---
title: "Daratumumab‑VCD for Newly Diagnosed AL Amyloidosis: ANDROMEDA Final Survival Analysis (Blood 2026)"
id: "pubmed-42118698"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42118698"
content_type: "clinical_feed_article"
specialty: "Hematology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42118698/"
doi: "10.1182/blood.2025032099"
published_at: "2026-08-27T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Daratumumab‑VCD for Newly Diagnosed AL Amyloidosis: ANDROMEDA Final Survival Analysis (Blood 2026)
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42118698
- **Specialty:** [Hematology](https://medichelpline.com/clinical-feed/hematology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42118698/)
- **DOI:** [10.1182/blood.2025032099](https://doi.org/10.1182%2Fblood.2025032099)
- **Published At:** 2026-08-27T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The publication reports the final survival analysis of the ANDROMEDA clinical trial evaluating **daratumumab** combined with bortezomib, cyclophosphamide and dexamethasone (VCD) in newly diagnosed amyloidosis (AL amyloidosis). - The article is a Clinical Trial report published in Blood on 2026 Aug 27 (Volume 148, Issue 9) with DOI 10.1182/blood.2025032099. - The paper lists a large, international group of investigators and collaborating centers under the ANDROMEDA Trial Investigators, indicating a multicenter effort across Europe, North America, Asia and other regions. - coauthors and affiliations include specialist amyloidosis and hematology centers and multiple academic institutions; several authors are affiliated with Johnson & Johnson. - The article is identified as the final survival analysis, implying longitudinal follow-up of trial participants to assess survival outcomes. - The PubMed record and abstract header are provided in the source, but the supplied source text does not include numerical results, survival statistics, hazard ratios, p values, subgroup outcomes, safety data, or explicit methodological details (randomization, sample size, eligibility criteria, follow‑up duration, or statistical methods). - Because the source text provided here is limited to the PubMed landing page and citation metadata, specific trial results, effect sizes, adverse events, and detailed conclusions are not reported in this source excerpt. - Any detailed interpretation of efficacy, safety, or practice implications cannot be drawn from the supplied text; readers should consult the full Blood article or full text links for complete data and prespecified analyses. - The record links to full-text sources (Blood/Silverchair, Elsevier) and notes the ANDROMEDA Trial Investigators and multiple collaborating authors and institutions, confirming broad investigator participation and industry collaboration in trial conduct or support.
## Clinical Analysis & Structured Key Points
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final survival analysis [Efstathios Kastritis](https://pubmed.ncbi.nlm.nih.gov/?term=Kastritis+E&cauthor_id=42118698)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-1 "Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece."), [Giovanni Palladini](https://pubmed.ncbi.nlm.nih.gov/?term=Palladini+G&cauthor_id=42118698)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-2 "Department of Molecular Medicine, University of Pavia, Pavia, Italy.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-3 "Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy."), [Monique C Minnema](https://pubmed.ncbi.nlm.nih.gov/?term=Minnema+MC&cauthor_id=42118698)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-4 "Department of Hematology, University Medical Center Utrecht, University Utrecht, Utrecht, The Netherlands."), [Ashutosh D Wechalekar](https://pubmed.ncbi.nlm.nih.gov/?term=Wechalekar+AD&cauthor_id=42118698)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-5 "University College London Hospital and National Amyloidosis Centre, University College London Royal Free Campus, London, United Kingdom."), [Arnaud Jaccard](https://pubmed.ncbi.nlm.nih.gov/?term=Jaccard+A&cauthor_id=42118698)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-6 "Reference Center for Amyloid Light-chain Amyloidosis, Limoges, France."), [Hans C Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+HC&cauthor_id=42118698)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-7 "Department of Lymphoma and Myeloma, Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX."), [Vaishali Sanchorawala](https://pubmed.ncbi.nlm.nih.gov/?term=Sanchorawala+V&cauthor_id=42118698)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-8 "Amyloidosis Center, Boston University School of Medicine and Boston Medical Center, Boston, MA."), [Peter Mollee](https://pubmed.ncbi.nlm.nih.gov/?term=Mollee+P&cauthor_id=42118698)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-9 "Department of Haematology, Princess Alexandra Hospital and University of Queensland Medical School, Brisbane, Australia."), [Jin Lu](https://pubmed.ncbi.nlm.nih.gov/?term=Lu+J&cauthor_id=42118698)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-10 "Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing, China."), [Stefan Schönland](https://pubmed.ncbi.nlm.nih.gov/?term=Sch%C3%B6nland+S&cauthor_id=42118698)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-11 "Universitätsklinikum Heidelberg Medizinische Klinik V, Heidelberg, Germany."), [Moshe E Gatt](https://pubmed.ncbi.nlm.nih.gov/?term=Gatt+ME&cauthor_id=42118698)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-12 "Hadassah Medical Center, Jerusalem, Israel."), [Kenshi Suzuki](https://pubmed.ncbi.nlm.nih.gov/?term=Suzuki+K&cauthor_id=42118698)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-13 "Japanese Red Cross Medical Center, Tokyo, Japan."), [Kihyun Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+K&cauthor_id=42118698)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-14 "Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Korea."), [M Teresa Cibeira](https://pubmed.ncbi.nlm.nih.gov/?term=Cibeira+MT&cauthor_id=42118698)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-15 "Amyloidosis and Myeloma Unit, Hospital Clinic of Barcelona, August Pi i Sunyer Biomedical Research Institute, Barcelona, Spain."), [Manisha Bhutani](https://pubmed.ncbi.nlm.nih.gov/?term=Bhutani+M&cauthor_id=42118698)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-16 "Department of Hematologic Oncology and Blood Disorders, Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC."), [Meral Beksac](https://pubmed.ncbi.nlm.nih.gov/?term=Beksac+M&cauthor_id=42118698)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-17 "Department of Hematology, Ankara University, Ankara, Turkey."), [Edward Libby](https://pubmed.ncbi.nlm.nih.gov/?term=Libby+E&cauthor_id=42118698)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-18 "Fred Hutchinson Cancer Center, Seattle, WA."), [Jason Valent](https://pubmed.ncbi.nlm.nih.gov/?term=Valent+J&cauthor_id=42118698)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-19 "Department of Hematology and Medical Oncology, Taussig Cancer Center, Cleveland Clinic, Cleveland, OH."), [Vania Hungria](https://pubmed.ncbi.nlm.nih.gov/?term=Hungria+V&cauthor_id=42118698)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-20 "Clínica São Germano, São Paulo, Brazil."), [Michael Rosenzweig](https://pubmed.ncbi.nlm.nih.gov/?term=Rosenzweig+M&cauthor_id=42118698)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-21 "Department of Hematology and Hematopoietic Cell Transplantation, The Judy and Bernard Briskin Center for Multiple Myeloma Research, City of Hope, Duarte, CA."), [Naresh Bumma](https://pubmed.ncbi.nlm.nih.gov/?term=Bumma+N&cauthor_id=42118698)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-22 "Division of Hematology, Ohio State University Comprehensive Cancer Center, Columbus, OH."), [Antoine Huart](https://pubmed.ncbi.nlm.nih.gov/?term=Huart+A&cauthor_id=42118698)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-23 "Département de Néphrologie et Transplantation d'Organes, Centre de Référence des Maladies Rénales Rares, Hôpital Rangueil, Centre Hospitalier Universitaire de Toulouse, Toulouse, France."), [Meletios A Dimopoulos](https://pubmed.ncbi.nlm.nih.gov/?term=Dimopoulos+MA&cauthor_id=42118698)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-1 "Department of Clinical Therapeutics, National and Kapodistrian University of Athens, School of Medicine, Athens, Greece.")[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-24 "Department of Medicine, Korea University, Seoul, Korea."), [Divaya Bhutani](https://pubmed.ncbi.nlm.nih.gov/?term=Bhutani+D&cauthor_id=42118698)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-25 "Division of Hematology/Oncology, Columbia University Medical Center, New York, NY."), [Adam J Waxman](https://pubmed.ncbi.nlm.nih.gov/?term=Waxman+AJ&cauthor_id=42118698)[ 26 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-26 "Penn Amyloidosis Program, Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA."), [Stacey A Goodman](https://pubmed.ncbi.nlm.nih.gov/?term=Goodman+SA&cauthor_id=42118698)[ 27 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-27 "Vanderbilt University Medical Center, Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN."), [Jeffrey A Zonder](https://pubmed.ncbi.nlm.nih.gov/?term=Zonder+JA&cauthor_id=42118698)[ 28 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-28 "Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI."), [Selay Lam](https://pubmed.ncbi.nlm.nih.gov/?term=Lam+S&cauthor_id=42118698)[ 29 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-29 "Division of Hematology, London Health Sciences Centre, Verspeeten Family Cancer Centre, Western University, London, ON, Canada."), [Kevin Song](https://pubmed.ncbi.nlm.nih.gov/?term=Song+K&cauthor_id=42118698)[ 30 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-30 "Division of Hematology, Vancouver General Hospital, BC Cancer, University of British Columbia, Vancouver, Canada."), [Timon Hansen](https://pubmed.ncbi.nlm.nih.gov/?term=Hansen+T&cauthor_id=42118698)[ 31 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-31 "Onkologicum Hämatologisch-Onkologische Praxis Altona, Hamburg, Germany."), [Salomon Manier](https://pubmed.ncbi.nlm.nih.gov/?term=Manier+S&cauthor_id=42118698)[ 32 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-32 "Department of Hematology, Centre Hospitalier Universitaire Lille, University of Lille, Lille, France."), [Wilfried Roeloffzen](https://pubmed.ncbi.nlm.nih.gov/?term=Roeloffzen+W&cauthor_id=42118698)[ 33 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-33 "Amyloidosis Center of Expertise, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands."), [Krzysztof Jamroziak](https://pubmed.ncbi.nlm.nih.gov/?term=Jamroziak+K&cauthor_id=42118698)[ 34 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-34 "Department of Hematology, Transplantation and Internal Medicine, Medical University of Warsaw, Warsaw, Poland."), [Fiona Kwok](https://pubmed.ncbi.nlm.nih.gov/?term=Kwok+F&cauthor_id=42118698)[ 35 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-35 "Department of Clinical Haematology, Westmead Hospital, Westmead, NSW, Australia."), [Chihiro Shimazaki](https://pubmed.ncbi.nlm.nih.gov/?term=Shimazaki+C&cauthor_id=42118698)[ 36 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-36 "Department of Hematology, Japan Community Health Care Organization Kyoto Kuramaguchi Medical Center, Kyoto, Japan."), [Jin-Seok Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+JS&cauthor_id=42118698)[ 37 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-37 "Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea."), [Edvan Crusoe](https://pubmed.ncbi.nlm.nih.gov/?term=Crusoe+E&cauthor_id=42118698)[ 38 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-38 "Clinica Centro de Hematologia e Oncologia, Rede D'Or Oncologia, Salvador, Brazil."), [NamPhuong Tran](https://pubmed.ncbi.nlm.nih.gov/?term=Tran+N&cauthor_id=42118698)[ 39 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-39 "Johnson & Johnson, Los Angeles, CA."), [Jianping Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+J&cauthor_id=42118698)[ 40 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-40 "Johnson & Johnson, Raritan, NJ."), [Yuping Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+Y&cauthor_id=42118698)[ 41 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-41 "Johnson & Johnson, Shanghai, China."), [Sandra Y Vasey](https://pubmed.ncbi.nlm.nih.gov/?term=Vasey+SY&cauthor_id=42118698)[ 42 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-42 "Johnson & Johnson, Spring House, PA."), [Jordan M Schecter](https://pubmed.ncbi.nlm.nih.gov/?term=Schecter+JM&cauthor_id=42118698)[ 40 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-40 "Johnson & Johnson, Raritan, NJ."), [Jessica Vermeulen](https://pubmed.ncbi.nlm.nih.gov/?term=Vermeulen+J&cauthor_id=42118698)[ 43 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-43 "Johnson & Johnson, Leiden, The Netherlands."), [Raymond L Comenzo](https://pubmed.ncbi.nlm.nih.gov/?term=Comenzo+RL&cauthor_id=42118698)[ 44 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-44 "John C. Davis Myeloma and Amyloid Program, Tufts Medical Center, Boston, MA."), [Giampaolo Merlini](https://pubmed.ncbi.nlm.nih.gov/?term=Merlini+G&cauthor_id=42118698)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-2 "Department of Molecular Medicine, University of Pavia, Pavia, Italy.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42118698/#full-view-affiliation-3 "Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Policlinico San Matteo, Pavia, Italy."); [ANDROMEDA Trial Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=ANDROMEDA+Trial+Investigators%5BCorporate+Author%5D) Collaborators, Affiliations Expand ### Collaborators * **ANDROMEDA Trial Investigators** : [Bradley Augustson](https://pubmed.ncbi.nlm.nih.gov/?term=Augustson+B), [Fiona Kwok](https://pubmed.ncbi.nlm.nih.gov/?term=Kwok+F), [Peter Mollee](https://pubmed.ncbi.nlm.nih.gov/?term=Mollee+P), [Simon Gibbs](https://pubmed.ncbi.nlm.nih.gov/?term=Gibbs+S), [Chantal Doyen](https://pubmed.ncbi.nlm.nih.gov/?term=Doyen+C), [Greet Bries](https://pubmed.ncbi.nlm.nih.gov/?term=Bries+G), [Isabelle Vande Broek](https://pubmed.ncbi.nlm.nih.gov/?term=Broek+IV), [Ka Lung Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+KL), [Koen Theunissen](https://pubmed.ncbi.nlm.nih.gov/?term=
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