---
title: "Extracellular Substrate for Temporary Memory Storage — preprint report"
id: "biorxiv-17-an-extracellular-substrate-for-the-temporary-storage-of-memories"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-17-an-extracellular-substrate-for-the-temporary-storage-of-memories"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.23.760812v1?rss=1"
published_at: "2026-10-24T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Extracellular Substrate for Temporary Memory Storage — preprint report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-17-an-extracellular-substrate-for-the-temporary-storage-of-memories
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.23.760812v1?rss=1)
- **Published At:** 2026-10-24T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The cited document is a bioRxiv preprint titled “An extracellular substrate for the temporary storage of memories.” - Authors are led by Ricardo Guajardo and include a multi-institutional team; affiliations listed include University of California San Francisco, UCLA, and University of Massachusetts Chan Medical School. - The paper has a DOI assigned on bioRxiv (10.64898/2026.10.23.760812) and is explicitly labelled as not peer reviewed. - The provided source excerpt contains author names, institutional affiliations and metadata, but the excerpt did not include experimental methods, results, specific data, or conclusions. - The source did not report primary endpoints, experimental design, model systems, sample sizes, or statistical outcomes in the excerpt available to this rewrite. - Key open questions remain: which extracellular molecule(s) are proposed as the storage substrate, which neural circuits were studied, what temporal window defines “temporary,” and what evidence supports causality versus correlation. - The preprint format indicates findings are preliminary; independent peer review and access to full methods and data will be required to evaluate reproducibility and interpretation.
## Clinical Analysis & Structured Key Points
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Ricardo Guajardo 1 Department of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Ricardo%2BGuajardo%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Guajardo%20R&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ARicardo%2BGuajardo%2B) * [ORCID record for Ricardo Guajardo](http://orcid.org/0000-0003-2379-3480 "Open in new tab") Ashley N Starnes 1 Department of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Ashley%2BN%2BStarnes%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Starnes%20AN&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAshley%2BN%2BStarnes%2B) * [ORCID record for Ashley N Starnes](http://orcid.org/0009-0007-7270-8314 "Open in new tab") Supriya M Mula 1 Department of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Supriya%2BM%2BMula%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Mula%20SM&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASupriya%2BM%2BMula%2B) * [ORCID record for Supriya M Mula](http://orcid.org/0009-0008-2545-0768 "Open in new tab") Dong Kyu Kim 1 Department of Psychiatry and Behavioral Sciences/Weill Institute for Neurosciences, University of California, San Francisco; * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Dong%2BKyu%2BKim%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Kim%20DK&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ADong%2BKyu%2BKim%2B) Maxwell Bennett 2 Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco; 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