---
title: "HPV-positive women: sexual function lower after prior LEEP compared with no LEEP"
id: "pubmed-42912654"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42912654"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42912654/"
doi: "10.1080/0167482X.2026.2753611"
published_at: "2026-10-23T23:18:54.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# HPV-positive women: sexual function lower after prior LEEP compared with no LEEP
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42912654
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42912654/)
- **DOI:** [10.1080/0167482X.2026.2753611](https://doi.org/10.1080%2F0167482X.2026.2753611)
- **Published At:** 2026-10-23T23:18:54.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Cross-sectional comparison of 226 **HPV**-positive women at a tertiary clinic in Mersin, Türkiye; groups: prior **LEEP** (n = 112) versus no LEEP (n = 114). - Primary outcome measured with the **Female Sexual Function Index (FSFI)**; additional instruments: HADS for anxiety/depression and SF-36 for generic health-related quality of life. - FSFI median scores were lower in the LEEP group (reported median difference and confidence interval in the source); the association persisted after multivariable adjustment. - Domain-level declines (desire, arousal, lubrication, satisfaction) remained significant after Holm correction for multiple comparisons. - No significant between-group differences were observed for anxiety, depression, or SF-36 domains according to the reported analyses. - Most participants who had LEEP carried higher-grade lesions (CIN2–3), whereas the control group did not, creating an important baseline imbalance. - Time elapsed since LEEP did not correlate with sexual function, psychological distress, or HRQoL in the reported data. - Investigators used Mann–Whitney U, χ2 tests, and multivariable regression with Holm correction; the source did not report additional trial-specific procedural or longitudinal follow-up details. - Authors cautioned that the cross-sectional design and absence of pretreatment baseline assessments prevent attributing lower sexual function directly to **LEEP** itself; they suggested sexual-health assessment during follow-up.
## Clinical Analysis & Structured Key Points
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Epub 2026 Oct 23. # Sexual function, psychological distress, and health-related quality of life in HPV-positive women with and without LEEP: a cross-sectional comparative study [Şahin Yüksek](https://pubmed.ncbi.nlm.nih.gov/?term=Y%C3%BCksek+%C5%9E&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#full-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Hasan Turan](https://pubmed.ncbi.nlm.nih.gov/?term=Turan+H&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#full-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Numan Bilgiç](https://pubmed.ncbi.nlm.nih.gov/?term=Bilgi%C3%A7+N&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#full-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Mürşide Çevikoğlu Kıllı](https://pubmed.ncbi.nlm.nih.gov/?term=%C3%87eviko%C4%9Flu+K%C4%B1ll%C4%B1+M&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#full-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Osman Doğan](https://pubmed.ncbi.nlm.nih.gov/?term=Do%C4%9Fan+O&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#full-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Mehmet Sait Bakır](https://pubmed.ncbi.nlm.nih.gov/?term=Bak%C4%B1r+MS&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#full-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye.") Affiliations Expand ### Affiliation * 1 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye. * PMID: **42912654** * DOI: [ 10.1080/0167482X.2026.2753611 ](https://doi.org/10.1080/0167482x.2026.2753611) Item in Clipboard Comparative Study # Sexual function, psychological distress, and health-related quality of life in HPV-positive women with and without LEEP: a cross-sectional comparative study Şahin Yüksek et al. J Psychosom Obstet Gynaecol. 2026. Show details Display options Display options Format Abstract PubMed PMID J Psychosom Obstet Gynaecol Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22J+Psychosom+Obstet+Gynaecol%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22J+Psychosom+Obstet+Gynaecol%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42912654/) . 2026 Dec 31;47(1):2753611. doi: 10.1080/0167482X.2026.2753611. Epub 2026 Oct 23. ### Authors [Şahin Yüksek](https://pubmed.ncbi.nlm.nih.gov/?term=Y%C3%BCksek+%C5%9E&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Hasan Turan](https://pubmed.ncbi.nlm.nih.gov/?term=Turan+H&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Numan Bilgiç](https://pubmed.ncbi.nlm.nih.gov/?term=Bilgi%C3%A7+N&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Mürşide Çevikoğlu Kıllı](https://pubmed.ncbi.nlm.nih.gov/?term=%C3%87eviko%C4%9Flu+K%C4%B1ll%C4%B1+M&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Osman Doğan](https://pubmed.ncbi.nlm.nih.gov/?term=Do%C4%9Fan+O&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye."), [Mehmet Sait Bakır](https://pubmed.ncbi.nlm.nih.gov/?term=Bak%C4%B1r+MS&cauthor_id=42912654)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42912654/#short-view-affiliation-1 "Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye.") ### Affiliation * 1 Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Mersin City Training and Research Hospital, Mersin, Türkiye. * PMID: **42912654** * DOI: [ 10.1080/0167482X.2026.2753611 ](https://doi.org/10.1080/0167482x.2026.2753611) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Objective:** To compare sexual function, psychological distress, and health-related quality of life (HRQoL) between HPV-positive women with and without prior loop electrosurgical excision procedure (LEEP). **Methods:** In this cross-sectional study, 226 HPV-positive women (LEEP, _n_ = 112; no LEEP, _n_ = 114) attending a tertiary clinic in Mersin, Türkiye, between January and June 2026 completed the FSFI (primary outcome), HADS, and SF-36. Analyzes used Mann-Whitney U and χ2 tests and multivariable regression, with Holm correction within prespecified families. **Results:** FSFI scores were lower in the LEEP group (median 14.6 vs 22.3; median difference -3.3, 95% CI -6.4 to -1.0; rank-biserial r = -0.23). The difference persisted after adjustment (-4.0, 95% CI -6.8 to -1.2) and among sexually active women. Desire, arousal, lubrication, and satisfaction were lower after Holm correction. Anxiety, depression, and SF-36 domains showed no significant differences. Most LEEP participants had CIN2-3, unlike controls. Time since LEEP was unrelated to outcomes. **Conclusion:** Prior LEEP was associated with modestly lower sexual function, without significant differences in psychological distress or HRQoL. Differences in lesion grade and absence of pretreatment assessments preclude attributing this association to LEEP itself. Sexual-health assessment may be useful during follow-up. **Keywords:** Female Sexual Function Index; Loop electrosurgical excision procedure; anxiety and depression; human papillomavirus; quality of life; sexual function. ## Plain language summary A history of LEEP was associated with lower sexual function scores in HPV-positive women.Desire, arousal, lubrication, and satisfaction scores were lower in the LEEP group.No significant differences were found in anxiety, depression, or generic quality of life.An HPV-positive comparison group limited confounding by HPV status, but not by lesion grade.The cross-sectional design does not allow causal conclusions about LEEP. 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