---
title: "Oropouche virus detected in rural Venezuela (2025): five cases linked to OROVBr2015-2024 lineage"
id: "pubmed-42661362"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42661362"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42661362/"
doi: "10.3201/eid3209.250678"
published_at: "2026-09-01T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Oropouche virus detected in rural Venezuela (2025): five cases linked to OROVBr2015-2024 lineage
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42661362
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42661362/)
- **DOI:** [10.3201/eid3209.250678](https://doi.org/10.3201%2Feid3209.250678)
- **Published At:** 2026-09-01T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Five human cases of **Oropouche virus** infection were detected in rural Venezuela in 2025, as reported in Emerg Infect Dis. - Viral isolates from these cases belonged to the **OROVBr2015-2024 reassortant lineage**, which is linked to the broader 2024–2025 epidemic. - The report underscores **ongoing transmission** of Oropouche virus in the region during 2024–2025. - Authors highlight a public health need for strengthened **surveillance** and **laboratory capacity** across South America to detect and respond to Oropouche virus activity. - The article provides genotype and lineage assignment for the isolates but does not report detailed patient demographics, specific clinical presentations, exact rural locations, vector data, or detailed laboratory methods in the PubMed abstract. - Keywords associated with the report include: **arbovirus**, **vector-borne infections**, **genotype**, **outbreak**, **zoonoses**, and **Oropouche orthobunyavirus**. - The finding is situated within recent regional activity of Oropouche virus, with related publications documenting re-emergence and importation events in Brazil and other South American settings during 2023–2025. - The report is indexed as PMID 42661362, DOI 10.3201/eid3209.250678, and appears in Emerg Infect Dis (2026 Sep;32(9):1523–1525).
## Clinical Analysis & Structured Key Points
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Emerg Infect Dis. 2026 Sep. Free article Show details Display options Display options Format Abstract PubMed PMID Emerg Infect Dis Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Emerg+Infect+Dis%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Emerg+Infect+Dis%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42661362/) . 2026 Sep;32(9):1523-1525. doi: 10.3201/eid3209.250678. ### Authors [Pierina D'Angelo](https://pubmed.ncbi.nlm.nih.gov/?term=D%27Angelo+P&cauthor_id=42661362), [Lieska Rodríguez](https://pubmed.ncbi.nlm.nih.gov/?term=Rodr%C3%ADguez+L&cauthor_id=42661362), [Víctor Alarcón](https://pubmed.ncbi.nlm.nih.gov/?term=Alarc%C3%B3n+V&cauthor_id=42661362), [Yoneira Sulbarán](https://pubmed.ncbi.nlm.nih.gov/?term=Sulbar%C3%A1n+Y&cauthor_id=42661362), [Norca García](https://pubmed.ncbi.nlm.nih.gov/?term=Garc%C3%ADa+N&cauthor_id=42661362), [Giulianna Antonelli](https://pubmed.ncbi.nlm.nih.gov/?term=Antonelli+G&cauthor_id=42661362), [Marwan Aguilar](https://pubmed.ncbi.nlm.nih.gov/?term=Aguilar+M&cauthor_id=42661362), [Martha Bravo](https://pubmed.ncbi.nlm.nih.gov/?term=Bravo+M&cauthor_id=42661362), [Zoila C Moros](https://pubmed.ncbi.nlm.nih.gov/?term=Moros+ZC&cauthor_id=42661362), [Carmen L Loureiro](https://pubmed.ncbi.nlm.nih.gov/?term=Loureiro+CL&cauthor_id=42661362), [Ferdinando Liprandi](https://pubmed.ncbi.nlm.nih.gov/?term=Liprandi+F&cauthor_id=42661362), [José L Zambrano](https://pubmed.ncbi.nlm.nih.gov/?term=Zambrano+JL&cauthor_id=42661362), [Rossana C Jaspe](https://pubmed.ncbi.nlm.nih.gov/?term=Jaspe+RC&cauthor_id=42661362), [Flor H Pujol](https://pubmed.ncbi.nlm.nih.gov/?term=Pujol+FH&cauthor_id=42661362) * PMID: **42661362** * DOI: [ 10.3201/eid3209.250678 ](https://doi.org/10.3201/eid3209.250678) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract We describe 5 cases of human Oropouche virus infection detected in rural Venezuela in 2025. All isolates belonged to the OROVBr2015-2024 reassortant lineage linked to the 2024-2025 epidemic. Our results emphasize ongoing transmission, which highlights the need for strengthened surveillance and laboratory capacity in South America. **Keywords:** Oropouche virus; Venezuela; arbovirus; genotype; outbreak; vector-borne infections; viruses; zoonoses. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Similar articles * [ Oropouche Virus: An Emerging Orthobunyavirus. ](https://pubmed.ncbi.nlm.nih.gov/39351896/) Tilston-Lunel NL.Tilston-Lunel NL.J Gen Virol. 2024 Oct;105(9):002027. doi: 10.1099/jgv.0.002027.J Gen Virol. 2024.PMID: 39351896Free PMC article.Review. * [ Re-emergence of Oropouche virus between 2023 and 2024 in Brazil: an observational epidemiological study. ](https://pubmed.ncbi.nlm.nih.gov/39423838/) Scachetti GC, Forato J, Claro IM, Hua X, Salgado BB, Vieira A, Simeoni CL, Barbosa ARC, Rosa IL, de Souza GF, Fernandes LCN, de Sena ACH, Oliveira SC, Singh CML, de Lima STS, de Jesus R, Costa MA, Kato RB, Rocha JF, Santos LC, Rodrigues JT, Cunha MP, Sabino EC, Faria NR, Weaver SC, Romano CM, Lalwani P, Proenca-Modena JL, de Souza WM.Scachetti GC, et al.Lancet Infect Dis. 2025 Feb;25(2):166-175. doi: 10.1016/S1473-3099(24)00619-4. Epub 2024 Oct 16.Lancet Infect Dis. 2025.PMID: 39423838Free PMC article. * [ Oropouche Virus Importation in Southern Brazil and Emerging Concern Calling for Enhanced Public Health Surveillance. ](https://pubmed.ncbi.nlm.nih.gov/40788114/) Dos Santos FM, de Melo ES, de Lima GB, da Silva AF, Paiva MHS, Acioli-Santos B, de Moraes CNL, Ruivo AP, Gregianini TS, Bauermann M, Bermann T, Lagranha VL, Baethgen LF, Godinho F, Wallau GDL, Veiga ABGD, Salvato RS.Dos Santos FM, et al.J Med Virol. 2025 Aug;97(8):e70557. doi: 10.1002/jmv.70557.J Med Virol. 2025.PMID: 40788114Free PMC article. * [ Emergence of Oropouche Virus in Espírito Santo State, Brazil, 2024. ](https://pubmed.ncbi.nlm.nih.gov/40401583/) Delatorre E, de Mendonça GC, Gatti FD, Có ACG, Del Piero Pereira J, Tavares EA, Nodari JZ, Rossi A, de Azevedo SSD, Sacchi CT, Campos KR, Bugno A, Rebello Alves LN, Bonela LAS, Goulart JP, de Jesus Sousa T, Naveca FG, Ribeiro-Rodrigues R.Delatorre E, et al.Emerg Infect Dis. 2025 Jun;31(6):1178-1188. doi: 10.3201/eid3106.241946. Epub 2025 May 22.Emerg Infect Dis. 2025.PMID: 40401583Free PMC article. * [ A Comprehensive Review of the Neglected and Emerging Oropouche Virus. ](https://pubmed.ncbi.nlm.nih.gov/40143366/) Bai F, Denyoh PMD, Urquhart C, Shrestha S, Yee DA.Bai F, et al.Viruses. 2025 Mar 19;17(3):439. doi: 10.3390/v17030439.Viruses. 2025.PMID: 40143366Free PMC article.Review. 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> [!CAUTION]
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