---
title: "Mitochondria and Antibacterial Immunity: Cross-talk with Nuclear-Encoded Innate Immune Molecules"
id: "frontiers-in-immunology-1-mitochondria-affect-antibacterial-immunity-in-cross-talk-with-innate-immune"
canonical_url: "https://medichelpline.com/clinical-feed/frontiers-in-immunology-1-mitochondria-affect-antibacterial-immunity-in-cross-talk-with-innate-immune"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "Frontiers in Immunology"
source_url: "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1918926"
published_at: "2026-09-21T00:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Mitochondria and Antibacterial Immunity: Cross-talk with Nuclear-Encoded Innate Immune Molecules
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/frontiers-in-immunology-1-mitochondria-affect-antibacterial-immunity-in-cross-talk-with-innate-immune
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** Frontiers in Immunology
- **Source URL:** [Original Journal Publication](https://www.frontiersin.org/articles/10.3389/fimmu.2026.1918926)
- **Published At:** 2026-09-21T00:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- The source article title indicates a focus on how **mitochondria** influence **antibacterial immunity** through interactions with innate immune molecules encoded by nuclear genes. - The article is hosted by Frontiers in Immunology; the provided source snippet is site navigation and does not include the article abstract, methods, results, or conclusions. - No experimental details, data, study design, organism model, or authorship were reported in the supplied source text. - Key conceptual elements from the title include mitochondrial contributions to immune signalling and coordination between organellar function and **innate immune response** components of nuclear origin. - Because the source content was limited to site and section navigation, specific mechanisms, pathways, or clinical implications described in the article were not available. - Readers are advised to consult the full Frontiers in Immunology article for primary data, detailed mechanisms, and any reported implications for infectious disease or therapeutics.
## Clinical Analysis & Structured Key Points
Frontiers | Mitochondria affect antibacterial immunity in cross talk with innate immune response molecules coded by genes of nuclear origin ORIGINAL RESEARCH article Front. Immunol. Sec. Comparative Immunology Volume 17 - 2026 | doi: 10.3389/fimmu.2026.1918926 Published in Frontiers in Immunology Comparative Immunology 7 impact factor 11.3 citescore Reviewers Reviewed by 2 A 2 Anonymous reviewers Outline ORIGINAL RESEARCH article Front. Immunol. Sec. Comparative Immunology Mitochondria affect antibacterial immunity in cross talk with innate immune response molecules coded by genes of nuclear origin A C Argha Chakraborty 1 A P ARUNA PAL 1 M D MANTI DEBNATH 1 J S Jyoti Sahu 1 A P Abantika Pal 2 J M Joydeep Mukherjee 1 R S Rajarshi Samanta 1 P N Paresh Nath Chatterjee 1 1. West Bengal University of Animal and Fishery Sciences, Kolkata, India 2. University of California San Francisco, San Francisco, United States Article metrics View details The final, formatted version of the article will be published soon. Notify me Select one of your emails You have multiple emails registered with Frontiers: Notify me Notify me on publication Please enter your email address: Email If you already have an account, please login You don't have a Frontiers account ? You can register here Notify me Abstract Mitochondria are dynamic, semi-autonomous organelles that, in addition to their central role in ATP production, regulate calcium homeostasis, iron metabolism, apoptosis, and innate immune signalling. Although the mitochondrial genome encodes only 37 genes, mitochondrial architecture, bioenergetic function, and dynamics are governed predominantly by nuclear-encoded proteins, necessitating highly coordinated communication between mitochondrial DNA (mtDNA) and the nuclear genome. Disruption of this bidirectional mitochondrial–nuclear crosstalk has been increasingly implicated in the pathogenesis of numerous diseases across species; however, the molecular mechanisms underlying this communication remain incompletely understood. In the present study, we used Anas platyrhynchos as a model of duck pasteurellosis to investigate mitochondrial–nuclear interactions in the regulation of innate immune responses during Pasteurella multocida infection. Our findings demonstrate that the mitochondrially encoded proteins cytochrome b and cytochrome c functionally interact with the nuclear-encoded immune regulators NLRP3, IL-18, and STING through the NOD-like receptor signalling pathway, phagocytic pathways, and the cytosolic DNA-sensing pathway. Furthermore, molecular docking analyses identified putative interaction sites between IL-18 and P. multocida, providing additional support for the functional relevance of these immune pathways during bacterial infection. To our knowledge, this study provides the first evidence in an animal model that mitochondrial retrograde signalling influences the regulation of nuclear immune genes during bacterial infection. These findings reveal a previously unrecognized mechanism through which mitochondrial gene products modulate host innate immune responses, thereby advancing our understanding of mitochondrial–nuclear communication in host–pathogen interactions. Summary Keywords Anas platyrhnchos, Antibacterial immunity, duck pasteurellosis, Mito chondrial genome, nulear gene Received 25 June 2026 Accepted 21 August 2026 Copyright © 2026 Chakraborty, PAL, DEBNATH, Sahu, Pal, Mukherjee, Samanta and Chatterjee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. *Correspondence: ARUNA PAL Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. Article metrics View details Share article Our quality Expert judgment makes science stronger Behind every published article stand expert reviewers safeguarding science. Discover our rigorous approach to peer review. Learn about peer review Outline Share article Facebook X LinkedIn Email WeChat Share on WeChat Scan with WeChat to share this article Article metrics
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