---
title: "Subcutaneous efgartigimod plus prednisone in moderate-to-severe pemphigus: phase III ADDRESS trial"
id: "pubmed-42723554"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42723554"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42723554/"
doi: "10.1093/bjd/ljag199"
published_at: "2026-10-19T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Subcutaneous efgartigimod plus prednisone in moderate-to-severe pemphigus: phase III ADDRESS trial
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42723554
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42723554/)
- **DOI:** [10.1093/bjd/ljag199](https://doi.org/10.1093%2Fbjd%2Fljag199)
- **Published At:** 2026-10-19T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PubMed record describes a global, **phase III**, randomised, double-blind, controlled trial titled ADDRESS that evaluated subcutaneous **efgartigimod** combined with prednisone in moderate-to-severe **pemphigus**. - The article is published in the British Journal of Dermatology (Br J Dermatol) and lists Pascal Joly et al. as primary authors; the DOI is 10.1093/bjd/ljag199 and the PMID is 42723554. - The citation indicates a clinical trial format and multiple international collaborators under the ADDRESS Investigator Study Group; institutional affiliation shown includes Rouen University Hospital, INSERM U1234 Normandie University. - The PubMed page supplied here contains metadata, author and collaborator lists, journal citation, DOI, and publication details, but the provided extract does not include the article abstract or numerical efficacy and safety outcomes. - The source did not report sample size, primary and secondary endpoints, statistical results, adverse-event rates, dosing regimen, treatment duration, or efficacy/safety conclusions in the visible content. - Key unanswered items from this source include efficacy outcomes, safety and tolerability data, corticosteroid-sparing effects, responder definitions, and planned regulatory or clinical next steps. - Readers should consult the full-text Br J Dermatol article (DOI above) for trial methodology, endpoints, results, and discussion because those core trial data are not present in the PubMed excerpt shown here.
## Clinical Analysis & Structured Key Points
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Joly](https://pubmed.ncbi.nlm.nih.gov/?term=Joly+P&cauthor_id=42723554)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42723554/#full-view-affiliation-1 "Department of Dermatology, Rouen University Hospital, INSERM U1234 Normandie University, Rouen, France."), [Dedee F Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DF&cauthor_id=42723554), [Yumi Aoyama](https://pubmed.ncbi.nlm.nih.gov/?term=Aoyama+Y&cauthor_id=42723554), [Frédéric Caux](https://pubmed.ncbi.nlm.nih.gov/?term=Caux+F&cauthor_id=42723554), [Dipankar De](https://pubmed.ncbi.nlm.nih.gov/?term=De+D&cauthor_id=42723554), [Marilena Flouri](https://pubmed.ncbi.nlm.nih.gov/?term=Flouri+M&cauthor_id=42723554), [Matthias Goebeler](https://pubmed.ncbi.nlm.nih.gov/?term=Goebeler+M&cauthor_id=42723554), [Chao Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+C&cauthor_id=42723554), [Dimitra Kiritsi](https://pubmed.ncbi.nlm.nih.gov/?term=Kiritsi+D&cauthor_id=42723554), [Meng Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+M&cauthor_id=42723554), [Aikaterini Patsatsi](https://pubmed.ncbi.nlm.nih.gov/?term=Patsatsi+A&cauthor_id=42723554), [Enno Schmidt](https://pubmed.ncbi.nlm.nih.gov/?term=Schmidt+E&cauthor_id=42723554), [Snejina Vassileva](https://pubmed.ncbi.nlm.nih.gov/?term=Vassileva+S&cauthor_id=42723554), [Lana Vandersarren](https://pubmed.ncbi.nlm.nih.gov/?term=Vandersarren+L&cauthor_id=42723554), [Ivaylo Stoykov](https://pubmed.ncbi.nlm.nih.gov/?term=Stoykov+I&cauthor_id=42723554), [Peter Verheesen](https://pubmed.ncbi.nlm.nih.gov/?term=Verheesen+P&cauthor_id=42723554), [Victoria P Werth](https://pubmed.ncbi.nlm.nih.gov/?term=Werth+VP&cauthor_id=42723554), [Russell P Hall](https://pubmed.ncbi.nlm.nih.gov/?term=Hall+RP&cauthor_id=42723554); [ADDRESS Investigator Study Group](https://pubmed.ncbi.nlm.nih.gov/?term=ADDRESS+Investigator+Study+Group%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **ADDRESS Investigator Study Group** : [Deirdre Dédée Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DD), [Johannes Kern](https://pubmed.ncbi.nlm.nih.gov/?term=Kern+J), [Snejina Vassileva](https://pubmed.ncbi.nlm.nih.gov/?term=Vassileva+S), [Vessel Kantardjiev](https://pubmed.ncbi.nlm.nih.gov/?term=Kantardjiev+V), [Dimitar Gospodinov](https://pubmed.ncbi.nlm.nih.gov/?term=Gospodinov+D), [Hang Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+H), [Wei Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+W), [Meng Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+M), [Yongfeng Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y), [Chao Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+C), [Shoumin Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S), [Sheng Fang](https://pubmed.ncbi.nlm.nih.gov/?term=Fang+S), [Jean-Luc Perrot](https://pubmed.ncbi.nlm.nih.gov/?term=Perrot+JL), [Isabelle Templier](https://pubmed.ncbi.nlm.nih.gov/?term=Templier+I), [Frédéric Caux](https://pubmed.ncbi.nlm.nih.gov/?term=Caux+F), [Pascal Joly](https://pubmed.ncbi.nlm.nih.gov/?term=Joly+P), [Irma Buchukuri](https://pubmed.ncbi.nlm.nih.gov/?term=Buchukuri+I), [Giorgi Galdava](https://pubmed.ncbi.nlm.nih.gov/?term=Galdava+G), [Joseph Kobakhidze](https://pubmed.ncbi.nlm.nih.gov/?term=Kobakhidze+J), [Michael Hertl](https://pubmed.ncbi.nlm.nih.gov/?term=Hertl+M), [Dimitra Kiritsi](https://pubmed.ncbi.nlm.nih.gov/?term=Kiritsi+D), [Andreas Pinter](https://pubmed.ncbi.nlm.nih.gov/?term=Pinter+A), [Matthias Hahn](https://pubmed.ncbi.nlm.nih.gov/?term=Hahn+M), [Matthias Goebeler](https://pubmed.ncbi.nlm.nih.gov/?term=Goebeler+M), [Sascha Gerdes](https://pubmed.ncbi.nlm.nih.gov/?term=Gerdes+S), [Claudia Günther](https://pubmed.ncbi.nlm.nih.gov/?term=G%C3%BCnther+C), [Vasiliki Chasapi](https://pubmed.ncbi.nlm.nih.gov/?term=Chasapi+V), [Dimitrios Ioannides](https://pubmed.ncbi.nlm.nih.gov/?term=Ioannides+D), [Evangelia Papadavid](https://pubmed.ncbi.nlm.nih.gov/?term=Papadavid+E), [Markos Papakonstantis](https://pubmed.ncbi.nlm.nih.gov/?term=Papakonstantis+M), [Aikaterini Patsatsi](https://pubmed.ncbi.nlm.nih.gov/?term=Patsatsi+A), [Alexander Stratigos](https://pubmed.ncbi.nlm.nih.gov/?term=Stratigos+A), [Zsuzsanna Bata-Csörgő](https://pubmed.ncbi.nlm.nih.gov/?term=Bata-Cs%C3%B6rg%C5%91+Z), [Éva Remenyik](https://pubmed.ncbi.nlm.nih.gov/?term=Remenyik+%C3%89), [Dipankar De](https://pubmed.ncbi.nlm.nih.gov/?term=De+D), [Bela Shah](https://pubmed.ncbi.nlm.nih.gov/?term=Shah+B), [Jayesh Mukhi](https://pubmed.ncbi.nlm.nih.gov/?term=Mukhi+J), [Amit Madan](https://pubmed.ncbi.nlm.nih.gov/?term=Madan+A), [Clara De Simone](https://pubmed.ncbi.nlm.nih.gov/?term=De+Simone+C), [Biagio Didona](https://pubmed.ncbi.nlm.nih.gov/?term=Didona+B), [Aurora Parodi](https://pubmed.ncbi.nlm.nih.gov/?term=Parodi+A), [Marzia Caproni](https://pubmed.ncbi.nlm.nih.gov/?term=Caproni+M), [Giuseppe Micali](https://pubmed.ncbi.nlm.nih.gov/?term=Micali+G), [Elisa Cinotti](https://pubmed.ncbi.nlm.nih.gov/?term=Cinotti+E), [Akio Tanaka](https://pubmed.ncbi.nlm.nih.gov/?term=Tanaka+A), [Yumi Aoyama](https://pubmed.ncbi.nlm.nih.gov/?term=Aoyama+Y), [Atsushi Osada](https://pubmed.ncbi.nlm.nih.gov/?term=Osada+A), [Hideyuki Ujiie](https://pubmed.ncbi.nlm.nih.gov/?term=Ujiie+H), [Daisuke Tsuruta](https://pubmed.ncbi.nlm.nih.gov/?term=Tsuruta+D), [Norito Ishii](https://pubmed.ncbi.nlm.nih.gov/?term=Ishii+N), [Yumi Kambayashi](https://pubmed.ncbi.nlm.nih.gov/?term=Kambayashi+Y), [Adam Reich](https://pubmed.ncbi.nlm.nih.gov/?term=Reich+A), [Kamila Placzek](https://pubmed.ncbi.nlm.nih.gov/?term=Placzek+K), [Jacek Szepietowski](https://pubmed.ncbi.nlm.nih.gov/?term=Szepietowski+J), [Agnieszka Zebrowska](https://pubmed.ncbi.nlm.nih.gov/?term=Zebrowska+A), [Adrian Lucian Baican](https://pubmed.ncbi.nlm.nih.gov/?term=Lucian+Baican+A), [Laura Gheucă Solovăstru](https://pubmed.ncbi.nlm.nih.gov/?term=Gheuc%C4%83+Solov%C4%83stru+L), [Alkes Khotko](https://pubmed.ncbi.nlm.nih.gov/?term=Khotko+A), [Sergey Skrek](https://pubmed.ncbi.nlm.nih.gov/?term=Skrek+S), [Vadim Temnikov](https://pubmed.ncbi.nlm.nih.gov/?term=Temnikov+V), [Muza Kokhan](https://pubmed.ncbi.nlm.nih.gov/?term=Kokhan+M), [Evgeny Sokolovskiy](https://pubmed.ncbi.nlm.nih.gov/?term=Sokolovskiy+E), [Zorica Gajinov](https://pubmed.ncbi.nlm.nih.gov/?term=Gajinov+Z), [Danica Tiodorovic](https://pubmed.ncbi.nlm.nih.gov/?term=Tiodorovic+D), [Jon Fulgencio Barbarin](https://pubmed.ncbi.nlm.nih.gov/?term=Barbarin+JF), [Jose-Manuel Mascaro Galy](https://pubmed.ncbi.nlm.nih.gov/?term=Mascaro+Galy+JM), [David Moyano Bueno](https://pubmed.ncbi.nlm.nih.gov/?term=Moyano+Bueno+D), [Zekayi Kutlubay](https://pubmed.ncbi.nlm.nih.gov/?term=Kutlubay+Z), [Nataliia Polion](https://pubmed.ncbi.nlm.nih.gov/?term=Polion+N), [Nataliya Reznichenko](https://pubmed.ncbi.nlm.nih.gov/?term=Reznichenko+N), [Bohdan Lytvynenko](https://pubmed.ncbi.nlm.nih.gov/?term=Lytvynenko+B), [Iryna Chaplyk-Chyzho](https://pubmed.ncbi.nlm.nih.gov/?term=Chaplyk-Chyzho+I), [Oleksandr Aleksandruk](https://pubmed.ncbi.nlm.nih.gov/?term=Aleksandruk+O), [Ser Ling Chua](https://pubmed.ncbi.nlm.nih.gov/?term=Ling+Chua+S), [Deborah Debbie Vanadin Shipley](https://pubmed.ncbi.nlm.nih.gov/?term=Vanadin+Shipley+DD), [Daniel Carrasco](https://pubmed.ncbi.nlm.nih.gov/?term=Carrasco+D), [Lauren Graham](https://pubmed.ncbi.nlm.nih.gov/?term=Graham+L), [Andrea Colton](https://pubmed.ncbi.nlm.nih.gov/?term=Colton+A), [Animesh Sinha](https://pubmed.ncbi.nlm.nih.gov/?term=Sinha+A), [Aaron Mangold](https://pubmed.ncbi.nlm.nih.gov/?term=Mangold+A), [Matt Peter Marinkovich](https://pubmed.ncbi.nlm.nih.gov/?term=Marinkovich+MP), [Russell Hall](https://pubmed.ncbi.nlm.nih.gov/?term=Hall+R), [Sylvia Hsu](https://pubmed.ncbi.nlm.nih.gov/?term=Hsu+S), [Maria Hurley](https://pubmed.ncbi.nlm.nih.gov/?term=Hurley+M), [Jill Waibel](https://pubmed.ncbi.nlm.nih.gov/?term=Waibel+J) ### Affiliation * 1 Department of Dermatology, Rouen University Hospital, INSERM U1234 Normandie University, Rouen, France. * PMID: **42723554** * DOI: [ 10.1093/bjd/ljag199 ](https://doi.org/10.1093/bjd/ljag199) Item in Clipboard Clinical Trial # Efficacy and safety of subcutaneous efgartigimod with prednisone in moderate-to-severe pemphigus (ADDRESS): a global, phase III, randomised controlled, double-blind trial Pascal Joly et al. Br J Dermatol. 2026. Show details Display options Display options Format Abstract PubMed PMID Br J Dermatol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Br+J+Dermatol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Br+J+Dermatol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42723554/) . 2026 Oct 19;195(5):750-762. doi: 10.1093/bjd/ljag199. ### Authors [Pascal Joly](https://pubmed.ncbi.nlm.nih.gov/?term=Joly+P&cauthor_id=42723554)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42723554/#short-view-affiliation-1 "Department of Dermatology, Rouen University Hospital, INSERM U1234 Normandie University, Rouen, France."), [Dedee F Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DF&cauthor_id=42723554), [Yumi Aoyama](https://pubmed.ncbi.nlm.nih.gov/?term=Aoyama+Y&cauthor_id=42723554), [Frédéric Caux](https://pubmed.ncbi.nlm.nih.gov/?term=Caux+F&cauthor_id=42723554), [Dipankar De](https://pubmed.ncbi.nlm.nih.gov/?term=De+D&cauthor_id=42723554), [Marilena Flouri](https://pubmed.ncbi.nlm.nih.gov/?term=Flouri+M&cauthor_id=42723554), [Matthias Goebeler](https://pubmed.ncbi.nlm.nih.gov/?term=Goebeler+M&cauthor_id=42723554), [Chao Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+C&cauthor_id=42723554), [Dimitra Kiritsi](https://pubmed.ncbi.nlm.nih.gov/?term=Kiritsi+D&cauthor_id=42723554), [Meng Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+M&cauthor_id=42723554), [Aikaterini Patsatsi](https://pubmed.ncbi.nlm.nih.gov/?term=Patsatsi+A&cauthor_id=42723554), [Enno Schmidt](https://pubmed.ncbi.nlm.nih.gov/?term=Schmidt+E&cauthor_id=42723554), [Snejina Vassileva](https://pubmed.ncbi.nlm.nih.gov/?term=Vassileva+S&cauthor_id=42723554), [Lana Vandersarren](https://pubmed.ncbi.nlm.nih.gov/?term=Vandersarren+L&cauthor_id=42723554), [Ivaylo Stoykov](https://pubmed.ncbi.nlm.nih.gov/?term=Stoykov+I&cauthor_id=42723554), [Peter Verheesen](https://pubmed.ncbi.nlm.nih.gov/?term=Verheesen+P&cauthor_id=42723554), [Victoria P Werth](https://pubmed.ncbi.nlm.nih.gov/?term=Werth+VP&cauthor_id=42723554), [Russell P Hall](https://pubmed.ncbi.nlm.nih.gov/?term=Hall+RP&cauthor_id=42723554); [ADDRESS Investigator Study Group](https://pubmed.ncbi.nlm.nih.gov/?term=ADDRESS+Investigator+Study+Group%5BCorporate+Author%5D) ### Collaborators * **ADDRESS Investigator Study Group** : [Deirdre Dédée Murrell](https://pubmed.ncbi.nlm.nih.gov/?term=Murrell+DD), [Johannes Kern](https://pubmed.ncbi.nlm.nih.gov/?term=Kern+J), [Snejina Vassileva](https://pubmed.ncbi.nlm.nih.gov/?term=Vassileva+S), [Vessel Kantardjiev](https://pubmed.ncbi.nlm.nih.gov/?term=Kantardjiev+V), [Dimitar Gospodinov](https://pubmed.ncbi.nlm.nih.gov/?term=Gospodinov+D), [Hang Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+H), [Wei Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+W), [Meng Pan](https://pubmed.ncbi.nlm.nih.gov/?term=Pan+M), [Yongfeng Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y), [Chao Ji](https://pubmed.ncbi.nlm.nih.gov/?term=Ji+C), [Shoumin Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S), [Sheng Fang](https://pubmed.ncbi.nlm.nih.gov/?term=Fang+S), [Jean-Luc Perrot](https://pubmed.ncbi.nlm.nih.gov/?term=Perrot+JL), [Isabelle Templier](https://pubmed.ncbi.nlm.nih.gov/?term=Templier+I), [Frédéric Caux](https://pubmed.ncbi.nlm.nih.gov/?term=Caux+F), [Pascal Joly](https://pubmed.ncbi.nlm.nih.gov/?term=Joly+P), [Irma Buchukuri](https://pubmed.ncbi.nlm.nih.gov/?term=Buchukuri+I), [Giorgi Galdava](https://pubmed.ncbi.nlm.nih.gov/?term=Galdava+G), [Joseph Kobakhidze](https://pubmed.ncbi.nlm.nih.gov/?term=Kobakhidze+J), [Michael Hertl](https://pubmed.ncbi.nlm.nih.gov/?term=Hertl+M), [Dimitra Kiritsi](https://pubmed.ncbi.nlm.nih.gov/?term=Kiritsi+D), [Andreas Pinter](https://pubmed.ncbi.nlm.nih.gov/?term=Pinter+A), [Matthias Hahn](https://pubmed.ncbi.nlm.nih.gov/?term=Hahn+M), [Matthias Goebeler](https://pubmed.ncbi.nlm.nih.gov/?term=Goebeler+M), [Sascha Gerdes](https://pubmed.ncbi.nlm.nih.gov/?term=Gerdes+S), [Claudia Günther](https://pubmed.ncbi.nlm.nih.gov/?term=G%C3%BCnther+C), [Vasiliki Chasapi](https://pubmed.ncbi.nlm.nih.gov/?term=Chasapi+V), [Dimitrios Ioannides](https://pubmed.ncbi.nlm.nih.gov/?term=Ioannides+D), [Evangelia Papadavid](https://pubmed.ncbi.nlm.nih.gov/?term=Papadavid+E), [Markos Papakonstantis](https://pubmed.ncbi.nlm.nih.gov/?term=Papakonstantis+M), [Aikaterini Patsatsi](https://pubmed.ncbi.nlm.nih.gov/?term=Patsatsi+A), [Alexander Stratigos](https://pubmed.ncbi.nlm.nih.gov/?term=Stratigos+A), [Zsuzsanna Bata-Csörgő](https://pubmed.ncbi.nlm.nih.gov/?term=Bata-Cs%C3%
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