---
title: "WHO issues first childhood obesity guidelines; Caribou Biosciences halts CAR-T program"
id: "stat-news-3-stat-pharmalittle-we-re-reading-about-who-obesity-guidelines-for-kids-doj"
canonical_url: "https://medichelpline.com/clinical-feed/stat-news-3-stat-pharmalittle-we-re-reading-about-who-obesity-guidelines-for-kids-doj"
content_type: "clinical_feed_article"
specialty: "General"
source_name: "STAT News"
source_url: "https://www.statnews.com/pharmalot/2026/10/07/who-obesity-guidelines-for-kids-doj-targets-pharma/?utm_campaign=rss"
published_at: "2026-10-07T12:56:49.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# WHO issues first childhood obesity guidelines; Caribou Biosciences halts CAR-T program
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/stat-news-3-stat-pharmalittle-we-re-reading-about-who-obesity-guidelines-for-kids-doj
- **Specialty:** [General](https://medichelpline.com/clinical-feed/general.md)
- **Primary Source:** STAT News
- **Source URL:** [Original Journal Publication](https://www.statnews.com/pharmalot/2026/10/07/who-obesity-guidelines-for-kids-doj-targets-pharma/?utm_campaign=rss)
- **Published At:** 2026-10-07T12:56:49.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The **World Health Organization** released its first guidelines addressing the global rise in **obesity among children and adolescents**, noting that prevalence in ages 5–19 rose from 2% in 1990 to 8% in 2024. In 2024, an estimated 170 million children and adolescents aged 5–19 years were living with obesity, including about 70 million children aged 5–9 and 100 million adolescents aged 10–19. - The WHO guidance explicitly does not recommend **pharmacological treatment, bariatric surgery, or weight-loss devices** for children aged 0–9 years. For adolescents 10–19 years, the guidelines state that treatment with approved drugs may be considered only after a supervised multimodal lifestyle program has failed to achieve desired results. - **Caribou Biosciences**, a biotech company founded from research by CRISPR scientist and Nobel laureate **Jennifer Doudna**, is shutting down after failing to raise funds needed to run a late-stage clinical trial of its off-the-shelf **CAR-T** therapy for lymphoma. - Caribou will discontinue development of two CRISPR-based CAR-T candidate therapies, including **vespa-cel** (also referenced as vispa-cel in the source) intended for advanced B-cell non-Hodgkin lymphoma. - The company had worked with the **U.S. Food and Drug Administration** to finalize a Phase 3 trial design for vespa-cel, but could not secure financing to support the study and broader clinical development. - The newsletter item references other reporting items (including a STAT+ exclusive about the **U.S. Department of Justice** targeting drugmakers) but details of that DOJ directive or other linked stories are not reported in the provided source text. - The item is part of the Pharmalittle/Pharmalot column by Ed Silverman and indicates that additional in-depth coverage of some items is behind STAT+ subscription paywall; some linked stories are labeled STAT+ exclusive and require subscription to read full content.
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Test your knowledge with our new weekday mini crossword [ Start solving ](https://www.statnews.com/stat-mini-crossword/) [STAT Plus](https://www.statnews.com/stat-plus/)Newsletter[Pharmalot](https://www.statnews.com/category/pharma/pharmalot/) # Pharmalittle: We’re reading about WHO obesity guidelines for kids, DOJ targeting pharma, and more ## Caribou Biosciences is shutting down after failing to raise funds for a CAR-T clinical trial * [Manage alerts for this article](https://www.statnews.com/my-account/edit/#emails) * [Save this story for later](https://www.statnews.com/my-account/saved/) * [Share this article](https://www.statnews.com/pharmalot/2026/10/07/who-obesity-guidelines-for-kids-doj-targets-pharma/?utm_campaign=rss) ![an anthropomorphized red and blue pill illustrated in the style of the famous american gothic painting](https://www.statnews.com/wp-content/uploads/2015/11/PHARMALOT_LITTLE-copy-645x645.jpg) Alex Hogan/STAT ![](https://www.statnews.com/wp-content/uploads/2021/02/ed-s-avatar-small4-80x80.png) By [Ed Silverman](https://www.statnews.com/staff/ed-silverman/) Oct. 7, 2026 Pharmalot Columnist, Senior Writer ![](https://www.statnews.com/wp-content/uploads/2021/02/ed-s-avatar-small4-80x80.png) [Ed Silverman](https://www.statnews.com/staff/ed-silverman/) 1. [](https://www.linkedin.com/in/edsilverman/ "Linkedin") 2. [](https://x.com/Pharmalot "X") ed.silverman@statnews.com Ed’s stories explore prescription drug pricing, affordability and access, as well issues surrounding patents, litigation, and legislation. He is also the author of the morning [Pharmalittle newsletter](https://www.statnews.com/signup/pharmalittle/) and the afternoon [Pharmalot newsletter](https://www.statnews.com/signup/pharmalot/). Good morning, everyone, and welcome to the middle of the week. Congratulations on making it this far, and remember there are only a few more days until the weekend arrives. So keep plugging away. After all, what are the alternatives? While you ponder the possibilities, we invite you to join us for a needed cuppa stimulation. Our choice today is ginseng peach, a favorite from our pantry. Meanwhile, here is the latest menu of tidbits to help you on your way. We hope you conquer the world and have a wonderful day. And as always, please do stay in touch. We appreciate feedback, tips, and criticism. … **The World Health Organization released its first guidelines addressing the sharp rise in obesity among children and adolescents** , [Health Policy Watch](https://healthpolicy-watch.news/glp-1-drugs-surgery-who-issues-guidelines-for-obesity-in-children/) says. In 2024, 170 million children and adolescents aged 5–19 years were living with obesity, including 70 million children aged 5 to 9 years and 100 million adolescents aged 10 to 19 years. Obesity prevalence in this age group quadrupled since 1990, rising from 2% to 8%. But the WHO does not recommend pharmacological treatment, bariatric surgery, or weight loss devices for children aged 0 to 9 years. For adolescents aged 10 to 19 years, treatment with approved drugs may be considered only when a supervised multimodal lifestyle program has not achieved desired results. Advertisement **Caribou Biosciences is shutting down after failing to raise the money necessary to fund a late-stage clinical trial of its off-the-shelf CAR-T therapy for lymphoma,** [STAT](https://www.statnews.com/2026/10/07/caribou-biosciences-shutting-down-lymphoma-car-t-therapy/) notes. The biotech, borne from the research lab of CRISPR scientist and Nobel laureate Jennifer Doudna, will discontinue clinical development of its two CRISPR-based CAR-T therapies, including vispa-cel for the treatment of advanced B-cell non-Hodgkin lymphoma. Over the past year, Caribou had worked successfully with the Food and Drug Administration to finalize the design of a Phase 3 trial for vespa-cel. Unfortunately, raising the money to pay for the study proved too difficult. STAT+ Exclusive Story Already have an account? 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