---
title: "Single Preoperative Low-Dose Dexamethasone Lowers 1-Year Mortality After Geriatric Intertrochanter"
id: "pubmed-40736223"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-40736223"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/40736223/"
doi: "10.1097/CM9.0000000000003731"
published_at: "2026-08-20T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Single Preoperative Low-Dose Dexamethasone Lowers 1-Year Mortality After Geriatric Intertrochanter
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-40736223
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/40736223/)
- **DOI:** [10.1097/CM9.0000000000003731](https://doi.org/10.1097%2FCM9.0000000000003731)
- **Published At:** 2026-08-20T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This randomized, single-blinded, placebo-controlled trial tested whether a single preoperative **low-dose dexamethasone** (10 mg IV) given 30 minutes before internal fixation reduces **1-year mortality** in geriatric femoral intertrochanteric fracture (ITF) patients. - The single-center study enrolled 160 patients between June 2020 and October 2022; participants were randomized 1:1 to dexamethasone (n=80) or placebo (2 mL saline, n=80). - All participants completed follow-up to one year. Overall, 41 participants died within one year: 15 (18.8%) in the dexamethasone group and 26 (32.5%) in the placebo group. - The reported hazard ratio for 1-year mortality was 0.51 (95% CI 0.27–0.96), with P = 0.04 by Log-rank test, indicating a statistically significant reduction in mortality for the dexamethasone group. - Secondary outcomes included in-hospital adverse events, Barthel activity of daily living (BADL) score and Parker-Palmer score (PPS) at 30, 90, 180 days and 1 year; survivors in the dexamethasone group had higher BADL and PPS scores numerically but differences were not statistically significant (P > 0.05). - No significant differences were found between groups for in-hospital infection events or hyperglycemia (P > 0.05). - The authors conclude that a single preoperative low-dose dexamethasone reduces 1-year mortality after internal fixation for geriatric ITF and may favorably affect functional recovery in survivors. - Trial registration: Chinese Clinical Trial Registry ChiCTR2200055281. Conflict of interest: none reported. - Details on other potential limitations, subgroup analyses, long-term adverse effects, or mechanistic data were not reported in the source abstract and would require full-text review for clarification.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/40736223/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F40736223%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/40736223/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/40736223/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/40736223/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/af7de7da-df5d-41c6-8de4-8c266af8ccfb/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/40736223/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/40736223/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/40736223/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F40736223%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F40736223%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/40736223/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/40736223/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/40736223/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/40736223/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Wolters Kluwer full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--static.lww.com-pubmed-wolters-kluwer-non-oa-articles.png) Wolters Kluwer ](https://www.ovid.com/10.1097/CM9.0000000000003731 "See full text options at Wolters Kluwer") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/40736223/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/40736223/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/40736223/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/40736223/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/40736223/#conflict-of-interest) * [ Figures ](https://pubmed.ncbi.nlm.nih.gov/40736223/#figures) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/40736223/#similar) * [ References ](https://pubmed.ncbi.nlm.nih.gov/40736223/#references) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/40736223/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/40736223/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/40736223/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/40736223/#related-links) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/40736223/#linkout) Title & authors Abstract Conflict of interest statement Figures Similar articles References Publication types MeSH terms Substances Related information LinkOut - more resources Randomized Controlled Trial Chin Med J (Engl) Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chin+Med+J+%28Engl%29%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Chin+Med+J+%28Engl%29%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) . 2026 Aug 20;139(16):2443-2449. doi: 10.1097/CM9.0000000000003731. Epub 2025 Jul 30. # Efficacy of a single preoperative low-dose dexamethasone on 1-year mortality in geriatric femoral intertrochanteric fracture patients after internal fixation surgery: A randomized, placebo-controlled clinical trial [Jianwen Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+J&cauthor_id=40736223)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40736223/#full-view-affiliation-1 "Department of Orthopaedic Surgery, Guangzhou First People's Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China."), [Yunfa Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Y&cauthor_id=40736223), [Xiaosheng Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+X&cauthor_id=40736223), [Zhonghe Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Z&cauthor_id=40736223) Affiliations Expand ### Affiliation * 1 Department of Orthopaedic Surgery, Guangzhou First People's Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China. * PMID: **40736223** * PMCID: [ PMC13485831 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13485831/) * DOI: [ 10.1097/CM9.0000000000003731 ](https://doi.org/10.1097/cm9.0000000000003731) Item in Clipboard Randomized Controlled Trial # Efficacy of a single preoperative low-dose dexamethasone on 1-year mortality in geriatric femoral intertrochanteric fracture patients after internal fixation surgery: A randomized, placebo-controlled clinical trial Jianwen Huang et al. Chin Med J (Engl). 2026. Show details Display options Display options Format Abstract PubMed PMID Chin Med J (Engl) Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chin+Med+J+%28Engl%29%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Chin+Med+J+%28Engl%29%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) . 2026 Aug 20;139(16):2443-2449. doi: 10.1097/CM9.0000000000003731. Epub 2025 Jul 30. ### Authors [Jianwen Huang](https://pubmed.ncbi.nlm.nih.gov/?term=Huang+J&cauthor_id=40736223)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/40736223/#short-view-affiliation-1 "Department of Orthopaedic Surgery, Guangzhou First People's Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China."), [Yunfa Yang](https://pubmed.ncbi.nlm.nih.gov/?term=Yang+Y&cauthor_id=40736223), [Xiaosheng Gao](https://pubmed.ncbi.nlm.nih.gov/?term=Gao+X&cauthor_id=40736223), [Zhonghe Xu](https://pubmed.ncbi.nlm.nih.gov/?term=Xu+Z&cauthor_id=40736223) ### Affiliation * 1 Department of Orthopaedic Surgery, Guangzhou First People's Hospital, the Second Affiliated Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong 510180, China. * PMID: **40736223** * PMCID: [ PMC13485831 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13485831/) * DOI: [ 10.1097/CM9.0000000000003731 ](https://doi.org/10.1097/cm9.0000000000003731) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** The prognosis of geriatric intertrochanteric fractures (ITF) remains unfavorable even with early surgical treatment due to the fragility associated with aging and stress induced by the fracture. Low-dose dexamethasone has been proposed to improve short-term survival. However, whether a single preoperative dose of low-dose dexamethasone improves survival one year after surgery remains unknown. **Methods:** This single-center, single-blinded, randomized, placebo-controlled study was conducted at Guangzhou First People's Hospital. A total of 160 participants admitted between June 2020 and October 2022 were randomly assigned to the dexamethasone group or the placebo group (80 participants per group). The dexamethasone group received 10 mg (2 mL) of dexamethasone and the placebo group received 2 mL of saline intravenously 30 min before surgery. The primary outcome was the prespecified 1-year mortality after surgery. Secondary outcomes included adverse events during hospitalization, Barthel activity of daily living (BADL) score and Parker-Palmer score (PPS) at 30 days, 90 days, 180 days, and 1 year after surgery. Statistical analyses included Studen's t -test or Mann-Whitney U test for quantitative variables, chi-squared test for categorical variables, and Log-rank test for survival differences. **Results:** All participants completed the follow-up. A total of 41 participants died within one year after surgery. There were 15 deaths (18.8%) in the dexamethasone group and 26 deaths (32.5%) in the placebo group (hazard ratio [HR] = 0.51, 95% confidence intervals [CI] = 0.27-0.96, P = 0.04). There were no significant differences in the risk of infection events or hyperglycemia during hospitalization between the dexamethasone and placebo groups ( P >0.05). Although survivors in the dexamethasone group had higher BADL and PPS scores at 30 days, 90 days, 180 days, and 1 year after surgery compared to those in the placebo group, no significant differences were found between the groups at these time points ( P >0.05). **Conclusions:** A single preoperative low-dose dexamethasone administration reduces 1-year mortality in geriatric ITF patients following internal fixation surgery and may positively impact functional recovery in survivors. **Trial registration:** Chinese Clinical Trial Registry, ChiCTR2200055281. **Keywords:** Aged; Dexamethasone; Hip fractures; Mortality; Survival. Copyright © 2025 The Chinese Medical Association, produced by Wolters Kluwer Health, LLC. under the CC-BY-NC-ND license. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement None. ## Figures [ ![Figure 1](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c4/13485831/0b2cc55dffd4/cm9-139-2443-g001.gif) ](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c4/13485831/c0a322f2caec/cm9-139-2443-g001.jpg) ** Figure 1 ** The study flowchart to evaluate… ** Figure 1 ** The study flowchart to evaluate the efficacy of a single preoperative low-dose dexamethasone… **Figure 1** The study flowchart to evaluate the efficacy of a single preoperative low-dose dexamethasone on 1-year mortality in geriatric femoral intertrochanteric fracture patients after internal fixation surgery. Dexa: Dexamethasone. [ ![Figure 2](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c4/13485831/802b30654067/cm9-139-2443-g002.gif) ](https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c4/13485831/08aa34dc9c91/cm9-139-2443-g002.jpg) ** Figure 2 ** Comparison of survival curves between… ** Figure 2 ** Comparison of survival curves between the two groups using the Log-rank test. A… **Figure 2** Comparison of survival curves between the two groups using the Log-rank test. A total of 41 patients died within one year after surgery, with 15 deaths (18.8%) in the dexamethasone (Dexa) group and 26 deaths (32.5%) in the placebo group (HR = 0.51, 95% CI = 0.27–0.96, _P_ = 0.04). HR: hazard ratio. [See this image and copyright information in PMC](https://pubmed.ncbi.nlm.nih.gov/40736223/) ## Similar articles * [ The impact of preoperative single low-dose dexamethasone on in-hospital prognosis in geriatric intertrochanteric fracture patients: Analysis of secondary outcomes in a randomized controlled trial. ](https://pubmed.ncbi.nlm.nih.gov/37481423/) Huang JW, Yang YF, Gao XS, Zhou M, Xiao N, Kuang JX, Xu ZH.Huang JW, et al.Surgery. 2023 Oct;174(4):1041-1049. doi: 10.1016/j.surg.2023.06.013. Epub 2023 Jul 21.Surgery. 2023.PMID: 37481423Clinical Trial. * [ Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas. ](https://pubmed.ncbi.nlm.nih.gov/36321557/) Crider K, Williams J, Qi YP, Gutman J, Yeung L, Mai C, Finkelstain J, Mehta S, Pons-Duran C, Menéndez C, Moraleda C, Rogers L, Daniels K, Green P.Crider K, et al.Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.Cochrane Database Syst Rev. 2022.Update in: [Cochrane Database Syst Rev. 2026 Feb 18;2:CD014217. doi: 10.1002/14651858.CD014217.pub2.](https://pubmed.ncbi.nlm.nih.gov/41705996/)PMID: 36321557Free PMC article.Updated. * [ Preoperative low-dose dexmedetomidine reduces postoperative delirium in elderly patients with hip fracture under spinal anesthesia: A randomized, double blind, controlled clinical study. ](https://pubmed.ncbi.nlm.nih.gov/40513143/) Geng P, Shang Z, Cheng F, Zhang Y, Deng X, Chen X, Zhan L, Zheng L, Liu X.Geng P, et al.J Clin Anesth. 2025 Jul;105:111897. doi: 10.1016/j.jclinane.2025.111897. Epub 2025 Jun 12.J Clin Anesth. 2025.PMID: 40513143Clinical Trial. * [ Prognostic Implications of Preoperative Pneumonia for Geriatric Patients Undergoing Hip Fracture Surgery or Arthroplasty. ](https://pubmed.ncbi.nlm.nih.gov/33112045/) Shen JW, Zhang PX, An YZ, Jiang BG.Shen JW, et al.Orthop Surg. 2020 Dec;12(6):1890-1899. doi: 10.1111/os.12830. Epub 2020 Oct 28.Orthop Surg. 2020.PMID: 33112045Free PMC article. * [ Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. ](https://pubmed.ncbi.nlm.nih.gov/33075160/) Weibel S, Rücker G, Eberhart LH, Pace NL, Hartl HM, Jordan OL, Mayer D, Riemer M, Schaefer MS, Raj D, Backhaus I, Helf A, Schlesinger T, Kienbaum P, Kranke P.Weibel S, et al.Cochrane Database Syst Rev. 2020 Oct 19;10(10):CD012859. doi: 10.1002/14651858.CD012859.pub2.Cochrane Database Syst Rev. 2020.PMID: 33075160Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=40736223) ## References 1. 1. Veronese N, Maggi S. Epidemiology and social costs of hip fracture. Injury 2018;49:1458–1460.doi: 10.1016/j.injury.2018.04.015. - [PubMed](https://pubmed.ncbi.nlm.nih.gov/29699731/) 2. 1. Rolland Y Abellan van Kan G Bénétos A Blain H Bonnefoy M Chassagne P, et al. Frailty, osteoporosis and hip fracture: causes, consequences and therapeutic perspectives. J Nutr Health Aging 2008;12:335–346.doi: 10.1007/bf02982665. - [PubMed](https://pubmed.ncbi.nlm.nih.gov/18443717/) 3. 1. Liu H, Yin P, Qi J, Zhou M. Burden of non-communicable diseases in China and its provinces, 1990-2021: Results from the Global Burden of Disease Study 2021. Chin Med J 2024;137:2325–2333. doi: 10.1097/CM9.0000000000003270. - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC11441934/) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/39193717/) 4. 1. Xia C Dong X Li H Cao M Sun D He S, et al. Cancer statistics in China and United States, 2022: profiles, trends, and determinants. Chin Med J 2022;135:584–590. doi: 10.1097/cm9.0000000000002108. - [PMC](https://pmc.ncbi.nlm.nih.gov/articles/PMC8920425/) - [PubMed](https://pubmed.ncbi.nlm.nih.gov/35143424/) 5. 1. Haentjens P, Autier P, Barette M, Venken K, Vanderschueren D, Boonen S. Survival and functional outcome according to hip fracture type: A one-year prospective cohort study in elderly women with an intertrochanteric or femoral neck fracture. Bone 2007;41:958–964. doi: 10.1016/j.bone.2007.08.026. - [PubMed](https://pubmed.ncbi.nlm.nih.gov/17913614/) Show all 46 references ## Publication types * Randomized Controlled Trial Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Randomized+Controlled+Trial%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Randomized+Controlled+Trial) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) ## MeSH terms * Aged Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) * Aged, 80 and over Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Aged%2C+80+and+over%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Aged%2C+80+and+over) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) * Dexamethasone* / administration & dosage Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Dexamethasone%2Fadministration+and+dosage%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Dexamethasone) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) * Dexamethasone* / therapeutic use Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Dexamethasone%2Ftherapeutic+use%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Dexamethasone) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/40736223/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&so
## Related Clinical Research

- [SGLT2 Inhibitors Linked to Suppression of the Sema3A/NRP1/Plexin-A1 Axis in Postmenopausal T2D Wom](https://medichelpline.com/clinical-feed/pubmed-42649130.md) (DOI: 10.1111/1753-0407.70262)
- [Piecing Together the Adrenal Puzzle: CAI Score and Postoperative Testing](https://medichelpline.com/clinical-feed/endocrine-news-1-piecing-together-the-adrenal-puzzle.md)
- [Intravenous dexamethasone prolongs analgesia after supraclavicular brachial plexus block: randomiz](https://medichelpline.com/clinical-feed/pubmed-42691058.md) (DOI: 10.1371/journal.pone.0338067)
- [OCTA quantifies choroidal and retinal thinning and blood flow loss in lens-induced myopia rats](https://medichelpline.com/clinical-feed/plos-one-17-quantitative-analysis-of-choroidal-and-retinal-thickness-and-blood-flow-in-a.md)
- [FRACTURE-ML: Nationwide machine-learning tool for population hip fracture prediction](https://medichelpline.com/clinical-feed/plos-medicine-2-a-clinical-decision-support-tool-for-accurate-hip-fracture-prediction-a.md)

## Navigation
- [← Back to General Feed](https://medichelpline.com/clinical-feed/general.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.