---
title: "Guillain-Barré Syndrome and Visual Impairment Associated with Emerging Oropouche Virus Lineage, Brazil, 2024"
id: "cdc-emerging-infectious-diseases-journal-6-guillain-barr-syndrome-and-visual-impairment-associated-with-emerging-oropouche-virus-lineage-brazil-2024"
canonical_url: "https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-6-guillain-barr-syndrome-and-visual-impairment-associated-with-emerging-oropouche-virus-lineage-brazil-2024"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "CDC Emerging Infectious Diseases Journal"
source_url: "https://wwwnc.cdc.gov/eid/article/32/4/25-0617_article"
published_at: "2026-04-10T04:00:00.000Z"
evidence_level: "Agency Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Guillain-Barré Syndrome and Visual Impairment Associated with Emerging Oropouche Virus Lineage, Brazil, 2024
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-6-guillain-barr-syndrome-and-visual-impairment-associated-with-emerging-oropouche-virus-lineage-brazil-2024
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** CDC Emerging Infectious Diseases Journal
- **Source URL:** [Original Journal Publication](https://wwwnc.cdc.gov/eid/article/32/4/25-0617_article)
- **Published At:** 2026-04-10T04:00:00.000Z
- **Evidence Rating:** Agency Feed
## Executive GIST (TL;DR)
Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released. We report a case of Guillain-Barré syndrome with visual impairment after confirmed Oropouche virus infection during the 2024 outbreak in Ceará, Brazil. Whole-genome sequencing revealed infection by a novel reassortant viral lineage (OROVBR_2025_2024), raising concern about the neurovirulence of this emerging orthobunyavirus strain. Oropouche virus (OROV), an orthobunyavirus transmitted by mosquitoes and Culicoides paraensis midges, is emerging as a major arboviral pathogen in Latin America. Although typically associated with mild febrile illness, the current outbreak, which is linked to the novel reassortant lineage OROV BR-2015–2024 ( 1 ), has been associated with severe cases, including fatalities, vertical transmission with fetal deaths ( 2 – 4 ), and Guillain-Barré syndrome (GBS) ( 5 ). We report a case of GBS with possible bilateral optic neuritis after OROV infection during the 2024 outbreak in Ceará state, Brazil.
## Clinical Analysis & Structured Key Points
CDC Emerging Infectious Diseases Journal published a clinical update in Infectious Disease on 10 Apr 2026. The item focuses on Guillain-Barré Syndrome and Visual Impairment Associated with Emerging Oropouche Virus Lineage, Brazil, 2024. Review the original article for the full source wording and details.
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