---
title: "Progression of multiple long-term conditions (multimorbidity) in England: a population-based descriptive study of 49·6 million adults"
id: "the-lancet-public-health-7-progression-of-multiple-long-term-conditions-multimorbidity-in-england-a-population-based-descriptive-study-of-49-6-million-adults"
canonical_url: "https://medichelpline.com/clinical-feed/the-lancet-public-health-7-progression-of-multiple-long-term-conditions-multimorbidity-in-england-a-population-based-descriptive-study-of-49-6-million-adults"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "The Lancet Public Health"
source_url: "https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(26)00052-6/fulltext?rss=yes"
doi: "10.1016/S2468-2667(26)00052-6"
published_at: "2026-05-01T00:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Progression of multiple long-term conditions (multimorbidity) in England: a population-based descriptive study of 49·6 million adults
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/the-lancet-public-health-7-progression-of-multiple-long-term-conditions-multimorbidity-in-england-a-population-based-descriptive-study-of-49-6-million-adults
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** The Lancet Public Health
- **Source URL:** [Original Journal Publication](https://www.thelancet.com/journals/lanpub/article/PIIS2468-2667(26)00052-6/fulltext?rss=yes)
- **DOI:** [10.1016/S2468-2667(26)00052-6](https://doi.org/10.1016%2FS2468-2667(26)00052-6)
- **Published At:** 2026-05-01T00:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
In this whole-population study of adults in England, eight long-term conditions (ie, depression, hypertension, cancer, diabetes, asthma, osteoarthritis, coronary heart disease, and cerebrovascular disease) account for the majority of the first conditions people acquire. The presence of existing conditions is associated with higher MLTC progression rate. Socioeconomic deprivation is strongly associated with progression, apart from in the Black ethnic group in which progression is high across all intersectional ethnicity and deprivation subgroups, highlighting the importance of intersectional approaches in public health policy and research.
## Clinical Analysis & Structured Key Points
In this whole-population study of adults in England, eight long-term conditions (ie, depression, hypertension, cancer, diabetes, asthma, osteoarthritis, coronary heart disease, and cerebrovascular disease) account for the majority of the first conditions people acquire. The presence of existing conditions is associated with higher MLTC progression rate. Socioeconomic deprivation is strongly associated with progression, apart from in the Black ethnic group in which progression is high across all intersectional ethnicity and deprivation subgroups, highlighting the importance of intersectional approaches in public health policy and research.
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