---
title: "Person-centered care and reengagement after HIV treatment interruptions in Zambia: post-hoc analys"
id: "pubmed-42679007"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42679007"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42679007/"
doi: "10.1371/journal.pmed.1005052"
published_at: "2026-09-01T12:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Person-centered care and reengagement after HIV treatment interruptions in Zambia: post-hoc analys
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42679007
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42679007/)
- **DOI:** [10.1371/journal.pmed.1005052](https://doi.org/10.1371%2Fjournal.pmed.1005052)
- **Published At:** 2026-09-01T12:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article is a post-hoc analysis of a **stepped-wedge cluster randomized trial** conducted in Zambia examining the effect of a **person-centered care (PCC)** intervention on return and sustained reengagement after HIV treatment interruptions (TIs). - The study was published in PLoS Medicine (2026) with PMID 42679007 and DOI 10.1371/journal.pmed.1005052. - The trial team includes investigators from Washington University, the Centre for Infectious Disease Research in Zambia, Johns Hopkins, University of California Davis, the Zambian Ministry of Health, Georgetown University, University of Alabama, and The Global Fund. - The abstract available in the source begins by stating that poor client–provider interactions contribute to cycles of treatment interruption and fear of return, undermining sustained retention in HIV care. - The source indicates that the authors previously demonstrated that a multi-component **person-centered care** intervention targeting healthcare worker behavior improved **client experience**, but the sentence is truncated and the subsequent findings are not shown in the provided excerpt. - The publicly available excerpt does not include the complete methods, numerical results, statistical analyses, or conclusions of the post-hoc analysis; those details were not reported in the source excerpt provided here. - Key study-level metadata available: study type (randomized controlled trial; stepped-wedge cluster randomized design), study setting (Zambia), publication date (2026 Sep 1), and full author list and affiliations. - Because outcome data and detailed methods are missing from the provided text, readers should consult the full PLoS Medicine article or the DOI link for complete results and interpretation.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42679007/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42679007/#conflict-of-interest) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42679007/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42679007/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42679007/#substances) Title & authors Abstract Conflict of interest statement Publication types MeSH terms Substances Randomized Controlled Trial PLoS Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PLoS+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22PLoS+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42679007/) . 2026 Sep 1;23(9):e1005052. doi: 10.1371/journal.pmed.1005052. eCollection 2026 Sep. # Effect of a person-centered care intervention on return and sustained reengagement after treatment interruptions from HIV care in Zambia: A post-hoc analysis of a stepped-wedged cluster randomized trial [Aaloke Mody](https://pubmed.ncbi.nlm.nih.gov/?term=Mody+A&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America."), [Kombatende Sikombe](https://pubmed.ncbi.nlm.nih.gov/?term=Sikombe+K&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-3 "Department of Public Health Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom."), [Sandra Simbeza](https://pubmed.ncbi.nlm.nih.gov/?term=Simbeza+S&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Njekwa Mukamba](https://pubmed.ncbi.nlm.nih.gov/?term=Mukamba+N&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Laura K Beres](https://pubmed.ncbi.nlm.nih.gov/?term=Beres+LK&cauthor_id=42679007)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-4 "Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America."), [Jake M Pry](https://pubmed.ncbi.nlm.nih.gov/?term=Pry+JM&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-5 "Department of Public Health Sciences, School of Medicine, University of California, Davis, California, United States of America."), [Anjali Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+A&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Jacob Mutale](https://pubmed.ncbi.nlm.nih.gov/?term=Mutale+J&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Alida Zulu Dube](https://pubmed.ncbi.nlm.nih.gov/?term=Dube+AZ&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Musunge Mulabe](https://pubmed.ncbi.nlm.nih.gov/?term=Mulabe+M&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Lloyd Mulenga](https://pubmed.ncbi.nlm.nih.gov/?term=Mulenga+L&cauthor_id=42679007)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-6 "Zambian Ministry of Health, Lusaka, Zambia."), [Suilanji Sivile](https://pubmed.ncbi.nlm.nih.gov/?term=Sivile+S&cauthor_id=42679007)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-6 "Zambian Ministry of Health, Lusaka, Zambia."), [April Ratliff](https://pubmed.ncbi.nlm.nih.gov/?term=Ratliff+A&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America."), [Charles W Goss](https://pubmed.ncbi.nlm.nih.gov/?term=Goss+CW&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America."), [Charles B Holmes](https://pubmed.ncbi.nlm.nih.gov/?term=Holmes+CB&cauthor_id=42679007)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-7 "Center for Innovation in Global Health, Georgetown University, Washington, D.C., United States of America."), [Carolyn Bolton Moore](https://pubmed.ncbi.nlm.nih.gov/?term=Moore+CB&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-8 "Division of Infectious Diseases, University of Alabama, Birmingham, Alabama, United States of America."), [Izukanji Sikazwe](https://pubmed.ncbi.nlm.nih.gov/?term=Sikazwe+I&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-9 "The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland."), [Elvin H Geng](https://pubmed.ncbi.nlm.nih.gov/?term=Geng+EH&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#full-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.") Affiliations Expand ### Affiliations * 1 Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America. * 2 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. * 3 Department of Public Health Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom. * 4 Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America. * 5 Department of Public Health Sciences, School of Medicine, University of California, Davis, California, United States of America. * 6 Zambian Ministry of Health, Lusaka, Zambia. * 7 Center for Innovation in Global Health, Georgetown University, Washington, D.C., United States of America. * 8 Division of Infectious Diseases, University of Alabama, Birmingham, Alabama, United States of America. * 9 The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland. * PMID: **42679007** * DOI: [ 10.1371/journal.pmed.1005052 ](https://doi.org/10.1371/journal.pmed.1005052) Item in Clipboard Randomized Controlled Trial # Effect of a person-centered care intervention on return and sustained reengagement after treatment interruptions from HIV care in Zambia: A post-hoc analysis of a stepped-wedged cluster randomized trial Aaloke Mody et al. PLoS Med. 2026. Show details Display options Display options Format Abstract PubMed PMID PLoS Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PLoS+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22PLoS+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42679007/) . 2026 Sep 1;23(9):e1005052. doi: 10.1371/journal.pmed.1005052. eCollection 2026 Sep. ### Authors [Aaloke Mody](https://pubmed.ncbi.nlm.nih.gov/?term=Mody+A&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America."), [Kombatende Sikombe](https://pubmed.ncbi.nlm.nih.gov/?term=Sikombe+K&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-3 "Department of Public Health Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom."), [Sandra Simbeza](https://pubmed.ncbi.nlm.nih.gov/?term=Simbeza+S&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Njekwa Mukamba](https://pubmed.ncbi.nlm.nih.gov/?term=Mukamba+N&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Laura K Beres](https://pubmed.ncbi.nlm.nih.gov/?term=Beres+LK&cauthor_id=42679007)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-4 "Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America."), [Jake M Pry](https://pubmed.ncbi.nlm.nih.gov/?term=Pry+JM&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-5 "Department of Public Health Sciences, School of Medicine, University of California, Davis, California, United States of America."), [Anjali Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+A&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Jacob Mutale](https://pubmed.ncbi.nlm.nih.gov/?term=Mutale+J&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Alida Zulu Dube](https://pubmed.ncbi.nlm.nih.gov/?term=Dube+AZ&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Musunge Mulabe](https://pubmed.ncbi.nlm.nih.gov/?term=Mulabe+M&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia."), [Lloyd Mulenga](https://pubmed.ncbi.nlm.nih.gov/?term=Mulenga+L&cauthor_id=42679007)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-6 "Zambian Ministry of Health, Lusaka, Zambia."), [Suilanji Sivile](https://pubmed.ncbi.nlm.nih.gov/?term=Sivile+S&cauthor_id=42679007)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-6 "Zambian Ministry of Health, Lusaka, Zambia."), [April Ratliff](https://pubmed.ncbi.nlm.nih.gov/?term=Ratliff+A&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America."), [Charles W Goss](https://pubmed.ncbi.nlm.nih.gov/?term=Goss+CW&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America."), [Charles B Holmes](https://pubmed.ncbi.nlm.nih.gov/?term=Holmes+CB&cauthor_id=42679007)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-7 "Center for Innovation in Global Health, Georgetown University, Washington, D.C., United States of America."), [Carolyn Bolton Moore](https://pubmed.ncbi.nlm.nih.gov/?term=Moore+CB&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-8 "Division of Infectious Diseases, University of Alabama, Birmingham, Alabama, United States of America."), [Izukanji Sikazwe](https://pubmed.ncbi.nlm.nih.gov/?term=Sikazwe+I&cauthor_id=42679007)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-2 "Centre for Infectious Disease Research in Zambia, Lusaka, Zambia.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-9 "The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland."), [Elvin H Geng](https://pubmed.ncbi.nlm.nih.gov/?term=Geng+EH&cauthor_id=42679007)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42679007/#short-view-affiliation-1 "Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America.") ### Affiliations * 1 Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America. * 2 Centre for Infectious Disease Research in Zambia, Lusaka, Zambia. * 3 Department of Public Health Environments and Society, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom. * 4 Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, United States of America. * 5 Department of Public Health Sciences, School of Medicine, University of California, Davis, California, United States of America. * 6 Zambian Ministry of Health, Lusaka, Zambia. * 7 Center for Innovation in Global Health, Georgetown University, Washington, D.C., United States of America. * 8 Division of Infectious Diseases, University of Alabama, Birmingham, Alabama, United States of America. * 9 The Global Fund to Fight AIDS, Tuberculosis and Malaria, Geneva, Switzerland. * PMID: **42679007** * DOI: [ 10.1371/journal.pmed.1005052 ](https://doi.org/10.1371/journal.pmed.1005052) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract **Background:** Poor client-provider interactions lead to reinforcing cycles of treatment interruptions (TIs) from HIV care and fear of return, undermining sustained retention. We previously demonstrated a multi-component person-centered care intervention (PCC) targeting healthcare worker (HCW) behavior improved client experience and r
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