---
title: "Minimal structural changes alter membrane interaction of short antimicrobial peptides: experimenta"
id: "pubmed-42030711"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42030711"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42030711/"
doi: "10.1016/j.ejmech.2026.118859"
published_at: "2026-08-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Minimal structural changes alter membrane interaction of short antimicrobial peptides: experimenta
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42030711
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42030711/)
- **DOI:** [10.1016/j.ejmech.2026.118859](https://doi.org/10.1016%2Fj.ejmech.2026.118859)
- **Published At:** 2026-08-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article titled “Effect of minimal structural modifications on the membrane interaction of short antimicrobial peptides: An experimental and computational study” was published in Eur J Med Chem and appears on PubMed (PMID: **42030711**, DOI: 10.1016/j.ejmech.2026.118859). - Publication metadata: Epub April 15, 2026; journal issue listed as 2026 Aug 5:312:118859. - The study is reported by Lucia Ferrazzano and coauthors from multiple Italian institutions, including the P4i Lab at the University of Bologna, Department of Pharmacy and Biotechnology (University of Bologna), CONCEPT Lab (IIT, Genova), University of Siena, and other collaborating units. - The article’s title indicates the research combined **experimental** and **computational** approaches to examine how very small or minimal **structural modifications** affect the **membrane interaction** of **short antimicrobial peptides**. - PubMed entry lists full author list and detailed institutional affiliations but the PubMed page content provided here does not include the abstract, experimental results, methods, numerical data, or conclusions from the paper. - Full text links are available via Elsevier Science on the PubMed record; however, the source content supplied does not contain the article’s abstract or findings. - Important study specifics — including peptide sequences, the precise structural modifications tested, experimental assays used, computational models or simulation details, quantitative outcomes, and the authors’ conclusions — were not reported in the supplied source text. - Users seeking methods, results, or clinical implications must consult the full text (publisher link) or the complete PubMed abstract; those details are not present in the provided source content.
## Clinical Analysis & Structured Key Points
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Epub 2026 Apr 15. # Effect of minimal structural modifications on the membrane interaction of short antimicrobial peptides: An experimental and computational study [Lucia Ferrazzano](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrazzano+L&cauthor_id=42030711)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-1 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: lucia.ferrazzano4@unibo.it."), [Francesca Bonvicini](https://pubmed.ncbi.nlm.nih.gov/?term=Bonvicini+F&cauthor_id=42030711)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-2 "Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy."), [Saha Satvati](https://pubmed.ncbi.nlm.nih.gov/?term=Satvati+S&cauthor_id=42030711)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-3 "Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia \(IIT\), Via E. Melen 83 \(B Block\), Genova, 16152, Italy; Department of Biotechnology, Chemistry and Pharmacy - DBCF, University of Siena, Via A. Moro 2, Siena, 53100, Italy; SetLance srl, Via Fiorentina 1, Siena, 53100, Italy."), [Dario Corbisiero](https://pubmed.ncbi.nlm.nih.gov/?term=Corbisiero+D&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Silvia Rizzo](https://pubmed.ncbi.nlm.nih.gov/?term=Rizzo+S&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Ilaria Di Stefano](https://pubmed.ncbi.nlm.nih.gov/?term=Di+Stefano+I&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Paolo Cantelmi](https://pubmed.ncbi.nlm.nih.gov/?term=Cantelmi+P&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Silvia Panzavolta](https://pubmed.ncbi.nlm.nih.gov/?term=Panzavolta+S&cauthor_id=42030711)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-5 "Biological Structures and Materials Lab, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Giovanna A Gentilomi](https://pubmed.ncbi.nlm.nih.gov/?term=Gentilomi+GA&cauthor_id=42030711)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-6 "Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy; Division of Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via G. Massarenti 9, Bologna, 40138, Italy."), [Walter Rocchia](https://pubmed.ncbi.nlm.nih.gov/?term=Rocchia+W&cauthor_id=42030711)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-7 "Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia \(IIT\), Via E. Melen 83 \(B Block\), Genova, 16152, Italy."), [Walter Cabri](https://pubmed.ncbi.nlm.nih.gov/?term=Cabri+W&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Alessandra Tolomelli](https://pubmed.ncbi.nlm.nih.gov/?term=Tolomelli+A&cauthor_id=42030711)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#full-view-affiliation-8 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: alessandra.tolomelli@unibo.it.") Affiliations Expand ### Affiliations * 1 P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: lucia.ferrazzano4@unibo.it. * 2 Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy. * 3 Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia (IIT), Via E. Melen 83 (B Block), Genova, 16152, Italy; Department of Biotechnology, Chemistry and Pharmacy - DBCF, University of Siena, Via A. Moro 2, Siena, 53100, Italy; SetLance srl, Via Fiorentina 1, Siena, 53100, Italy. * 4 P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. * 5 Biological Structures and Materials Lab, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. * 6 Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy; Division of Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via G. Massarenti 9, Bologna, 40138, Italy. * 7 Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia (IIT), Via E. Melen 83 (B Block), Genova, 16152, Italy. * 8 P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: alessandra.tolomelli@unibo.it. * PMID: **42030711** * DOI: [ 10.1016/j.ejmech.2026.118859 ](https://doi.org/10.1016/j.ejmech.2026.118859) Item in Clipboard # Effect of minimal structural modifications on the membrane interaction of short antimicrobial peptides: An experimental and computational study Lucia Ferrazzano et al. Eur J Med Chem. 2026. Show details Display options Display options Format Abstract PubMed PMID Eur J Med Chem Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Eur+J+Med+Chem%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Eur+J+Med+Chem%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42030711/) . 2026 Aug 5:312:118859. doi: 10.1016/j.ejmech.2026.118859. Epub 2026 Apr 15. ### Authors [Lucia Ferrazzano](https://pubmed.ncbi.nlm.nih.gov/?term=Ferrazzano+L&cauthor_id=42030711)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-1 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: lucia.ferrazzano4@unibo.it."), [Francesca Bonvicini](https://pubmed.ncbi.nlm.nih.gov/?term=Bonvicini+F&cauthor_id=42030711)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-2 "Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy."), [Saha Satvati](https://pubmed.ncbi.nlm.nih.gov/?term=Satvati+S&cauthor_id=42030711)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-3 "Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia \(IIT\), Via E. Melen 83 \(B Block\), Genova, 16152, Italy; Department of Biotechnology, Chemistry and Pharmacy - DBCF, University of Siena, Via A. Moro 2, Siena, 53100, Italy; SetLance srl, Via Fiorentina 1, Siena, 53100, Italy."), [Dario Corbisiero](https://pubmed.ncbi.nlm.nih.gov/?term=Corbisiero+D&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Silvia Rizzo](https://pubmed.ncbi.nlm.nih.gov/?term=Rizzo+S&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Ilaria Di Stefano](https://pubmed.ncbi.nlm.nih.gov/?term=Di+Stefano+I&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Paolo Cantelmi](https://pubmed.ncbi.nlm.nih.gov/?term=Cantelmi+P&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Silvia Panzavolta](https://pubmed.ncbi.nlm.nih.gov/?term=Panzavolta+S&cauthor_id=42030711)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-5 "Biological Structures and Materials Lab, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Giovanna A Gentilomi](https://pubmed.ncbi.nlm.nih.gov/?term=Gentilomi+GA&cauthor_id=42030711)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-6 "Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy; Division of Microbiology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Via G. Massarenti 9, Bologna, 40138, Italy."), [Walter Rocchia](https://pubmed.ncbi.nlm.nih.gov/?term=Rocchia+W&cauthor_id=42030711)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-7 "Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia \(IIT\), Via E. Melen 83 \(B Block\), Genova, 16152, Italy."), [Walter Cabri](https://pubmed.ncbi.nlm.nih.gov/?term=Cabri+W&cauthor_id=42030711)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-4 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy."), [Alessandra Tolomelli](https://pubmed.ncbi.nlm.nih.gov/?term=Tolomelli+A&cauthor_id=42030711)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42030711/#short-view-affiliation-8 "P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: alessandra.tolomelli@unibo.it.") ### Affiliations * 1 P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. Electronic address: lucia.ferrazzano4@unibo.it. * 2 Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy. * 3 Computational mOdelling of NanosCalE and bioPhysical sysTems - CONCEPT Lab, Fondazione Istituto Italiano di Tecnologia (IIT), Via E. Melen 83 (B Block), Genova, 16152, Italy; Department of Biotechnology, Chemistry and Pharmacy - DBCF, University of Siena, Via A. Moro 2, Siena, 53100, Italy; SetLance srl, Via Fiorentina 1, Siena, 53100, Italy. * 4 P4i Lab - Peptidomimetics and Peptides Targeting Protein-Protein Interaction, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. * 5 Biological Structures and Materials Lab, Department of Chemistry "Giacomo Ciamician", Alma Mater Studiorum - University of Bologna, Via P. Gobetti 85, Bologna, 40129, Italy. * 6 Department of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via G. Massarenti 9, Bologna, 40138, Italy; Division of Microbiology, IRCCS
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