---
title: "Retraction Notice: Duplicate image concerns in osteopontin ocular surface study"
id: "plos-one-19-retraction-early-expression-of-osteopontin-glycoprotein-on-the-ocular-surface"
canonical_url: "https://medichelpline.com/clinical-feed/plos-one-19-retraction-early-expression-of-osteopontin-glycoprotein-on-the-ocular-surface"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PLOS ONE (Medicine)"
source_url: "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314"
published_at: "2026-09-01T14:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Retraction Notice: Duplicate image concerns in osteopontin ocular surface study
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/plos-one-19-retraction-early-expression-of-osteopontin-glycoprotein-on-the-ocular-surface
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PLOS ONE (Medicine)
- **Source URL:** [Original Journal Publication](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314)
- **Published At:** 2026-09-01T14:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- This PLOS One article is a formal **retraction** of a 2024 research paper reporting early expression of **osteopontin** on the ocular surface and in tear fluid in type 2 diabetic mice. - The retraction was issued by the **PLOS One** Editors and published with DOI 10.1371/journal.pone.0357314 on September 1, 2026. - The retraction stems from concerns about Figure 6A, where multiple labeled panels appear to derive from the same two images. - Specifically flagged panel groupings include: WT Week 4, WT Week 6, OPN-/- Week 4, OPN-/- Week 6, OPN-/- Week 8; and a second group WT Week 8, WT Week 10, OPN-/- Week 10, OPN-/- Week 16. - The corresponding author acknowledged that an error occurred during preparation of Figure 6A. - Despite that acknowledgement, the editors concluded the concerns about validity and integrity of the published results remained unresolved and therefore retracted the article. - Two authors (initials AD and MN) did not agree with the retraction; the author XYL either did not respond or could not be reached. - The retraction notice cites the original (now retracted) article reference and retains links to the original article page, PDF, and related metadata. - The notice is openly licensed under Creative Commons and is part of the journal record; it notes the retraction pertains to the earlier PLOS One article (e0313027 / pmid:39480896). - The editors’ statement focuses on image integrity in a key figure and documents the editorial decision, authors’ responses, and bibliographic details without providing additional experimental or corrective data.
## Clinical Analysis & Structured Key Points
[ Skip to main content ](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314#main-content) Advertisement * [plos.org](https://plos.org/) * [Create account](https://community.plos.org/registration/new) * [Sign in](https://journals.plos.org/user/secure/login?page=%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0357314) * * About * Browse * Publish * [](https://journals.plos.org/plosone/ "PLOS One") * Search [advanced search](https://journals.plos.org/plosone/search) * [Browse Topics](https://journals.plos.org/plosone/subjectAreaBrowse) Browse Subject Areas ? Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click [here](https://github.com/PLOS/plos-thesaurus/blob/master/README.md "Link opens in new window"). [](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314) [](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314) * 0 [Save](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#savedHeader) [Total Mendeley and Citeulike bookmarks.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#savedHeader) * 0 [Citation](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#citedHeader) [Paper's citation count computed by Dimensions.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#citedHeader) * 22 [View](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#viewedHeader) [PLOS views and downloads.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#viewedHeader) * 0 [Share](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#discussedHeader) [Sum of Facebook, Twitter, Reddit and Wikipedia activity.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314#discussedHeader) Open Access Retraction # Retraction: Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice * The PLOS One Editors # Retraction: Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice * The PLOS One Editors ![PLOS](https://journals.plos.org/resource/img/logo-plos-full-color.svg) x * Published: September 1, 2026 * * [Article](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314) * [Metrics](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357314) * [Comments](https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0357314) * [Media Coverage](http://plos.altmetric.com/details/doi/10.1371/journal.pone.0357314) * [Reference](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314#reference) * [Reader Comments](https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0357314) Following the publication of this article [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314#pone.0357314.ref001)], concerns were raised about Fig 6A. Specifically, the following panels appear to originate from the same two images: * WT Week 4, WT Week 6, OPN-/- Week 4, OPN-/- Week 6, and OPN-/- Week 8 * WT Week 8, WT Week 10, OPN-/- Week 10, and OPN-/- Week 16 The corresponding author stated that an error occurred during the preparation of Fig 6A. In light of the above unresolved concerns that question the validity and integrity of the published results in [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357314#pone.0357314.ref001)], the _PLOS One_ Editors retract this article. AD and MN did not agree with the retraction. XYL either did not respond directly or could not be reached. ## Reference 1. 1. Datta A, Li XY, Nagpaul M. RETRACTED: Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. PLoS One. 2024;19(10):e0313027. pmid:39480896 * [ View Article ](https://doi.org/10.1371/journal.pone.0313027 "Go to article") * [ PubMed/NCBI ](http://www.ncbi.nlm.nih.gov/pubmed/39480896 "Go to article in PubMed") * [ Google Scholar ](http://scholar.google.com/scholar?q=RETRACTED%3A+Early+expression+of+osteopontin+glycoprotein+on+the+ocular+surface+and+in+tear+fluid+contributes+to+ocular+surface+diseases+in+type+2+diabetic+mice+Datta+2024 "Go to article in Google Scholar") **Citation:** The _PLOS One_ Editors (2026) Retraction: Early expression of osteopontin glycoprotein on the ocular surface and in tear fluid contributes to ocular surface diseases in type 2 diabetic mice. PLoS One 21(9): e0357314. https://doi.org/10.1371/journal.pone.0357314 **Published:** September 1, 2026 **Copyright:** © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the [Creative Commons Attribution License](http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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) 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