---
title: "ODORTRAP mapping shows odor-evoked brain activity and disruption by diet-induced obesity"
id: "biorxiv-3-odor-evoked-activity-outside-canonical-areas-of-olfactory-information"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-3-odor-evoked-activity-outside-canonical-areas-of-olfactory-information"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1?rss=1"
published_at: "2026-10-05T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# ODORTRAP mapping shows odor-evoked brain activity and disruption by diet-induced obesity
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-3-odor-evoked-activity-outside-canonical-areas-of-olfactory-information
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1?rss=1)
- **Published At:** 2026-10-05T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The study used a brain-wide activity mapping approach termed **ODORTRAP**, implemented with the FOSTRAP method, to identify neuronal ensembles preferentially engaged during odor stimulation. The source odor was isopropyl tiglate (IPT), a ligand for olfactory receptor 160 previously linked to vulnerability to diet-induced obesity. - Odor exposure to IPT increased labeling in the **olfactory bulb (OB)** and in higher olfactory cortices including the anterior olfactory nucleus, piriform cortex, and cortical amygdala, with statistically significant elevation compared with controls. - IPT also recruited hypothalamic feeding centers: the arcuate nucleus (ARC), dorsomedial hypothalamus (DMH), and lateral hypothalamus (LH) showed increased ODORTRAP activity, while the ventromedial hypothalamic nucleus and suprachiasmatic nucleus did not show changes. - In mice maintained on a moderately high-fat (MHF) diet and rendered obese, the brain activation pattern differed from controls: ARC showed a loss of odor-evoked ODORTRAP activity, and DMH and LH showed elevated baseline activity that obscured odor-linked changes. - Reward- and limbic-related regions such as the nucleus accumbens and medial septum were activated by IPT in control mice, but obese mice did not show ODORTRAP changes in these regions. - The findings identify a set of brain regions linking chemosensation and metabolic state and demonstrate that an obesogenic diet remodels odor-evoked activity, particularly within hypothalamic domains involved in feeding regulation. - Specific methodological details, sample sizes, exact timelines of diet exposure, and full quantitative results beyond reported significance levels were not reported in the source abstract and would require consulting the full preprint for complete experimental parameters.
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Saptarsi Mitra Florida State University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Saptarsi%2BMitra%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Mitra%20S&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ASaptarsi%2BMitra%2B) * [ORCID record for Saptarsi Mitra](http://orcid.org/0009-0007-4130-013X "Open in new tab") Franklin A Pacheco Florida State University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Franklin%2BA%2BPacheco%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Pacheco%20FA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3AFranklin%2BA%2BPacheco%2B) * [ORCID record for Franklin A Pacheco](http://orcid.org/0009-0001-8214-191X "Open in new tab") Debra Ann Fadool Florida State University * [Find this author on Google Scholar](https://www.biorxiv.org/lookup/google-scholar?link_type=googlescholar&gs_type=author&author%5B0%5D=Debra%2BAnn%2BFadool%2B "Open in new tab") * [Find this author on PubMed](https://www.biorxiv.org/lookup/external-ref?access_num=Fadool%20DA&link_type=AUTHORSEARCH "Open in new tab") * [Search for this author on this site](https://www.biorxiv.org/search/author1%3ADebra%2BAnn%2BFadool%2B) * [ORCID record for Debra Ann Fadool](http://orcid.org/0000-0002-0546-3720 "Open in new tab") * For correspondence: dfadool@bio.fsu.edu * [Abstract](https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_art/node:5840325/1) * [Info/History](https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1.article-info)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_info/node:5840325/1) * [Metrics](https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1.article-metrics)[](https://www.biorxiv.org/panels_ajax_tab/article_tab_metrics/node:5840325/1) * [ Preview PDF](https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1.full.pdf+html)[](https://www.biorxiv.org/panels_ajax_tab/biorxiv_tab_pdf/node:5840325/1) ![Loading](https://www.biorxiv.org/sites/all/modules/contrib/panels_ajax_tab/images/loading.gif) ## Abstract Enhanced excitability of output neurons in the olfactory bulb (OB) has been linked to regulation of energy homeostasis. The mechanism by which the olfactory system can drive metabolic state while processing odor information remains elusive yet must depend upon integration and relay to the rest of the brain. Herein, we screened brain-wide neuronal ensembles that preferentially engaged during odor stimulation (referred to as ODORTRAP) utilizing FOSTRAP activity mapping. Mice were exposed to the odor isopropyl tiglate (IPT), a preferred ligand for the olfactory receptor 160, previously shown to be vulnerable to diet-induced obesity. Odor activation resulted in elevated labelling in the olfactory bulb (ODORTRAP) (p 0.05). In mice that were maintained on moderately high-fat (MHF) diets, we discovered that obesity re-models the activation pattern across the brain. Obese mice exhibited loss of ODORTRAP activity in the ARC (p 0.05). Our study identifies key brain regions linking chemosensation and metabolic state, specifically demonstrating alteration in activity in hypothalamic domains upon obesogenic diet. ### Competing Interest Statement The authors have declared no competing interest. ## Funder Information Declared National Institutes of Health, R01DK133464 Florida State University, https://ror.org/05g3dte14 Copyright The copyright holder for this preprint is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under a [CC-BY-NC-ND 4.0 International license](http://creativecommons.org/licenses/by-nc-nd/4.0/). bioRxiv and medRxiv thank the following for their generous financial support: > The Chan Zuckerberg Initiative, Cold Spring Harbor Laboratory, the Sergey Brin Family Foundation, California Institute of Technology, Centre National de la Recherche Scientifique, Fred Hutchinson Cancer Center, Imperial College London, Massachusetts Institute of Technology, Stanford University, The University of Edinburgh, University of Washington, and Vrije Universiteit Amsterdam. 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[ Download PDF](https://www.biorxiv.org/content/10.64898/2026.09.28.755029v1.full.pdf) Print/Save Options [Download PDF](https://www.biorxiv.org/content/biorxiv/early/2026/10/05/2026.09.28.755029.full.pdf)Full Text & In-line FiguresXML [More Info](https://www.biorxiv.org/about/FAQ#PrintOptions "More Information on Print/Save Options") [ Email](https://www.biorxiv.org/ "Email this Article") [ Share](https://www.biorxiv.org/) Odor-evoked activity outside canonical areas of olfactory information transmission is visualized by ODORTRAP and modulated by diet-induced obesity Saptarsi Mitra, Franklin A Pacheco, Debra Ann Fadool bioRxiv 2026.09.28.755029; doi: https://doi.org/10.64898/2026.09.28.755029 This article is a preprint and has not been certified by peer review [[what does this mean?](https://www.biorxiv.org/about/FAQ#unrefereed)]. 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