---
title: "Pythium oligandrum Alters Potato Rhizosphere Networks and Early Blight Control"
id: "biorxiv-8-building-bridges-belowground-pythium-oligandrum-en-hances-rhizosphere-network"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-8-building-bridges-belowground-pythium-oligandrum-en-hances-rhizosphere-network"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1?rss=1"
published_at: "2026-10-25T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Pythium oligandrum Alters Potato Rhizosphere Networks and Early Blight Control
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-8-building-bridges-belowground-pythium-oligandrum-en-hances-rhizosphere-network
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1?rss=1)
- **Published At:** 2026-10-25T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- Field trial on starch potato cultivar Kuras evaluated the biological control agent **Pythium oligandrum** against early blight and compared a laboratory strain, the commercial product **Polygandron**, and conventional fungicides. - The laboratory strain suppressed **early blight** at plant senescence, but investigators reported that suppression did not persist until harvest; fungicide treatment produced near-complete disease control throughout the season. - Rhizosphere fungal community composition showed a transient shift at flowering after **P. oligandrum** application; this change was not described as long-lasting by the authors. - Bacterial community richness varied over sampling times in untreated controls, according to the study team; overall bacterial composition was not substantially altered by **P. oligandrum** treatments. - Network-level analysis of bacterial co-occurrence revealed treatment-specific changes in connectivity: the laboratory strain increased network connectivity, producing almost a threefold rise in mean degree and greater interconnectedness among taxa. - In contrast, **Polygandron** and fungicide treatments reduced mean degree, indicating lower bacterial network connectivity under those interventions. - Fungicide application also altered network organisation metrics such as increased betweenness centrality and changes in modularity, the authors observed. - The investigators concluded that microbial network structure can reveal ecological effects of BCAs not visible in community-level metrics and recommended integrating network analyses when assessing BCAs. - The report is a preprint and has not been peer reviewed; the source did not report detailed dosing regimens or some procedural specifics in the abstract, and these details appear in supplementary material or full text rather than the abstract alone.
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Andersen, [ View ORCID Profile](http://orcid.org/0000-0002-9086-208X)Maja Brus-Szkale, [ View ORCID Profile](http://orcid.org/0000-0001-8124-0054)Linnea J. Stridh, [ View ORCID Profile](http://orcid.org/0000-0002-0850-4081)Asa Lankinen, [ View ORCID Profile](http://orcid.org/0000-0001-5910-3651)Laura J. Grenville-Briggs doi: https://doi.org/10.64898/2026.10.22.761010 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Natalia Ramirez Carrera Swedish University of Agricultural Sciences * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Natalia%2BRamirez%2BCarrera%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Ramirez%20Carrera%20N&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ANatalia%2BRamirez%2BCarrera%2B) * [ORCID record for Natalia Ramirez Carrera](http://orcid.org/0000-0003-4316-4104 "Open in new tab") * For correspondence: natalia.ramirez@slu.se Christian B. Andersen Swedish University of Agricultural Sciences * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Christian%2BB.%2BAndersen%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Andersen%20CB&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AChristian%2BB.%2BAndersen%2B) * [ORCID record for Christian B. Andersen](http://orcid.org/0000-0003-0824-8337 "Open in new tab") Maja Brus-Szkale Swedish University of Agricultural Sciences * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Maja%2BBrus-Szkale%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Brus-Szkale%20M&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMaja%2BBrus-Szkale%2B) * [ORCID record for Maja Brus-Szkale](http://orcid.org/0000-0002-9086-208X "Open in new tab") Linnea J. Stridh Swedish University of Agricultural Sciences * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Linnea%2BJ.%2BStridh%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Stridh%20LJ&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ALinnea%2BJ.%2BStridh%2B) * [ORCID record for Linnea J. Stridh](http://orcid.org/0000-0001-8124-0054 "Open in new tab") Asa Lankinen Swedish University of Agricultural Sciences * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Asa%2BLankinen%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Lankinen%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAsa%2BLankinen%2B) * [ORCID record for Asa Lankinen](http://orcid.org/0000-0002-0850-4081 "Open in new tab") Laura J. Grenville-Briggs Swedish University of Agricultural Sciences * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Laura%2BJ.%2BGrenville-Briggs%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=J.%20Grenville-Briggs%20L&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ALaura%2BJ.%2BGrenville-Briggs%2B) * [ORCID record for Laura J. Grenville-Briggs](http://orcid.org/0000-0001-5910-3651 "Open in new tab") * [Abstract](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5901350/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5901350/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5901350/1) * [Supplementary material](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.supplementary-material)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_data/node:5901350/1) * [Data/Code](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.external-links)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_data_code/node:5901350/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5901350/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Biological control agents (BCAs) offer a potential sustainable alternative to fungicides for crop dis-ease management, but their effects on resident plant microbiomes and microbial interactions remain poorly understood. Here, we investigated the effects of the BCA Pythium oligandrum on disease con-trol and the rhizosphere microbiome of starch potato cv. Kuras in a field trial. We compared a labora-tory strain and a commercial formulation (Polygandron) with commonly used fungicides during early blight development. The laboratory strain suppressed early blight at plant senescence, but this effect did not persist until harvest, whereas fungicide treatment provided near-complete disease suppression throughout the growing season. P. oligandrum caused transient changes in rhizosphere fungal com-munity composition at flowering, while bacterial community richness varied among sampling times in untreated controls. However, bacterial co-occurrence network analysis revealed pronounced treat-ment-specific changes in microbial connectivity. Application of the laboratory strain increased net-work connectivity, resulting in almost a threefold increase in mean degree and greater interconnected-ness among bacterial taxa. In contrast, Polygandron and fungicide treatments reduced mean degree, indicating reduced connectivity within the bacterial network. Fungicide treatment additionally altered network organisation, including increased betweenness centrality and changes in modularity. Togeth-er, our results show that P. oligandrum can modify microbial interactions in the potato rhizosphere without substantially altering overall bacterial community composition, highlighting the value of in-tegrating microbial network structure with community-level analyses when evaluating the ecological effects of BCAs. ### Competing Interest Statement The authors have declared no competing interest. ## Footnotes * ## Funder Information Declared The Swedish Research council, 2018-04354, 2023-05529 The Swedish Research Council Formas, 2019-00881, 2024-02274 SLU Grogrund The Carl Trygger foundation European Union’s Horizon 2020 research and innovation programme, MSCA-ITN-2017, 766048 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC-ND 4.0 International license](http://creativecommons.org/licenses/by-nc-nd/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. [Donate to openRxiv ](https://www.zeffy.com/en-US/donation-form/donate-to-make-a-difference-10981) [ Back to top](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1?rss=1#page) [ Previous](https://www.biorxiv.org/content/10.64898/2026.10.22.761036v1 "Anti-GABAB receptor autoimmunity causes cognitive decline by presynaptic pathology") Posted October 25, 2026. [ Download PDF](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/10/25/2026.10.22.761010.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [Supplementary Material ](https://www.biorxiv.org/content/10.64898/2026.10.22.761010v1.supplementary-material) [ Data/Code](https://www.biorxiv.org/content/early/2026/10/25/2026.10.22.761010.external-links) [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) Building Bridges Belowground: Pythium oligandrum En-hances Rhizosphere Network Connectivity Natalia Ramirez Carrera, Christian B. Andersen, Maja Brus-Szkale, Linnea J. Stridh, Asa Lankinen, Laura J. Grenville-Briggs bioRxiv 2026.10.22.761010; doi: https://doi.org/10.64898/2026.10.22.761010 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. 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