and elevated **TCP4** transcript levels in light-grown plants, indicating a positive regulatory relationship. - Chromatin immunoprecipitation, electrophoretic mobility shift assays, and transcriptional activation analysis showed that investigators reported direct binding of GATA25 to the **TCP4** promoter and activation of its transcription. - A glucocorticoid receptor-based inducible system provided inducible evidence that the study team observed activation of **TCP4** by GATA25 under permissive conditions (the source described the system but did not present dosing or timing parameters). - Yeast two-hybrid and bimolecular fluorescence complementation assays indicated a physical interaction between GATA25 and the E3 ubiquitin ligase **COP1**, suggesting post-translational regulation. - Overexpression of GATA25 failed to raise **TCP4** transcripts in dark conditions; data indicated suppression of GATA25 activity in darkness. - The authors proposed a model in which **COP1** destabilizes GATA25 in the dark, restricting **TCP4** activation to light conditions, thereby linking the daily light/dark cycle to cell elongation. - The source did not report specific molecular details for COP1-mediated destabilization, nor did it provide quantitative kinetics of GATA25 turnover or in planta ubiquitination assays in the text provided.
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Kihwan Kim Kyungpook National University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Kihwan%2BKim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kim%20K&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AKihwan%2BKim%2B) * [ORCID record for Kihwan Kim](http://orcid.org/0009-0005-9871-3248 "Open in new tab") Junseop Shin Kyungpook National University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Junseop%2BShin%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Shin%20J&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJunseop%2BShin%2B) * [ORCID record for Junseop Shin](http://orcid.org/0009-0008-3627-136X "Open in new tab") Won-Chan Kim Kyungpook National University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Won-Chan%2BKim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kim%20W&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AWon-Chan%2BKim%2B) * [ORCID record for Won-Chan Kim](http://orcid.org/0000-0002-8238-0865 "Open in new tab") * For correspondence: kwc@knu.ac.kr * [Abstract](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5894145/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5894145/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5894145/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5894145/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Plants coordinate cell elongation with the daily light/dark cycle, an important adaptive strategy for optimizing growth under changing environmental conditions. However, the transcriptional mechanisms linking light signals to plant developmental growth remain poorly understood. In this study, we identified the GATA25 transcription factor as a regulator of petiole and hypocotyl elongation in response to light and photoperiod. Overexpression of GATA25 in Arabidopsis thaliana increased petiole and hypocotyl lengths and elevated TCP4 transcript levels. We demonstrated that GATA25 directly binds to the promoter of TCP4 and activates its transcription using transcriptional activation analysis, a glucocorticoid receptor-based inducible system, chromatin immunoprecipitation, and electrophoretic mobility shift assays. Furthermore, yeast two-hybrid assay and bimolecular fluorescence complementation analyses showed that GATA25 physically interacts with the E3 ubiquitin ligase COP1. Notably, overexpression of GATA25 did not increase TCP4 transcript levels in dark conditions, suggesting that GATA25 activity is suppressed in dark conditions. Based on these findings, we propose a model in which GATA25 is destabilized by COP1 in dark conditions, restricting TCP4 activation to the light conditions. Taken together, these findings provide a framework for understanding how the daily light/dark cycle regulates cell elongation in a photoperiod-dependent manner through the GATA25-TCP4 module. ### Competing Interest Statement The authors have declared no competing interest. Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY 4.0 International license](http://creativecommons.org/licenses/by/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. [Donate to openRxiv ](https://www.zeffy.com/en-US/donation-form/donate-to-make-a-difference-10981) [ Back to top](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1?rss=1#page) [ Previous](https://www.biorxiv.org/content/10.64898/2026.10.16.759433v1 "Acute scalp EEG signatures of anterior thalamic DBS in epilepsy:reproducible gamma power enhancement within an aperiodic spectral-state shift") Posted October 22, 2026. [ Download PDF](https://www.biorxiv.org/content/10.64898/2026.10.19.760297v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/10/22/2026.10.19.760297.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) Light-dependent activation of _TCP4_ by the GATA25 transcription factor promotes petiole and hypocotyl elongation in _Arabidopsis thaliana_ Kihwan Kim, Junseop Shin, Won-Chan Kim bioRxiv 2026.10.19.760297; doi: https://doi.org/10.64898/2026.10.19.760297 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. 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