---
title: "Which adolescent KAP changes after school-based PrevHPV interventions increase HPV vaccine uptake?"
id: "pubmed-42753385"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42753385"
content_type: "clinical_feed_article"
specialty: "Infectious Disease"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42753385/"
doi: "10.1016/j.vaccine.2026.129150"
published_at: "2026-10-24T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Which adolescent KAP changes after school-based PrevHPV interventions increase HPV vaccine uptake?
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42753385
- **Specialty:** [Infectious Disease](https://medichelpline.com/clinical-feed/infectious-disease.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42753385/)
- **DOI:** [10.1016/j.vaccine.2026.129150](https://doi.org/10.1016%2Fj.vaccine.2026.129150)
- **Published At:** 2026-10-24T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PrevHPV study was a randomized controlled trial in France aiming to raise **HPV vaccine** (HPVV) coverage among **adolescents**. - Investigators tested three intervention components: educational and motivational activities (EMM), school-based vaccination campaigns (FA), and General Practitioner (GP) training. - The trial compared combinations of these components to assess effects on vaccination uptake and vaccination intentions. - The published record available in this source identifies a mediation analysis question: which changes in knowledge, attitudes, and practices (KAP) following the intervention were associated with increased uptake and intentions. - The abstract and bibliographic record in the provided source list authors, affiliations, journal citation (Vaccine) and DOI, but the excerpt stops before reporting outcomes, effect sizes, or statistical results. - The source text did not report detailed methods (randomization ratio, sample size, KAP instrument specifics), nor did it report mediation analysis methods or numerical findings in the provided excerpt. - Readers should consult the full article for primary endpoints, quantitative mediation results, and subgroup analyses because those data were not available in the supplied source text.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 17. # Which changes in adolescents' knowledge, attitudes, and practices following a school-based intervention in France increase HPV vaccination uptake and intentions? A mediation analysis [Amanda Munoz](https://pubmed.ncbi.nlm.nih.gov/?term=Munoz+A&cauthor_id=42753385)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-1 "Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France. Electronic address: amanda.munoz@pasteur.fr."), [Amandine Gagneux-Brunon](https://pubmed.ncbi.nlm.nih.gov/?term=Gagneux-Brunon+A&cauthor_id=42753385)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-2 "Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, France; CIC INSERM 1408 Vaccinologie, CHU de Saint-Etienne, France."), [Anne-Sophie Le Duc-Banaszuk](https://pubmed.ncbi.nlm.nih.gov/?term=Le+Duc-Banaszuk+AS&cauthor_id=42753385)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-3 "Centre Régional de Coordination des Dépistages des cancers-Pays de la Loire, Angers, France."), [Sébastien Bruel](https://pubmed.ncbi.nlm.nih.gov/?term=Bruel+S&cauthor_id=42753385)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-4 "Department of General Practice, Faculté de Médecine Jacques Lisfranc Université Jean Monnet, Université de Lyon, Saint-Etienne, France; Health, Systemic, Process UR 4129 Research Unit, University Claude Bernard, University of Lyon, Lyon, France."), [Morgane Michel](https://pubmed.ncbi.nlm.nih.gov/?term=Michel+M&cauthor_id=42753385)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-5 "Université Paris Cité, ECEVE, UMR 1123, Inserm, F-75010 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de santé publique, équipe REPERES, F-75019 Paris, France."), [Aurélie Gauchet](https://pubmed.ncbi.nlm.nih.gov/?term=Gauchet+A&cauthor_id=42753385)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-6 "Univ. Savoie Mont Blanc, Univ. Grenoble Alpes, LIP/PC2S, 38000 Grenoble, France."), [Damien Oudin Doglioni](https://pubmed.ncbi.nlm.nih.gov/?term=Doglioni+DO&cauthor_id=42753385)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-7 "Univ. Grenoble Alpes, Univ. Savoie Mont-Blanc, LIP/PC2S, 38000 Grenoble, France."), [Anne-Sophie Barret](https://pubmed.ncbi.nlm.nih.gov/?term=Barret+AS&cauthor_id=42753385)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-8 "Santé publique France, 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex, France."), [Jocelyn Raude](https://pubmed.ncbi.nlm.nih.gov/?term=Raude+J&cauthor_id=42753385)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-9 "Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS \(Recherche sur les Services et Management en Santé\) - U 1309, F-35000 Rennes, France."), [Nathalie Thilly](https://pubmed.ncbi.nlm.nih.gov/?term=Thilly+N&cauthor_id=42753385)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-10 "Université de Lorraine, APEMAC, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Département Méthodologie, Promotion, Investigation, F-54000 Nancy, France."), [Judith E Mueller](https://pubmed.ncbi.nlm.nih.gov/?term=Mueller+JE&cauthor_id=42753385)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#full-view-affiliation-11 "Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France; Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS \(Recherche sur les Services et Management en Santé\) - U 1309, F-35000 Rennes, France."); [PrevHPV Consortium](https://pubmed.ncbi.nlm.nih.gov/?term=PrevHPV+Consortium%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France. Electronic address: amanda.munoz@pasteur.fr. * 2 Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, France; CIC INSERM 1408 Vaccinologie, CHU de Saint-Etienne, France. * 3 Centre Régional de Coordination des Dépistages des cancers-Pays de la Loire, Angers, France. * 4 Department of General Practice, Faculté de Médecine Jacques Lisfranc Université Jean Monnet, Université de Lyon, Saint-Etienne, France; Health, Systemic, Process UR 4129 Research Unit, University Claude Bernard, University of Lyon, Lyon, France. * 5 Université Paris Cité, ECEVE, UMR 1123, Inserm, F-75010 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de santé publique, équipe REPERES, F-75019 Paris, France. * 6 Univ. Savoie Mont Blanc, Univ. Grenoble Alpes, LIP/PC2S, 38000 Grenoble, France. * 7 Univ. Grenoble Alpes, Univ. Savoie Mont-Blanc, LIP/PC2S, 38000 Grenoble, France. * 8 Santé publique France, 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex, France. * 9 Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, F-35000 Rennes, France. * 10 Université de Lorraine, APEMAC, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Département Méthodologie, Promotion, Investigation, F-54000 Nancy, France. * 11 Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France; Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, F-35000 Rennes, France. * PMID: **42753385** * DOI: [ 10.1016/j.vaccine.2026.129150 ](https://doi.org/10.1016/j.vaccine.2026.129150) Free article Item in Clipboard Randomized Controlled Trial # Which changes in adolescents' knowledge, attitudes, and practices following a school-based intervention in France increase HPV vaccination uptake and intentions? A mediation analysis Amanda Munoz et al. Vaccine. 2026. Free article Show details Display options Display options Format Abstract PubMed PMID Vaccine Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Vaccine%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Vaccine%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42753385/) . 2026 Oct 24:92:129150. doi: 10.1016/j.vaccine.2026.129150. Epub 2026 Sep 17. ### Authors [Amanda Munoz](https://pubmed.ncbi.nlm.nih.gov/?term=Munoz+A&cauthor_id=42753385)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-1 "Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France. Electronic address: amanda.munoz@pasteur.fr."), [Amandine Gagneux-Brunon](https://pubmed.ncbi.nlm.nih.gov/?term=Gagneux-Brunon+A&cauthor_id=42753385)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-2 "Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, France; CIC INSERM 1408 Vaccinologie, CHU de Saint-Etienne, France."), [Anne-Sophie Le Duc-Banaszuk](https://pubmed.ncbi.nlm.nih.gov/?term=Le+Duc-Banaszuk+AS&cauthor_id=42753385)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-3 "Centre Régional de Coordination des Dépistages des cancers-Pays de la Loire, Angers, France."), [Sébastien Bruel](https://pubmed.ncbi.nlm.nih.gov/?term=Bruel+S&cauthor_id=42753385)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-4 "Department of General Practice, Faculté de Médecine Jacques Lisfranc Université Jean Monnet, Université de Lyon, Saint-Etienne, France; Health, Systemic, Process UR 4129 Research Unit, University Claude Bernard, University of Lyon, Lyon, France."), [Morgane Michel](https://pubmed.ncbi.nlm.nih.gov/?term=Michel+M&cauthor_id=42753385)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-5 "Université Paris Cité, ECEVE, UMR 1123, Inserm, F-75010 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de santé publique, équipe REPERES, F-75019 Paris, France."), [Aurélie Gauchet](https://pubmed.ncbi.nlm.nih.gov/?term=Gauchet+A&cauthor_id=42753385)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-6 "Univ. Savoie Mont Blanc, Univ. Grenoble Alpes, LIP/PC2S, 38000 Grenoble, France."), [Damien Oudin Doglioni](https://pubmed.ncbi.nlm.nih.gov/?term=Doglioni+DO&cauthor_id=42753385)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-7 "Univ. Grenoble Alpes, Univ. Savoie Mont-Blanc, LIP/PC2S, 38000 Grenoble, France."), [Anne-Sophie Barret](https://pubmed.ncbi.nlm.nih.gov/?term=Barret+AS&cauthor_id=42753385)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-8 "Santé publique France, 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex, France."), [Jocelyn Raude](https://pubmed.ncbi.nlm.nih.gov/?term=Raude+J&cauthor_id=42753385)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-9 "Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS \(Recherche sur les Services et Management en Santé\) - U 1309, F-35000 Rennes, France."), [Nathalie Thilly](https://pubmed.ncbi.nlm.nih.gov/?term=Thilly+N&cauthor_id=42753385)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-10 "Université de Lorraine, APEMAC, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Département Méthodologie, Promotion, Investigation, F-54000 Nancy, France."), [Judith E Mueller](https://pubmed.ncbi.nlm.nih.gov/?term=Mueller+JE&cauthor_id=42753385)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42753385/#short-view-affiliation-11 "Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France; Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS \(Recherche sur les Services et Management en Santé\) - U 1309, F-35000 Rennes, France."); [PrevHPV Consortium](https://pubmed.ncbi.nlm.nih.gov/?term=PrevHPV+Consortium%5BCorporate+Author%5D) ### Affiliations * 1 Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France. Electronic address: amanda.munoz@pasteur.fr. * 2 Centre International de Recherche en Infectiologie, Team GIMAP, Univ Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, Inserm, U1111, CNRS, UMR530, France; CIC INSERM 1408 Vaccinologie, CHU de Saint-Etienne, France. * 3 Centre Régional de Coordination des Dépistages des cancers-Pays de la Loire, Angers, France. * 4 Department of General Practice, Faculté de Médecine Jacques Lisfranc Université Jean Monnet, Université de Lyon, Saint-Etienne, France; Health, Systemic, Process UR 4129 Research Unit, University Claude Bernard, University of Lyon, Lyon, France. * 5 Université Paris Cité, ECEVE, UMR 1123, Inserm, F-75010 Paris, France; Assistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, Service de santé publique, équipe REPERES, F-75019 Paris, France. * 6 Univ. Savoie Mont Blanc, Univ. Grenoble Alpes, LIP/PC2S, 38000 Grenoble, France. * 7 Univ. Grenoble Alpes, Univ. Savoie Mont-Blanc, LIP/PC2S, 38000 Grenoble, France. * 8 Santé publique France, 12 rue du Val d'Osne, 94415 Saint-Maurice Cedex, France. * 9 Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, F-35000 Rennes, France. * 10 Université de Lorraine, APEMAC, F-54000 Nancy, France; Université de Lorraine, CHRU-Nancy, Département Méthodologie, Promotion, Investigation, F-54000 Nancy, France. * 11 Emerging Disease Epidemiology Unit, Institut Pasteur, Université Paris Cité, 25 rue du Dr Roux, 75015 Paris, France; Université de Rennes, EHESP, CNRS, Inserm, Arènes - UMR 6051, RSMS (Recherche sur les Services et Management en Santé) - U 1309, F-35000 Rennes, France. * PMID: **42753385** * DOI: [ 10.1016/j.vaccine.2026.129150 ](https://doi.org/10.1016/j.vaccine.2026.129150) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID Linked Discoveries ## Abstract **Background:** In France, human papillomavirus vaccine (HPVV) coverage among adolescents remains below the national objective. The PrevHPV randomised trial assessed three intervention components to improve HPVV coverage among adolescents: educational and motivational activities (EMM); vaccination campaigns (FA) in middle schools; and General Practitioner (GP) training. F
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