---
title: "Phase 1 trials and PARTNERS platform target Bundibugyo Ebola strain"
id: "medical-news-today-40-phase-1-trials-for-ebola-treatments-and-vaccines-offer-hope-say-experts"
canonical_url: "https://medichelpline.com/clinical-feed/medical-news-today-40-phase-1-trials-for-ebola-treatments-and-vaccines-offer-hope-say-experts"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "Medical News Today"
source_url: "https://www.medicalnewstoday.com/articles/ebola-treatment-clinical-trial-bundibugyo-virus-3-questions/"
published_at: "2026-08-05T10:36:01.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Phase 1 trials and PARTNERS platform target Bundibugyo Ebola strain
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/medical-news-today-40-phase-1-trials-for-ebola-treatments-and-vaccines-offer-hope-say-experts
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** Medical News Today
- **Source URL:** [Original Journal Publication](https://www.medicalnewstoday.com/articles/ebola-treatment-clinical-trial-bundibugyo-virus-3-questions/)
- **Published At:** 2026-08-05T10:36:01.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- On July 2, 2026, the World Health Organization (WHO) and the Institut National de Recherche Biomédicale (INRB) began enrolling participants in a clinical trial targeting infections with the **Bundibugyo virus**, the cause of the recent Ebola outbreak in the DRC and Uganda. - The WHO and partners confirmed on August 4, 2026, that international trials have commenced for prophylactic drugs, vaccines, and treatments specific to the Bundibugyo strain. - The adaptive platform trial, called **PARTNERS**, is sponsored by WHO and led by INRB, coordinated with the Institute of Tropical Medicine (Belgium), University of Oxford (UK), and supported by Africa CDC. - PARTNERS is active at three sites in Ituri province, DRC, with over 50 enrolled Ebola patients; the platform is designed to add additional candidate therapies as evidence supports. - There is currently no licensed vaccine or targeted treatment for the Bundibugyo species; present clinical care is supportive only. - Preventive studies include a prophylactic oral agent, **obeldesivir**, being tested in the Ituri province over 10 days in people at high exposure risk, and phase 1 vaccine trials: **ChAdOx1 BDBV** (Oxford/Serum Institute) in the UK and **mRNA-1469** (Moderna) at three sites in Canada. - ChAdOx1 BDBV uses the same platform as the Oxford–AstraZeneca COVID-19 vaccine and entered phase 1 on July 24, 2026, assessing safety and immune response in ~50 healthy adults aged 18–55. Moderna's mRNA-1469 phase 1 will evaluate safety and immunogenicity in an estimated 80 healthy adults. - The PARTNERS therapeutic comparisons include the monoclonal antibody combination **MBP134** (two human monoclonal antibodies derived from an Ebola survivor) and **remdesivir**, studied alone and in combination to assess effects on survival. - Preclinical data cited include non-human primate studies showing MBP134 reversed symptoms of a Sudan strain; WHO and investigators selected candidates based on existing evidence and prior outbreak experience. - WHO cautions that trial results will take several months; completion timing depends on case numbers and enrollment, with investigators optimistic about relatively brisk participation but emphasizing careful, unhurried assessment of efficacy and safety.
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Cohut, Ph.D. — Fact checked by Jill Seladi-Schulman, Ph.D. — Updated on August 5, 2026 ![Black patient lying in hospital bed awaiting treatment](https://media.post.rvohealth.io/wp-content/uploads/sites/3/2026/07/getty_1972427119_header_1296x728-1024x575.jpg)[Share on Pinterest](https://www.pinterest.com/pin/create/button/?url=https%3A%2F%2Fwww.medicalnewstoday.com%2Farticles%2Febola-treatment-clinical-trial-bundibugyo-virus-3-questions&media=https%3A%2F%2Fmedia.post.rvohealth.io%2Fwp-content%2Fuploads%2Fsites%2F3%2F2026%2F07%2Fgetty_1972427119_header_1296x728-1024x575.jpg&description=Ebola%3A%20Treatments%2C%20vaccine%20trials%20for%20unchallenged%20viral%20strain%20begin "Share on Pinterest")Clinical trials for targeted new Ebola vaccine and treatments have now begun. PixelCatchers/Getty Images * **On July 2, 2026, the World Health Organization (WHO) and the Institut National de Recherche Biomédicale (INRB) announced the start of participant enrollment for a new clinical trial investigating targeted treatments for infections with the Bundibugyo virus.** * **On August 4, 2026, they confirmed the start of international clinical trials looking at both prophylactic medications and vaccines that might help prevent infection and at treatments targeting infections with the Bundibugyo strain.** * **The Bundibugyo virus caused the latest outbreak of Ebola in the Democratic Republic of the Congo (DRC) and Uganda.** * **There is currently no vaccine for this particular viral strain, nor a targeted treatment.** * **The trial, currently open for participants in the DRC, will be investigating three potential therapeutic approaches, with the aim of improving survival rates.** On July 2, 2026, the World Health Organization (WHO) [announcedTrusted Source](https://www.who.int/news/item/02-07-2026-patient-enrolment-begins-in-a-scientific-trial-to-identify-the-first-effective-treatments-for-bundibugyo-virus-disease) the start of participant enrollment for a new clinical trial investigating targeted treatments for infections with the Bundibugyo virus, which caused the latest [outbreak](https://www.medicalnewstoday.com/articles/epidemiologist-3-frequently-asked-questions-about-the-ebola-outbreak) of [Ebola](https://www.medicalnewstoday.com/articles/280598) in the Democratic Republic of the Congo (DRC) and Uganda. The trial — called “Platform adaptive randomized trial for new and repurposed Filovirus treatments ([PARTNERSTrusted Source](https://www.who.int/publications/m/item/partners-platform-adaptive-randomized-trial-for-new-and-repurpose-filovirus-treatments-core-trial-protocol))” — is sponsored by the WHO and led by the Institut National de Recherche Biomédicale (INRB) in the DRC. PARTNERS is further coordinated by research teams from the Institute of Tropical Medicine in Belgium and the University of Oxford in the United Kingdom, and is also supported by the Africa Centres for Disease Control and Prevention (Africa CDC). A month later, on July 4, 2026, at United Nations (UN) [press briefing](https://www.unognewsroom.org/story/en/3215/un-geneva-press-briefing-04-august-2026) held in Geneva, Switzerland, WHO representatives confirmed the start of clinical trials looking at both prophylactic drugs and vaccines that could help prevent infection, and treatments for infections with the Bundibugyo virus. During the briefing, WHO officials also stressed the importance of these research efforts, citing 3,748 confirmed cases of Ebola, including 1,657 deaths and 708 recoveries, as of August 1, 2026. The PARTNERS trial has now started operations at three sites across the Ituri province of the DRC, with over 50 Ebola patients currently enrolled as participants. Besides this, several phase 1 clinical trials of potential preventive medications or vaccines have also begun at research facilities around the world. ## Why are the trials necessary? There is currently no preventive vaccine or targeted treatment for infections with the [Bundibugyo strainTrusted Source](https://www.who.int/emergencies/disease-outbreak-news/item/2026-DON602) of the Ebola virus, which caused the current Ebola outbreak. “The current Ebola outbreak in the DRC is caused by a strain called the Bundibugyo virus, which is a distinct species of the Ebolavirus family without current vaccines or treatments,” [Monica Gandhi](https://profiles.ucsf.edu/monica.gandhi), MD, MPH, an infectious disease specialist and professor of medicine at the University of California, San Francisco, explained to _Medical News Today_. For the moment, healthcare professionals are only providing [supportive care](https://www.medicalnewstoday.com/articles/who-declares-ebola-global-health-emergency-what-to-know) for Ebola patients, meaning that they are monitoring [blood pressure](https://www.medicalnewstoday.com/articles/270644) and bleeding events, and attempting to prevent [organ failure](https://www.medicalnewstoday.com/articles/multiple-organ-dysfunction-syndrome). > “By the time the WHO declared [a public health emergency of international concernTrusted Source](https://www.who.int/news/item/17-05-2026-epidemic-of-ebola-disease-in-the-democratic-republic-of-the-congo-and-uganda-determined-a-public-health-emergency-of-international-concern) on May 17, the virus had already spread considerably and – without any vaccines or treatment- the only way to contain the virus is isolation of someone who is sick, contact tracing, and quarantine of exposed contacts. Given the deadly nature of Ebola, a treatment and eventually, a vaccine, are of the utmost importance.” > – Monica Gandhi, MD, MPH ## What new preventive approaches are under investigation? A trial of a potential prophylactic medication — oral [obeldesivirTrusted Source](https://www.thelancet.com/journals/laninf/article/PIIS1473-3099\(25\)00238-5/fulltext?rss=yes), previously tested for the prevention of [SARS-CoV-2](https://www.medicalnewstoday.com/articles/covid-19-symptoms) infections — has now begun in the Ituri province, with “over 25” participants considered at high risk of infection due to exposure to the Bundibugyo virus enrolled. The obeldesivir trial will test the oral medication over 10 days to see if this prophylactic treatment is able to prevent the onset of Ebola. This trial is led by the National Institute for Biomedical Research in the DRC. At the same time, the first Bundibugyo strain-specific vaccine candidate — developed by Oxford University in the U.K. and the Serum Institute of India — has entered phase 1 clinical trial in the U.K. on July, 24, 2026, WHO representatives noted during the recent press briefing in Geneva. Oxford University scientists developed the vaccine candidate — dubbed [ChAdOx1 BDBVTrusted Source](https://www.bmj.com/content/394/bmj-2026-100286) — in only 8 weeks, using a similar technology to that used in the development of the [Oxford-AstraZeneca COVID-19 vaccine](https://www.medicalnewstoday.com/articles/oxford-astrazeneca-vaccine-what-to-know-about-side-effects). The trial is assessing for “safety and immune response” in 50 healthy participants aged 18–55. Additionally, Moderna has also started a phase 1 clinical trial for its own vaccine candidate — [mRNA-1469](https://feeds.issuerdirect.com/news-release.html?newsid=5531328107885644&symbol=MRNA) — at three sites in Canada. Moderna’s vaccine candidate also uses the same technology the company had employed in the development of its [COVID-19 vaccine](https://www.medicalnewstoday.com/articles/moderna-vaccine-for-coronavirus). This trial is likewise evaluating the safety of the vaccine candidate, and its effectiveness in generating an immune response. Moderna estimates the trial will involve 80 healthy adult participants. ## What potential treatments is the PARTNERS trial testing? The PARTNERS trial is assessing whether using the [monoclonal antibody therapeuticTrusted Source](https://www.cancer.org/cancer/managing-cancer/treatment-types/immunotherapy/monoclonal-antibodies.html) MBP134, [remdesivir](https://www.medicalnewstoday.com/articles/veklury), an antiviral approved for the treatment of [COVID-19](https://www.medicalnewstoday.com/articles/progression-of-covid-19-symptoms), and effective in treating [some Ebolavirus strains](https://pmc.ncbi.nlm.nih.gov/articles/PMC7836944/), or a combination of the two therapies, might help improve survival. “The first treatment, MBP134, is made up of two human monoclonal antibodies (ADI-15878 and ADI-23774) isolated from a survivor of the 2013-2016 West African Ebola outbreak,” Gandhi explained. “MBP134 targets binding sites on the ebolavirus that are common to multiple strains, including neutralizing multiple strains, including Ebola (Zaire), Sudan, and Bundibugyo,” she detailed. **“A[study in non-human primates](https://pmc.ncbi.nlm.nih.gov/articles/PMC9228268/) show complete reverse of symptoms of a Sudan strain of Ebola with administration of MBP134. The second treatment, remdesivir, is a well-known antiviral used to treat SARS-CoV-2, the agent of COVID-19, and both treatments are being studied alone and in combination,” Gandhi added.** The WHO reiterated to _MNT_ that the research teams decided on these therapeutic approaches after reviewing the existing evidence supporting their potential and safety, as well as evidence based on real-world outcomes from “previous outbreak responses,” following a [strict protocolTrusted Source](https://www.who.int/news/item/28-05-2026-experts-convened-by-who-advise-on-candidate-treatments-and-vaccines-for-ebola-disease-caused-by-bundibugyo-virus). Furthermore, the trial is designed as a platform trial, meaning that further treatments can be added to the trial as they become available, if the WHO Technical Advisory Group deems there is enough evidence to support testing them in this context. ## How long will the PARTNERS trial last? While the PARTNERS trial is bringing hope for better outcomes for those infected with the Bundibugyo virus, the WHO emphasized that, in order to ensure efficacy and safety, the trial timeline must not be rushed. **“The clinical trial will take some time for results to be known — at least several months,” the WHO told _Medical News Today_.** Speaking to _MNT_ , Gandhi expressed optimism about the results of this new trial. “I am very hopeful that this important study has started, as treatments for this deadly disease are greatly needed,” she said. “The time to complete the trial will depend on the number of cases and participation, but I imagine enrollment will be brisk and patients willing to participate, so hopefully, we will see completion soon [maybe even] within a year,” concluded Gandhi. * [Ebola](https://www.medicalnewstoday.com/categories/ebola) * [Clinical Trials / Drug Trials](https://www.medicalnewstoday.com/categories/clinical_trials) * [Infectious Diseases / Bacteria / Viruses](https://www.medicalnewstoday.com/categories/infectious_diseases) Share this article [](https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fwww.medicalnewstoday.com%2Farticles%2Febola-treatment-clinical-trial-bundibugyo-virus-3-questions%3Futm_medium%3Dsocial%26utm_source%3Dfacebook%26utm_campaign%3Dsocial-sharebar-referred-desktop "Share on Facebook") [](https://twitter.com/intent/tweet?via=mnt&text=Ebola%3A%20Treatments%2C%20vaccine%20trials%20for%20unchallenged%20viral%20strain%20begin&url=https%3A%2F%2Fwww.medicalnewstoday.com%2Farticles%2Febola-treatment-clinical-trial-bundibugyo-virus-3-questions%3Futm_medium%3Dsocial%26utm_source%3Dx%26utm_campaign%3Dsocial-sharebar-referred-desktop "Share on X") ![](https://i0.wp.com/post.medicalnewstoday.com/wp-content/uploads/sites/3/2020/06/500x500_Maria_Cohut.png?w=105&h=105) Written by Maria Cohut, Ph.D. — Fact checked by Jill Seladi-Schulman, Ph.D. — Updated on August 5, 2026 ## Was this article helpful? YesNo ### Read next * [![Thumbnail for article: Ebola vaccine set for human trials after inducing long-term immunity in monkeys](https://media.post.rvohealth.io/wp-content/uploads/sites/3/2020/02/ebola-virus-8.jpg)](https://www.medicalnewstoday.com/articles/282145/?utm_source=ReadNextRAAS) [Ebola vaccine set for human trials after inducing long-term immunity in monkeys](https://www.medicalnewstoday.com/articles/282145/?utm_source=ReadNextRAAS) [Researchers from the National Institutes of Health have developed a vaccine that they say promotes durable immunity in monkeys against Ebola virus. It is now entering human trials.](https://www.medicalnewstoday.com/articles/282145/?utm_source=ReadNextRAAS) * [![Thumbnail for article: Promising results in Ebola vaccine safety trial](https://media.post.rvohealth.io/wp-content/uploads/sites/3/2020/02/ebola-trial-volunteer-receiving-vaccine.jpg)](https://www.medicalnewstoday.com/articles/286129/?utm_source=ReadNextRAAS) [Promising results in Ebola vaccine safety trial](https://w
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