---
title: "GIRK Channel Loss of Function Raises Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy"
id: "biorxiv-0-girk-channel-loss-of-function-increases-dendritic-excitability-in-a-mouse-model"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-0-girk-channel-loss-of-function-increases-dendritic-excitability-in-a-mouse-model"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1?rss=1"
published_at: "2026-08-13T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# GIRK Channel Loss of Function Raises Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-0-girk-channel-loss-of-function-increases-dendritic-excitability-in-a-mouse-model
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1?rss=1)
- **Published At:** 2026-08-13T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- GNB1 encephalopathy (GNB1-E) is a neurodevelopmental disorder caused by mutations in Gβ1 and is associated with motor dysfunction, epilepsy and learning disability. - Prior work implicated altered Gβ1 in disrupting activation of **GIRK** (G-protein-coupled inwardly rectifying potassium) channels and in dysregulating neuronal excitability. - The study uses a mouse model carrying the pathogenic p.I80T mutation (heterozygous Gnb1I80T/+) that reproduces features consistent with human **GNB1-E**, including developmental delay, reduced locomotion and increased anxiety. - Brain histology, whole-cell patch-clamp electrophysiology and pharmacology were performed in ex vivo hippocampal slices to probe cellular, synaptic and dendritic effects. - Hippocampal neurons from Gnb1I80T/+ mice show simplified dendritic morphology compared with controls. - Synaptic inhibition mediated by metabotropic **GABAB** receptors is decreased in mutant mice, indicating impaired inhibitory regulation upstream of GIRK channels. - Mutant neurons exhibit increased dendritic excitability manifested as longer-duration dendritic calcium spikes after synaptic afferent stimulation. - A selective **GIRK** activator, ML297, reverses the prolonged dendritic calcium spike phenotype in slices, supporting a causal role for GIRK loss of function. - Because dendritic calcium spikes drive burst firing and synaptic plasticity, increased dendritic excitability provides a plausible mechanism linking GIRK dysfunction to seizure susceptibility and learning deficits in **GNB1-E**. - The study suggests that pharmacologically targeting dendritic excitability via GIRK activation could have therapeutic potential; details on long-term outcomes, in vivo efficacy and safety were not reported in the source.
## Clinical Analysis & Structured Key Points
[](https://www.biorxiv.org/cdn-cgi/content?id=sxj8go_toj_pM76bAqXQ1PWr0rmIRnTT_w6izFyeFis-1786627058.3486395-1.2.1.1-3qb6mZAdPGeFenp9e5NZUwR4SInNBWhBXkoP1DssKrnwLA50RWAEG0T3EZzSocPa) [Skip to main content](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1?rss=1#main-content) [![bioRxiv](https://www.biorxiv.org/sites/default/files/biorxiv_article_logo.jpg)](https://www.biorxiv.org/) * [Home](https://www.biorxiv.org/) * [Submit](https://www.biorxiv.org/submit-a-manuscript) * [FAQ](https://www.biorxiv.org/about/FAQ) * [Blog](https://connect.biorxiv.org/news/) * [ALERTS / RSS](https://www.biorxiv.org/content/alertsrss) * [Resources](https://connect.biorxiv.org/resources/) * [About](https://www.biorxiv.org/content/about-biorxiv) * [Channels](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1?rss=1) * [4D Nucleome](https://connect.biorxiv.org/relate/content/66) * [Academia Sinica](https://connect.biorxiv.org/group/content/38) * [Advances in Genome Biology and Technology (AGBT) General Meeting 2016 #AGBT16](https://connect.biorxiv.org/relate/content/10) * [Albert Einstein College of Medicine](https://connect.biorxiv.org/group/content/4) * [Aligning Science Across Parkinson's (ASAP)](https://connect.biorxiv.org/relate/content/195) * [Allen Institute for Cell Science](https://connect.biorxiv.org/relate/content/71) * [Arc Institute](https://connect.biorxiv.org/relate/content/224) * [Babraham Institute](https://connect.biorxiv.org/relate/content/197) * [BICCN/BICAN](https://connect.biorxiv.org/relate/content/208) * [BioImaging North America](https://connect.biorxiv.org/relate/content/194) * [Biology of Genomes 2016 #BOG16](https://connect.biorxiv.org/relate/content/19) * [Breakthrough Discoveries for Thriving with Bipolar Disorder](https://connect.biorxiv.org/relate/content/236) * [Brown University](https://connect.biorxiv.org/group/content/9) * [California Institute of Technology](https://connect.biorxiv.org/group/content/32) * [Carnegie Mellon University](https://connect.biorxiv.org/group/content/19) * [Case Western Reserve University](https://connect.biorxiv.org/group/content/36) * [Central Oxford Structural Microscopy and Imaging](https://connect.biorxiv.org/relate/content/143) * [Centre for Microbiology and Environmental Systems Science](https://connect.biorxiv.org/relate/content/190) * [Chan Zuckerberg Biohub](https://connect.biorxiv.org/relate/content/121) * [Columbia University](https://connect.biorxiv.org/group/content/27) * [Donders Institute for Brain, Cognition and Behaviour](https://connect.biorxiv.org/relate/content/184) * [DREAM](https://connect.biorxiv.org/relate/content/153) * [Drug Development and Clinical Therapeutics](https://connect.biorxiv.org/relate/content/52) * [ENCODE](https://connect.biorxiv.org/relate/content/177) * [Ernst Strüngmann Institute (ESI) for Neuroscience](https://connect.biorxiv.org/relate/content/211) * [European Molecular Biology Laboratory (EMBL)](https://connect.biorxiv.org/relate/content/159) * [Francis Crick Institute](https://connect.biorxiv.org/relate/content/88) * [Fred Hutchinson Cancer Center](https://connect.biorxiv.org/group/content/28) * [Georgia Institute of Technology](https://connect.biorxiv.org/group/content/20) * [Harvard Program in Therapeutic Sciences](https://connect.biorxiv.org/relate/content/151) * [The Howard Hughes Medical Institute (HHMI)](https://connect.biorxiv.org/relate/content/227) * [Human Cell Atlas](https://connect.biorxiv.org/relate/content/163) * [Human Pangenome Reference Consortium (HPRC)](https://connect.biorxiv.org/relate/content/215) * [IMO Workshop](https://connect.biorxiv.org/relate/content/8) * [Impact of Genomic Variation on Function (IGVF)](https://connect.biorxiv.org/relate/content/214) * [Institut Pasteur](https://connect.biorxiv.org/relate/content/235/channel) * [Institute of Science and Technology Austria](https://connect.biorxiv.org/group/content/12) * [International Human Epigenome Consortium (IHEC)](https://connect.biorxiv.org/relate/content/219) * [International Mouse Phenotyping Consortium (IMPC)](https://connect.biorxiv.org/relate/content/185) * [Iowa State University](https://connect.biorxiv.org/group/content/6) * [Johns Hopkins University](https://connect.biorxiv.org/group/content/47) * [Mathematical Oncology](https://connect.biorxiv.org/relate/content/1) * [Micron Oxford](https://connect.biorxiv.org/relate/content/116) * [Michigan State University](https://connect.biorxiv.org/group/content/7) * [Morgridge Institute](https://connect.biorxiv.org/group/content/57) * [National Taiwan University](https://connect.biorxiv.org/group/content/39) * [NCI Cancer Systems Biology Consortium](https://connect.biorxiv.org/relate/content/210) * [NF Open Science Initiative](https://connect.biorxiv.org/relate/content/213) * [NCI Human Tumor Atlas Network](https://connect.biorxiv.org/relate/content/171) * [Neuromatch Conference](https://connect.biorxiv.org/relate/content/209) * [NeurotechEU](https://connect.biorxiv.org/relate/content/189) * [North Carolina State University](https://connect.biorxiv.org/group/content/37) * [Northeastern University](https://connect.biorxiv.org/group/content/54) * [Oregon Health & Sciences University](https://connect.biorxiv.org/group/content/22) * [RNA Therapeutics Institute at UMass Chan Med School](https://connect.biorxiv.org/relate/content/243) * [Rosetta Commons](https://connect.biorxiv.org/relate/content/191) * [Rutgers University](https://connect.biorxiv.org/group/content/31) * [SeroNet](https://connect.biorxiv.org/relate/content/192) * [Simons Foundation Autism Research Initiative (SFARI)](https://connect.biorxiv.org/relate/content/74) * [Society for Molecular Biology and Evolution #SMBE2016](https://connect.biorxiv.org/relate/content/29) * [Somatic Cell Genome Editing Program](https://connect.biorxiv.org/relate/content/167) * [Somatic Mosaicism across the Human Tissues Network](https://connect.biorxiv.org/relate/content/222) * [SPARC](https://connect.biorxiv.org/relate/content/187) * [Stowers Institute for Medical Research](https://connect.biorxiv.org/group/content/3) * [Stockholm University](https://connect.biorxiv.org/group/content/14) * [Tel Aviv University](https://connect.biorxiv.org/group/content/8) * [The Michael J. Fox Foundation](https://connect.biorxiv.org/relate/content/207) * [The Rockefeller University](https://connect.biorxiv.org/group/content/2) * [The Sainsbury Laboratory](https://connect.biorxiv.org/relate/content/98) * [The Whitehead Institute](https://connect.biorxiv.org/relate/content/212) * [University of Connecticut Health Center](https://connect.biorxiv.org/group/content/16) * [University of California, Berkeley](https://connect.biorxiv.org/group/content/13) * [University of California, San Diego](https://connect.biorxiv.org/group/content/41) * [University of California, San Francisco](https://connect.biorxiv.org/group/content/10) * [University of Chicago](https://connect.biorxiv.org/group/content/42) * [University of Geneva](https://connect.biorxiv.org/group/content/26) * [University of Guelph](https://connect.biorxiv.org/group/content/23) * [University of Hong Kong](https://connect.biorxiv.org/group/content/29) * [University of Illinois Chicago](https://connect.biorxiv.org/group/content/43) * [University of Iowa](https://connect.biorxiv.org/group/content/24) * [University of Kansas](https://connect.biorxiv.org/group/content/33) * [University of Massachusetts Chan Medical School](https://connect.biorxiv.org/group/content/44) * [University of New South Wales](https://connect.biorxiv.org/group/content/25) * [University of Ottawa](https://connect.biorxiv.org/group/content/35) * [University of Sydney](https://connect.biorxiv.org/group/content/50) * [Vanderbilt University](https://connect.biorxiv.org/group/content/30) * [Vienna BioCenter](https://connect.biorxiv.org/relate/content/186) * [Washington University in St. Louis](https://connect.biorxiv.org/group/content/11) * [Weizmann Institute of Science](https://connect.biorxiv.org/group/content/15) * [Yale University](https://connect.biorxiv.org/group/content/53) Search for this keyword [Advanced Search](https://www.biorxiv.org/search) New Results Follow this preprint # GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy [ View ORCID Profile](http://orcid.org/0000-0002-8071-119X)Samuel Gritz, Anshul Voleti, [ View ORCID Profile](http://orcid.org/0000-0002-4306-7569)Matthew S Scarnati, [ View ORCID Profile](http://orcid.org/0000-0001-9602-4274)Alessandro R Galloni, [ View ORCID Profile](http://orcid.org/0000-0002-7186-5779)Aaron D Milstein doi: https://doi.org/10.64898/2026.08.08.743706 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Samuel Gritz Rutgers University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Samuel%2BGritz%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Gritz%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASamuel%2BGritz%2B) * [ORCID record for Samuel Gritz](http://orcid.org/0000-0002-8071-119X "Open in new tab") Anshul Voleti Rutgers University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Anshul%2BVoleti%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Voleti%20A&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAnshul%2BVoleti%2B) Matthew S Scarnati Rutgers University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Matthew%2BS%2BScarnati%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Scarnati%20MS&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AMatthew%2BS%2BScarnati%2B) * [ORCID record for Matthew S Scarnati](http://orcid.org/0000-0002-4306-7569 "Open in new tab") Alessandro R Galloni Rutgers University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Alessandro%2BR%2BGalloni%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Galloni%20AR&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAlessandro%2BR%2BGalloni%2B) * [ORCID record for Alessandro R Galloni](http://orcid.org/0000-0001-9602-4274 "Open in new tab") Aaron D Milstein Rutgers University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Aaron%2BD%2BMilstein%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Milstein%20AD&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AAaron%2BD%2BMilstein%2B) * [ORCID record for Aaron D Milstein](http://orcid.org/0000-0002-7186-5779 "Open in new tab") * For correspondence: milstein@cabm.rutgers.edu * [Abstract](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5701218/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5701218/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5701218/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5701218/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract GNB1 encephalopathy (GNB1-E) is a rare neurodevelopmental disorder associated with motor dysfunction, epilepsy and learning disability caused by mutations in the gene encoding the G protein subunit Gβ1. Previous work has shown that altered Gβ1 can disrupt activation of G-protein-coupled inwardly rectifying potassium (GIRK) channels, dysregulate neuronal excitability and cause seizures. However, the relevant upstream regulators of Gβ1 and the consequences of GIRK dysfunction for neuronal synaptic, cellular and circuit function have not been characterized. Here we report that mice of both sexes carrying the deleterious p.I80T mutation in Gnb1 present features consistent with GNB1-E, including developmental delay, decreased locomotion and increased anxiety. Using histology, whole-cell patch-clamp electrophysiology and pharmacology in ex vivo brain slices, we find that hippocampal neurons in heterozygous Gnb1I80T/+ mice exhibit simplified dendritic morphologies, decreased synaptic inhibition mediated by metabotropic GABAB receptors and increased dendritic excitability. These phenotypes result in longer duration dendritic calcium spikes in response to synaptic afferent stimulation, an effect that is reversed by a specific activator of GIRK channels, ML297. Given the known roles of dendritic calcium spikes in driving burst firing and inducing synaptic plasticity, these findings suggest that targeting dendritic excitability has therapeutic potential to address both the seizure susceptibility and learning deficits associated with GNB1-E. ### Competing Interest Statement The authors have declared no competing interest. ## Funder Information Declared National Institute of Mental Health, R01MH131296, RF1MH135576 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY 4.0 International license](http://creativecommons.org/licenses/by/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. [Donate to openRxiv ](https://www.zeffy.com/en-US/donation-form/donate-to-make-a-difference-10981) [ Back to top](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1?rss=1#page) [ Previous](https://www.biorxiv.org/content/10.64898/2026.08.08.743694v1 "HaloUMI: Physics-informed analysis of inhibition halo assays") Posted August 13, 2026. [ Download PDF](https://www.biorxiv.org/content/10.64898/2026.08.08.743706v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/08/13/2026.08.08.743706.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) GIRK Channel Loss of Function Increases Dendritic Excitability in a Mouse Model of GNB1 Encephalopathy Samuel Gritz, Anshul Voleti, Matthew S Scarnati, Alessandro R Galloni, Aaron D Milstein bioRxiv 2026.08.08.743706; doi: https://doi.org/10.64898/2026.08.08.743706 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. Share This Article: Copy [![Twitter logo](https://www.biorxiv.org/sites/all/modules/highwire/highwire/images/twitter.png)](https://www.biorxiv.org/highwire_log/share/twitter?link=http%3A%2F%2Ftwitter.com%2Fshare%3Furl%3Dhttps%253A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.64898%2F2026.08.08.743706v1%26text%3DGIRK%2520Channel%2520Loss%2520of%2520Function%2520Increases%2520Dendritic%2520Excitability%2520in%2520a%2520Mouse%2520Model%2520of%2520GNB1%2520Encephalopathy "Share this on Twitter") [![Facebook logo](https://www.biorxiv.org/sites/all/modules/highwire/highwire/images/fb-blue.png)](https://www.biorxiv.org/highwire_log/share/facebook?link=http%3A%2F%2Fwww.facebook.com%2Fsharer.php%3Fu%3Dhttps%253A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.64898%2F2026.08.08.743706v1%26t%3DGIRK%2520Channel%2520Loss%2520of%2520Function%2520Increases%2520Dendritic%2520Excitability%2520in%2520a%2520Mouse%2520Model%2520of%2520GNB1%2520Encephalopathy "Share on Facebook") [![LinkedIn logo](https://www.biorxiv.org/sites/all/modules/highwire/highwire/images/linkedin-32px.png)](https://www.biorxiv.org/highwire_log/share/linkedin?link=http%3A%2F%2Fwww.linkedin.com%2FshareArticle%3Fmini%3Dtrue%26url%3Dhttps%253A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.64898%2F2026.08.08.743706v1%26title%3DGIRK%2520Channel%2520Loss%2520of%2520Function%2520Increases%2520Dendritic%2520Excitability%2520in%2520a%2520Mouse%2520Model%2520of%2520GNB1%2520Encephalopathy%26summary%3D%26source%3DbioRxiv "Publish this post to LinkedIn") [![Mendeley logo](https://www.biorxiv.org/sites/all/modules/highwire/highwire/images/mendeley.png)](https://www.biorxiv.org/highwire_log/share/mendeley?link=http%3A%2F%2Fwww.mendeley.com%2Fimport%2F%3Furl%3Dhttps%253A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.64898%2F2026.08.08.743706v1%26title%3DGIRK%2520Channel%2520Loss%2520of%2520Function%2520Increases%2520Dendritic%2520Excitability%2520in%2520a%2520Mouse%2520Model%2520of%2520GNB1%2520Encephalopathy "Share on Mendeley") [ Citation Tools](https://www.biorxiv.org/ "Citation Tools") [ Get QR code](https://connect.biorxiv.org/qr/2026.08.08.743706) * [Tweet Widget](http://twitter.com/share?url=https%3A//www.biorxiv.org/content/10.64898/2026.08.08.743706v1&count=horizontal&via=&text=GIRK%20Channel%20Loss%20of%20Function%20Increases%20Dendritic%20Excitability%20in%20a%20Mouse%20Model%20of%20GNB1%20Encephalopathy&counturl=www.biorxiv.org/content/10.64898/2026.08.08.743706v1 "Tweet This") Reviews and Context 0 Comment 0 TRIP Peer Reviews 0 Community Reviews 0 Automated Services 0 Blogs/Media 0 Author Videos **Subject Areas** [**All Articles**](https://www.biorxiv.org/content/early/recent) * [Animal Behavior and Cognition](https://www.biorxiv.org/collection/animal-behavior-and-cognition) (7882) * [Biochemistry](https://www.biorxiv.org/collection/biochemistry) (18449) * [Bioengineering](https://www.biorxiv.org/collection/bioengineering) (14605) * [Bioinformatics](https://www.biorxiv.org/collection/bioinformatics) (43613) * [Biophysics](https://www.biorxiv.org/collection/biophysics) (22212) * [Cancer Biology](https://www.biorxiv.org/collection/cancer-biology) (19338) * [Cell Biology](https://www.biorxiv.org/collection/cell-biology) (26475) * [Clinical Trials](https://www.biorxiv.org/collection/clinical-trials) (138) * [Developmental Biology](https://www.biorxiv.org/collection/developmental-biology) (13776) * [Ecology](https://www.biorxiv.org/collection/ecology) (20647) * [Epidemiology](https://www.biorxiv.org/collection/epidemiology) (2067) * [Evolutionary Biology](https://www.biorxiv.org/collec
## Related Clinical Research

- [SV2C Structural Basis for Ligand Selectivity and Effects on Dopamine Release](https://medichelpline.com/clinical-feed/biorxiv-16-structural-determinants-of-synaptic-vesicle-protein-2c-ligand-selectivity-and.md)
- [EEG-derived indices classify sporadic Creutzfeldt-Jakob disease from Alzheimer’s and healthy aging](https://medichelpline.com/clinical-feed/plos-one-17-classification-of-sporadic-creutzfeldt-jakob-disease-based-on-resting-state.md)
- [Bupropion Hydrochloride for Improving Recovery in Acute Ischaemic Stroke: BASE Trial Protocol](https://medichelpline.com/clinical-feed/bmj-open-4-protocol-for-base-a-multicentre-double-blind-randomised-controlled-trial-of.md)
- [Presynaptic basis of epileptiform rhythms in forward-programmed human excitatory neuronal networks](https://medichelpline.com/clinical-feed/biorxiv-14-presynaptic-mechanism-of-epileptiform-activities-in-forward-programmed-human.md)
- [Neurofeedback with Implanted DBS Electrodes in Parkinson’s Disease: Multi-Day Explorative Study](https://medichelpline.com/clinical-feed/pubmed-42342023.md) (DOI: 10.1016/j.neuroscience.2026.06.016)

## Navigation
- [← Back to Neurology Feed](https://medichelpline.com/clinical-feed/neurology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.