---
title: "Matched Plasma and Tissue Proteomics Using Olink Explore HT in Human Aging Cohort"
id: "biorxiv-0-matched-plasma-and-tissue-proteomics-reveal-the-selective-nature-of-circulating"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-0-matched-plasma-and-tissue-proteomics-reveal-the-selective-nature-of-circulating"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1?rss=1"
published_at: "2026-10-24T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Matched Plasma and Tissue Proteomics Using Olink Explore HT in Human Aging Cohort
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-0-matched-plasma-and-tissue-proteomics-reveal-the-selective-nature-of-circulating
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1?rss=1)
- **Published At:** 2026-10-24T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The preprint reports matched plasma and tissue proteomic profiling focused on **human aging**. The authors measured **5,415 proteins** using **Olink Explore HT**. - The cohort included **178 adults** with ages reported as 20–87 years; the excerpt lists that age range but does not provide additional demographic breakdowns. - The source excerpt names multiple coauthors and institutional affiliations, with correspondence to Nathan D. Price; it notes the work is a preprint and not peer reviewed. - The excerpt documents the assay platform and the number of proteins profiled; however, it does not include outcome measures, statistical analyses, or specific tissue types profiled in the truncated abstract. - The excerpt does not report primary endpoints, age-associated biomarkers identified, effect sizes, or p-values. Those methodological and result details are absent from the provided text. - The available text references supplementary material and data/code links on the bioRxiv page, implying additional information exists but was not included in the copied excerpt. - Investigators reported matched plasma and tissue sampling as the study design feature of interest, yet the excerpt lacks protocol details such as sampling timing, handling, normalization, or quality-control metrics. - Clinical relevance and translational claims are not present in the excerpt; the authors’ interpretations, conclusions, and limitations beyond the preprint notice are not shown in the provided content. - Readers should consult the full preprint PDF or supplementary files for complete methods, full results, and any stated limitations or next steps because the excerpt omits these elements.
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Watson, [ View ORCID Profile](http://orcid.org/0000-0002-8239-911X)John C. Earls, [ View ORCID Profile](http://orcid.org/0000-0001-8643-2055)Noa Rappaport, Heather L. Gregory, John Stone, [ View ORCID Profile](http://orcid.org/0000-0002-4181-5543)Maryellen G. Pavone, [ View ORCID Profile](http://orcid.org/0000-0002-0106-1150)Jamie N. Justice, [ View ORCID Profile](http://orcid.org/0000-0002-2743-7099)Bumsoo Ahn, Ryan P. Lamers, [ View ORCID Profile](http://orcid.org/0000-0001-9691-3741)Annalise Schweickart, [ View ORCID Profile](http://orcid.org/0000-0001-5479-4641)Christopher C. Benz, [ View ORCID Profile](http://orcid.org/0000-0002-3756-9394)Francesca E. Duncan, [ View ORCID Profile](http://orcid.org/0000-0001-9907-2749)Birgit Schilling, [ View ORCID Profile](http://orcid.org/0000-0002-4157-0267)Nathan D. Price doi: https://doi.org/10.64898/2026.10.19.759783 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Qiongrong Huang 1 Buck Institute for Research on Aging, Novato, CA, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Qiongrong%2BHuang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Huang%20Q&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AQiongrong%2BHuang%2B) * [ORCID record for Qiongrong Huang](http://orcid.org/0009-0004-5248-9597 "Open in new tab") Mark A. Watson 1 Buck Institute for Research on Aging, Novato, CA, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Mark%2BA.%2BWatson%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Watson%20MA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMark%2BA.%2BWatson%2B) * [ORCID record for Mark A. Watson](http://orcid.org/0000-0002-5423-4457 "Open in new tab") John C. Earls 1 Buck Institute for Research on Aging, Novato, CA, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=John%2BC.%2BEarls%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Earls%20JC&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJohn%2BC.%2BEarls%2B) * [ORCID record for John C. Earls](http://orcid.org/0000-0002-8239-911X "Open in new tab") Noa Rappaport 2 Buck Institute for Research on Aging, Novato, CA, USA; Phenome Health, Seattle, WA, USA; Institute for Systems Biology, Seattle, WA, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Noa%2BRappaport%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Rappaport%20N&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ANoa%2BRappaport%2B) * [ORCID record for Noa Rappaport](http://orcid.org/0000-0001-8643-2055 "Open in new tab") Heather L. Gregory 3 Wake Forest University School of Medicine, Winston-Salem, NC, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Heather%2BL.%2BGregory%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Gregory%20HL&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AHeather%2BL.%2BGregory%2B) John Stone 3 Wake Forest University School of Medicine, Winston-Salem, NC, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=John%2BStone%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Stone%20J&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJohn%2BStone%2B) Maryellen G. 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Justice 5 Wake Forest University School of Medicine, Winston-Salem, NC, USA; XPRIZE Foundation, Culver City, CA, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Jamie%2BN.%2BJustice%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Justice%20JN&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJamie%2BN.%2BJustice%2B) * [ORCID record for Jamie N. Justice](http://orcid.org/0000-0002-0106-1150 "Open in new tab") Bumsoo Ahn 3 Wake Forest University School of Medicine, Winston-Salem, NC, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Bumsoo%2BAhn%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ahn%20B&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ABumsoo%2BAhn%2B) * [ORCID record for Bumsoo Ahn](http://orcid.org/0000-0002-2743-7099 "Open in new tab") Ryan P. 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Duncan 7 Buck Institute for Research on Aging, Novato, CA, USA; Northwestern University; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Francesca%2BE.%2BDuncan%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Duncan%20FE&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AFrancesca%2BE.%2BDuncan%2B) * [ORCID record for Francesca E. Duncan](http://orcid.org/0000-0002-3756-9394 "Open in new tab") Birgit Schilling 1 Buck Institute for Research on Aging, Novato, CA, USA; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Birgit%2BSchilling%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Schilling%20B&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ABirgit%2BSchilling%2B) * [ORCID record for Birgit Schilling](http://orcid.org/0000-0001-9907-2749 "Open in new tab") Nathan D. Price 8 Buck Institute for Research on Aging, Novato, CA, USA; Thorne HealthTech, New York, NY, USA * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Nathan%2BD.%2BPrice%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Price%20ND&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ANathan%2BD.%2BPrice%2B) * [ORCID record for Nathan D. Price](http://orcid.org/0000-0002-4157-0267 "Open in new tab") * For correspondence: nprice@buckinstitute.org * [Abstract](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5899656/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5899656/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5899656/1) * [Supplementary material](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1.supplementary-material)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_data/node:5899656/1) * [Data/Code](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1.external-links)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_data_code/node:5899656/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.10.19.759783v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5899656/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Aging is systemic, yet how circulating proteins reflect molecular aging within solid tissues remains unclear. We profiled 5,415 proteins using Olink Explore HT in 178 adults aged 20-87 ye
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