---
title: "Schiff base‑triazole‑pleuromutilin conjugates: reported broad‑spectrum antibacterials with anti‑MR"
id: "pubmed-42208466"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42208466"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42208466/"
doi: "10.1016/j.bioorg.2026.110029"
published_at: "2026-09-05T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Schiff base‑triazole‑pleuromutilin conjugates: reported broad‑spectrum antibacterials with anti‑MR
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42208466
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42208466/)
- **DOI:** [10.1016/j.bioorg.2026.110029](https://doi.org/10.1016%2Fj.bioorg.2026.110029)
- **Published At:** 2026-09-05T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PubMed record reports a 2026 Bioorganic Chemistry article titled “Discovery of Schiff base-triazole-pleuromutilin conjugates as broad-spectrum antibacterial agents with potent anti-MRSA activity.” - The study is authored by Cai‑Xiang Zhang and colleagues from Guangxi Normal University and affiliated Chinese laboratories; corresponding authors and contact emails are listed in the record. - Bibliographic details include PubMed ID **42208466**, DOI 10.1016/j.bioorg.2026.110029, and electronic publication on 25 May 2026 with a journal issue date of 5 September 2026. - The title indicates the novel chemical class studied: **Schiff base‑triazole‑pleuromutilin conjugates**, and claims **broad‑spectrum antibacterial** activity with **potent anti‑MRSA** effects. - The PubMed page links to Elsevier Science full‑text options but the PubMed record shown here does not include the article abstract, experimental details, quantitative results, MIC values, in vitro/in vivo study design, or safety/pharmacology data. - Affiliations specify research groups focused on medicinal chemistry and molecular engineering of medicinal resources and multimodal biomarkers and precision diagnosis at institutions in Guilin, Guangxi, PR China. - The PubMed entry does not report conflict of interest statements, detailed methods, specific bacterial strains tested, comparative agents, structure–activity relationships, or conclusions beyond the title claim; those details require access to the full text. - Because the source content is limited to bibliographic metadata and title, no additional study outcomes, numerical data, or experimental claims are inferred or added here; readers are directed to the full text link for complete results and methods.
## Clinical Analysis & Structured Key Points
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Epub 2026 May 25. # Discovery of Schiff base-triazole-pleuromutilin conjugates as broad-spectrum antibacterial agents with potent anti-MRSA activity [Cai-Xiang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+CX&cauthor_id=42208466)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-1 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China; Guangxi Key Laboratory of Multimodal Biomarkers and Precision Diagnosis, College of Medical Laboratory and Biotechnology, Guilin Medical University,Guilin, Guangxi 541004, PR China."), [Shaoting Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+S&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Hongdong Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Ziying Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Z&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Hazrat Bilal](https://pubmed.ncbi.nlm.nih.gov/?term=Bilal+H&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Hong Liang](https://pubmed.ncbi.nlm.nih.gov/?term=Liang+H&cauthor_id=42208466)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-3 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: hliang@gxnu.edu.cn."), [Yanghan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Y&cauthor_id=42208466)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-4 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: liuyanghan@mailbox.gxnu.edu.cn."), [Zhen-Feng Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+ZF&cauthor_id=42208466)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#full-view-affiliation-5 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: chenzf@mailbox.gxnu.edu.cn.") Affiliations Expand ### Affiliations * 1 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China; Guangxi Key Laboratory of Multimodal Biomarkers and Precision Diagnosis, College of Medical Laboratory and Biotechnology, Guilin Medical University,Guilin, Guangxi 541004, PR China. * 2 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. * 3 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: hliang@gxnu.edu.cn. * 4 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: liuyanghan@mailbox.gxnu.edu.cn. * 5 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: chenzf@mailbox.gxnu.edu.cn. * PMID: **42208466** * DOI: [ 10.1016/j.bioorg.2026.110029 ](https://doi.org/10.1016/j.bioorg.2026.110029) Item in Clipboard # Discovery of Schiff base-triazole-pleuromutilin conjugates as broad-spectrum antibacterial agents with potent anti-MRSA activity Cai-Xiang Zhang et al. Bioorg Chem. 2026. Show details Display options Display options Format Abstract PubMed PMID Bioorg Chem Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Bioorg+Chem%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Bioorg+Chem%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42208466/) . 2026 Sep 5:179:110029. doi: 10.1016/j.bioorg.2026.110029. Epub 2026 May 25. ### Authors [Cai-Xiang Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+CX&cauthor_id=42208466)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-1 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China; Guangxi Key Laboratory of Multimodal Biomarkers and Precision Diagnosis, College of Medical Laboratory and Biotechnology, Guilin Medical University,Guilin, Guangxi 541004, PR China."), [Shaoting Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+S&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Hongdong Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Ziying Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+Z&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Hazrat Bilal](https://pubmed.ncbi.nlm.nih.gov/?term=Bilal+H&cauthor_id=42208466)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-2 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China."), [Hong Liang](https://pubmed.ncbi.nlm.nih.gov/?term=Liang+H&cauthor_id=42208466)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-3 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: hliang@gxnu.edu.cn."), [Yanghan Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+Y&cauthor_id=42208466)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-4 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: liuyanghan@mailbox.gxnu.edu.cn."), [Zhen-Feng Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+ZF&cauthor_id=42208466)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42208466/#short-view-affiliation-5 "Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources \(Ministry of Education of China\), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources \(Guangxi\), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China. Electronic address: chenzf@mailbox.gxnu.edu.cn.") ### Affiliations * 1 Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Guangxi Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources, University Engineering Research Center for Chemistry of Characteristic Medicinal Resources (Guangxi), School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, PR China; Guangxi Key La
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