---
title: "FilmArray Pneumonia Plus: Multiplex PCR Improves Diagnosis and Antibiotic Stewardship in LRTI"
id: "pubmed-42671413"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42671413"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42671413/"
doi: "10.4103/lungindia.lungindia_30_26"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# FilmArray Pneumonia Plus: Multiplex PCR Improves Diagnosis and Antibiotic Stewardship in LRTI
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42671413
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42671413/)
- **DOI:** [10.4103/lungindia.lungindia_30_26](https://doi.org/10.4103%2Flungindia.lungindia_30_26)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Study enrolled 103 hospitalized adults with lower respiratory tract infection (LRTI) to evaluate a multiplex PCR panel, the **FilmArray Pneumonia Plus Panel (FAPP)**, against conventional culture for pathogen detection and impact on antimicrobial management. - **FAPP** detected at least one pathogen in 92 of 103 specimens, whereas conventional culture yielded a pathogen in 36 cases (34.9%). - Mean duration of antibiotic therapy was shorter when FAPP was positive (4.89 ± 1.84 days) versus FAPP-negative cases (7.2 ± 3.83 days); P = 0.019. - Hospital length of stay was shorter for FAPP-positive cases (5.136 ± 1.73 days) versus FAPP-negative cases (7.6 ± 3.36 days); P = 0.007. - Turnaround time (TAT) for FAPP was substantially shorter than conventional culture, enabling earlier results. - Antimicrobial modification guided by FAPP occurred in 83 of 103 patients (80.6%), a markedly higher rate than with culture-guided changes. - FAPP also provided enhanced detection of resistance markers compared with culture. - Overall, the authors conclude that in hospitalized patients with LRTI, use of **multiplex PCR** via FAPP improved diagnostic sensitivity, accelerated actionable results, increased potential for antimicrobial streamlining, reduced antibiotic days, and shortened hospital stay. - Keywords highlighted in the source include **antimicrobial stewardship**, FilmArray Pneumonia Plus Panel, diagnostic yield, lower respiratory tract infection, and multiplex PCR.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 29. # Utility of multiplex PCR panels for optimum management of lower respiratory Infections Employing FilmArray Pneumonia Plus Testing-results of the UPLIFT study [Rajesh Venkitakrishnan](https://pubmed.ncbi.nlm.nih.gov/?term=Venkitakrishnan+R&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Bismil Aisha Basheer](https://pubmed.ncbi.nlm.nih.gov/?term=Basheer+BA&cauthor_id=42671413)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-2 "Department of Pulmonary Medicine, Family Health Centre, Kerala Health Services, Thiruvananthapuram, Kerala, India."), [Melcy Cleetus](https://pubmed.ncbi.nlm.nih.gov/?term=Cleetus+M&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Divya Ramachandran](https://pubmed.ncbi.nlm.nih.gov/?term=Ramachandran+D&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Anand Vijay](https://pubmed.ncbi.nlm.nih.gov/?term=Vijay+A&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Hasha Thankam Somson](https://pubmed.ncbi.nlm.nih.gov/?term=Somson+HT&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Sonya Joy](https://pubmed.ncbi.nlm.nih.gov/?term=Joy+S&cauthor_id=42671413)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-3 "Department of Clinical Microbiology, Rajagiri Hospital, Kochi, Kerala, India."), [Neethu Susan Philip](https://pubmed.ncbi.nlm.nih.gov/?term=Philip+NS&cauthor_id=42671413)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-3 "Department of Clinical Microbiology, Rajagiri Hospital, Kochi, Kerala, India."), [Susan John](https://pubmed.ncbi.nlm.nih.gov/?term=John+S&cauthor_id=42671413)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#full-view-affiliation-4 "Department of Clinical Epidemiology, Rajagiri Hospital, Kochi, Kerala, India.") Affiliations Expand ### Affiliations * 1 Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India. * 2 Department of Pulmonary Medicine, Family Health Centre, Kerala Health Services, Thiruvananthapuram, Kerala, India. * 3 Department of Clinical Microbiology, Rajagiri Hospital, Kochi, Kerala, India. * 4 Department of Clinical Epidemiology, Rajagiri Hospital, Kochi, Kerala, India. * PMID: **42671413** * DOI: [ 10.4103/lungindia.lungindia_30_26 ](https://doi.org/10.4103/lungindia.lungindia_30_26) Item in Clipboard # Utility of multiplex PCR panels for optimum management of lower respiratory Infections Employing FilmArray Pneumonia Plus Testing-results of the UPLIFT study Rajesh Venkitakrishnan et al. Lung India. 2026. Show details Display options Display options Format Abstract PubMed PMID Lung India Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lung+India%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lung+India%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42671413/) . 2026 Sep 1;43(5):536-544. doi: 10.4103/lungindia.lungindia_30_26. Epub 2026 Aug 29. ### Authors [Rajesh Venkitakrishnan](https://pubmed.ncbi.nlm.nih.gov/?term=Venkitakrishnan+R&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Bismil Aisha Basheer](https://pubmed.ncbi.nlm.nih.gov/?term=Basheer+BA&cauthor_id=42671413)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-2 "Department of Pulmonary Medicine, Family Health Centre, Kerala Health Services, Thiruvananthapuram, Kerala, India."), [Melcy Cleetus](https://pubmed.ncbi.nlm.nih.gov/?term=Cleetus+M&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Divya Ramachandran](https://pubmed.ncbi.nlm.nih.gov/?term=Ramachandran+D&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Anand Vijay](https://pubmed.ncbi.nlm.nih.gov/?term=Vijay+A&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Hasha Thankam Somson](https://pubmed.ncbi.nlm.nih.gov/?term=Somson+HT&cauthor_id=42671413)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-1 "Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India."), [Sonya Joy](https://pubmed.ncbi.nlm.nih.gov/?term=Joy+S&cauthor_id=42671413)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-3 "Department of Clinical Microbiology, Rajagiri Hospital, Kochi, Kerala, India."), [Neethu Susan Philip](https://pubmed.ncbi.nlm.nih.gov/?term=Philip+NS&cauthor_id=42671413)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-3 "Department of Clinical Microbiology, Rajagiri Hospital, Kochi, Kerala, India."), [Susan John](https://pubmed.ncbi.nlm.nih.gov/?term=John+S&cauthor_id=42671413)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42671413/#short-view-affiliation-4 "Department of Clinical Epidemiology, Rajagiri Hospital, Kochi, Kerala, India.") ### Affiliations * 1 Department of Pulmonary Medicine, Rajagiri Hospital, Kochi, Kerala, India. * 2 Department of Pulmonary Medicine, Family Health Centre, Kerala Health Services, Thiruvananthapuram, Kerala, India. * 3 Department of Clinical Microbiology, Rajagiri Hospital, Kochi, Kerala, India. * 4 Department of Clinical Epidemiology, Rajagiri Hospital, Kochi, Kerala, India. * PMID: **42671413** * DOI: [ 10.4103/lungindia.lungindia_30_26 ](https://doi.org/10.4103/lungindia.lungindia_30_26) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background and objective:** The objectives of this study were to assess the yield of multiplex PCR testing in LRTI and its utility in antimicrobial streamlining. Establishing the microbial aetiology is of paramount importance for tailored antimicrobial therapy in lower respiratory tract infections (LRTI). Multiplex PCR panels (FilmArray Pneumonia Plus Panel [FAPP]) have been shown to provide better diagnostic yield in LRTI. **Methods:** A total of 103 patients hospitalized with LRTI were enrolled. The culture isolates, their sensitivity pattern, and antimicrobial resistance were noted. Time taken for availability of FAPP results as well as culture positivity was documented. Antibiotic modification made based on identification of the pathogens along with their resistant gene patterns from appropriate samples and time taken to reach that decision was noted and compared between conventional culture and FAPP. **Results:** FAPP detected at least one pathogen in (92/103) of tested specimens. Conventional culture detected at least one pathogen in 36 (34.9%) cases only. The mean duration of antibiotic therapy in FAPP-positive cases was 4.89 ± 1.84 days versus 7.2 ± 3.83 days in cases where FAPP was negative ( P value of 0.019). Similarly, the duration of hospital stay in FAPP-positive cases versus -negative cases was 5.136 ± 1.73 days versus 7.6 ± 3.36 days, respectively ( P value 0.007). Mean turnaround time (TAT) for the FAPP was strikingly low with FAPP. Antimicrobial modification guided by FAPP was achieved in 83 out of 103 patients (80.6%), substantially higher than with conventional culture. **Conclusion:** In hospitalized patients with LRTI, FAPP provided better diagnostic sensitivity, better detection of resistance, faster TAT, higher potential for antimicrobial modification, lesser days of antibiotic use, and shorter hospital stay compared to culture. **Keywords:** Antimicrobial stewardship; FilmArray Pneumonia Plus Panel; diagnostic yield; lower respiratory tract infection; multiplex PCR. Copyright © 2026 Indian Chest Society. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## References 1. 1. Sirota SB, Bender RG, Dominguez RV, Movo A, Swetschinski LR, Araki DT, et al. GBD 2023 Lower Respiratory Infections and Antimicrobial Resistance Collaborators. Global burden of lower respiratory infections and aetiologies, 1990-2023: A systematic analysis for the Global Burden of Disease Study 2023. Lancet Infect Dis 2025:S1473-3099(25)00689-9. [doi: 10.1016/S1473-3099(25)00689-9]. - [DOI](https://doi.org/10.1016/s1473-3099\(25\)00689-9) 2. 1. Martin-Loeches I, Torres A, Nagavci B, Aliberti S, Antonelli M, Bassetti M, et al. ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Intensive Care Med 2023;49:615-32. 3. 1. Metlay JP, Waterer GW, Long AC, et al. Diagnosis and treatment of adults with community-acquired pneumonia. An Official Clinical Practice Guideline of the American Thoracic Society and Infectious Diseases Society of America. Am J Respir Crit Care Med 2019;200:e45-67. 4. 1. Vikhe VB, Faruqi AA, Patil RS, Reddy A, Khandol D. Correction: A systematic review of community-acquired pneumonia in Indian adults. Cureus 2025;17:c265. 5. 1. Murphy SL, Xu J, Kochanek KD. Deaths: Final data for 2010. Natl Vital Stat Rep 2013;61:1-117. 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