---
title: "Comparative Effectiveness of Treatments for Relapse Prevention in MOG Antibody–Associated Disease"
id: "pubmed-42842889"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42842889"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42842889/"
doi: "10.1212/WNL.0000000000218508"
published_at: "2026-10-07T22:07:45.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Comparative Effectiveness of Treatments for Relapse Prevention in MOG Antibody–Associated Disease
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42842889
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42842889/)
- **DOI:** [10.1212/WNL.0000000000218508](https://doi.org/10.1212%2FWNL.0000000000218508)
- **Published At:** 2026-10-07T22:07:45.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article is a comparative study titled “Comparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease,” published in Neurology (2026). It is identified by PMID **42842889** and DOI 10.1212/WNL.0000000000218508. - The paper lists a large multi-institutional author group led by Akash Virupakshaiah and includes contributors from UCSF, University of Utah, Washington University in St. Louis, Mayo Clinic, MGH/Harvard, Boston Children’s Hospital, Cleveland Clinic, NYU Langone, Baylor/Texas Children’s, Loma Linda University Children’s Hospital, University of Alabama at Birmingham, Children’s Hospital Colorado, and Children’s Hospital of Philadelphia. - The publication date shown is 2026 Oct 27 (volume 107, issue 8, article e218508) with electronic publication on 2026 Oct 7. - The article’s scope per the title is comparative effectiveness of treatments for **relapse prevention** in **Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease** (commonly abbreviated MOGAD). - The PubMed page records article type as a Comparative Study and the journal as Neurology. - The source page as provided does not include the study abstract, methods, sample size, specific treatments compared, statistical results, effect sizes, safety data, or authors’ conclusions. - Because the abstract and full text content were not present in the provided source, details on study design, inclusion criteria, outcome measures, duration of follow-up, comparative findings, and clinical recommendations were not reported and cannot be inferred. - Users should consult the full text (Neurology, DOI 10.1212/WNL.0000000000218508) to obtain the trial or observational data, treatment comparisons, quantitative results, and practice implications that are not available on the supplied PubMed page excerpt.
## Clinical Analysis & Structured Key Points
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Epub 2026 Oct 7. # Comparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease [Akash Virupakshaiah](https://pubmed.ncbi.nlm.nih.gov/?term=Virupakshaiah+A&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Vinicius Andreoli Schoeps](https://pubmed.ncbi.nlm.nih.gov/?term=Schoeps+VA&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-2 "University of Utah, Salt Lake City."), [Jonathan Race](https://pubmed.ncbi.nlm.nih.gov/?term=Race+J&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-2 "University of Utah, Salt Lake City."), [Claudia Gambrah-Lyles](https://pubmed.ncbi.nlm.nih.gov/?term=Gambrah-Lyles+C&cauthor_id=42842889)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-3 "Washington University in St. Louis, MO."), [Gina Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+G&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Michael Waltz](https://pubmed.ncbi.nlm.nih.gov/?term=Waltz+M&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-2 "University of Utah, Salt Lake City."), [Parinaz Nasr](https://pubmed.ncbi.nlm.nih.gov/?term=Nasr+P&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Carson E Moseley](https://pubmed.ncbi.nlm.nih.gov/?term=Moseley+CE&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Scott S Zamvil](https://pubmed.ncbi.nlm.nih.gov/?term=Zamvil+SS&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-4 "Program in Immunology, University of California, San Francisco."), [Alice Rutatangwa Edwards](https://pubmed.ncbi.nlm.nih.gov/?term=Edwards+AR&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Carla Francisco](https://pubmed.ncbi.nlm.nih.gov/?term=Francisco+C&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [T Charles Casper](https://pubmed.ncbi.nlm.nih.gov/?term=Casper+TC&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-2 "University of Utah, Salt Lake City."), [John W Rose](https://pubmed.ncbi.nlm.nih.gov/?term=Rose+JW&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-2 "University of Utah, Salt Lake City."), [Eoin P Flanagan](https://pubmed.ncbi.nlm.nih.gov/?term=Flanagan+EP&cauthor_id=42842889)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-5 "Mayo Clinic, Rochester, MN."), [Moses Rodriguez](https://pubmed.ncbi.nlm.nih.gov/?term=Rodriguez+M&cauthor_id=42842889)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-5 "Mayo Clinic, Rochester, MN."), [Jan-Mendelt Tillema](https://pubmed.ncbi.nlm.nih.gov/?term=Tillema+JM&cauthor_id=42842889)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-5 "Mayo Clinic, Rochester, MN."), [Tanuja Chitnis](https://pubmed.ncbi.nlm.nih.gov/?term=Chitnis+T&cauthor_id=42842889)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-6 "Massachusetts General Hospital, Harvard Medical School, Boston."), [Mark P Gorman](https://pubmed.ncbi.nlm.nih.gov/?term=Gorman+MP&cauthor_id=42842889)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-7 "Boston Children's Hospital, MA."), [Leslie A Benson](https://pubmed.ncbi.nlm.nih.gov/?term=Benson+LA&cauthor_id=42842889)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-7 "Boston Children's Hospital, MA."), [Jennifer S Graves](https://pubmed.ncbi.nlm.nih.gov/?term=Graves+JS&cauthor_id=42842889)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-8 "Department of Neurosciences, University of California, San Diego."), [Mary Rensel](https://pubmed.ncbi.nlm.nih.gov/?term=Rensel+M&cauthor_id=42842889)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-9 "Cleveland Clinic, OH."), [Aaron W Abrams](https://pubmed.ncbi.nlm.nih.gov/?term=Abrams+AW&cauthor_id=42842889)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-9 "Cleveland Clinic, OH."), [Lauren B Krupp](https://pubmed.ncbi.nlm.nih.gov/?term=Krupp+LB&cauthor_id=42842889)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-10 "NYU Langone, New York."), [Kimberly A O'Neill](https://pubmed.ncbi.nlm.nih.gov/?term=O%27Neill+KA&cauthor_id=42842889)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-10 "NYU Langone, New York."), [Timothy E Lotze](https://pubmed.ncbi.nlm.nih.gov/?term=Lotze+TE&cauthor_id=42842889)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-11 "Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston."), [Kristen S Fisher](https://pubmed.ncbi.nlm.nih.gov/?term=Fisher+KS&cauthor_id=42842889)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-11 "Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston."), [Nikita Malani Shukla](https://pubmed.ncbi.nlm.nih.gov/?term=Shukla+NM&cauthor_id=42842889)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-11 "Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston."), [Gregory S Aaen](https://pubmed.ncbi.nlm.nih.gov/?term=Aaen+GS&cauthor_id=42842889)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-12 "Loma Linda University Children's Hospital, CA."), [Yolanda S Wheeler](https://pubmed.ncbi.nlm.nih.gov/?term=Wheeler+YS&cauthor_id=42842889)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-13 "University of Alabama at Birmingham."), [Teri L Schreiner](https://pubmed.ncbi.nlm.nih.gov/?term=Schreiner+TL&cauthor_id=42842889)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-14 "Children's Hospital Colorado, Denver; and."), [Amy Tara Waldman](https://pubmed.ncbi.nlm.nih.gov/?term=Waldman+AT&cauthor_id=42842889)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-15 "Children's Hospital of Philadelphia, PA."), [Janet Chong](https://pubmed.ncbi.nlm.nih.gov/?term=Chong+J&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Emmanuelle Waubant](https://pubmed.ncbi.nlm.nih.gov/?term=Waubant+E&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Soe S Mar](https://pubmed.ncbi.nlm.nih.gov/?term=Mar+SS&cauthor_id=42842889)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#full-view-affiliation-3 "Washington University in St. Louis, MO.") Affiliations Expand ### Affiliations * 1 UCSF Weill Institute for Neurosciences, University of California, San Francisco. * 2 University of Utah, Salt Lake City. * 3 Washington University in St. Louis, MO. * 4 Program in Immunology, University of California, San Francisco. * 5 Mayo Clinic, Rochester, MN. * 6 Massachusetts General Hospital, Harvard Medical School, Boston. * 7 Boston Children's Hospital, MA. * 8 Department of Neurosciences, University of California, San Diego. * 9 Cleveland Clinic, OH. * 10 NYU Langone, New York. * 11 Division of Pediatric Neurology and Developmental Neuroscience, Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston. * 12 Loma Linda University Children's Hospital, CA. * 13 University of Alabama at Birmingham. * 14 Children's Hospital Colorado, Denver; and. * 15 Children's Hospital of Philadelphia, PA. * PMID: **42842889** * DOI: [ 10.1212/WNL.0000000000218508 ](https://doi.org/10.1212/wnl.0000000000218508) Item in Clipboard Comparative Study # Comparative Effectiveness of Treatments for Relapse Prevention in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Akash Virupakshaiah et al. Neurology. 2026. Show details Display options Display options Format Abstract PubMed PMID Neurology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Neurology%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Neurology%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42842889/) . 2026 Oct 27;107(8):e218508. doi: 10.1212/WNL.0000000000218508. Epub 2026 Oct 7. ### Authors [Akash Virupakshaiah](https://pubmed.ncbi.nlm.nih.gov/?term=Virupakshaiah+A&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Vinicius Andreoli Schoeps](https://pubmed.ncbi.nlm.nih.gov/?term=Schoeps+VA&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-2 "University of Utah, Salt Lake City."), [Jonathan Race](https://pubmed.ncbi.nlm.nih.gov/?term=Race+J&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-2 "University of Utah, Salt Lake City."), [Claudia Gambrah-Lyles](https://pubmed.ncbi.nlm.nih.gov/?term=Gambrah-Lyles+C&cauthor_id=42842889)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-3 "Washington University in St. Louis, MO."), [Gina Chang](https://pubmed.ncbi.nlm.nih.gov/?term=Chang+G&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Michael Waltz](https://pubmed.ncbi.nlm.nih.gov/?term=Waltz+M&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-2 "University of Utah, Salt Lake City."), [Parinaz Nasr](https://pubmed.ncbi.nlm.nih.gov/?term=Nasr+P&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Carson E Moseley](https://pubmed.ncbi.nlm.nih.gov/?term=Moseley+CE&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Scott S Zamvil](https://pubmed.ncbi.nlm.nih.gov/?term=Zamvil+SS&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-4 "Program in Immunology, University of California, San Francisco."), [Alice Rutatangwa Edwards](https://pubmed.ncbi.nlm.nih.gov/?term=Edwards+AR&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [Carla Francisco](https://pubmed.ncbi.nlm.nih.gov/?term=Francisco+C&cauthor_id=42842889)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-1 "UCSF Weill Institute for Neurosciences, University of California, San Francisco."), [T Charles Casper](https://pubmed.ncbi.nlm.nih.gov/?term=Casper+TC&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-2 "University of Utah, Salt Lake City."), [John W Rose](https://pubmed.ncbi.nlm.nih.gov/?term=Rose+JW&cauthor_id=42842889)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-2 "University of Utah, Salt Lake City."), [Eoin P Flanagan](https://pubmed.ncbi.nlm.nih.gov/?term=Flanagan+EP&cauthor_id=42842889)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-5 "Mayo Clinic, Rochester, MN."), [Moses Rodriguez](https://pubmed.ncbi.nlm.nih.gov/?term=Rodriguez+M&cauthor_id=42842889)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-5 "Mayo Clinic, Rochester, MN."), [Jan-Mendelt Tillema](https://pubmed.ncbi.nlm.nih.gov/?term=Tillema+JM&cauthor_id=42842889)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-5 "Mayo Clinic, Rochester, MN."), [Tanuja Chitnis](https://pubmed.ncbi.nlm.nih.gov/?term=Chitnis+T&cauthor_id=42842889)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-6 "Massachusetts General Hospital, Harvard Medical School, Boston."), [Mark P Gorman](https://pubmed.ncbi.nlm.nih.gov/?term=Gorman+MP&cauthor_id=42842889)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42842889/#short-view-affiliation-7 "Boston Children's Hospital, MA."), [Leslie A Benson](https://pubmed.ncbi.nlm.nih.gov/?term=Benson+LA&cauthor_id=42842889)[ 7 ](https://pubm
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