---
title: "Gamma-frequency (40-Hz) firing produces lasting intrinsic potentiation in retinal ganglion cells"
id: "biorxiv-8-gamma-frequency-firing-persistently-enhances-intrinsic-excitability-in-retinal"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-8-gamma-frequency-firing-persistently-enhances-intrinsic-excitability-in-retinal"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.22.760873v1?rss=1"
published_at: "2026-10-24T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Gamma-frequency (40-Hz) firing produces lasting intrinsic potentiation in retinal ganglion cells
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-8-gamma-frequency-firing-persistently-enhances-intrinsic-excitability-in-retinal
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.22.760873v1?rss=1)
- **Published At:** 2026-10-24T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The study used whole-cell recordings from juvenile rat retina to examine whether patterned firing alters intrinsic excitability at the retinal output stage. - Investigators delivered **40-Hz** firing and observed sustained increases in intrinsic excitability in A-type retinal ganglion cells (**RGCs**) and rapid potentiation in B-type RGCs. - In A-type bursting RGCs, long-term potentiation of intrinsic excitability (**LTP-IE**) required **Cav1** calcium channels for induction; the authors reported that blocking these channels prevented LTP-IE. - LTP-IE correlated with a hyperpolarized spike threshold and reduced spike time jitter, physiological changes the team attributed to decreased function of **Kv1** potassium-family channels. - Potentiation increased the likelihood that visually evoked synaptic events triggered action potentials, altering RGC input-output transformation. - The source reported cell-type differences (low-input-resistance A-type versus high-input-resistance B-type) but did not provide detailed dose-response or developmental age windows beyond 'juvenile rats'. - The authors noted that patterned gamma-frequency firing persistently reconfigures retinal output through Cav1-dependent regulation of Kv1 channels; the preprint has not been peer-reviewed. - The article did not report long-term behavioral consequences, exact pharmacological agents and concentrations used, or sample sizes in the abstract; those methodological details are not included in the provided source excerpt.
## Clinical Analysis & Structured Key Points
Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells | bioRxiv Skip to main content New Results Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells View ORCID Profile Prithvi Ramtohul , Laure Molinieres , View ORCID Profile Victor M Calbiague Garcia , Maria Laura Musella , Fabrice Abate , View ORCID Profile Aurore Aziz , Thierry David , Daniele Denis , View ORCID Profile Olivier Marre , View ORCID Profile Michael Russier , View ORCID Profile Dominique Debanne doi: https://doi.org/10.64898/2026.10.22.760873 Prithvi Ramtohul 1 INSERM-AMU; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Prithvi Ramtohul Laure Molinieres 1 INSERM-AMU; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Victor M Calbiague Garcia 2 Vision Institute; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Victor M Calbiague Garcia Maria Laura Musella 1 INSERM-AMU; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Fabrice Abate 1 INSERM-AMU; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Aurore Aziz 3 AP-HM; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Aurore Aziz Thierry David 3 AP-HM; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Daniele Denis 3 AP-HM; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Olivier Marre 4 Sorbonne Universite; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Olivier Marre Michael Russier 5 INSERM; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Michael Russier Dominique Debanne 6 INSERM -AMU Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Dominique Debanne For correspondence: dominique.debanne{at}univ-amu.fr Abstract Info/History Metrics Preview PDF Abstract Experience-dependent plasticity is usually attributed to synaptic changes, but neuronal output also depends on changes in intrinsic excitability. Whether intrinsic excitability is persistently modified at the retinal output stage is unknown. Using whole-cell recordings from retinal ganglion cells (RGCs) of juvenile rats, we found that 40-Hz firing produced sustained potentiation of intrinsic excitability in low-input-resistance A-type RGCs and rapid potentiation of intrinsic excitability in high-input-resistance B-type RGCs. In A-type bursting RGCs, long-term potentiation of intrinsic excitability (LTP-IE) required Cav1 calcium channels for its induction. LTP-IE was associated with hyperpolarization of spike threshold and reduction of spike time jitter, due to reduced Kv1 potassium-family channel function. Potentiation also increased the probability that visually-evoked synaptic events triggered action potentials. Patterned firing therefore persistently reconfigures RGC input-output transformation through the Cav1-dependent regulation of Kv1 channels, revealing intrinsic plasticity at the retinal output stage. Competing Interest Statement The authors have declared no competing interest. Funder Information Declared Agence Nationale de la Recherche, https://ror.org/00rbzpz17 , ANR-21-CE16-0013 , ANR-23-CE16-0020 , AMX-22-RE-AB-187 , AMX-22-RE-V2-007 Fondation pour la Recherche Médicale, https://ror.org/04w6kn183 , DEQ2018-0839483 , DVS20131228768 , FDT2024-04018600 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a CC-BY-NC-ND 4.0 International license . Back to top Previous Next Posted October 24, 2026. Download PDF Email Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. 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Share Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells Prithvi Ramtohul , Laure Molinieres , Victor M Calbiague Garcia , Maria Laura Musella , Fabrice Abate , Aurore Aziz , Thierry David , Daniele Denis , Olivier Marre , Michael Russier , Dominique Debanne bioRxiv 2026.10.22.760873; doi: https://doi.org/10.64898/2026.10.22.760873 Share This Article: Copy Citation Tools Gamma-frequency firing persistently enhances intrinsic excitability in retinal ganglion cells Prithvi Ramtohul , Laure Molinieres , Victor M Calbiague Garcia , Maria Laura Musella , Fabrice Abate , Aurore Aziz , Thierry David , Daniele Denis , Olivier Marre , Michael Russier , Dominique Debanne bioRxiv 2026.10.22.760873; doi: https://doi.org/10.64898/2026.10.22.760873 Citation Manager Formats BibTeX Bookends EasyBib EndNote (tagged) EndNote 8 (xml) Medlars Mendeley Papers RefWorks Tagged Ref Manager RIS Zotero Tweet Widget Facebook Like Google Plus One Subject Areas All Articles Animal Behavior and Cognition (8164) Biochemistry (19027) Bioengineering (15171) Bioinformatics (45345) Biophysics (22958) Cancer Biology (20115) Cell Biology (27308) Clinical Trials (138) Developmental Biology (14146) Ecology (21400) Epidemiology (2067) Evolutionary Biology (25811) Genetics (16343) Genomics (23841) Immunology (19027) Microbiology (43196) Molecular Biology (18345) Neuroscience (95083) Paleontology (713) Pathology (3034) Pharmacology and Toxicology (5200) Physiology (8284) Plant Biology (16271) Scientific Communication and Education (2116) Synthetic Biology (4646) Systems Biology (10386) Zoology (2427)
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