---
title: "Spatiotemporal atlas maps the mesenchymal-epithelial stem cell axis in human hair follicle aging a"
id: "biorxiv-9-spatiotemporal-atlas-resolves-the-mesenchymal-epithelial-stem-cell-axis"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-9-spatiotemporal-atlas-resolves-the-mesenchymal-epithelial-stem-cell-axis"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.22.753364v1?rss=1"
published_at: "2026-09-23T09:50:14.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Spatiotemporal atlas maps the mesenchymal-epithelial stem cell axis in human hair follicle aging a
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-9-spatiotemporal-atlas-resolves-the-mesenchymal-epithelial-stem-cell-axis
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.22.753364v1?rss=1)
- **Published At:** 2026-09-23T09:50:14.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- This source is a bioRxiv preprint entitled “Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology.” - The study appears focused on a **spatiotemporal atlas** that characterizes the **mesenchymal-epithelial stem cell axis** relevant to **human hair follicle aging** and associated pathology. - A large multi-author team from BGI Research and affiliated institutions (including Westlake University and other centers) authored the preprint; multiple laboratories and key laboratories of spatial omics/genomics are represented. - The document provided is a preprint (not peer-reviewed) with DOI https://doi.org/10.64898/2026.09.22.753364; the source page lists authors, affiliations, and article metadata. - The source text available for this rewrite includes title, author list, affiliations and metadata but does not include the manuscript abstract, methods, results, figures, or conclusions in the provided excerpt. - Because the supplied source content omits experimental details, specific findings, methods, sample sizes, and data are not reported here and therefore cannot be restated or summarized beyond the high-level focus described in the title. - The preprint likely addresses cellular organization, spatial relationships, and temporal dynamics of stem cell populations in the hair follicle, but concrete data and conclusions were not available in the provided text. - Readers should consult the full preprint on bioRxiv for complete methods, results, data access, and any subsequent peer-reviewed publication for validated conclusions. - Key terms for search and indexing based on the source include **spatiotemporal atlas**, **mesenchymal-epithelial stem cell axis**, **hair follicle aging**, and **pathology**. - The document is intended for researchers in stem cell biology, dermatology research, aging biology, and spatial omics, but detailed applicability or translational claims were not reported in the excerpt provided.
## Clinical Analysis & Structured Key Points
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Xiaoyu Wei 1 State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou 310030, China; Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou 310030, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Xiaoyu%2BWei%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Wei%20X&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AXiaoyu%2BWei%2B) Yanwen Xu 2 Department of Medical Cosmetic Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Yanwen%2BXu%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Xu%20Y&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AYanwen%2BXu%2B) Jiaxin Du 3 BGI Research, Hangzhou 310030, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Jiaxin%2BDu%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Du%20J&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AJiaxin%2BDu%2B) Ruikang Li 4 BGI Research, Hangzhou 310030, China; College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; Key Laboratory of Resources Biology and Biotechnology in Western China, Ministry of Education, Provincial Key Laboratory of B; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Ruikang%2BLi%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Li%20R&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ARuikang%2BLi%2B) Zhentao Zhou 2 Department of Medical Cosmetic Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Zhentao%2BZhou%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Zhou%20Z&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AZhentao%2BZhou%2B) Yeya Yu 5 Key Laboratory of Brain Cell Mapping of Zhejiang Province, BGI Research, Hangzhou 310030, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Yeya%2BYu%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Yu%20Y&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AYeya%2BYu%2B) Zishuo Yuan 6 State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou 310030, China; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou 310030, China; BGI Research, Shenzhen 518083, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Zishuo%2BYuan%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Yuan%20Z&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AZishuo%2BYuan%2B) Hanxiao Cheng 2 Department of Medical Cosmetic Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Hanxiao%2BCheng%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Cheng%20H&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AHanxiao%2BCheng%2B) Yujia Jiang 7 Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou 310030, China; Department of Biology, University of Copenhagen, DK-2100 Copenhagen, Denmark; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Yujia%2BJiang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Jiang%20Y&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AYujia%2BJiang%2B) Fei Zhu 2 Department of Medical Cosmetic Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Fei%2BZhu%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Zhu%20F&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AFei%2BZhu%2B) Pengfei Cai 6 State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou 310030, China; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou 310030, China; BGI Research, Shenzhen 518083, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Pengfei%2BCai%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Cai%20P&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3APengfei%2BCai%2B) Haiyan Shen 2 Department of Medical Cosmetic Center, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Haiyan%2BShen%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Shen%20H&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AHaiyan%2BShen%2B) Shuai Wang 8 BGI Research, HangzhouCollege of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China; BGI Research, Shenzhen 518083, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Shuai%2BWang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Wang%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AShuai%2BWang%2B) Yue Yuan 6 State Key Laboratory of Genome and Multi-omics Technologies, BGI Research, Hangzhou 310030, China; Key Laboratory of Spatial Omics of Zhejiang Province, BGI Research, Hangzhou 310030, China; BGI Research, Shenzhen 518083, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Yue%2BYuan%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Yuan%20Y&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AYue%2BYuan%2B) Xiawei Liu 9 BGI Research, Qingdao 266555, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Xiawei%2BLiu%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Liu%20X&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AXiawei%2BLiu%2B) Tao Yang 10 China National GeneBank, BGI Research, Shenzhen 518120, China; Guangdong Provincial Genomics Data Center, BGI Research, Shenzhen 518120, China; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Tao%2BYang%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Yang%20T&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ATao%2BYang%2B) Yinghua Huang 11 BGI Cell, Hangzhou 310030, China; 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