---
title: "Post‑PicoWay laser skin barrier repair and anti‑aging evaluation of a niacinamide, Pro‑Xylane, pan"
id: "pubmed-42686896"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42686896"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42686896/"
doi: "10.1007/s10103-026-04995-1"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Post‑PicoWay laser skin barrier repair and anti‑aging evaluation of a niacinamide, Pro‑Xylane, pan
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42686896
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42686896/)
- **DOI:** [10.1007/s10103-026-04995-1](https://doi.org/10.1007%2Fs10103-026-04995-1)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This randomized controlled study evaluated a comprehensive topical regimen (REGENMEDIC cream and serum) applied after **PicoWay laser** treatment to assess skin barrier repair and anti‑aging effects. - The investigational topical products contain **Pro‑Xylane**, **niacinamide**, and **panthenol** among other active agents; Pro‑Xylane is highlighted as a potent anti‑aging ingredient. - The trial duration was 112 days and enrolled 88 Chinese female participants who were randomized into two arms: a test group receiving REGENMEDIC cream plus serum after laser, and a control group receiving a standard care regimen with a standard cream. - Early skin barrier repair was specifically assessed during the first 14 days following a single application of REGENMEDIC cream after PicoWay laser. - Longer‑term endpoints reported in the abstract included measures of **skin elasticity**, **firmness**, and **wrinkles**, but the available source text is truncated and does not provide outcome data or statistical results. - The abstract frames the study as addressing the knowledge gap about whether combining **Pro‑Xylane**, niacinamide, and panthenol with other actives in a post‑procedure regimen can provide synergistic benefits for barrier recovery and anti‑aging. - Study metadata in the source: Lasers Med Sci. 2026 Sep 3;41(1):212. PMID 42686896. DOI 10.1007/s10103-026-04995-1. - Affiliations include Medical Department and Research & Innovation Center, L'Oréal Dermatological Beauty and La Roche‑Posay units in China and France; full author list is provided in the source. - The abstract as provided is incomplete; specific numerical results, statistical analyses, safety/tolerability data, and detailed methods beyond what is summarized were not reported in the available source text.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42686896/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42686896/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42686896/#references) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42686896/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42686896/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42686896/#substances) Title & authors Abstract Conflict of interest statement References Publication types MeSH terms Substances Randomized Controlled Trial Lasers Med Sci Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lasers+Med+Sci%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lasers+Med+Sci%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42686896/) . 2026 Sep 3;41(1):212. doi: 10.1007/s10103-026-04995-1. # Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study [Huijuan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Baiyu Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+B&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Xiaofeng He](https://pubmed.ncbi.nlm.nih.gov/?term=He+X&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Rui Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+R&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Runlin Mi](https://pubmed.ncbi.nlm.nih.gov/?term=Mi+R&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Chunyu Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+C&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-3 "La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China."), [Caixia Ye](https://pubmed.ncbi.nlm.nih.gov/?term=Ye+C&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Wenna Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Hequn Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Zailing Zhu](https://pubmed.ncbi.nlm.nih.gov/?term=Zhu+Z&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Xiaoyin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+X&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Kungchi Hsu](https://pubmed.ncbi.nlm.nih.gov/?term=Hsu+K&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Andrew Steel](https://pubmed.ncbi.nlm.nih.gov/?term=Steel+A&cauthor_id=42686896)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-3 "La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China."), [Jie Qiu](https://pubmed.ncbi.nlm.nih.gov/?term=Qiu+J&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Yi Yi](https://pubmed.ncbi.nlm.nih.gov/?term=Yi+Y&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Yueqing Niu](https://pubmed.ncbi.nlm.nih.gov/?term=Niu+Y&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Claire Huguet](https://pubmed.ncbi.nlm.nih.gov/?term=Huguet+C&cauthor_id=42686896)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-4 "North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China."), [Wei Xiong](https://pubmed.ncbi.nlm.nih.gov/?term=Xiong+W&cauthor_id=42686896)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-4 "North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China."), [Valentine Beguin](https://pubmed.ncbi.nlm.nih.gov/?term=Beguin+V&cauthor_id=42686896)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-4 "North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China."), [Delphine Kerob](https://pubmed.ncbi.nlm.nih.gov/?term=Kerob+D&cauthor_id=42686896)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-5 "La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France, France."), [Yijie Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+Y&cauthor_id=42686896)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-6 "La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. Zhengyijie20171@outlook.com.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#full-view-affiliation-7 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. Zhengyijie20171@outlook.com.") Affiliations Expand ### Affiliations * 1 Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. * 2 Research and Innovation Center, L'Oréal China, Shanghai, China. * 3 La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. * 4 North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China. * 5 La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France, France. * 6 La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. Zhengyijie20171@outlook.com. * 7 Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. Zhengyijie20171@outlook.com. * PMID: **42686896** * DOI: [ 10.1007/s10103-026-04995-1 ](https://doi.org/10.1007/s10103-026-04995-1) Item in Clipboard Randomized Controlled Trial # Skin barrier repairing and anti-aging effects evaluation of a comprehensive topical regimen incorporating niacinamide, Pro-Xylane, and panthenol after PicoWay laser: a randomized controlled study Huijuan Liu et al. Lasers Med Sci. 2026. Show details Display options Display options Format Abstract PubMed PMID Lasers Med Sci Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lasers+Med+Sci%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lasers+Med+Sci%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42686896/) . 2026 Sep 3;41(1):212. doi: 10.1007/s10103-026-04995-1. ### Authors [Huijuan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Baiyu Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+B&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Xiaofeng He](https://pubmed.ncbi.nlm.nih.gov/?term=He+X&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Rui Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+R&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Runlin Mi](https://pubmed.ncbi.nlm.nih.gov/?term=Mi+R&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Chunyu Zhao](https://pubmed.ncbi.nlm.nih.gov/?term=Zhao+C&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-3 "La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China."), [Caixia Ye](https://pubmed.ncbi.nlm.nih.gov/?term=Ye+C&cauthor_id=42686896)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-1 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China."), [Wenna Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+W&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Hequn Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+H&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Zailing Zhu](https://pubmed.ncbi.nlm.nih.gov/?term=Zhu+Z&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Xiaoyin Zhou](https://pubmed.ncbi.nlm.nih.gov/?term=Zhou+X&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Kungchi Hsu](https://pubmed.ncbi.nlm.nih.gov/?term=Hsu+K&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Andrew Steel](https://pubmed.ncbi.nlm.nih.gov/?term=Steel+A&cauthor_id=42686896)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-3 "La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China."), [Jie Qiu](https://pubmed.ncbi.nlm.nih.gov/?term=Qiu+J&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Yi Yi](https://pubmed.ncbi.nlm.nih.gov/?term=Yi+Y&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Yueqing Niu](https://pubmed.ncbi.nlm.nih.gov/?term=Niu+Y&cauthor_id=42686896)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-2 "Research and Innovation Center, L'Oréal China, Shanghai, China."), [Claire Huguet](https://pubmed.ncbi.nlm.nih.gov/?term=Huguet+C&cauthor_id=42686896)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-4 "North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China."), [Wei Xiong](https://pubmed.ncbi.nlm.nih.gov/?term=Xiong+W&cauthor_id=42686896)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-4 "North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China."), [Valentine Beguin](https://pubmed.ncbi.nlm.nih.gov/?term=Beguin+V&cauthor_id=42686896)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-4 "North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China."), [Delphine Kerob](https://pubmed.ncbi.nlm.nih.gov/?term=Kerob+D&cauthor_id=42686896)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-5 "La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France, France."), [Yijie Zheng](https://pubmed.ncbi.nlm.nih.gov/?term=Zheng+Y&cauthor_id=42686896)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-6 "La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. Zhengyijie20171@outlook.com.")[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42686896/#short-view-affiliation-7 "Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. Zhengyijie20171@outlook.com.") ### Affiliations * 1 Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. * 2 Research and Innovation Center, L'Oréal China, Shanghai, China. * 3 La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. * 4 North Asia L'Oréal Dermatological Beauty, L'Oréal North Asia, Shanghai, China. * 5 La Roche-Posay Laboratoire Pharmaceutique, Levallois Perret, La Roche-Posay, France, France. * 6 La Roche Posay, L'Oréal Dermatological Beauty, L'Oréal China, Shanghai, China. Zhengyijie20171@outlook.com. * 7 Medical Department, L'Oréal Dermatological Beauty, L'Oréal, Shanghai, China. Zhengyijie20171@outlook.com. * PMID: **42686896** * DOI: [ 10.1007/s10103-026-04995-1 ](https://doi.org/10.1007/s10103-026-04995-1) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Pro-Xylane is a potent anti-aging ingredient; however, there is limited knowledge regarding whether a comprehensive post-procedure regimen incorporating a combination of Pro-Xylane, niacinamide, and panthenol alongside other active agents can deliver synergistic benefits for both skin barrier repair and anti-aging. This study assesses the effectiveness of the REGENMEDIC cream (anti-aging cream) and REGENMEDIC serum (anti-aging serum) in promoting skin barrier recovery and enhancing anti-aging effects following PicoWay laser treatment. A 112-day randomized controlled trial was conducted with 88 Chinese females, who were divided into two groups: the test group, using REGENMEDIC cream and Serum following PicoWay laser treatment, and the control group, using standard care regimen consisting of a standard cream. Skin barrier-repairing effects were assessed during the initial 14 days following a single use of REGENMEDIC cream, while skin elasticity, firmness, wrinkles and s
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