---
title: "Carfilzomib, Lenalidomide, and Dexamethasone After Autologous Stem-Cell Transplantation in Multi"
id: "the-lancet-haematology-14-carfilzomib-lenalidomide-and-dexamethasone-compared-with-lenalidomide-treatment-after-autologous-haematopoietic-stem-cell-transplantation-in-patients-with-multiple-myeloma-atlas-primary-analysis-of-a-randomised-open-label-phase-3-trial"
canonical_url: "https://medichelpline.com/clinical-feed/the-lancet-haematology-14-carfilzomib-lenalidomide-and-dexamethasone-compared-with-lenalidomide-treatment-after-autologous-haematopoietic-stem-cell-transplantation-in-patients-with-multiple-myeloma-atlas-primary-analysis-of-a-randomised-open-label-phase-3-trial"
content_type: "clinical_feed_article"
specialty: "Hematology"
source_name: "The Lancet Haematology"
source_url: "https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(26)00011-6/fulltext?rss=yes"
doi: "10.1016/S2352-3026(26)00011-6"
published_at: "2026-03-11T23:30:02.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Carfilzomib, Lenalidomide, and Dexamethasone After Autologous Stem-Cell Transplantation in Multi
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/the-lancet-haematology-14-carfilzomib-lenalidomide-and-dexamethasone-compared-with-lenalidomide-treatment-after-autologous-haematopoietic-stem-cell-transplantation-in-patients-with-multiple-myeloma-atlas-primary-analysis-of-a-randomised-open-label-phase-3-trial
- **Specialty:** [Hematology](https://medichelpline.com/clinical-feed/hematology.md)
- **Primary Source:** The Lancet Haematology
- **Source URL:** [Original Journal Publication](https://www.thelancet.com/journals/lanhae/article/PIIS2352-3026(26)00011-6/fulltext?rss=yes)
- **DOI:** [10.1016/S2352-3026(26)00011-6](https://doi.org/10.1016%2FS2352-3026(26)00011-6)
- **Published At:** 2026-03-11T23:30:02.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
The enhanced efficacy of carfilzomib–lenalidomide–dexamethasone treatment following autologous HSCT in patients with newly diagnosed multiple myeloma, assessed within a framework of de-escalation based on MRD status and individual risk, supports strategies for maintenance therapy intensification in this setting.
## Clinical Analysis & Structured Key Points
The Lancet Haematology published a clinical update in Oncology on 11 Mar 2026. The item focuses on Carfilzomib, lenalidomide, and dexamethasone compared with lenalidomide treatment after autologous haematopoietic stem-cell transplantation in patients with multiple myeloma (ATLAS): primary analysis of a randomised, open-label, phase 3 trial. Review the original article for the full source wording and details.
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