---
title: "Effector-memory T cell program links peripheral EBV priming to CNS autoimmunity — preprint summary"
id: "biorxiv-1-a-pro-inflammatory-effector-memory-t-cell-program-links-peripheral-ebv-priming"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-1-a-pro-inflammatory-effector-memory-t-cell-program-links-peripheral-ebv-priming"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.28.753741v1?rss=1"
published_at: "2026-10-01T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Effector-memory T cell program links peripheral EBV priming to CNS autoimmunity — preprint summary
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-1-a-pro-inflammatory-effector-memory-t-cell-program-links-peripheral-ebv-priming
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.28.753741v1?rss=1)
- **Published At:** 2026-10-01T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- This preprint reports that a **pro-inflammatory effector-memory T cell** program provides a mechanistic link between peripheral priming by **EBV** (Epstein–Barr virus) and **CNS autoimmunity**. - The work is presented as a research preprint on bioRxiv and has not been peer reviewed. - The lead and contributing authors are affiliated predominantly with University Hospital Erlangen, with additional contributors from Technical University of Denmark, St. Jude Children’s Research Hospital, and Otto-von-Guericke University Magdeburg. - DOI for the preprint is provided in the source: https://doi.org/10.64898/2026.09.28.753741. - The article title conveys the principal conclusion but the excerpted source text does not include experimental details, datasets, methods, subject characteristics, or specific results. - Because the source excerpt is limited, details on study design, assays used, sample sizes, statistical outcomes, or direct evidence supporting the title claim were not reported in the provided content. - Readers should note the preprint status and consult the full manuscript or subsequent peer-reviewed publication for complete methods, results, and interpretation.
## Clinical Analysis & Structured Key Points
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Benotmane, Lucia Klotz, [ View ORCID Profile](http://orcid.org/0009-0008-0673-1898)Philipp Hilgendorf, [ View ORCID Profile](http://orcid.org/0000-0002-8432-6045)Myriam Grotz, Mariana Sousa, [ View ORCID Profile](http://orcid.org/0000-0003-0904-6753)Lasse F. Voss, [ View ORCID Profile](http://orcid.org/0000-0002-6860-5079)Stefan Schattgen, Vanessa Lang, [ View ORCID Profile](http://orcid.org/0000-0002-7336-2008)Hannah Reimann, Cosima Storr, [ View ORCID Profile](http://orcid.org/0000-0003-0502-3677)Roland Lang, Bernd Spriewald, [ View ORCID Profile](http://orcid.org/0000-0003-2605-3429)Felix B. Engel, [ View ORCID Profile](http://orcid.org/0000-0003-2911-8830)Martin Boettcher, [ View ORCID Profile](http://orcid.org/0000-0002-2817-6660)Dimitrios Mougiakakos, [ View ORCID Profile](http://orcid.org/0000-0003-4439-4374)Stefanie Schreiber, [ View ORCID Profile](http://orcid.org/0000-0002-9258-3033)Dieter H. Heiland, [ View ORCID Profile](http://orcid.org/0000-0002-2844-9091)Simone Mader, [ View ORCID Profile](http://orcid.org/0000-0001-7955-0256)Paul G. Thomas, [ View ORCID Profile](http://orcid.org/0000-0002-5937-4344)Sine Reker Hadrup, [ View ORCID Profile](http://orcid.org/0000-0003-0296-843X)Veit Rothhammer, [ View ORCID Profile](http://orcid.org/0000-0001-9323-9472)Kilian Schober doi: https://doi.org/10.64898/2026.09.28.753741 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Nikolaj Pagh Kristensen 1 University Hospital Erlangen; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Nikolaj%2BPagh%2BKristensen%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kristensen%20NP&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ANikolaj%2BPagh%2BKristensen%2B) * [ORCID record for Nikolaj Pagh Kristensen](http://orcid.org/0000-0002-5073-7153 "Open in new tab") Thanos Tsaktanis 1 University Hospital Erlangen; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Thanos%2BTsaktanis%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Tsaktanis%20T&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AThanos%2BTsaktanis%2B) * [ORCID record for Thanos Tsaktanis](http://orcid.org/0009-0002-7889-1256 "Open in new tab") Sina Frischholz 1 University Hospital Erlangen; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Sina%2BFrischholz%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Frischholz%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASina%2BFrischholz%2B) * [ORCID record for Sina Frischholz](http://orcid.org/0009-0004-9376-9309 "Open in new tab") Jasim K. 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