---
title: "Cinnamomum verum Bark Methanolic Extract: Antibacterial, Antibiofilm Activity and Preliminary Anti"
id: "pubmed-42673111"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42673111"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42673111/"
doi: "10.1002/cbdv.71634"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Cinnamomum verum Bark Methanolic Extract: Antibacterial, Antibiofilm Activity and Preliminary Anti
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42673111
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42673111/)
- **DOI:** [10.1002/cbdv.71634](https://doi.org/10.1002%2Fcbdv.71634)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The study chemically characterized a **Cinnamomum verum** bark methanolic extract by HPLC‑MS and identified 17 compounds; **trans‑cinnamaldehyde** was the predominant quantified constituent, followed by quinic acid, rutin, and protocatechuic acid. - Antibacterial activity was tested against reference and multidrug‑resistant strains using broth microdilution to determine **MIC** and **MBC**, with values of 0.625–5 mg/mL (MIC) and 2.5–20 mg/mL (MBC). - MBC/MIC ratios reported were consistent with bactericidal activity for the tested organisms. **Imipenem‑resistant Acinetobacter baumannii** isolates showed the greatest susceptibility to the extract. - The extract reduced biofilm biomass in a concentration‑dependent and strain‑dependent manner as measured by the crystal‑violet assay, indicating **antibiofilm** potential. - A disk‑diffusion screen evaluated antibiotic–extract interactions; results were antibiotic‑ and isolate‑dependent. Some combinations increased inhibition zones (notably cefoxitin and fosfomycin against MRSA and selected combinations against A. baumannii), while others showed no change or smaller zones; formal pharmacological synergy was not established. - Exploratory molecular docking prioritized quercetin, 1,3‑di‑O‑caffeoylquinic acid, and quercetin‑3‑O‑rhamnoside as candidate phytochemicals for further target‑based validation versus bacterial targets GyrB, LasA, and PBP1a. - Methods used: HPLC‑MS for phytochemical profiling; broth microdilution for MIC/MBC; crystal‑violet biofilm biomass assay; disk diffusion for interaction screening; molecular docking as a hypothesis‑generating approach. - The study is preliminary and hypothesis‑generating: docking results and disk‑diffusion interaction findings require follow‑up with target‑based validation and quantitative synergy testing.
## Clinical Analysis & Structured Key Points
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Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug-Resistant Bacteria: Preliminary Antibiotic-Interaction Screening and Exploratory Molecular Docking [Hayet Edziri](https://pubmed.ncbi.nlm.nih.gov/?term=Edziri+H&cauthor_id=42673111)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-1 "Laboratory of Transmissible Diseases and Biologically Active Substances, \(LR99ES27\), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."), [Sarra Elmsehli](https://pubmed.ncbi.nlm.nih.gov/?term=Elmsehli+S&cauthor_id=42673111)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-1 "Laboratory of Transmissible Diseases and Biologically Active Substances, \(LR99ES27\), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."), [Assia Kenich](https://pubmed.ncbi.nlm.nih.gov/?term=Kenich+A&cauthor_id=42673111)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-2 "Laboratory of Organic Chemistry Natural Substances and Analysis \(C.O.S.N.A.\), Abu Bekr Belkaid University, Tlemcen, Algeria."), [Mabrouk Horchani](https://pubmed.ncbi.nlm.nih.gov/?term=Horchani+M&cauthor_id=42673111)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-3 "Laboratory Of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products \(LR11ES39\), Department of Chemistry, Faculty of Sciences Of Monastir, University Of Monastir, Monastir, Tunisia."), [Hanen Najjaa](https://pubmed.ncbi.nlm.nih.gov/?term=Najjaa+H&cauthor_id=42673111)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-4 "Institute of Arid Land \(IRA\) Range Ecology Laboratory, Médenine, Tunisia."), [Naima Najah](https://pubmed.ncbi.nlm.nih.gov/?term=Najah+N&cauthor_id=42673111)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-1 "Laboratory of Transmissible Diseases and Biologically Active Substances, \(LR99ES27\), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."), [Hasan Aljohi](https://pubmed.ncbi.nlm.nih.gov/?term=Aljohi+H&cauthor_id=42673111)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-5 "Applied Genetics Technology Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia."), [Mohammad Nasser Alkhrayef](https://pubmed.ncbi.nlm.nih.gov/?term=Alkhrayef+MN&cauthor_id=42673111)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-6 "Disability Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia."), [Roberta Ascrizzi](https://pubmed.ncbi.nlm.nih.gov/?term=Ascrizzi+R&cauthor_id=42673111)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-7 "Department of Pharmacy, University of Pisa, Pisa, Italy."), [Guido Flamini](https://pubmed.ncbi.nlm.nih.gov/?term=Flamini+G&cauthor_id=42673111)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-7 "Department of Pharmacy, University of Pisa, Pisa, Italy."), [Ibrahim O Alanazi](https://pubmed.ncbi.nlm.nih.gov/?term=Alanazi+IO&cauthor_id=42673111)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-8 "The Healthy Aging Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia."), [Mozaniel Santana de Oliveira](https://pubmed.ncbi.nlm.nih.gov/?term=de+Oliveira+MS&cauthor_id=42673111)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#full-view-affiliation-9 "Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Postgraduate Program in Pharmaceutical Sciences \(PPGCF\), Federal University of Pará., Belém, Pará, Brazil.") Affiliations Expand ### Affiliations * 1 Laboratory of Transmissible Diseases and Biologically Active Substances, (LR99ES27), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia. * 2 Laboratory of Organic Chemistry Natural Substances and Analysis (C.O.S.N.A.), Abu Bekr Belkaid University, Tlemcen, Algeria. * 3 Laboratory Of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products (LR11ES39), Department of Chemistry, Faculty of Sciences Of Monastir, University Of Monastir, Monastir, Tunisia. * 4 Institute of Arid Land (IRA) Range Ecology Laboratory, Médenine, Tunisia. * 5 Applied Genetics Technology Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia. * 6 Disability Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia. * 7 Department of Pharmacy, University of Pisa, Pisa, Italy. * 8 The Healthy Aging Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia. * 9 Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Postgraduate Program in Pharmaceutical Sciences (PPGCF), Federal University of Pará., Belém, Pará, Brazil. * PMID: **42673111** * DOI: [ 10.1002/cbdv.71634 ](https://doi.org/10.1002/cbdv.71634) Item in Clipboard # Antibacterial and Antibiofilm Activity of a Chemically Characterized Cinnamomum verum Bark Methanolic Extract Against Multidrug-Resistant Bacteria: Preliminary Antibiotic-Interaction Screening and Exploratory Molecular Docking Hayet Edziri et al. Chem Biodivers. 2026 Sep. Show details Display options Display options Format Abstract PubMed PMID Chem Biodivers Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Chem+Biodivers%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Chem+Biodivers%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42673111/) . 2026 Sep;23(9):e71634. doi: 10.1002/cbdv.71634. ### Authors [Hayet Edziri](https://pubmed.ncbi.nlm.nih.gov/?term=Edziri+H&cauthor_id=42673111)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-1 "Laboratory of Transmissible Diseases and Biologically Active Substances, \(LR99ES27\), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."), [Sarra Elmsehli](https://pubmed.ncbi.nlm.nih.gov/?term=Elmsehli+S&cauthor_id=42673111)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-1 "Laboratory of Transmissible Diseases and Biologically Active Substances, \(LR99ES27\), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."), [Assia Kenich](https://pubmed.ncbi.nlm.nih.gov/?term=Kenich+A&cauthor_id=42673111)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-2 "Laboratory of Organic Chemistry Natural Substances and Analysis \(C.O.S.N.A.\), Abu Bekr Belkaid University, Tlemcen, Algeria."), [Mabrouk Horchani](https://pubmed.ncbi.nlm.nih.gov/?term=Horchani+M&cauthor_id=42673111)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-3 "Laboratory Of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products \(LR11ES39\), Department of Chemistry, Faculty of Sciences Of Monastir, University Of Monastir, Monastir, Tunisia."), [Hanen Najjaa](https://pubmed.ncbi.nlm.nih.gov/?term=Najjaa+H&cauthor_id=42673111)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-4 "Institute of Arid Land \(IRA\) Range Ecology Laboratory, Médenine, Tunisia."), [Naima Najah](https://pubmed.ncbi.nlm.nih.gov/?term=Najah+N&cauthor_id=42673111)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-1 "Laboratory of Transmissible Diseases and Biologically Active Substances, \(LR99ES27\), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia."), [Hasan Aljohi](https://pubmed.ncbi.nlm.nih.gov/?term=Aljohi+H&cauthor_id=42673111)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-5 "Applied Genetics Technology Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia."), [Mohammad Nasser Alkhrayef](https://pubmed.ncbi.nlm.nih.gov/?term=Alkhrayef+MN&cauthor_id=42673111)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-6 "Disability Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia."), [Roberta Ascrizzi](https://pubmed.ncbi.nlm.nih.gov/?term=Ascrizzi+R&cauthor_id=42673111)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-7 "Department of Pharmacy, University of Pisa, Pisa, Italy."), [Guido Flamini](https://pubmed.ncbi.nlm.nih.gov/?term=Flamini+G&cauthor_id=42673111)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-7 "Department of Pharmacy, University of Pisa, Pisa, Italy."), [Ibrahim O Alanazi](https://pubmed.ncbi.nlm.nih.gov/?term=Alanazi+IO&cauthor_id=42673111)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-8 "The Healthy Aging Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia."), [Mozaniel Santana de Oliveira](https://pubmed.ncbi.nlm.nih.gov/?term=de+Oliveira+MS&cauthor_id=42673111)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42673111/#short-view-affiliation-9 "Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Postgraduate Program in Pharmaceutical Sciences \(PPGCF\), Federal University of Pará., Belém, Pará, Brazil.") ### Affiliations * 1 Laboratory of Transmissible Diseases and Biologically Active Substances, (LR99ES27), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia. * 2 Laboratory of Organic Chemistry Natural Substances and Analysis (C.O.S.N.A.), Abu Bekr Belkaid University, Tlemcen, Algeria. * 3 Laboratory Of Heterocyclic Chemistry, Natural Products and Reactivity, Medicinal Chemistry and Natural Products (LR11ES39), Department of Chemistry, Faculty of Sciences Of Monastir, University Of Monastir, Monastir, Tunisia. * 4 Institute of Arid Land (IRA) Range Ecology Laboratory, Médenine, Tunisia. * 5 Applied Genetics Technology Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia. * 6 Disability Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia. * 7 Department of Pharmacy, University of Pisa, Pisa, Italy. * 8 The Healthy Aging Research Institute, King Abdulaziz City For Science and Technology, Riyadh, Saudi Arabia. * 9 Laboratory of Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Postgraduate Program in Pharmaceutical Sciences (PPGCF), Federal University of Pará., Belém, Pará, Brazil. * PMID: **42673111** * DOI: [ 10.1002/cbdv.71634 ](https://doi.org/10.1002/cbdv.71634) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract This study characterized the phytochemical composition of a methanolic bark extract of Cinnamomum verum and evaluated its antibacterial, bactericidal, biofilm-biomass-reducing, and preliminary antibiotic-potentiating effects against reference and multidrug-resistant bacterial strains. The extract was characterized by HPLC-MS; MIC and MBC values were determined by broth microdilution; biofilm biomass was assessed using the crystal-violet assay; and antibiotic-extract interactions were screened by disk diffusion. Molecular docking was used as a hypothesis-generating approach to investigate interactions between identified phytochemicals and GyrB, LasA, and PBP1a. Seventeen compounds were identified, with trans-cinnamaldehyde as the predominant quantified constituent, followed by quinic acid, rutin, and protocatechuic acid. The extract inhibited all tested bacteria, with MIC and MBC values of 0.625-5 and 2.5-20 mg/mL, respectively, and MBC/MIC ratios consistent with bactericidal activity. Imipenem-resistant Acinetobacter baumannii isolates were the most susceptible. The extract also reduced biofilm biomass in a concentration-dependent and strain-dependent manner. Disk-diffusion screening identified antibiotic- and isolate-dependent increases in inhibition zones, particularly for cefoxitin and fosfomycin against MRSA and for selected combinations against A. baumannii; however, some combinations were unchanged or produced smaller zones, and pharmacological synergy was not established. Docking prioritized quercetin, 1,3-di-O-caffeoylquinic acid, and quercetin-3-O-rhamnoside as candidates for subsequent target-based validation. **Keywords:** Cinnamomum verum; antibiotic potentiation; antimicrobial resistance; biofilm; molecular docking; phytochemicals. © 2026 The Author(s). Chemistry & Biodiversity published by Wiley‐VHCA AG. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## References 1. 1. S. K. Ahmed, S. Hussein, K. Qurbani, et al., “Antimicrobial Resistance: Impacts, Challenges, and Future Prospects,” Journal of Medical Surgery and Public Health 2 (2024): 100081, . 2. 1. P. E. Murray, J. A. Coffman, and F. Garciá‐Godoy, “Antimicrobial Resistance: A Bibliometric Review of Patient Health, Mechanisms, and Therapeutic Strategies,” Pathogens 15 (2026): 288, . 3. 1. R. G. Elbaiomy, A. H. El‐Sappah, R. Guo, et al., “Antibiotic Resistance: A Genetic and Physiological Perspective,” MedComm 6, no. 11 (2025): e70447, . 4. 1. A. Zhao, J. Sun, and Y. Liu, “Understanding Bacterial Biofilms: From Definition to Treatment Strategies,” Frontiers in Cellular and Infection Microbiology 13 (2023): 1137947, . 5. 1. L. M. Yaki, “Bacterial Biofilms and Antimicrobial Resistance: A Global Threat,” Discovered Bacteria 3 (2026): 15, [https://doi.org/10.1007/s44351‐025‐00035‐5](https://doi.org/10.1007/s44351%E2%80%90025%E2%80%9000035%E2%80%905). Show all 90 references ## MeSH terms * Acinetobacter baumannii / drug effects Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Acinetobacter+baumannii%2Fdrug+effects%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Acinetobacter+baumannii) * [ Add to Search ](h
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