---
title: "Rezpegaldesleukin (REZOLVE-AD) phase 2b: 16-week induction study of moderate-to-severe atopic derm"
id: "pubmed-42628554"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42628554"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42628554/"
doi: "10.1016/S0140-6736(26)01143-8"
published_at: "2026-08-29T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Rezpegaldesleukin (REZOLVE-AD) phase 2b: 16-week induction study of moderate-to-severe atopic derm
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42628554
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42628554/)
- **DOI:** [10.1016/S0140-6736(26)01143-8](https://doi.org/10.1016%2FS0140-6736(26)01143-8)
- **Published At:** 2026-08-29T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The REZOLVE-AD study evaluated **rezpegaldesleukin** in adults with moderate-to-severe **atopic dermatitis** during a 16-week induction period. - The trial was an international, randomized, double-blind, placebo-controlled **phase 2b** study. - The final results from the 16-week induction period were published in Lancet (Aug 29, 2026; Epub Aug 22, 2026). - The article lists a large, multi-country investigator group and numerous collaborating sites and investigators, reflecting a global study network. - The publication includes many academic and clinical authors and contributors from Nektar Therapeutics and multiple dermatology centers. - The PubMed entry provides bibliographic details (DOI: 10.1016/S0140-6736(26)01143-8) and a link to Elsevier Science full text options. - The abstract and PubMed record visible here describe study design and authorship but do not include outcome data, efficacy, or safety results in the provided excerpt. - Details such as participant numbers, baseline characteristics, primary and secondary endpoint results, statistical outcomes, and safety findings were not reported in the source excerpt available here. - Readers should consult the full Lancet article or publisher site for complete efficacy and safety data and for full methods, statistical analysis, and supplementary materials.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 22. # Rezpegaldesleukin treatment of moderate-to-severe atopic dermatitis (REZOLVE-AD): final results from the 16-week induction period of an international, double-blind, placebo-controlled, randomised phase 2b study [Jonathan I Silverberg](https://pubmed.ncbi.nlm.nih.gov/?term=Silverberg+JI&cauthor_id=42628554)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-1 "Department of Dermatology, George Washington University School of Medicine, Washington, DC, USA. Electronic address: jonathanisilverberg@gmail.com."), [David Rosmarin](https://pubmed.ncbi.nlm.nih.gov/?term=Rosmarin+D&cauthor_id=42628554)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-2 "Indiana University School of Medicine, Indianapolis, IN, USA."), [Thomas Bieber](https://pubmed.ncbi.nlm.nih.gov/?term=Bieber+T&cauthor_id=42628554)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-3 "Department of Dermatology and Allergy, Ludwig-Maximilians University Hospital, Munich, Germany."), [Raj Chovatiya](https://pubmed.ncbi.nlm.nih.gov/?term=Chovatiya+R&cauthor_id=42628554)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-4 "Rosalind Franklin University of Medicine and Science Chicago Medical School, North Chicago, IL, USA; Center for Medical Dermatology + Immunology Research, Chicago, IL, USA."), [Melinda Gooderham](https://pubmed.ncbi.nlm.nih.gov/?term=Gooderham+M&cauthor_id=42628554)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-5 "Department of Medicine, Queen's University, Kingston, ON, Canada."), [Spyridon Gkalpakiotis](https://pubmed.ncbi.nlm.nih.gov/?term=Gkalpakiotis+S&cauthor_id=42628554)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-6 "Department of Dermatovenereology, Third Faculty of Medicine, Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic."), [Adam Reich](https://pubmed.ncbi.nlm.nih.gov/?term=Reich+A&cauthor_id=42628554)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-7 "Department of Dermatology, Faculty of Medicine, Medical College of Rzeszów University, Rzeszów, Poland."), [Dedee F Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DF&cauthor_id=42628554)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-8 "School of Medicine, University of New South Wales, Sydney, NSW, Australia."), [Justyna Skibinska](https://pubmed.ncbi.nlm.nih.gov/?term=Skibinska+J&cauthor_id=42628554)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-9 "Klinika Ambroziak, Warsaw, Poland."), [Neil Sadick](https://pubmed.ncbi.nlm.nih.gov/?term=Sadick+N&cauthor_id=42628554)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-10 "Department Of Dermatology, Weill Cornell Medicine, New York, NY, USA; Sadick Research Group, New York, NY, USA."), [Iva Blajić](https://pubmed.ncbi.nlm.nih.gov/?term=Blaji%C4%87+I&cauthor_id=42628554)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-11 "Department of Dermatology, Sestre milosrdnice University Hospital Center, School of Medicine, Catholic University of Croatia, Zagreb, Croatia; Solmed Clinic, Zagreb, Croatia."), [Athanasios Tsianakas](https://pubmed.ncbi.nlm.nih.gov/?term=Tsianakas+A&cauthor_id=42628554)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-12 "Fachklinik Bad Bentheim, Bad Bentheim, Germany."), [Pablo Fernandez-Penas](https://pubmed.ncbi.nlm.nih.gov/?term=Fernandez-Penas+P&cauthor_id=42628554)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-13 "Department of Dermatology, Westmead Hospital, Sydney, NSW, Australia; Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, NSW, Australia."), [Johannes S Kern](https://pubmed.ncbi.nlm.nih.gov/?term=Kern+JS&cauthor_id=42628554)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-14 "The School of Translational Medicine, Monash University, and Department of Dermatology, Alfred Hospital, Melbourne, VIC, Australia."), [Trinidad Montero-Vílchez](https://pubmed.ncbi.nlm.nih.gov/?term=Montero-V%C3%ADlchez+T&cauthor_id=42628554)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-15 "Department of Dermatology at Hospital Universitario Virgen de las Nieves, Granada, Spain."), [Todor A Popov](https://pubmed.ncbi.nlm.nih.gov/?term=Popov+TA&cauthor_id=42628554)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-16 "University Hospital St Ivan Rilski, Sofia, Bulgaria."), [Anil Kurian](https://pubmed.ncbi.nlm.nih.gov/?term=Kurian+A&cauthor_id=42628554)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-17 "VIDA Clinical Research, Edmonton, ON, Canada."), [Maxwell B Sauder](https://pubmed.ncbi.nlm.nih.gov/?term=Sauder+MB&cauthor_id=42628554)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-18 "University of Toronto, Toronto, ON, Canada; Probity Medical Research, Waterloo, ON, Canada."), [Vivian T Laquer](https://pubmed.ncbi.nlm.nih.gov/?term=Laquer+VT&cauthor_id=42628554)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-19 "First OC Dermatology Research Inc, Fountain Valley, CA, USA."), [Sohail Chaudhry](https://pubmed.ncbi.nlm.nih.gov/?term=Chaudhry+S&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Zachary H Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+ZH&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Maria Hannaway](https://pubmed.ncbi.nlm.nih.gov/?term=Hannaway+M&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Danni Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+D&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Yi Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Y&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Christie Fanton](https://pubmed.ncbi.nlm.nih.gov/?term=Fanton+C&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Hong Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+H&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Brian Kotzin](https://pubmed.ncbi.nlm.nih.gov/?term=Kotzin+B&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Mary Tagliaferri](https://pubmed.ncbi.nlm.nih.gov/?term=Tagliaferri+M&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Jonathan Zalevsky](https://pubmed.ncbi.nlm.nih.gov/?term=Zalevsky+J&cauthor_id=42628554)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-20 "Nektar Therapeutics, San Francisco, CA, USA."), [Richard B Warren](https://pubmed.ncbi.nlm.nih.gov/?term=Warren+RB&cauthor_id=42628554)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42628554/#full-view-affiliation-21 "Dermatology Centre, Northern Care Alliance NHS Foundation Trust and Division of Musculoskeletal and Dermatological Sciences, NIHR Manchester Biomedical Research Centre, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK."); [REZOLVE-AD Study Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=REZOLVE-AD+Study+Investigators%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **REZOLVE-AD Study Investigators** : [Idalia A Acosta](https://pubmed.ncbi.nlm.nih.gov/?term=Acosta+IA), [Lorne E Albrecht](https://pubmed.ncbi.nlm.nih.gov/?term=Albrecht+LE), [Suresh Anne](https://pubmed.ncbi.nlm.nih.gov/?term=Anne+S), [Karolina Antkowiak-Piatyszek](https://pubmed.ncbi.nlm.nih.gov/?term=Antkowiak-Piatyszek+K), [Miguel A Aponte](https://pubmed.ncbi.nlm.nih.gov/?term=Aponte+MA), [Eddie Armas](https://pubmed.ncbi.nlm.nih.gov/?term=Armas+E), [Wojciech Baran](https://pubmed.ncbi.nlm.nih.gov/?term=Baran+W), [Andrea Bartlova](https://pubmed.ncbi.nlm.nih.gov/?term=Bartlova+A), [Iva Blajic](https://pubmed.ncbi.nlm.nih.gov/?term=Blajic+I), [Wanda Boote](https://pubmed.ncbi.nlm.nih.gov/?term=Boote+W), [Petyo Brezoev](https://pubmed.ncbi.nlm.nih.gov/?term=Brezoev+P), [Simona Bukalova](https://pubmed.ncbi.nlm.nih.gov/?term=Bukalova+S), [Dianne E Burrows](https://pubmed.ncbi.nlm.nih.gov/?term=Burrows+DE), [Lauren S Campbell](https://pubmed.ncbi.nlm.nih.gov/?term=Campbell+LS), [Tadeusz Debniak](https://pubmed.ncbi.nlm.nih.gov/?term=Debniak+T), [Malgorzata Dyczek](https://pubmed.ncbi.nlm.nih.gov/?term=Dyczek+M), [Samantha Eisman](https://pubmed.ncbi.nlm.nih.gov/?term=Eisman+S), [Brian J Feinstein](https://pubmed.ncbi.nlm.nih.gov/?term=Feinstein+BJ), [Pablo Fernandez-Penas](https://pubmed.ncbi.nlm.nih.gov/?term=Fernandez-Penas+P), [Lara Ferrandiz-Pulido](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrandiz-Pulido+L), [Ryszard Galus](https://pubmed.ncbi.nlm.nih.gov/?term=Galus+R), [Jorge Garcia-Zuazaga](https://pubmed.ncbi.nlm.nih.gov/?term=Garcia-Zuazaga+J), [Spyridon Gkalpakiotis](https://pubmed.ncbi.nlm.nih.gov/?term=Gkalpakiotis+S), [Melinda J Gooderham](https://pubmed.ncbi.nlm.nih.gov/?term=Gooderham+MJ), [Suzana L Hadzavdic](https://pubmed.ncbi.nlm.nih.gov/?term=Hadzavdic+SL), [Sameh Hanna](https://pubmed.ncbi.nlm.nih.gov/?term=Hanna+S), [Adelaide Hebert](https://pubmed.ncbi.nlm.nih.gov/?term=Hebert+A), [Anna Janowicz](https://pubmed.ncbi.nlm.nih.gov/?term=Janowicz+A), [Virginie Kelly](https://pubmed.ncbi.nlm.nih.gov/?term=Kelly+V), [Johannes S Kern](https://pubmed.ncbi.nlm.nih.gov/?term=Kern+JS), [Mark Knautz](https://pubmed.ncbi.nlm.nih.gov/?term=Knautz+M), [Joanna Kolinek](https://pubmed.ncbi.nlm.nih.gov/?term=Kolinek+J), [Tomasz Kolodziej](https://pubmed.ncbi.nlm.nih.gov/?term=Kolodziej+T), [Dorota Kolodziejczyk](https://pubmed.ncbi.nlm.nih.gov/?term=Kolodziejczyk+D), [Gordana Krnjevic-Pezic](https://pubmed.ncbi.nlm.nih.gov/?term=Krnjevic-Pezic+G), [Anil Kurian](https://pubmed.ncbi.nlm.nih.gov/?term=Kurian+A), [Vivian T Laquer](https://pubmed.ncbi.nlm.nih.gov/?term=Laquer+VT), [Jessie Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+J), [Aleksandra Lesiak](https://pubmed.ncbi.nlm.nih.gov/?term=Lesiak+A), [Anna Luty](https://pubmed.ncbi.nlm.nih.gov/?term=Luty+A), [Charles W Lynde](https://pubmed.ncbi.nlm.nih.gov/?term=Lynde+CW), [Bernadetta Majorek-Olechowska](https://pubmed.ncbi.nlm.nih.gov/?term=Majorek-Olechowska+B), [Grisha Mateev](https://pubmed.ncbi.nlm.nih.gov/?term=Mateev+G), [Virgil-Oreste Mihaescu](https://pubmed.ncbi.nlm.nih.gov/?term=Mihaescu+VO), [Ali Moiin](https://pubmed.ncbi.nlm.nih.gov/?term=Moiin+A), [Trinidad Montero-Vilchez](https://pubmed.ncbi.nlm.nih.gov/?term=Montero-Vilchez+T), [Servando M Moya](https://pubmed.ncbi.nlm.nih.gov/?term=Moya+SM), [Dedee F Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DF), [Aleksandra Okuniewska](https://pubmed.ncbi.nlm.nih.gov/?term=Okuniewska+A), [Witold Owczarek](https://pubmed.ncbi.nlm.nih.gov/?term=Owczarek+W), [Cindy E Owen](https://pubmed.ncbi.nlm.nih.gov/?term=Owen+CE), [Kamila Padlewska](https://pubmed.ncbi.nlm.nih.gov/?term=Padlewska+K), [Andreas Pinter](https://pubmed.ncbi.nlm.nih.gov/?term=Pinter+A), [Todor A Popov](https://pubmed.ncbi.nlm.nih.gov/?term=Popov+TA), [Vimal H Prajapati](https://pubmed.ncbi.nlm.nih.gov/?term=Prajapati+VH), [Grazyna Pulka](https://pubmed.ncbi.nlm.nih.gov/?term=Pulka+G), [Mani Raman](https://pubmed.ncbi.nlm.nih.gov/?term=Raman+M), [Maria Ratkova](https://pubmed.ncbi.nlm.nih.gov/?term=Ratkova+M), [Katherine Reed](https://pubmed.ncbi.nlm.nih.gov/?term=Reed+K), [Adam Reich](https://pubmed.ncbi.nlm.nih.gov/?term=Reich+A), [Joanna Renczynska-Matysko](https://pubmed.ncbi.nlm.nih.gov/?term=Renczynska-Matysko+J), [Craig Rohan](https://pubmed.ncbi.nlm.nih.gov/?term=Rohan+C), [David Rosmarin](https://pubmed.ncbi.nlm.nih.gov/?term=Rosmarin+D), [Juan Ruano-Ruiz](https://pubmed.ncbi.nlm.nih.gov/?term=Ruano-Ruiz+J), [Franziska Ruéff](https://pubmed.ncbi.nlm.nih.gov/?term=Ru%C3%A9ff+F), [Neil S Sadick](https://pubmed.ncbi.nlm.nih.gov/?term=Sadick+NS), [Marina Sankeva](https://pubmed.ncbi.nlm.nih.gov/?term=Sankeva+M), [Maxwell B Sauder](https://pubmed.ncbi.nlm.nih.gov/?term=Sauder+MB), [Michał Seneczko](https://pubmed.ncbi.nlm.nih.gov/?term=Seneczko+M), [Maryam Shayesteh Alam](https://pubmed.ncbi.nlm.nih.gov/?term=Shayesteh+Alam+M), [Elliot Shin](https://pubmed.ncbi.nlm.nih.gov/?term=Shin+E), [Shireen K Sidhu](https://pubmed.ncbi.nlm.nih.gov/?term=Sidhu+SK), [Joanna Sieniawska](https://pubmed.ncbi.nlm.nih.gov/?term=Sieniawska+J), [Juan Francisco Silvestre Salvador](https://pubmed.ncbi.nlm.nih.gov/?term=Silvestre+Salvador+JF), [Jan C Simon](https://pubmed.ncbi.nlm.nih.gov/?term=Simon+JC), [Margrit Si
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> [!CAUTION]
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