---
title: "Bundibugyo virus infection treated with MBP134 monoclonal antibodies and remdesivir: a case report"
id: "nature-0-a-case-of-bundibugyo-virus-disease-treated-with-monoclonal-antibodies-and"
canonical_url: "https://medichelpline.com/clinical-feed/nature-0-a-case-of-bundibugyo-virus-disease-treated-with-monoclonal-antibodies-and"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "Nature Medicine"
source_url: "https://www.nature.com/articles/s41591-026-04663-5"
published_at: "2026-08-24T12:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Bundibugyo virus infection treated with MBP134 monoclonal antibodies and remdesivir: a case report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/nature-0-a-case-of-bundibugyo-virus-disease-treated-with-monoclonal-antibodies-and
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** Nature Medicine
- **Source URL:** [Original Journal Publication](https://www.nature.com/articles/s41591-026-04663-5)
- **Published At:** 2026-08-24T12:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- A previously healthy 39-year-old healthcare worker acquired **Bundibugyo virus (BDBV)** infection in Ituri Province, DRC, and was evacuated to Germany for care. - The patient received MBP134, an investigational two-antibody monoclonal combination, under an FDA Emergency Investigational New Drug (eIND) authorization, alongside **remdesivir** and supportive care. - Viral RNA concentrations were highest in oropharyngeal swabs and plasma early in illness and became undetectable in blood, throat swabs, urine and stool by day 13 after symptom onset; semen was negative by day 25. - The patient’s serum showed neutralizing activity against the outbreak BDBV strain and other orthoebolaviruses, indicating broad neutralizing capacity in vitro or ex vivo as reported. - BDBV-specific antibody responses attributable to the patient’s own immune system were detected and could not be explained by MBP134 administration or prior vaccination, indicating endogenous humoral immunity developed during combination antiviral therapy. - The patient recovered clinically and was discharged on day 22 after symptom onset. - The report provides detailed clinical, virologic and immune-response observations for BDBV infection during combined antiviral therapy but notes that larger clinical studies are required to determine efficacy and clinical utility of these treatments. - Specifics such as dosing regimens, timing of each intervention relative to symptom onset, detailed laboratory values and imaging findings were not reported in the sourced summary and therefore are not described here.
## Clinical Analysis & Structured Key Points
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[brief communications](https://www.nature.com/nm/articles?type=brief-communication) 4. article A case of Bundibugyo virus disease treated with monoclonal antibodies and remdesivir [ Download PDF ](https://www.nature.com/articles/s41591-026-04663-5_reference.pdf) * Brief Communication * [Open access](https://www.springernature.com/gp/open-science/about/the-fundamentals-of-open-access-and-open-research) * Published: 24 August 2026 # A case of Bundibugyo virus disease treated with monoclonal antibodies and remdesivir * [Alexander Uhrig](https://www.nature.com/articles/s41591-026-04663-5#auth-Alexander-Uhrig-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1), * [Frieder Pfäfflin](https://www.nature.com/articles/s41591-026-04663-5#auth-Frieder-Pf_fflin-Aff1) [ORCID: orcid.org/0000-0003-2777-2548](https://orcid.org/0000-0003-2777-2548)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1), * [Pinkus Tober-Lau](https://www.nature.com/articles/s41591-026-04663-5#auth-Pinkus-Tober_Lau-Aff1) [ORCID: orcid.org/0000-0002-9148-3663](https://orcid.org/0000-0002-9148-3663)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1), * [Victor M. Corman](https://www.nature.com/articles/s41591-026-04663-5#auth-Victor_M_-Corman-Aff2-Aff3-Aff4)[2](https://www.nature.com/articles/s41591-026-04663-5#Aff2),[3](https://www.nature.com/articles/s41591-026-04663-5#Aff3),[4](https://www.nature.com/articles/s41591-026-04663-5#Aff4) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1), * [Miriam S. Stegemann](https://www.nature.com/articles/s41591-026-04663-5#auth-Miriam_S_-Stegemann-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1), * [Paulina Tarnow](https://www.nature.com/articles/s41591-026-04663-5#auth-Paulina-Tarnow-Aff5) [ORCID: orcid.org/0000-0003-0011-2128](https://orcid.org/0000-0003-0011-2128)[5](https://www.nature.com/articles/s41591-026-04663-5#Aff5), * [Monika Rottstegge](https://www.nature.com/articles/s41591-026-04663-5#auth-Monika-Rottstegge-Aff6-Aff7)[6](https://www.nature.com/articles/s41591-026-04663-5#Aff6),[7](https://www.nature.com/articles/s41591-026-04663-5#Aff7), * [Katrin Moira Heim](https://www.nature.com/articles/s41591-026-04663-5#auth-Katrin_Moira-Heim-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1), * [Felix Bremer](https://www.nature.com/articles/s41591-026-04663-5#auth-Felix-Bremer-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1), * [Thomas Cronen](https://www.nature.com/articles/s41591-026-04663-5#auth-Thomas-Cronen-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1), * [Tilman Lingscheid](https://www.nature.com/articles/s41591-026-04663-5#auth-Tilman-Lingscheid-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1), * [Han Ngoc Le](https://www.nature.com/articles/s41591-026-04663-5#auth-Han-Ngoc_Le-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1), * [Dominik Geus](https://www.nature.com/articles/s41591-026-04663-5#auth-Dominik-Geus-Aff1)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1), * [Mary J. Choi](https://www.nature.com/articles/s41591-026-04663-5#auth-Mary_J_-Choi-Aff8-Aff9)[8](https://www.nature.com/articles/s41591-026-04663-5#Aff8),[9](https://www.nature.com/articles/s41591-026-04663-5#Aff9), * [William A. Fischer II](https://www.nature.com/articles/s41591-026-04663-5#auth-William_A_-Fischer-Aff10) [ORCID: orcid.org/0000-0002-4900-098X](https://orcid.org/0000-0002-4900-098X)[10](https://www.nature.com/articles/s41591-026-04663-5#Aff10), * [Wesley R. Campbell](https://www.nature.com/articles/s41591-026-04663-5#auth-Wesley_R_-Campbell-Aff11-Aff12) [ORCID: orcid.org/0000-0002-8157-0771](https://orcid.org/0000-0002-8157-0771)[11](https://www.nature.com/articles/s41591-026-04663-5#Aff11),[12](https://www.nature.com/articles/s41591-026-04663-5#Aff12), * [Aneesh K. Mehta](https://www.nature.com/articles/s41591-026-04663-5#auth-Aneesh_K_-Mehta-Aff13) [ORCID: orcid.org/0000-0002-6552-9162](https://orcid.org/0000-0002-6552-9162)[13](https://www.nature.com/articles/s41591-026-04663-5#Aff13), * [Marylyn M. Addo](https://www.nature.com/articles/s41591-026-04663-5#auth-Marylyn_M_-Addo-Aff7-Aff14-Aff15) [ORCID: orcid.org/0000-0003-2836-9224](https://orcid.org/0000-0003-2836-9224)[7](https://www.nature.com/articles/s41591-026-04663-5#Aff7),[14](https://www.nature.com/articles/s41591-026-04663-5#Aff14),[15](https://www.nature.com/articles/s41591-026-04663-5#Aff15), * [Placide Mbala-Kingebeni](https://www.nature.com/articles/s41591-026-04663-5#auth-Placide-Mbala_Kingebeni-Aff16-Aff17) [ORCID: orcid.org/0000-0003-1556-3570](https://orcid.org/0000-0003-1556-3570)[16](https://www.nature.com/articles/s41591-026-04663-5#Aff16),[17](https://www.nature.com/articles/s41591-026-04663-5#Aff17), * [David Hillus](https://www.nature.com/articles/s41591-026-04663-5#auth-David-Hillus-Aff1-Aff18) [ORCID: orcid.org/0000-0002-3138-9050](https://orcid.org/0000-0002-3138-9050)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1),[18](https://www.nature.com/articles/s41591-026-04663-5#Aff18), * [Christian Gaebler](https://www.nature.com/articles/s41591-026-04663-5#auth-Christian-Gaebler-Aff1-Aff18) [ORCID: orcid.org/0000-0001-7295-8128](https://orcid.org/0000-0001-7295-8128)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1),[18](https://www.nature.com/articles/s41591-026-04663-5#Aff18), * [Stephan Becker](https://www.nature.com/articles/s41591-026-04663-5#auth-Stephan-Becker-Aff19) [ORCID: orcid.org/0000-0002-6621-9350](https://orcid.org/0000-0002-6621-9350)[19](https://www.nature.com/articles/s41591-026-04663-5#Aff19), * [Janine Michel](https://www.nature.com/articles/s41591-026-04663-5#auth-Janine-Michel-Aff20) [ORCID: orcid.org/0000-0001-6227-3125](https://orcid.org/0000-0001-6227-3125)[20](https://www.nature.com/articles/s41591-026-04663-5#Aff20), * [Andreas Nitsche](https://www.nature.com/articles/s41591-026-04663-5#auth-Andreas-Nitsche-Aff20)[20](https://www.nature.com/articles/s41591-026-04663-5#Aff20), * [Andreas Kurth](https://www.nature.com/articles/s41591-026-04663-5#auth-Andreas-Kurth-Aff20)[20](https://www.nature.com/articles/s41591-026-04663-5#Aff20), * [Martin Witzenrath](https://www.nature.com/articles/s41591-026-04663-5#auth-Martin-Witzenrath-Aff1-Aff21) [ORCID: orcid.org/0000-0002-9787-5633](https://orcid.org/0000-0002-9787-5633)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1),[21](https://www.nature.com/articles/s41591-026-04663-5#Aff21), * [Till D. Best](https://www.nature.com/articles/s41591-026-04663-5#auth-Till_D_-Best-Aff2-Aff3-Aff4) [ORCID: orcid.org/0000-0001-7323-827X](https://orcid.org/0000-0001-7323-827X)[2](https://www.nature.com/articles/s41591-026-04663-5#Aff2),[3](https://www.nature.com/articles/s41591-026-04663-5#Aff3),[4](https://www.nature.com/articles/s41591-026-04663-5#Aff4), * [Stephan Günther](https://www.nature.com/articles/s41591-026-04663-5#auth-Stephan-G_nther-Aff6-Aff7)[6](https://www.nature.com/articles/s41591-026-04663-5#Aff6),[7](https://www.nature.com/articles/s41591-026-04663-5#Aff7), * [Lisa Oestereich](https://www.nature.com/articles/s41591-026-04663-5#auth-Lisa-Oestereich-Aff6-Aff7)[6](https://www.nature.com/articles/s41591-026-04663-5#Aff6),[7](https://www.nature.com/articles/s41591-026-04663-5#Aff7), * [Manuel Koch](https://www.nature.com/articles/s41591-026-04663-5#auth-Manuel-Koch-Aff22) [ORCID: orcid.org/0000-0002-2962-7814](https://orcid.org/0000-0002-2962-7814)[22](https://www.nature.com/articles/s41591-026-04663-5#Aff22), * [Matthias Zehner](https://www.nature.com/articles/s41591-026-04663-5#auth-Matthias-Zehner-Aff5-Aff23-Aff24-Aff25) [ORCID: orcid.org/0000-0001-5745-0836](https://orcid.org/0000-0001-5745-0836)[5](https://www.nature.com/articles/s41591-026-04663-5#Aff5),[23](https://www.nature.com/articles/s41591-026-04663-5#Aff23),[24](https://www.nature.com/articles/s41591-026-04663-5#Aff24),[25](https://www.nature.com/articles/s41591-026-04663-5#Aff25), * [Henning Gruell](https://www.nature.com/articles/s41591-026-04663-5#auth-Henning-Gruell-Aff5-Aff23) [ORCID: orcid.org/0000-0002-0725-7138](https://orcid.org/0000-0002-0725-7138)[5](https://www.nature.com/articles/s41591-026-04663-5#Aff5),[23](https://www.nature.com/articles/s41591-026-04663-5#Aff23), * [Christian Drosten](https://www.nature.com/articles/s41591-026-04663-5#auth-Christian-Drosten-Aff2-Aff3) [ORCID: orcid.org/0000-0001-7923-0519](https://orcid.org/0000-0001-7923-0519)[2](https://www.nature.com/articles/s41591-026-04663-5#Aff2),[3](https://www.nature.com/articles/s41591-026-04663-5#Aff3), * [Florian Klein](https://www.nature.com/articles/s41591-026-04663-5#auth-Florian-Klein-Aff5-Aff23) [ORCID: orcid.org/0000-0003-1376-1792](https://orcid.org/0000-0003-1376-1792)[5](https://www.nature.com/articles/s41591-026-04663-5#Aff5),[23](https://www.nature.com/articles/s41591-026-04663-5#Aff23), * [Charité Ebola Task Force](https://www.nature.com/articles/s41591-026-04663-5#group-1), * [Florian Kurth](https://www.nature.com/articles/s41591-026-04663-5#auth-Florian-Kurth-Aff1-Aff21-Aff26) [ORCID: orcid.org/0000-0002-3807-473X](https://orcid.org/0000-0002-3807-473X)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1),[21](https://www.nature.com/articles/s41591-026-04663-5#Aff21),[26](https://www.nature.com/articles/s41591-026-04663-5#Aff26) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1) & * … * [Leif E. Sander](https://www.nature.com/articles/s41591-026-04663-5#auth-Leif_E_-Sander-Aff1-Aff19-Aff21) [ORCID: orcid.org/0000-0002-0476-9947](https://orcid.org/0000-0002-0476-9947)[1](https://www.nature.com/articles/s41591-026-04663-5#Aff1),[19](https://www.nature.com/articles/s41591-026-04663-5#Aff19),[21](https://www.nature.com/articles/s41591-026-04663-5#Aff21) [na1](https://www.nature.com/articles/s41591-026-04663-5#na1) Show authors [_Nature Medicine_](https://www.nature.com/nm) (2026) [Cite this article](https://www.nature.com/articles/s41591-026-04663-5#citeas) [ Save article ](https://www.nature.com/articles/s41591-026-04663-5/save-research?_csrf=2MErZFOKCB1x0jsGzdG7QDrb0TI97ovW) [ View saved research ](https://www.nature.com/saved-research) We’re sharing this article early to provide faster access to peer-reviewed, accepted research. It is citable and carries a permanent DOI. This version is subject to further edits and will be replaced automatically by the final Version of Record. All legal disclaimers apply. ## Abstract Clinical data on Bundibugyo virus (BDBV) infection are limited, and no approved virus-specific treatment exists. We describe the case of a previously healthy 39-year-old healthcare worker who acquired BDBV infection while working in Ituri Province, Democratic Republic of the Congo (DRC), and was medically evacuated to Germany. He received MBP134, an investigational combination of two monoclonal antibodies, under an FDA Emergency Investigational New Drug (eIND) authorization, together with remdesivir and supportive care. Viral RNA concentrations were highest in oropharyngeal swabs and plasma, and became undetectable in blood, throat swabs, urine, and stool by day 13 after symptom onset and in semen by day 25. The patient’s serum demonstrated neutralizing activity against the current BDBV outbreak strain and other orthoebolaviruses. We detected BDBV-induced antibody responses not attributable to MBP134 or prior vaccination, providing evidence of endogenous humoral immunity following combined antiviral treatment. The patient recovered and was discharged on day 22 after symptom onset. This case report provides detailed insights into the clinical course, virologic dynamics and immune responses in BDBV infection during combined antiviral treatment, while larger clinical studies are needed to assess the efficacy and clinical utility of these therapeutic approaches. [ Download PDF ](https://www.nature.com/articles/s41591-026-04663-5_reference.pdf) ## Author information Author notes 1. These authors contributed equally: Alexander Uhrig, Frieder Pfäfflin, Pinkus Tober-Lau, Victor M. Corman, Miriam S. Stegemann, Florian Kurth, Leif E. Sander. ### Authors and Affiliations 1. Department of Infectious Diseases, Respiratory, and Critical Care Medicine, Charité – University Medical Center Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany Alexander Uhrig, Frieder Pfäfflin, Pinkus Tober-Lau, Miriam S. Stegemann, Katrin Moira Heim, Felix Bremer, Thomas Cronen, Tilman Lingscheid, Han Ngoc Le, Dominik Geus, David Hillus, Christian Gaebler, Martin Witzenrath, Joram Arzig, Lara Bardtke, Clara Bergmann, Andreas Binke, Markus Brack, Katharina Breuer, Sophia Brumhard, Carolin Burschberg, Martin Büttner, Nilgün Cetrefli, Anika Cleemann, Jan Doehn, Daniel Dyba, Martin Eicher, Jana Faller, Paul Feldmann, Susanne Fieberg, Frieder Gabriel, Louise Götze, Julia Gradwohl, Chris Grätz, Matthias Gröschel, Tamara Hartmann, Wolfgang Hinkeldey, Julius Hoffmann, Johanna Hopp, Johanna Horn, Mareen Höwler, Silvija Ilic, Jannina Kadereit, Jonas Kerbaum, Katharina Klement, Thomas Klotzkowski, Christoph Knoch, Sören Kolbe, Anett Kolizius, Helene Kriedemann, Tassilo Kruis, Julia Lichtblau, Rebecca Lorenz, Felix Machleidt, Shima Mecklenbräuker, Nikolai Menner, Gina Maria Michalsky, Miriam Müller, Holger Müller-Redetzky, Joanna Muszynska, Viola Marie Nagata, Anne Österby, Michela Perotti, Lennart Pfannkuch, Moritz Pfeiffer, Ursula Pfitzner, Peter Radünzel, Sibylle Reinsch, Julia Riedmann, Stephanie Rohrbach, Laura Rose, Violeta Sanchez Alvarez, Bricel Selene Santiago Quintana, Sylvia Schaber, Renate Schaffernicht, Melanie Schmele, Birgit Schnödewind, Maike Schröder, Saskia Schulz, Josua Sellmaier, Rincy Simon, Benjamin Stadtmann, Clara Steinacker, Ansgar Stenzel, Yasmin Stoppe, Montana Louis Tatum, Michael Weber, Nadine Weeverink, Friedrich Welz, Dana Wolff, Ellen Wrzolek, Desiree Zeegers-Bachmann, Thomas Zoller, Florian Kurth & Leif E. Sander 2. Institute of Virology, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany Victor M. Corman, Till D. Best, Christian Drosten, Tobias Bleicker, Kim Heimsch, Terence C. Jones, Fiona Lawrenz, Tiina Mauno, Julia Melchert, Marcel A. Müller, Marie L. Schmidt, Talitha Veith & Nikolai W. Zaki 3. German Centre for Infection Research (DZIF), Partner Site Charité, Berlin, Germany Victor M. Corman, Till D. Best & Christian Drosten 4. Labor Berlin, Charité-Vivantes GmbH, Berlin, Germany Victor M. Corman & Till D. Best 5. Institute of Virology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany Paulina Tarnow, Matthias Zehner, Henning Gruell & Florian Klein 6. Bernhard-Nocht-Institute for Tropical Medicine, Hamburg, Germany Monika Rottstegge, Stephan Günther & Lisa Oestereich
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