---
title: "Treatment of Severe Ocular Mpox with Cidofovir and Tecovirimat"
id: "cdc-emerging-infectious-diseases-journal-4-treatment-of-severe-ocular-mpox-with-cidofovir-and-tecovirimat"
canonical_url: "https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-4-treatment-of-severe-ocular-mpox-with-cidofovir-and-tecovirimat"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "CDC Emerging Infectious Diseases Journal"
source_url: "https://wwwnc.cdc.gov/eid/article/32/4/25-0882_article"
published_at: "2026-04-10T04:00:00.000Z"
evidence_level: "Agency Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Treatment of Severe Ocular Mpox with Cidofovir and Tecovirimat
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/cdc-emerging-infectious-diseases-journal-4-treatment-of-severe-ocular-mpox-with-cidofovir-and-tecovirimat
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** CDC Emerging Infectious Diseases Journal
- **Source URL:** [Original Journal Publication](https://wwwnc.cdc.gov/eid/article/32/4/25-0882_article)
- **Published At:** 2026-04-10T04:00:00.000Z
- **Evidence Rating:** Agency Feed
## Executive GIST (TL;DR)
Disclaimer: Early release articles are not considered as final versions. Any changes will be reflected in the online version in the month the article is officially released. Mpox, a reemerging zoonotic disease since 2022, primarily affects the skin; ocular involvement is rarely reported. We present a case of mpox-caused disciform keratitis treated with a combination of cidofovir and tecovirimat. The patient recovered without residual ocular sequelae, suggesting these drugs are an option to treat ocular mpox manifestations. Mpox is a reemerging zoonotic disease, with >140,000 cases reported worldwide since 2022 ( 1 ). A major outbreak of mpox caused by clade IIb monkeypox virus (MPXV) occurred in Western Europe and the United States in 2022, although MPXV clade I has caused high mortality rates in Central Africa for decades ( 2 ). MPXV, a member of the Poxviridae family ( 3 ), is primarily transmitted through close physical contact between humans and typically causes disseminated cutaneomucosal lesions ( 4 ). Ocular involvement occurs in ≈1%–10% of cases, with a higher frequency in MPXV clade I infections ( 5 ).
## Clinical Analysis & Structured Key Points
CDC Emerging Infectious Diseases Journal published a clinical update in Infectious Disease on 10 Apr 2026. The item focuses on Treatment of Severe Ocular Mpox with Cidofovir and Tecovirimat. Review the original article for the full source wording and details.
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