---
title: "Basolateral amygdala neurons are selectively recruited by oscillatory states to form valence-speci"
id: "biorxiv-20-basolateral-amygdala-neurons-await-oscillatory-recruitment-into-valence"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-20-basolateral-amygdala-neurons-await-oscillatory-recruitment-into-valence"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.15.751884v1?rss=1"
published_at: "2026-09-20T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Basolateral amygdala neurons are selectively recruited by oscillatory states to form valence-speci
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-20-basolateral-amygdala-neurons-await-oscillatory-recruitment-into-valence
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.15.751884v1?rss=1)
- **Published At:** 2026-09-20T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The basolateral amygdala (BLA) is central to **valence** processing, a rapid evaluation of stimuli as positive or negative that is essential for adaptive behavior. - Prior work had identified BLA valence ensembles by anatomy, projection targets, and genetic markers, and separately implicated distinct BLA **oscillatory** states in driving valence. - This study reconciles those lines of evidence by showing that subpopulations of BLA principal neurons are selectively recruited by specific frequencies of **optogenetically-driven oscillations**. - Recruitment into ensembles reflects individual neurons’ sensitivity to input frequency rather than only anatomy or genetic identity. - Interneuron-driven oscillatory states can generate these frequency-selective inputs and thereby gate recruitment of distinct neuron populations. - Stimulating interneurons to generate oscillations activated **projection-specific** BLA populations and could reactivate ensembles that are behaviorally relevant. - The findings support a neural computation in which **interneuron-driven oscillatory states** selectively recruit frequency-, projection-, and valence-specific BLA neurons to produce distinct behavioral outcomes. - The report indicates a mechanistic link between oscillatory state, projection specificity, and valence ensemble activation, but specific experimental parameters, quantitative outcomes, and broader translational implications were not reported in the source summary.
## Clinical Analysis & Structured Key Points
Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles | bioRxiv Skip to main content New Results Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles View ORCID Profile Kenneth A Amaya , Yingchu He , Grant L Weiss , Pantelis Antonoudiou , Jamie L Maguire doi: https://doi.org/10.64898/2026.09.15.751884 Kenneth A Amaya Tufts University Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Kenneth A Amaya For correspondence: kenneth.amaya{at}tufts.edu Yingchu He Tufts University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Grant L Weiss Tufts University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Pantelis Antonoudiou Tufts University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Jamie L Maguire Tufts University Find this author on Google Scholar Find this author on PubMed Search for this author on this site Abstract Info/History Metrics Preview PDF Abstract Impaired valence processing is a core feature of psychiatric illnesses. The ability to rapidly evaluate situations and stimuli and determine whether they have positive or negative implications, termed valence processing, is a highly adaptive brain function that is essential for survival. Despite its importance, we still lack a complete understanding of the neural computations involved. The basolateral amygdala (BLA) plays a critical role in valence processing and valence ensembles have been identified by their anatomical location within the BLA, their projection targets, their genetic identity, or some combination of these factors. In parallel, distinct BLA oscillatory states have been shown to drive divergent valence states. Despite abundant evidence separately supporting these processes, we have failed to reconcile these disparate contributions to valence processing. Here, we demonstrate that subpopulations of BLA principal neurons are recruited in response to specific frequencies of optogenetically-driven oscillations. We provide evidence showing ensemble recruitment is a product of individual neuronal sensitivities to input frequencies that can be driven by interneuron-driven oscillatory states. We also demonstrate that oscillations driven by interneuron stimulations can activate projection-specific populations and reactivate behaviorally-relevant ensembles. Together, these findings reveal a novel neural computational mechanism governing valence processing involving the ability of interneuron-driven oscillatory states to selectively recruit populations of frequency-, projection-, and valence-specific BLA neurons to evoke distinct behavioral outcomes. Competing Interest Statement Jamie L. Maguire serves as a member of the scientific advisory board for Ovid Therapeutics, Inc. for work unrelated to this project. Funder Information Declared National Institutes of Health, https://ror.org/01cwqze88 , MH128235 , MH130162 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC 4.0 International license . Back to top Previous Next Posted September 20, 2026. Download PDF Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. You are going to email the following Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website. Your Personal Message CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions. Share Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles Kenneth A Amaya , Yingchu He , Grant L Weiss , Pantelis Antonoudiou , Jamie L Maguire bioRxiv 2026.09.15.751884; doi: https://doi.org/10.64898/2026.09.15.751884 Share This Article: Copy Citation Tools Basolateral amygdala neurons await oscillatory recruitment into valence-relevant ensembles Kenneth A Amaya , Yingchu He , Grant L Weiss , Pantelis Antonoudiou , Jamie L Maguire bioRxiv 2026.09.15.751884; doi: https://doi.org/10.64898/2026.09.15.751884 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Area Neuroscience Subject Areas All Articles Animal Behavior and Cognition (8013) Biochemistry (18739) Bioengineering (14888) Bioinformatics (44418) Biophysics (22599) Cancer Biology (19723) Cell Biology (26899) Clinical Trials (138) Developmental Biology (13965) Ecology (21005) Epidemiology (2067) Evolutionary Biology (25455) Genetics (16166) Genomics (23507) Immunology (18705) Microbiology (42503) Molecular Biology (18059) Neuroscience (93451) Paleontology (700) Pathology (2977) Pharmacology and Toxicology (5095) Physiology (8114) Plant Biology (15999) Scientific Communication and Education (2095) Synthetic Biology (4560) Systems Biology (10235) Zoology (2391)
## Related Clinical Research

- [Correction: Data-driven framework for modeling the dendritic spine continuum — funding and corresp](https://medichelpline.com/clinical-feed/plos-one-1-correction-a-data-driven-framework-for-modeling-the-dendritic-spine-continuum.md)
- [Serum Na–Cl Difference as a Noninvasive Screen for CO2 Retention in ALS](https://medichelpline.com/clinical-feed/plos-one-2-serum-na-cl-value-from-routine-blood-tests-reflects-co-2-retention-in.md)
- [Periodised Power Training (POWER) Pilot RCT Protocol for Chronic Stroke Recovery](https://medichelpline.com/clinical-feed/bmj-open-9-periodised-power-training-in-community-dwelling-adults-with-chronic-stroke-a.md)
- [Night-onset Stroke Linked to Worse 3‑Month Outcomes After Reperfusion Therapy](https://medichelpline.com/clinical-feed/bmj-open-19-association-of-time-of-day-at-stroke-onset-with-functional-outcomes-after.md)
- [Excitatory progenitor diversification in the rhombic lip drives evolution of new cerebellar nuclei](https://medichelpline.com/clinical-feed/biorxiv-18-evolution-of-new-cerebellar-nuclei-by-excitatory-progenitor-diversification-in.md)

## Navigation
- [← Back to Neurology Feed](https://medichelpline.com/clinical-feed/neurology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.