---
title: "Strategic research priorities for the human microbiome, from an HHS-convened expert group"
id: "nature-0-the-human-microbiome-and-chronic-disease-ten-strategic-priorities-for-research"
canonical_url: "https://medichelpline.com/clinical-feed/nature-0-the-human-microbiome-and-chronic-disease-ten-strategic-priorities-for-research"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "Nature Medicine"
source_url: "https://www.nature.com/articles/s41591-026-04730-x"
published_at: "2026-10-23T09:52:10.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Strategic research priorities for the human microbiome, from an HHS-convened expert group
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/nature-0-the-human-microbiome-and-chronic-disease-ten-strategic-priorities-for-research
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** Nature Medicine
- **Source URL:** [Original Journal Publication](https://www.nature.com/articles/s41591-026-04730-x)
- **Published At:** 2026-10-23T09:52:10.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- An international panel of microbiome experts convened by the **US Department of Health and Human Services** issued a strategic vision for linking the **human microbiome** to chronic disease and public health. - The published piece is a comment-style consensus; it outlines priorities rather than reporting new trial data or primary experimental results. - The article lists many leading authors and institutional contributors; specific operational details of the proposed priorities were not available in the previewed content. - Investigators referenced a broad evidence base, including prior reviews and primary studies spanning microbiome associations with diet, immunity and disease, but the preview did not reproduce the ten priorities verbatim. - The authors acknowledged support from federal agencies, including the **NIH** and the **FDA**, and noted HHS facilitation of the inaugural roundtable; funding statements and acknowledgements are included. - The source provided a figure (Fig. 1) and an extensive reference list; however, the preview page restricted access to the full text and the detailed roadmap. - Data indicated this output is framed as a strategic research and public-health agenda rather than a clinical trial or guideline document. - The preview did not report implementation timelines, prioritized research methodologies, measurable endpoints, or regulatory milestones. - The cohort of authors included multiple high-profile microbiome investigators; author affiliations and ORCID identifiers were listed in the preview. - Limitations in the publicly available preview include paywalled access to the full text and absence of granular recommendations, leaving key translational and policy details unreported.
## Clinical Analysis & Structured Key Points
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[nature](https://www.nature.com/) 2. [nature medicine](https://www.nature.com/nm) 3. [comments](https://www.nature.com/nm/articles?type=comment) 4. article * Comment * Published: 23 October 2026 # The human microbiome and chronic disease: ten strategic priorities for research and public health * [Martin J. Blaser](https://www.nature.com/articles/s41591-026-04730-x#auth-Martin_J_-Blaser-Aff1) [ORCID: orcid.org/0000-0003-2447-2443](https://orcid.org/0000-0003-2447-2443)[1](https://www.nature.com/articles/s41591-026-04730-x#Aff1), * [Frederic D. Bushman](https://www.nature.com/articles/s41591-026-04730-x#auth-Frederic_D_-Bushman-Aff2) [ORCID: orcid.org/0000-0003-4740-4056](https://orcid.org/0000-0003-4740-4056)[2](https://www.nature.com/articles/s41591-026-04730-x#Aff2), * [Maria Gloria Dominguez-Bello](https://www.nature.com/articles/s41591-026-04730-x#auth-Maria_Gloria-Dominguez_Bello-Aff1)[1](https://www.nature.com/articles/s41591-026-04730-x#Aff1), * [Eran Elinav](https://www.nature.com/articles/s41591-026-04730-x#auth-Eran-Elinav-Aff3-Aff4) [ORCID: orcid.org/0000-0002-5775-2110](https://orcid.org/0000-0002-5775-2110)[3](https://www.nature.com/articles/s41591-026-04730-x#Aff3),[4](https://www.nature.com/articles/s41591-026-04730-x#Aff4), * [Sangeeta Khare](https://www.nature.com/articles/s41591-026-04730-x#auth-Sangeeta-Khare-Aff5)[5](https://www.nature.com/articles/s41591-026-04730-x#Aff5), * [Rob Knight](https://www.nature.com/articles/s41591-026-04730-x#auth-Rob-Knight-Aff6)[6](https://www.nature.com/articles/s41591-026-04730-x#Aff6), * [Jennie H. Kwon](https://www.nature.com/articles/s41591-026-04730-x#auth-Jennie_H_-Kwon-Aff7)[7](https://www.nature.com/articles/s41591-026-04730-x#Aff7), * [Sarkis K. Mazmanian](https://www.nature.com/articles/s41591-026-04730-x#auth-Sarkis_K_-Mazmanian-Aff8) [ORCID: orcid.org/0000-0003-2713-1513](https://orcid.org/0000-0003-2713-1513)[8](https://www.nature.com/articles/s41591-026-04730-x#Aff8), * [Majdi Osman](https://www.nature.com/articles/s41591-026-04730-x#auth-Majdi-Osman-Aff9-Aff10)[9](https://www.nature.com/articles/s41591-026-04730-x#Aff9),[10](https://www.nature.com/articles/s41591-026-04730-x#Aff10), * [Nicola Segata](https://www.nature.com/articles/s41591-026-04730-x#auth-Nicola-Segata-Aff11) [ORCID: orcid.org/0000-0002-1583-5794](https://orcid.org/0000-0002-1583-5794)[11](https://www.nature.com/articles/s41591-026-04730-x#Aff11), * [Tim Spector](https://www.nature.com/articles/s41591-026-04730-x#auth-Tim-Spector-Aff12) [ORCID: orcid.org/0000-0002-9795-0365](https://orcid.org/0000-0002-9795-0365)[12](https://www.nature.com/articles/s41591-026-04730-x#Aff12), * [Jennifer A. Wargo](https://www.nature.com/articles/s41591-026-04730-x#auth-Jennifer_A_-Wargo-Aff13) [ORCID: orcid.org/0000-0003-3438-7576](https://orcid.org/0000-0003-3438-7576)[13](https://www.nature.com/articles/s41591-026-04730-x#Aff13) & * … * [Suchitra K. Hourigan](https://www.nature.com/articles/s41591-026-04730-x#auth-Suchitra_K_-Hourigan-Aff14-Aff15) [ORCID: orcid.org/0000-0003-2656-5694](https://orcid.org/0000-0003-2656-5694)[14](https://www.nature.com/articles/s41591-026-04730-x#Aff14),[15](https://www.nature.com/articles/s41591-026-04730-x#Aff15) Show authors [_Nature Medicine_](https://www.nature.com/nm) (2026) [Cite this article](https://www.nature.com/articles/s41591-026-04730-x#citeas) Save article [ View saved research ](https://www.nature.com/saved-research) The human microbiome has emerged as one of the most consequential frontiers in biomedical science. An international group of leading microbiome scientists, convened by the US Department of Health and Human Services, presents a strategic vision for realizing its potential to transform public health. This is a preview of subscription content, [access via your institution](https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41591-026-04730-x) ## Access options [ Access through your institution ](https://wayf.springernature.com?redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41591-026-04730-x) Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription 27.99 € / 30 days cancel any time [Learn more](https://shop.nature.com/products/plus/?region=ROW) Subscribe to this journal Receive 12 print issues and online access 251.40 € per year only 20.95 € per issue [Learn more](https://www.nature.com/nm/subscribe) Buy this article * Purchase on SpringerLink * Instant access to the full article PDF. 39,95 € Prices may be subject to local taxes which are calculated during checkout ### Additional access options: * [Log in](https://idp.nature.com/auth/personal/springernature?client_id=grover&redirect_uri=https%3A%2F%2Fwww.nature.com%2Farticles%2Fs41591-026-04730-x) * [Learn about institutional subscriptions](https://www.springernature.com/gp/librarians/licensing/license-options) * [Read our FAQs](https://support.nature.com/en/support/home) * [Contact customer support](https://www.springernature.com/gp/contact) **Fig. 1** ![](https://media.springernature.com/m312/springer-static/image/art%3A10.1038%2Fs41591-026-04730-x/MediaObjects/41591_2026_4730_Fig1_HTML.png) ## References 1. 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S.K.H. was the chair of the committee. ## Funding This research was supported (in part) by the Intramural Research Program of the National Institutes of Health (NIH). The contributions of the NIH author are considered Works of the US Government. This research was supported (in part) by the Food and Drug Administration (FDA). The contributions of the FDA author are considered works of the US Government. The findings and conclusions presented in this paper are those of the author(s) and do not necessarily reflect the views of the NIH, FDA or the US Department of Health and Human Services. ## Author information ### Authors and Affiliations 1. Department of Medicine and Pathology & Laboratory Medicine, Center for Advanced Biotechnology and Medicine, Rutgers University, New Brunswick, NJ, USA Martin J. Blaser & Maria Gloria Dominguez-Bello 2. Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA Frederic D. Bushman 3. Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel Eran Elinav 4. Microbiome & Cancer Division, German Cancer Research Center (DKFZ), Heidelberg, Germany Eran Elinav 5. Division of Microbiology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA Sangeeta Khare 6. Department of Pediatrics, Bioengineering, and Computer Science & Engineering, UC San Diego, La Jolla, CA, USA Ro
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