---
title: "Correction: Funding and supporting files for VPA rat model study of altered stress and fear respon"
id: "plos-one-9-correction-altered-stress-and-fear-responses-in-the-vpa-rat-model-of-autism"
canonical_url: "https://medichelpline.com/clinical-feed/plos-one-9-correction-altered-stress-and-fear-responses-in-the-vpa-rat-model-of-autism"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "PLOS ONE (Medicine)"
source_url: "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445"
published_at: "2026-09-01T14:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Correction: Funding and supporting files for VPA rat model study of altered stress and fear respon
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/plos-one-9-correction-altered-stress-and-fear-responses-in-the-vpa-rat-model-of-autism
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** PLOS ONE (Medicine)
- **Source URL:** [Original Journal Publication](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445)
- **Published At:** 2026-09-01T14:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- This is a published correction to the PLOS ONE article reporting altered stress and fear responses in the **VPA rat model** of autism. The correction updates the Funding statement and replaces several supporting files that were uploaded incorrectly. - The corrected Funding statement reports support from CAPES (Brazil; grant #88882.376056/2019–1 to DH) and CNPq (partial support #383539/2025–0 to DH, and CNPq #010186/2018–2 and #421955/2023–6 to RNRP). - Supporting files S1 Table and S1–S6 Figs were re-uploaded; S1 Table summarizes animal and litter allocation across experiments to avoid litter confounds. - S1 Fig describes the method for assigning ultrasonic vocalizations (USVs) to demonstrator (DEM) or observer (OBS) animals using USV power thresholds; calls with intermediate power were excluded (~9.8% of calls). - S2 Fig shows sex-related comparisons in touch-induced defecation: no significant sex differences were reported for CTL or VPA groups (p > 0.05). - S3 Fig reports tactile and nociceptive threshold measures, noting no overall group differences (p > 0.05) but a reported sex difference in tactile thresholds (& p = 0.007). - S4 Fig outlines the fear memory retrieval paradigm and reports no between-group differences in prevalence of freezing during retrieval (p > 0.05); within-group freezing increased from baseline to retrieval (p < 0.001). - S5 Fig presents sex-related differences in emotional contagion freezing responses and provides percent-time-freezing by sex for CTL and VPA animals across experimental blocks. - S6 Fig summarizes demonstrator (DEM) behavioral and vocal responses during emotional contagion: foot shock increased freezing prevalence and vocalizations in shocked groups (dC+ and dV+), with no significant differences between VPA-treated and control demonstrators in freezing duration or call acoustic properties. - Across DEM groups, shocked animals increased freezing from block B1 onward and showed increased USV emission from block B2 or later; call duration and principal frequency did not differ between dV+ and dC+. - The correction notice includes links and DOIs for the corrected supporting files and references the original article citation. Details reported here are limited to the content provided in the correction notice and the supplementary file legends; no additional experimental data or results outside that text are introduced.
## Clinical Analysis & Structured Key Points
[ Skip to main content ](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#main-content) Advertisement * [plos.org](https://plos.org/) * [Create account](https://community.plos.org/registration/new) * [Sign in](https://journals.plos.org/user/secure/login?page=%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0357445) * * About * Browse * Publish * [](https://journals.plos.org/plosone/ "PLOS One") * Search [advanced search](https://journals.plos.org/plosone/search) * [Browse Topics](https://journals.plos.org/plosone/subjectAreaBrowse) Browse Subject Areas ? Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click [here](https://github.com/PLOS/plos-thesaurus/blob/master/README.md "Link opens in new window"). [](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445) [](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445) * 0 [Save](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#savedHeader) [Total Mendeley and Citeulike bookmarks.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#savedHeader) * 0 [Citation](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#citedHeader) [Paper's citation count computed by Dimensions.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#citedHeader) * 13 [View](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#viewedHeader) [PLOS views and downloads.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#viewedHeader) * 0 [Share](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#discussedHeader) [Sum of Facebook, Twitter, Reddit and Wikipedia activity.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445#discussedHeader) Open Access Correction # Correction: Altered stress and fear responses in the VPA rat model of autism: Behavioral dissociation across tactile, nociceptive, and social contexts * Debora Hashiguchi, * Ana Luiza Dias, * Rodrigo Neves Romcy-Pereira # Correction: Altered stress and fear responses in the VPA rat model of autism: Behavioral dissociation across tactile, nociceptive, and social contexts * Debora Hashiguchi, * Ana Luiza Dias, * Rodrigo Neves Romcy-Pereira ![PLOS](https://journals.plos.org/resource/img/logo-plos-full-color.svg) x * Published: September 1, 2026 * * [Article](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445) * [Metrics](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0357445) * [Comments](https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0357445) * [Media Coverage](http://plos.altmetric.com/details/doi/10.1371/journal.pone.0357445) * [Supporting information](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#sec001) * [Reference](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#reference) * [Reader Comments](https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0357445) There are errors in the Funding statement. The correct Funding statement is as follows: This work was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES, Brazil; #88882.376056/2019–1 to DH), partially by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, #383539/2025–0 to DH), and by CNPq (#010186/2018–2 and #421955/2023–6 to RNRP). [S1 Table](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s001) and [S1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s002) to [S6 Figs](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007) were uploaded incorrectly. Please see the correct [S1 Table](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s001) and [S1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s002) to [S6 Figs](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007) here. ## Supporting information ### [S1 Table. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s001)Summary of animals and litters used across experiments. Offspring from multiple litters were distributed across experimental conditions to minimize potential confounding effects of litter identity. Within each experimental paradigm, independent litters were assigned to the CTL and VPA groups, such that no litter contributed animals to both treatment conditions. (TIFF) ### [S1 Fig. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s002)Assignment of observer (OBS) and demonstrator (DEM) vocalizations. Vocalizations produced during the emotional contagion paradigm were assigned to DEM or OBS animals based on ultrasonic vocalization (USV) power intensity. Thresholds were established experimentally (A–C) by comparing the power of USVs recorded with a microphone positioned either in the same chamber as the vocalizing animal or in the opposite chamber. (A–B) Mean USV power during maternal separation at postnatal days P08 and P14 (#_p_ −76 dB were classified as originating from animals located in the microphone chamber (DEM chamber), whereas vocalizations (TIFF) ### [S2 Fig. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s003)Sex-related differences in touch-induced defecation responses. (A) Schematic illustration of the touch sensitivity experimental design. (B) Number of fecal pellets released on each experimental day by female and male CTL animals (p > 0.050). (C) Number of fecal pellets released on each experimental day by female and male VPA-treated animals (p > 0.050). Mann–Whitney test, CTL: _n_ = 18 (9 females, 9 males); VPA: _n_ = 21 (10 females, 11 males). (TIFF) ### [S3 Fig. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s004)Tactile and nociceptive thresholds. (A) Tactile and nociceptive thresholds (#_p_ > 0.050; *_p_ (TIFF) ### [S4 Fig. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s005)Fear memory retrieval. (A) Schematic illustration of the experimental design. Rats were placed in the center of the apparatus facing one of the metal walls and remained in the chamber for 5 min before being returned to their home cage. (B) Percentage of animals displaying freezing behavior during fear conditioning memory retrieval (p > 0.05). (C) Percentage of time spent freezing during the fear conditioning baseline (B0) and memory retrieval session (_p_ (TIFF) ### [S5 Fig. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s006)Sex-related differences in emotional contagion freezing responses. (A) Schematic illustration of the emotional contagion experimental design. (B) Percentage of time spent freezing in each experimental block by female and male CTL animals. (C) Percentage of time spent freezing in each experimental block by female and male VPA-treated animals. The dotted line indicates the 20% reference value. Repeated-measures two-way ANOVA, NoC + : _n_ = 16 (8 females, 8 males); NoV + : _n_ = 15 (8 females, 7 males). (TIFF) ### [S6 Fig. ](https://journals.plos.org/plosone/article/file?type=supplementary&id=10.1371/journal.pone.0357445.s007)Behavioral and vocal responses of DEM animals during emotional contagion. (A) Schematic illustration of the emotional contagion experimental design. Following a 4-min period of free exploration, DEM animals received five electrical shock stimuli. After the final stimulus, animals remained in the chamber for an additional 4 min of free exploration. (B) Percentage of animals displaying freezing behavior in each experimental block (CTL: #_p_ ≤ 0.011; VPA: #_p_ ≤ 0.021; dC + : *_p_ 0.050). (H) Principal frequency of USVs emitted during blocks B1–B5 (p > 0.050). Panels B, D, and E: Fisher’s exact test. Panel C: repeated-measures two-way ANOVA. Panel F: Friedman test. Panels G–H: Mann–Whitney test. Panels B–E: ndC − = 15 (7 females, 8 males); ndV − = 15 (7 females, 8 males); ndC + = 16 (8 females, 8 males); ndV + = 15 (8 females, 7 males). Panel F: noC − = 5 (2 females, 3 males); noV − = 6 (2 females, 4 males); noC + = 16 (8 females, 8 males); noV + = 14 (8 females, 6 males). Panels G–H: noC + = 16 (8 females, 8 males); noV + = 14 (8 females, 6 males). # indicates significant differences between Shock (+) and non-Shock (−) groups; * indicates significant within-group differences compared with block B0. Because the behavioral responses of observer (OBS) rats are expected to depend on the behavior of demonstrator (DEM) rats, we quantified freezing behavior and ultrasonic vocalizations (USVs) emitted by DEM animals during the emotional contagion paradigm. As expected, foot shock exposure significantly increased the prevalence of freezing behavior in both shocked groups (dC+ and dV+) compared to their respective non-shocked controls (dC- and dV-), regardless of prenatal treatment ([S6A](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007) and [S6B Fig](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007)). No significant differences in freezing prevalence were found between dV+ and dC+ animals or between dV- and dC- animals.Among responsive individuals, both the dC+ and dV+ groups exhibited a sharp, significant increase in freezing time following the onset of shock stimuli ([S6C Fig](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007)). Specifically, compared to baseline (B0) levels, dC+ and dV+ animals increased their freezing behavior at block B1, reaching a plateau sustained from B2 to B5. Conversely, dV- and dC- controls showed no deviations from B0 freezing levels. Crucially, no significant differences in freezing duration were detected in between-group comparisons (dC + vs. dV+ or dC- vs. dV-; p > 0.05).Shocked demonstrators also showed a higher prevalence of vocalization compared to non-shocked controls ([S6D Fig](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007)). Analysis of vocal engagement across experimental blocks revealed: (1) no significant differences between dV + vs. dC+ or between dV- vs. dC-; (2) significant differences between dV + vs. dV (beginning at block B2) and between dC + vs. dC- (beginning at block B1); and (3) a significant increase in vocalization prevalence relative to B0 in both dV+ and dC+ groups from block B2 onward ([S6E Fig](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007)). Control dV- and dC- rats maintained baseline-like vocal engagement throughout the experiment.In terms of call volume, DEM rats exhibited robust USV emission following foot shock exposure. While the total number of emitted USVs did not differ significantly between the dV+ and dC+ groups, both shocked groups demonstrated a marked increase in call numbers from block B4 onward relative to their respective non-shocked controls (dC- and dV-; [S6F Fig](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007)). Furthermore, relative to baseline (B0), a significant increase in vocal production was observed in dV+ (blocks B2–B5), dC+ (blocks B2 and B4–B5), and dV- (block B1) animals. No significant within-group changes over time were found for the dC- controls. Finally, bioacoustic properties—namely call duration and principal frequency (F0)—did not differ between dV+ and dC+ animals ([S6G](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007) and [S6H Fig](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445#pone.0357445.s007)). Due to the low number of vocalizations emitted by dV- and dC- animals (median of 3 calls per block), their acoustic properties were excluded from further statistical analysis. (TIFF) ## Reference 1. 1. Hashiguchi D, Dias AL, Romcy-Pereira RN. Altered stress and fear responses in the VPA rat model of autism: Behavioral dissociation across tactile, nociceptive, and social contexts. PLoS One. 2026;21(7):e0353839. pmid:42467635 * [ View Article ](https://doi.org/10.1371/journal.pone.0353839 "Go to article") * [ PubMed/NCBI ](http://www.ncbi.nlm.nih.gov/pubmed/42467635 "Go to article in PubMed") * [ Google Scholar ](http://scholar.google.com/scholar?q=Altered+stress+and+fear+responses+in+the+VPA+rat+model+of+autism%3A+Behavioral+dissociation+across+tactile%2C+nociceptive%2C+and+social+contexts+Hashiguchi+2026 "Go to article in Google Scholar") **Citation:** Hashiguchi D, Dias AL, Romcy-Pereira RN (2026) Correction: Altered stress and fear responses in the VPA rat model of autism: Behavioral dissociation across tactile, nociceptive, and social contexts. PLoS One 21(9): e0357445. https://doi.org/10.1371/journal.pone.0357445 **Published:** September 1, 2026 **Copyright:** © 2026 Hashiguchi et al. This is an open access article distributed under the terms of the [Creative Commons Attribution License](http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. [Download PDF](https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357445&type=printable) * [Citation](https://journals.plos.org/plosone/article/citation?id=10.1371/journal.pone.0357445) * [XML](https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0357445&type=manuscript) [Print](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0357445) Share * [![Reddit](https://journals.plos.org/resource/img/icon.reddit.16.png)Reddit](https://www.reddit.com/submit?url=https%3A%2F%2Fdx.plos.org%2F10.1371%2Fjournal.pone.0357445 "Submit to Reddit") * [![Facebook](https://journals.plos.org/resource/img/icon.fb.16.png)Facebook](https://www.facebook.com/share.php?u=https%3A%2F%2Fdx.plos.org%2F10.1371%2Fjournal.pone.0357445&t=Correction:%20Altered%20stress%20and%20fear%20responses%20in%20the%20VPA%20rat%20model%20of%20autism:%20Behavioral%20dissociation%20across%20tactile,%20nociceptive,%20and%20social%20contexts "Share on Facebook") * [![LinkedIn](https://journals.plos.org/resource/img/icon.linkedin.16.png)LinkedIn](https://www.linkedin.com/shareArticle?url=https%3A%2F%2Fdx.plos.org%2F10.1371%2Fjournal.pone.0357445&title=Correction:%20Altered%20stress%20and%20fear%20responses%20in%20the%20VPA%20rat%20model%20of%20autism:%20Behavioral%20dissociation%20across%20tactile,%20nociceptive,%20and%20social%20contexts&summary=Checkout%20this%20article%20I%20found%20at%20PLOS "Add to LinkedIn") * [![Mendeley](https://journals.plos.org/resource/img/icon.mendeley.16.png)Mendeley](https://www.mendeley.com/import/?url=https%3A%2F%2Fdx.plos.org%2F10.1371%2Fjournal.pone.0357445 "Add to Mendeley") * [![Bluesky](https://journals.plos.org/resource/img/icon.bluesky.light.png)Bluesky](https://bsky.app/intent/compose?text=Checkout%20this%20article%20I%20found%20at%20PLOS:%20https%3A%2F%2Fdx.plos.org%2F10.1371%2Fjournal.pone.0357445 "Share on Bluesky") * ![Email](https://journals.plos.org/resource/img/icon.email.16.png)Email ![Check for updates via CrossMark](https://crossmark-cdn.crossref.org/widget/v2.0/logos/CROSSMARK_BW_horizontal.svg) ### Related PLOS Articles * **CORRECTION pertains to** * Altered stress and fear responses in the VPA rat model of autism: Behavioral dissociation across tactile, nociceptive, and social contexts * [View Page](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0353839) * [PDF](https://journals.plos.org/plosone/article/file?type=printable&id=10.1371/journal.pone.0353839 "PDF opens in new window") Advertisement * [Publications](https://plos.org/our-journals/) * [PLOS Aging and Health](https://journals.plos.org/agingandhealth/) * [PLOS Biology](https://journals.plos.org/plosbiology/) * [PLOS Climate](https://journals.plos.org/climate/) * [PLOS Complex Systems](https://journals.plos.org/complexsystems/) * [PLOS Computational Biology](https://journals.plos.org/ploscompbiol/) * [PLOS Digital Health](https://journals.plos.org/digitalhealth/) * [PLOS Ecosystems](https://journals.plos.org/ecosystems/) * [PLOS Genetics](https://journals.plos.org/plosgenetics/) * [PLOS Global Public Health](https://journals.plos.org/globalpublichealth/) * [PLOS Medicine](https://journals.plos.org/plosmedicine/) * [PLOS Mental Health](https://journals.plos.org/mentalhealth/) * [PLOS Neglected Tropical Diseases](https://journals.plos.org/plosntds/) * [PLOS One](https://journals.plos.org/plosone/) * [PLOS Pathogens](https://journals.plos.org/plospathogens/) * [PLOS Sustainability and Transformation](https://journals.plos.org/sustainabilitytransformation/) * [PLOS Water](https://journals.plos.org/water/) * [Home](https://plos.org) * [Blogs](https://blogs.plos.org) * [Collections](https://collections.plos.org/) * Give feedback * [LOCKSS](https://journals.plos.org/plosone/lockss-manifest) * [Privacy Policy](https:/
## Related Clinical Research

- [Public perceptions of concussion reporting in live sport broadcasts](https://medichelpline.com/clinical-feed/plos-one-15-concussion-in-live-sport-broadcast-coverage-how-do-the-public-perceive-it.md)
- [ICF-based content overlap between tinnitus distress and depression questionnaires](https://medichelpline.com/clinical-feed/plos-one-21-an-icf-based-content-analysis-of-the-overlap-between-questionnaires-assessing.md)
- [CBT-I for Insomnia Linked to Slower Biological Aging in Older Adults](https://medichelpline.com/clinical-feed/medical-news-today-0-could-treating-insomnia-slow-biological-aging-study-finds-promising-link.md)
- [How family history differentiates monogenic from polygenic ALS: simulation study using APECS](https://medichelpline.com/clinical-feed/medrxiv-5-the-value-of-a-family-history-to-distinguish-monogenic-from-polygenic.md)
- [Genetic Links to Alzheimer’s, Lewy Body and Vascular Neuropathology: Shared Genes and Distinct Var](https://medichelpline.com/clinical-feed/medrxiv-10-genetic-associations-with-alzheimer-s-lewy-body-and-vascular-neuropathology.md)

## Navigation
- [← Back to Neurology Feed](https://medichelpline.com/clinical-feed/neurology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.