---
title: "PLOS One Retracts Cissus tuberosa Parkinson’s Disease Study Over Data and Image Concerns"
id: "plos-one-1-retraction-anti-neuroinflammatory-and-neuroprotective-potential-of-cissus"
canonical_url: "https://medichelpline.com/clinical-feed/plos-one-1-retraction-anti-neuroinflammatory-and-neuroprotective-potential-of-cissus"
content_type: "clinical_feed_article"
specialty: "Neurology"
source_name: "PLOS ONE (Medicine)"
source_url: "https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896"
published_at: "2026-10-20T14:00:00.000Z"
evidence_level: "Journal Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# PLOS One Retracts Cissus tuberosa Parkinson’s Disease Study Over Data and Image Concerns
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/plos-one-1-retraction-anti-neuroinflammatory-and-neuroprotective-potential-of-cissus
- **Specialty:** [Neurology](https://medichelpline.com/clinical-feed/neurology.md)
- **Primary Source:** PLOS ONE (Medicine)
- **Source URL:** [Original Journal Publication](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896)
- **Published At:** 2026-10-20T14:00:00.000Z
- **Evidence Rating:** Journal Feed
## Executive GIST (TL;DR)
- PLOS One issued a formal retraction of a 2024 article that reported anti-neuroinflammatory and neuroprotective effects of **Cissus tuberosa** ethanol extract in a Parkinson’s disease model. - The editors cited reproducibility and integrity concerns arising from the article’s Tables 6–7 and from unpublished image data supplied with the submission. - Reported standard errors in Tables 6 and 7 were described by editors as unusually repetitive, prompting further scrutiny of the underlying numerical data. - Multiple image panels in the unpublished submission appeared similar to different experimental-condition panels published elsewhere, creating potential duplication across publications. - Specific flagged image similarities linked unpublished material for this article to figures in two other papers: one now retracted and another published in a separate journal, as indicated in the retraction notice. - The corresponding author acknowledged figure-preparation errors for some images and said material from another paper was used without authorization; the notice states these were the authors’ responses. - The authors supplied individual-level data for the graphs and tables; editorial assessment of those data generated additional concerns about their integrity and reliability. - The PLOS One Editors therefore retracted the paper; the notice records varied author engagement—two authors responded without clarifying their position, while several others did not respond or could not be reached. - The retraction notice lists the full citation and cross-references two related articles, one of which was also retracted, and includes editorial metadata such as DOI and publication date.
## Clinical Analysis & Structured Key Points
[ Skip to main content ](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#main-content) Advertisement * [plos.org](https://plos.org/) * [Create account](https://community.plos.org/registration/new) * [Sign in](https://journals.plos.org/user/secure/login?page=%2Fplosone%2Farticle%3Fid%3D10.1371%2Fjournal.pone.0360896) * * About * Browse * Publish * [](https://journals.plos.org/plosone/ "PLOS One") * Search [advanced search](https://journals.plos.org/plosone/search) * [Browse Topics](https://journals.plos.org/plosone/subjectAreaBrowse) Browse Subject Areas ? Click through the PLOS taxonomy to find articles in your field. For more information about PLOS Subject Areas, click [here](https://github.com/PLOS/plos-thesaurus/blob/master/README.md "Link opens in new window"). [](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896) [](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896) * 0 [Save](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#savedHeader) [Total Mendeley and Citeulike bookmarks.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#savedHeader) * 0 [Citation](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#citedHeader) [Paper's citation count computed by Dimensions.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#citedHeader) * 35 [View](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#viewedHeader) [PLOS views and downloads.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#viewedHeader) * 0 [Share](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#discussedHeader) [Sum of Facebook, Twitter, Reddit and Wikipedia activity.](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896#discussedHeader) Open Access Retraction # Retraction: Anti-neuroinflammatory and neuroprotective potential of _Cissus tuberosa_ ethanol extract in Parkinson’s disease model through the modulation of neuroinflammatory markers * The PLOS One Editors # Retraction: Anti-neuroinflammatory and neuroprotective potential of _Cissus tuberosa_ ethanol extract in Parkinson’s disease model through the modulation of neuroinflammatory markers * The PLOS One Editors ![PLOS](https://journals.plos.org/resource/img/logo-plos-full-color.svg) x * Published: October 20, 2026 * * [Article](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896) * [Metrics](https://journals.plos.org/plosone/article/metrics?id=10.1371/journal.pone.0360896) * [Comments](https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0360896) * [Media Coverage](http://plos.altmetric.com/details/doi/10.1371/journal.pone.0360896) * [References](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#references) * [Reader Comments](https://journals.plos.org/plosone/article/comments?id=10.1371/journal.pone.0360896) Following the publication of this article [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref001)] concerns were raised about results published in Tables 6-7 and unpublished image data provided with the original submission of [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref001)]. Specifically, * In Tables 6 and 7, the reported values for the standard error of the mean appear unusually repetitive. * The following panels appear similar, despite being used to represent different experimental conditions: * C Heart in unpublished material submitted for [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref001)] and Fig 2 CG:Heart of [[2](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref002)] * C Liver in unpublished material submitted for [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref001)] and Fig 2:TR Liver of [[2](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref002)] * The CG panel in unpublished material submitted for [[1](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref001)] and the Fig 3 CG panel of [3, retracted in 4] Regarding the concerns with similarities between the unpublished material for this article and the material published in [3, retracted in 4], the corresponding author stated that errors were made during the figure preparation of the images presented in the original version of this manuscript, which were corrected in subsequent revisions. Regarding the concerns with similarities between the unpublished material in this article and the material published in [[2](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref002)], the corresponding author stated that the material in [[2](https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0360896#pone.0360896.ref002)] was used without the data owner’s authorization. The corresponding author provided the individual-level data underlying the graphs and tables presented in this article. Editorial assessment of these data raised additional concerns about the integrity and reliability of these data. In light of the concerns observed with the individual-level data underlying this study, the _PLOS One_ Editors retract this article. ZC and MA responded but did not clarify either agreement or disagreement. MS, ASehar, RS, HT, SAB, and ASethi either did not respond directly or could not be reached. ## References 1. 1. Saadullah M, Sehar A, Chauhdary Z, Siddique R, Tariq H, Asif M, et al. RETRACTED: Anti-neuroinflammatory and neuroprotective potential of _Cissus tuberosa_ ethanol extract in Parkinson’s disease model through the modulation of neuroinflammatory markers. PLoS One. 2024;19(12):e0311140. pmid:39642134 * [ View Article ](https://doi.org/10.1371/journal.pone.0311140 "Go to article") * [ PubMed/NCBI ](http://www.ncbi.nlm.nih.gov/pubmed/39642134 "Go to article in PubMed") * [ Google Scholar ](http://scholar.google.com/scholar?q=RETRACTED%3A+Anti-neuroinflammatory+and+neuroprotective+potential+of+Cissus+tuberosa+ethanol+extract+in+Parkinson%E2%80%99s+disease+model+through+the+modulation+of+neuroinflammatory+markers+Saadullah+2024 "Go to article in Google Scholar") 2. 2. Tariq H, Ishfaq K, Chauhdari T, Sarwar F, Ismail F. Neuroprotective potential of _dombeya wallichii_ ameliorates Parkinson’s activity in paraquat-induced Rat’s model via modulation of neuro-inflammatory cytokines. J Ayurveda Integr Med. 2025;16(4):101162. pmid:40602107 * [ View Article ](https://doi.org/10.1016/j.jaim.2025.101162 "Go to article") * [ PubMed/NCBI ](http://www.ncbi.nlm.nih.gov/pubmed/40602107 "Go to article in PubMed") * [ Google Scholar ](http://scholar.google.com/scholar?q=Neuroprotective+potential+of+dombeya+wallichii+ameliorates+Parkinson%E2%80%99s+activity+in+paraquat-induced+Rat%E2%80%99s+model+via+modulation+of+neuro-inflammatory+cytokines+Tariq+2025 "Go to article in Google Scholar") 3. 3. Saadullah M, Tariq H, Chauhdary Z, Saleem U, Anwer Bukhari S, Sehar A, et al. RETRACTED: Biochemical properties and biological potential of _Syzygium heyneanum_ with antiparkinson’s activity in paraquat induced rodent model. PLoS One. 2024;19(3):e0298986. pmid:38551975 * [ View Article ](https://doi.org/10.1371/journal.pone.0298986 "Go to article") * [ PubMed/NCBI ](http://www.ncbi.nlm.nih.gov/pubmed/38551975 "Go to article in PubMed") * [ Google Scholar ](http://scholar.google.com/scholar?q=RETRACTED%3A+Biochemical+properties+and+biological+potential+of+Syzygium+heyneanum+with+antiparkinson%E2%80%99s+activity+in+paraquat+induced+rodent+model+Saadullah+2024 "Go to article in Google Scholar") 4. 4. The _PLOS One_ Editors. Retraction: Biochemical properties and biological potential of _Syzygium heyneanum_ with antiparkinson’s activity in paraquat induced rodent model. PLoS One. 2026;21(10): e0360894. * [ View Article ](https://doi.org/10.1371/journal.pone.0360894 "Go to article") * [ Google Scholar ](http://scholar.google.com/scholar?q=Retraction%3A+Biochemical+properties+and+biological+potential+of+Syzygium+heyneanum+with+antiparkinson%E2%80%99s+activity+in+paraquat+induced+rodent+model++ "Go to article in Google Scholar") **Citation:** The _PLOS One_ Editors (2026) Retraction: Anti-neuroinflammatory and neuroprotective potential of _Cissus tuberosa_ ethanol extract in Parkinson’s disease model through the modulation of neuroinflammatory markers. PLoS One 21(10): e0360896. https://doi.org/10.1371/journal.pone.0360896 **Published:** October 20, 2026 **Copyright:** © 2026 The PLOS One Editors. This is an open access article distributed under the terms of the [Creative Commons Attribution License](http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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) 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