---
title: "HIV DNA and Transcription Patterns in Natural Controllers Before and After ART"
id: "pubmed-42635429"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42635429"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42635429/"
doi: "10.1128/jvi.00482-26"
published_at: "2026-09-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# HIV DNA and Transcription Patterns in Natural Controllers Before and After ART
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42635429
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42635429/)
- **DOI:** [10.1128/jvi.00482-26](https://doi.org/10.1128%2Fjvi.00482-26)
- **Published At:** 2026-09-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Natural HIV-1 controllers suppress plasma HIV RNA without ART and were compared to ART-suppressed noncontrollers to define differences in reservoir size and transcription. - Longitudinal blood samples were analyzed before ART and up to 3–5 years on suppressive ART from 10 controllers (5 elite, 5 viremic) and compared with ART-suppressed noncontrollers. - Controllers had lower levels of most measured **HIV DNA** regions compared with noncontrollers, but levels of **intact proviruses** were not lower in controllers according to the reported results. - Total levels of initiated and completed **HIV RNA** were lower in controllers than in noncontrollers, consistent with a smaller or less active reservoir overall. - When normalized per provirus, controllers paradoxically exhibited higher levels of initiated and 5' elongated HIV transcripts per provirus, suggesting more short or prematurely terminated transcription events per infected cell. - Controllers showed a lower ratio of completed/elongated HIV RNA, and after ART they had lower levels of multiply spliced HIV RNA and a lower multiply spliced/completed HIV RNA ratio, indicating selective restriction of transcript completion and splicing. - Initiation and elongation of short transcripts appear less restricted than completion and splicing in controllers; mechanisms of natural control may therefore limit infection frequency and selectively reduce completed and spliced transcript production or increase clearance of cells producing those transcripts. - Starting ART in controllers resulted in further rises in CD4+ T-cell counts and decreases in HIV DNA and some HIV transcripts, supporting a potential clinical benefit of ART for controllers. - The study supports a model where natural control combines fewer infected cells with specific blockade or increased removal of cells producing fully elongated and spliced HIV RNA. - Specific numerical values, full noncontroller sample size, detailed assay methods and statistical measures beyond those summarized in the abstract were not reported in the source abstract and would require consultation of the full text for complete details.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42635429/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42635429%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42635429/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42635429/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42635429/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/c24ab723-7c80-48cd-9c68-022ded852586/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42635429/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42635429/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42635429/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42635429%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42635429%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42635429/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42635429/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42635429/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42635429/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Atypon full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--journals.asm.org-pb-assets-pubmed-pubmed_JVI.png) Atypon ](https://journals.asm.org/doi/10.1128/jvi.00482-26?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed "See full text options at Atypon") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42635429/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42635429/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42635429/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42635429/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42635429/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42635429/#similar) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42635429/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42635429/#substances) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42635429/#related-links) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42635429/#grants) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42635429/#linkout) Title & authors Abstract Conflict of interest statement Similar articles MeSH terms Substances Related information Grants and funding LinkOut - more resources J Virol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Virol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Virol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42635429/) . 2026 Sep 22;100(9):e0048226. doi: 10.1128/jvi.00482-26. Epub 2026 Aug 24. # HIV DNA and transcription before and after ART in natural controllers compared to noncontrollers [Sun Jin Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+SJ&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Julie Janssens](https://pubmed.ncbi.nlm.nih.gov/?term=Janssens+J&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Cordelia Isbell](https://pubmed.ncbi.nlm.nih.gov/?term=Isbell+C&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Adam Wedrychowski](https://pubmed.ncbi.nlm.nih.gov/?term=Wedrychowski+A&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Alton Barbehenn](https://pubmed.ncbi.nlm.nih.gov/?term=Barbehenn+A&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Rebecca Hoh](https://pubmed.ncbi.nlm.nih.gov/?term=Hoh+R&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Michael J Peluso](https://pubmed.ncbi.nlm.nih.gov/?term=Peluso+MJ&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Sulggi A Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+SA&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Satish K Pillai](https://pubmed.ncbi.nlm.nih.gov/?term=Pillai+SK&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-2 "Vitalant Research Institute, San Francisco, California, USA."), [Timothy J Henrich](https://pubmed.ncbi.nlm.nih.gov/?term=Henrich+TJ&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Nadia R Roan](https://pubmed.ncbi.nlm.nih.gov/?term=Roan+NR&cauthor_id=42635429)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-3 "Department of Urology, University of California, San Francisco \(UCSF\), San Francisco, California, USA.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-4 "Gladstone Institutes, San Francisco, California, USA."), [Steven G Deeks](https://pubmed.ncbi.nlm.nih.gov/?term=Deeks+SG&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Steven A Yukl](https://pubmed.ncbi.nlm.nih.gov/?term=Yukl+SA&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#full-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA.") Affiliations Expand ### Affiliations * 1 Department of Medicine, University of California, San Francisco (UCSF), San Francisco, California, USA. * 2 Vitalant Research Institute, San Francisco, California, USA. * 3 Department of Urology, University of California, San Francisco (UCSF), San Francisco, California, USA. * 4 Gladstone Institutes, San Francisco, California, USA. * PMID: **42635429** * DOI: [ 10.1128/jvi.00482-26 ](https://doi.org/10.1128/jvi.00482-26) Item in Clipboard # HIV DNA and transcription before and after ART in natural controllers compared to noncontrollers Sun Jin Kim et al. J Virol. 2026. Show details Display options Display options Format Abstract PubMed PMID J Virol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Virol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Virol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42635429/) . 2026 Sep 22;100(9):e0048226. doi: 10.1128/jvi.00482-26. Epub 2026 Aug 24. ### Authors [Sun Jin Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+SJ&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Julie Janssens](https://pubmed.ncbi.nlm.nih.gov/?term=Janssens+J&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Cordelia Isbell](https://pubmed.ncbi.nlm.nih.gov/?term=Isbell+C&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Adam Wedrychowski](https://pubmed.ncbi.nlm.nih.gov/?term=Wedrychowski+A&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Alton Barbehenn](https://pubmed.ncbi.nlm.nih.gov/?term=Barbehenn+A&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Rebecca Hoh](https://pubmed.ncbi.nlm.nih.gov/?term=Hoh+R&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Michael J Peluso](https://pubmed.ncbi.nlm.nih.gov/?term=Peluso+MJ&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Sulggi A Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+SA&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Satish K Pillai](https://pubmed.ncbi.nlm.nih.gov/?term=Pillai+SK&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-2 "Vitalant Research Institute, San Francisco, California, USA."), [Timothy J Henrich](https://pubmed.ncbi.nlm.nih.gov/?term=Henrich+TJ&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Nadia R Roan](https://pubmed.ncbi.nlm.nih.gov/?term=Roan+NR&cauthor_id=42635429)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-3 "Department of Urology, University of California, San Francisco \(UCSF\), San Francisco, California, USA.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-4 "Gladstone Institutes, San Francisco, California, USA."), [Steven G Deeks](https://pubmed.ncbi.nlm.nih.gov/?term=Deeks+SG&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA."), [Steven A Yukl](https://pubmed.ncbi.nlm.nih.gov/?term=Yukl+SA&cauthor_id=42635429)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42635429/#short-view-affiliation-1 "Department of Medicine, University of California, San Francisco \(UCSF\), San Francisco, California, USA.") ### Affiliations * 1 Department of Medicine, University of California, San Francisco (UCSF), San Francisco, California, USA. * 2 Vitalant Research Institute, San Francisco, California, USA. * 3 Department of Urology, University of California, San Francisco (UCSF), San Francisco, California, USA. * 4 Gladstone Institutes, San Francisco, California, USA. * PMID: **42635429** * DOI: [ 10.1128/jvi.00482-26 ](https://doi.org/10.1128/jvi.00482-26) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract HIV-1 natural controllers can limit plasma HIV RNA levels in the absence of antiretroviral therapy (ART). Although controllers have less HIV DNA, it remains unclear how HIV transcription differs from noncontrollers, and whether ART further reduces HIV DNA or RNA in controllers. To address these questions, we quantified different HIV transcripts and HIV DNA regions/proviruses in longitudinal blood samples collected before ART and up to 3-5 years on suppressive ART from 10 controllers (5 "elite" and 5 viremic) and compared them to ART-suppressed noncontrollers. Compared to noncontrollers, controllers exhibited lower levels of most HIV DNA regions (but not intact proviruses) and lower total levels of initiated and completed HIV RNA, but paradoxically higher levels per provirus of initiated and 5' elongated HIV transcripts. Controllers also showed a lower ratio of completed/elongated HIV RNA. After ART, controllers showed lower levels of multiply spliced HIV RNA and a lower ratio of multiply spliced/completed HIV RNA. These results suggest that natural controllers limit HIV infection frequency and selectively restrict HIV transcript completion and splicing. ART treatment of controllers led to further increases in CD4 counts and decreases in HIV DNA and some HIV transcripts, supporting the potential for clinical benefits in this population.IMPORTANCENatural HIV controllers can suppress HIV-1 replication without antiretroviral therapy (ART) and serve as a model for an HIV functional cure, but the mechanisms are unclear. We found that natural control was associated with mechanisms that reduce levels of total HIV DNA and the HIV promoter regions to below the levels seen in ART-treated noncontrollers (NC), resulting in lower total levels of most HIV transcripts. When corrected for HIV DNA levels, natural controllers exhibited higher levels per provirus of short, prematurely terminated HIV transcripts but lower proportions of completed and spliced HIV transcripts. These findings suggest that the mechanisms of natural control do not only limit HIV infection frequency, but specifically limit production or increase clearance of infected cells making completed and spliced HIV transcripts. ART treatment of controllers led to further increases in CD4+ T-cell counts and decreases in HIV DNA and RNA, suggesting that ART should be offered to controllers. **Keywords:** DNA; HIV; HIV-1; RNA; controller; provirus; transcription. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement The authors declare no conflict of interest. ## Similar articles * [ Differential decreases in various HIV DNA regions and HIV transcripts after ART initiation during chronic infection. ](https://pubmed.ncbi.nlm.nih.gov/40626705/) Janssens J, Isbell C, Kim SJ, Wedrychowski A, Barbehenn A, Hoh R, Pillai SK, Peluso MJ, Lee SA, Henrich TJ, Roan NR, Deeks SG, Yukl SA.Janssens J, et al.J Virol. 2025 Aug 19;99(8):e0068325. doi: 10.1128/jvi.00683-25. Epub 2025 Jul 8.J Virol. 2025.PMID: 40626705Free PMC article. * [ Longitudinal changes in the transcriptionally active and intact HIV reservoir after starting ART during acute infection. ](https://pubmed.ncbi.nlm.nih.gov/39907283/) Janssens J, Wedrychowski A, Kim SJ, Isbell C, Hoh R, Pillai SK, Henrich TJ, Deeks SG, Roan NR, Lee SA, Yukl SA.Janssens J, et al.J Virol. 2025 Mar 18;99(3):e0143124. doi: 10.1128/jvi.01431-24. Epub 2025 Feb 5.J Virol. 2025.PMID: 39907283Free PMC article. * [ Comparison of HIV DNA and RNA in gut-associated lymphoid tissue of HIV-infected controllers and noncontrollers. ](https://pubmed.ncbi.nlm.nih.gov/24157906/) Hatano H, Somsouk M, Sinclair E, Harvill K, Gilman L, Cohen M, Hoh R, Hunt PW, Martin JN, Wong JK, Deeks SG, Yukl SA.Hatano H, et al.AIDS. 2013 Sep 10;27(14):2255-60. doi: 10.1097/QAD.0b013e328362692f.AIDS. 2013.PMID: 24157906Free PMC article. * [ HIV Proviral Burden, Genetic Diversity, and Dynamics in Viremic Controllers Who Subsequently Initiated Suppressive Antir
## Related Clinical Research

- [Estimated Size and Distribution of College MSM in Hainan Using the Blued App](https://medichelpline.com/clinical-feed/plos-one-11-exploration-of-the-population-size-of-men-who-have-sex-with-men-in-hainan.md)
- [Defective HIV-1 Proviral Transcription Drives Interferon Responses in Myeloid Cells](https://medichelpline.com/clinical-feed/pubmed-42573264.md) (DOI: 10.1128/jvi.00552-26)
- [Adverse events with long-acting injectable cabotegravir and rilpivirine in people with HIV: SCOLTA](https://medichelpline.com/clinical-feed/pubmed-42765669.md) (DOI: 10.1080/25787489.2026.2703324)
- [Extragenital HPV Condylomas on the Neck in an Immunocompetent Man: Case Report and Implications](https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-9-human-papillomavirus-condylomas-of-extragenital-site-in-immunocompetent-man-new.md)
- [COVID-19 mortality among people with HIV in Florida before and after COVID-19 vaccine availability](https://medichelpline.com/clinical-feed/plos-one-13-covid-19-mortality-risk-among-people-with-hiv-in-florida-before-and-after-the.md)

## Navigation
- [← Back to Infectious Disease Feed](https://medichelpline.com/clinical-feed/infectious-disease.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.