---
title: "Multidrug-Resistant Campylobacter coli ST10042 Lineage Spreads Across Europe, 2018–2025"
id: "cdc-emerging-infectious-diseases-journal-0-multisectoral-emergence-of-multidrug-resistant-campylobacter-coli-sequence-type"
canonical_url: "https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-0-multisectoral-emergence-of-multidrug-resistant-campylobacter-coli-sequence-type"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "CDC Emerging Infectious Diseases Journal"
source_url: "https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article"
published_at: "2026-09-18T04:00:00.000Z"
evidence_level: "Agency Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Multidrug-Resistant Campylobacter coli ST10042 Lineage Spreads Across Europe, 2018–2025
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-0-multisectoral-emergence-of-multidrug-resistant-campylobacter-coli-sequence-type
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** CDC Emerging Infectious Diseases Journal
- **Source URL:** [Original Journal Publication](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article)
- **Published At:** 2026-09-18T04:00:00.000Z
- **Evidence Rating:** Agency Feed
## Executive GIST (TL;DR)
- The study reports sustained, previously underrecognized circulation of a multidrug-resistant **Campylobacter coli** sequence type **ST10042** lineage across multiple European countries during 2018–2025. - Researchers analyzed **whole-genome sequencing (WGS)** data from 217 isolates collected from nine countries and diverse sectors: human, animal, food, and environmental sources. - Genomic analyses identified cross-border clusters and a large lineage primarily linking Portugal and Luxembourg, with additional detections in Germany, Ireland, Spain, and the United Kingdom. - Data indicate ongoing clonal expansion of ST10042 with increasing genomic diversification over time, demonstrating that some **C. coli** infections are part of sustained international transmission rather than isolated sporadic cases. - Isolates shared a conserved **multidrug-resistant** phenotype: resistance to fluoroquinolones, tetracyclines, and β-lactams; reduced susceptibility to carbapenems was also observed. - Molecular resistance markers included **GyrA Thr86Ile**, **tet(O/32/O)/tet(O)** genes, and variants in the **bla_OXA-61** promoter. Variation in **porA** alleles was associated with variable susceptibility to amoxicillin/clavulanic acid and ertapenem, consistent with a role in altered outer-membrane permeability. - The investigation leveraged ongoing WGS-based surveillance in Portugal, with retrospective sequencing of isolates from 2016–2021 that exhibited the ST10042 AMR phenotype and systematic WGS implementation since 2022 with ≈90% coverage for C. coli. - Findings emphasize the need for coordinated, cross-sector genomic surveillance to detect and monitor emerging antimicrobial-resistant Campylobacter lineages. - Specifics of some methods, detailed phylogenetic metrics, and comprehensive country-by-country isolate counts and timelines were not fully reported in the excerpt provided.
## Clinical Analysis & Structured Key Points
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2018–2025](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) * [ BACK ](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) **Multisectoral Emergence of Multidrug-Resistant Campylobacter coli Sequence Type 10042 Lineage, Europe, 2018–2025** * [ BACK ](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) **Early Release****Multisectoral Emergence of Multidrug-Resistant Campylobacter coli Sequence Type 10042 Lineage, Europe, 2018–2025** * [ BACK ](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) **Articles****Early Release****Multisectoral Emergence of Multidrug-Resistant Campylobacter coli Sequence Type 10042 Lineage, Europe, 2018–2025** * [Figure 1](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f1) * [Figure 2](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f2) * [Figure 3](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f3) * [Figure 4](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f4) * [Table 1](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-t1) * 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[EID Journal](https://wwwnc.cdc.gov/eid/) 2. [Volume 32](https://wwwnc.cdc.gov/eid/early-release) 3. [Early Release](https://wwwnc.cdc.gov/eid/early-release#issue-1346) 4. [Main Article](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) * [Facebook](https://www.facebook.com/sharer/sharer.php?u=%2Feid%2Farticle%2F32%2F10%2F26-0512_article "Share to Facebook") * [Twitter](http://twitter.com/share?url=%2Feid%2Farticle%2F32%2F10%2F26-0512_article&text= "Share to Twitter") * [LinkedIn](https://www.linkedin.com/shareArticle?url=%2Feid%2Farticle%2F32%2F10%2F26-0512_article&title= "Share to LinkedIn") * [Syndicate](https://tools.cdc.gov/medialibrary/index.aspx#/sharecontent//eid/article/32/10/26-0512_article "Embed this Page") [ Emerging Infectious Disease journal ISSN: 1080-6059 ](https://wwwnc.cdc.gov/eid/) _Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released._ #### Volume 32, Number 10—October 2026 ##### _Research_ ### Multisectoral Emergence of Multidrug-Resistant _Campylobacter coli_ Sequence Type 10042 Lineage, Europe, 2018–2025 On This Page [Materials and Methods](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) * * * [Results](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) * * * [Discussion](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) * * * [Suggested Citation](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) Figures [Figure 1](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f1) * * * [Figure 2](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f2) * * * [Figure 3](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f3) * * * [Figure 4](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-f4) Tables [Table 1](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-t1) * * * [Table 2](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-t2) * * * [Table 3](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-t3) Downloads [Appendix ](https://wwwnc.cdc.gov/eid/article/32/10/26-0512-app1.xlsx) * * * [RIS [TXT - 2 KB] ](https://wwwnc.cdc.gov/eid/article/32/10/26-0512.ris) Article Metrics [Metric Details](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article) Related Articles [Macrolide-Resistant _Bordetella pertussis_ , Peru](https://wwwnc.cdc.gov/eid/article/32/10/25-1477_article) * * * [_Salmonella_ Infantis Carrying _bla_ CTX-M-65 Gene](https://wwwnc.cdc.gov/eid/article/32/10/25-1758_article) * * * [Group B _Streptococcus_ Rates among Pregnant Women](https://wwwnc.cdc.gov/eid/article/32/10/26-0687_article) * * * [More articles on Antimicrobial Resistance](https://wwwnc.cdc.gov/eid/spotlight/antimicrobial-resistance) Mónica Azevedo[1](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#fn1), Alexandra Nunes[1](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#fn1), Maria-Leonor Lemos, Paulo Martins Costa, Ana Amaro, Lurdes Clemente, Célia Leão, Sónia Ramos, Isabel Santos, Katrine Grimstrup Joensen, Catherine Ragimbeau, Lena de Baets, Joël Mossong, Sangeeta Banerji, Antje Flieger, Diana Espadinha, William Byrne, Oda van den Berg, Andries Augustus Kampfraath, Quentin Jehanne, Philippe Lehours, João Paulo Gomes, and Mónica Oleastro[![Comments to Author](https://wwwnc.cdc.gov/eid/content/images/icon/email.gif)](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#comment) Author affiliation: National Institute of Health Doutor Ricardo Jorge (INSA), Lisbon, Portugal (M. Azevedo, A. Nunes, M.-L. Lemos, J.P. Gomes); Research in Veterinary Medicine (I-MVET)/Animal and Veterinary Research Center (CECAV), Faculty of Veterinary Medicine, Lusófona University—Lisbon University Centre, Lisbon (A. Nunes, S. Ramos, I. Santos, J.P. Gomes); ICBAS-Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal (M.-L. Lemos, P.M. Costa); Laboratory of Bacteriology and Mycology, National Institute of Agrarian and Veterinary Research, Oeiras, Portugal (A. Amaro, L. Clemente, C. Leão); Statens Serum Institut, Copenhagen, Denmark (K.G. Joensen); Laboratoire National de Santé, Dudelange, Luxembourg (C. Ragimbeau); Laboratoire Vétérinaire et Alimentaire, Division of the Luxembourg Veterinary and Food Administration, Dudelange (L. de Baets); Ministère de la Santé et de la Sécurité Sociale, Direction de la Santé, Luxembourg, Luxembourg (J. Mossong); Robert Koch-Institute, Wernigerode, Germany (S. Banerji, A. Flieger); Public Health Laboratory Dublin, Health Service Executive, Dublin, Ireland (D. Espadinha); Backweston Complex, Celbridge, Ireland (W. Byrne); National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands (O. van den Berg); European Centre for Disease Prevention and Control, Stockholm, Sweden (O. van den Berg); Wageningen Bioveterinary Research, Wageningen UR, Lelystad, the Netherlands (A.A. Kampfraath); French National Reference Centre for Campylobacters and Helicobacters, Bordeaux Hospital University Centre, Bordeaux, France (Q. Jehanne, P. Lehours); University of Bordeaux, INSERM, Bordeaux Institute of Oncology, Bordeaux (P. Lehours) [Suggested citation for this article](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#suggestedcitation) ### Abstract _Campylobacter_ spp. remain the leading bacterial cause of foodborne gastroenteritis in Western countries. We report sustained, previously unrecognized circulation of a multidrug-resistant _Campylobacter coli_ sequence type 10042 lineage across Europe during 2018–2025. Whole-genome sequencing of 217 isolates from 9 countries spanning human, animal, food, and environmental sources identified cross-border clusters, including a large lineage linking primarily Portugal and Luxembourg, as well as Germany, Ireland, Spain, and the United Kingdom. Genomic data indicates ongoing clonal expansion with increasing diversification over time. Isolates exhibited a conserved multidrug-resistant phenotype, including resistance to fluoroquinolones, tetracyclines, and β-lactams; reduced susceptibility to carbapenems was observed. Resistance was associated with GyrA Thr86Ile, _tet_(O/32/O)/_tet_(O) genes, and _bla_ OXA-61 promoter variants; variation in _porA_ was linked to variable amoxicillin/clavulanic acid and ertapenem susceptibility. Those findings demonstrate that _C. coli_ infections can involve sustained international transmission rather than sporadic cases and highlight the need for coordinated, cross-sector genomic surveillance to detect emerging antimicrobial-resistant lineages. Since 2005, campylobacteriosis has been the most frequently reported foodborne zoonosis in the European Union (EU); 168,396 human cases were reported in 2024 ([_1_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r1 "1")). Infections affect all age groups but are most severe in young children, the elderly, and immunocompromised persons ([_2_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r2 "2")). Campylobacteriosis typically manifests as bloody or watery diarrhea, abdominal cramping, fever, vomiting, and nausea ([_3_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r3 "3"),[_4_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r4 "4")). Severe or prolonged infections can lead to complications, such as bacteremia, that occasionally require hospitalization or result in death ([_3_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r3 "3"),[_4_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r4 "4")). Antimicrobial therapy is warranted in those cases, highlighting growing concerns regarding _Campylobacter_ antimicrobial resistance (AMR), particularly to fluoroquinolones, macrolides, and carbapenems ([_4_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r4 "4"),[_5_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r5 "5")). Campylobacteriosis cases are primarily caused by _Campylobacter jejuni_ (≈90%) and _C. coli_ (≈10%) ([_2_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r2 "2")). Poultry is the main reservoir, although livestock commodities, domestic and wild animals, humans, and contaminated water or soil also contribute to transmission ([_2_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r2 "2"),[_6_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r6 "6")). Although most _Campylobacter_ infections have historically been considered sporadic ([_7_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r7 "7")), recent whole-genome sequencing (WGS)–based surveillance has demonstrated that many cases occur as genetically related clusters ([_8_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r8 "8")–[ _12_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r12 "12")). Genomic surveillance leveraging WGS-based approaches, including whole-genome and core-genome multilocus sequence typing (MLST), has markedly enhanced identification of outbreaks, investigation of transmission pathways, and detection of emerging epidemic lineages, providing high-resolution insights into genetic diversity, AMR determinants, and source attribution ([_8_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r8 "8")–[ _12_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r12 "12")). WGS data also expand knowledge on novel AMR determinants, such as _porA_ gene, which encodes the major _Campylobacter_ outer-membrane porin and whose allelic variants might reduce β-lactam and carbapenem influx through altered membrane permeability ([_5_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r5 "5"),[_13_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r13 "13")). _C. coli_ is less frequently associated with outbreaks, despite its broad ecologic niche, which includes broilers, pigs, and wild birds, emphasizing the risk for zoonotic transmission and environmental contamination ([_1_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r1 "1"),[_14_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r14 "14"),[_15_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r15 "15")). Taking advantage of ongoing WGS-based surveillance in Portugal, we aimed to characterize the multidrug-resistant _C. coli_ sequence type (ST) 10042 strain, which is associated with a peak of _C. coli_ infections in Portugal and has been detected in other countries (Germany, Luxembourg, France, Ireland, Denmark, the Netherlands, the United Kingdom, and Spain) and diverse sectors (human, animal, food, and environment). The objectives were to elucidate its transmission dynamics and AMR determinants, assess its potential public health significance as an emerging _C. coli_ lineage, and provide a more refined perspective on _Campylobacter_ surveillance and the pathogen’s overall burden. ### Materials and Methods ##### _Campylobacter_ Surveillance in Portugal Since 2013, the Portuguese National Reference Laboratory for Gastrointestinal Infections (NRL-GI) at the National Institute of Health Doutor Ricardo Jorge has coordinated sentinel laboratory-based surveillance of human campylobacteriosis, involving hospital laboratories from the 3 (of 5 total) most populated geographic areas in mainland Portugal (the North, Centre, and Metropolitan Lisbon Area regions) and from 2 private laboratory networks covering the entire mainland. The network routinely submits _Campylobacter_ isolates on a monthly basis, covering the entire year ([_16_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r16 "16")). Since 2022, WGS has been systematically implemented, achieving ≈90% coverage for _C. coli_ WGS and antimicrobial susceptibility testing (AST). Animal and food-chain surveillance programs are conducted by the National Institute for Agricultural and Veterinary Research. Livestock isolates are recovered from cattle, broiler, and turkey cecal contents at slaughter under the Europe monitoring framework established by Commission Decision 2020/1729 ([_17_](https://wwwnc.cdc.gov/eid/article/32/10/26-0512_article#r17 "17")). We obtained environmental isolates and additional isolates from animals and meat products from collaborative research projects, including screening in poultry meat in retail (2022**–** 2025) (A. Nunes et al., unpub. data) and targeted studies on dogs (2022–2023) (M.-L. Lemos et al., unpub. data). ##### _C. coli_ ST10042 Study Sample This study included _C. coli_ ST10042 isolates identified since the start of WGS-based surveillance in Portugal in 2022. To ensure temporal completeness, we retrospectively sequenced all _C. coli_ isolates received at the NRL-GI during 2016–2021 exhibiting the conserved ST10042 AMR phenotype. ST10042 had been previously underrecognized in public databases; WGS surveillance in Portugal revealed it as a predominant and relevant ST. Collaborating partners in Germany
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