---
title: "[177Lu]Lu-PSMA-617 for PSMA-positive metastatic androgen-pathway–sensitive prostate cancer (PSMAdd"
id: "pubmed-42561994"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42561994"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42561994/"
doi: "10.1016/S0140-6736(26)01092-5"
published_at: "2026-08-29T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# [177Lu]Lu-PSMA-617 for PSMA-positive metastatic androgen-pathway–sensitive prostate cancer (PSMAdd
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42561994
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42561994/)
- **DOI:** [10.1016/S0140-6736(26)01092-5](https://doi.org/10.1016%2FS0140-6736(26)01092-5)
- **Published At:** 2026-08-29T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The article reports the PSMAddition phase 3, **randomised, controlled trial** evaluating **[177Lu]Lu-PSMA-617** in patients with **PSMA-positive metastatic androgen pathway modulator‑naive/sensitive prostate cancer**, as stated in the title. - The trial is named **PSMAddition** and enrolled patients described as PSMA‑positive with metastatic disease who were naive or sensitive to androgen pathway modulators, per the title. - Publication: Lancet; citation lists 2026 Aug 29;408(10557):793–807 with DOI 10.1016/S0140-6736(26)01092-5 and PubMed PMID 42561994. An Elsevier/Lancet full-text link is provided on PubMed. - Large, multi‑institutional and international author group is listed, including academic centers across North America, Europe, Asia, and authors affiliated with Novartis Pharmaceuticals, indicating a broad collaborative effort. - Lead and senior authors include Scott T Tagawa and Michael J Morris among many multinational investigators; full author list and institutional affiliations are reported on PubMed. - The PubMed entry identifies the study as a Clinical Trial and provides bibliographic and affiliation metadata; the abstract text, detailed methods, numerical results, safety data, and conclusions are not included in the provided source excerpt. - The PubMed record shows Epub 2026 Aug 6 and print date 2026 Aug 29; it lists DOI and PMID for reference and links to full-text options but does not present trial outcomes or statistical findings in the accessible excerpt. - Because the PubMed source excerpt lacks outcome, efficacy, safety, sample size, randomisation details, endpoints, and follow-up data, readers must consult the Lancet full text for trial methods and results.
## Clinical Analysis & Structured Key Points
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Epub 2026 Aug 6. # [177Lu]Lu-PSMA-617 in patients with PSMA-positive metastatic androgen pathway modulator-naive/sensitive prostate cancer (PSMAddition): a phase 3 randomised, controlled trial [Scott T Tagawa](https://pubmed.ncbi.nlm.nih.gov/?term=Tagawa+ST&cauthor_id=42561994)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-1 "Weill Cornell Medicine, New York, NY, USA."), [Oliver Sartor](https://pubmed.ncbi.nlm.nih.gov/?term=Sartor+O&cauthor_id=42561994)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-2 "LCMC Health, New Orleans, LA, USA."), [Josep M Piulats](https://pubmed.ncbi.nlm.nih.gov/?term=Piulats+JM&cauthor_id=42561994)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-3 "Institut Català d'Oncologia, Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain."), [Fred Saad](https://pubmed.ncbi.nlm.nih.gov/?term=Saad+F&cauthor_id=42561994)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-4 "The University of Montreal Hospital Center, Montreal, QC, Canada."), [Karim Fizazi](https://pubmed.ncbi.nlm.nih.gov/?term=Fizazi+K&cauthor_id=42561994)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-5 "Centre Oscar Lambret, University of Paris-Saclay, Lille, France."), [Alison Reid](https://pubmed.ncbi.nlm.nih.gov/?term=Reid+A&cauthor_id=42561994)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-6 "The Royal Marsden NHS Foundation Trust, London, UK."), [Himisha Beltran](https://pubmed.ncbi.nlm.nih.gov/?term=Beltran+H&cauthor_id=42561994)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-7 "Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA."), [Gero Kramer](https://pubmed.ncbi.nlm.nih.gov/?term=Kramer+G&cauthor_id=42561994)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-8 "Department of Urology, Medical University of Vienna, Vienna, Austria."), [Hakim Mahammedi](https://pubmed.ncbi.nlm.nih.gov/?term=Mahammedi+H&cauthor_id=42561994)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-9 "Centre Jean Perrin and INSERM U1240 IMost Université Clermont Auvergne, Clermont-Ferrand, France."), [Matthias Eiber](https://pubmed.ncbi.nlm.nih.gov/?term=Eiber+M&cauthor_id=42561994)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-10 "School of Medicine and Health, Technical University of Munich, TUM University Hospital, Munich, Germany."), [Shilpa Gupta](https://pubmed.ncbi.nlm.nih.gov/?term=Gupta+S&cauthor_id=42561994)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-11 "Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA."), [Daniel Castellano](https://pubmed.ncbi.nlm.nih.gov/?term=Castellano+D&cauthor_id=42561994)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-12 "Hospital Universitario 12 de Octubre, Madrid, Spain."), [Ralph Hauke](https://pubmed.ncbi.nlm.nih.gov/?term=Hauke+R&cauthor_id=42561994)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-13 "Nebraska Cancer Specialists, Omaha, NE, USA."), [Hyun Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+H&cauthor_id=42561994)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-14 "Washington University School of Medicine, St. Louis, MO, USA."), [Cheol Kwak](https://pubmed.ncbi.nlm.nih.gov/?term=Kwak+C&cauthor_id=42561994)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-15 "Seoul National University Hospital, Seoul, South Korea."), [See Tong Pang](https://pubmed.ncbi.nlm.nih.gov/?term=Pang+ST&cauthor_id=42561994)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-16 "Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang Gung University, Taoyuan, Taiwan."), [Philippe Barthélémy](https://pubmed.ncbi.nlm.nih.gov/?term=Barth%C3%A9l%C3%A9my+P&cauthor_id=42561994)[ 17 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-17 "University Hospital Strasbourg, Strasbourg, France."), [Dong Dai](https://pubmed.ncbi.nlm.nih.gov/?term=Dai+D&cauthor_id=42561994)[ 18 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-18 "Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for China, Tianjin, China; Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin, China."), [Jae Lyun Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+JL&cauthor_id=42561994)[ 19 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-19 "Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea."), [Luke Nordquist](https://pubmed.ncbi.nlm.nih.gov/?term=Nordquist+L&cauthor_id=42561994)[ 20 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-20 "XCancer, Omaha, NE, USA."), [Russell Z Szmulewitz](https://pubmed.ncbi.nlm.nih.gov/?term=Szmulewitz+RZ&cauthor_id=42561994)[ 21 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-21 "University of Chicago, Chicago, IL, USA."), [Paweł Wiechno](https://pubmed.ncbi.nlm.nih.gov/?term=Wiechno+P&cauthor_id=42561994)[ 22 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-22 "Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland."), [Alejandro Yovine](https://pubmed.ncbi.nlm.nih.gov/?term=Yovine+A&cauthor_id=42561994)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-23 "Novartis Pharmaceuticals, Basel, Switzerland."), [Lauren Smith](https://pubmed.ncbi.nlm.nih.gov/?term=Smith+L&cauthor_id=42561994)[ 24 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-24 "Novartis Pharmaceuticals UK, London, UK."), [Emmanuel Bouillaud](https://pubmed.ncbi.nlm.nih.gov/?term=Bouillaud+E&cauthor_id=42561994)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-23 "Novartis Pharmaceuticals, Basel, Switzerland."), [Olga Sakharova](https://pubmed.ncbi.nlm.nih.gov/?term=Sakharova+O&cauthor_id=42561994)[ 23 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-23 "Novartis Pharmaceuticals, Basel, Switzerland."), [Michael J Morris](https://pubmed.ncbi.nlm.nih.gov/?term=Morris+MJ&cauthor_id=42561994)[ 25 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#full-view-affiliation-25 "Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: morrism@mskcc.org."); [PSMAddition Investigators](https://pubmed.ncbi.nlm.nih.gov/?term=PSMAddition+Investigators%5BCorporate+Author%5D) Affiliations Expand ### Affiliations * 1 Weill Cornell Medicine, New York, NY, USA. * 2 LCMC Health, New Orleans, LA, USA. * 3 Institut Català d'Oncologia, Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain. * 4 The University of Montreal Hospital Center, Montreal, QC, Canada. * 5 Centre Oscar Lambret, University of Paris-Saclay, Lille, France. * 6 The Royal Marsden NHS Foundation Trust, London, UK. * 7 Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA. * 8 Department of Urology, Medical University of Vienna, Vienna, Austria. * 9 Centre Jean Perrin and INSERM U1240 IMost Université Clermont Auvergne, Clermont-Ferrand, France. * 10 School of Medicine and Health, Technical University of Munich, TUM University Hospital, Munich, Germany. * 11 Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA. * 12 Hospital Universitario 12 de Octubre, Madrid, Spain. * 13 Nebraska Cancer Specialists, Omaha, NE, USA. * 14 Washington University School of Medicine, St. Louis, MO, USA. * 15 Seoul National University Hospital, Seoul, South Korea. * 16 Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang Gung University, Taoyuan, Taiwan. * 17 University Hospital Strasbourg, Strasbourg, France. * 18 Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for China, Tianjin, China; Tianjin Cancer Hospital Airport Hospital, National Clinical Research Center for Cancer, Tianjin, China. * 19 Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. * 20 XCancer, Omaha, NE, USA. * 21 University of Chicago, Chicago, IL, USA. * 22 Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland. * 23 Novartis Pharmaceuticals, Basel, Switzerland. * 24 Novartis Pharmaceuticals UK, London, UK. * 25 Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: morrism@mskcc.org. * PMID: **42561994** * DOI: [ 10.1016/S0140-6736(26)01092-5 ](https://doi.org/10.1016/s0140-6736\(26\)01092-5) Item in Clipboard Clinical Trial # [177Lu]Lu-PSMA-617 in patients with PSMA-positive metastatic androgen pathway modulator-naive/sensitive prostate cancer (PSMAddition): a phase 3 randomised, controlled trial Scott T Tagawa et al. Lancet. 2026. Show details Display options Display options Format Abstract PubMed PMID Lancet Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Lancet%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Lancet%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42561994/) . 2026 Aug 29;408(10557):793-807. doi: 10.1016/S0140-6736(26)01092-5. Epub 2026 Aug 6. ### Authors [Scott T Tagawa](https://pubmed.ncbi.nlm.nih.gov/?term=Tagawa+ST&cauthor_id=42561994)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-1 "Weill Cornell Medicine, New York, NY, USA."), [Oliver Sartor](https://pubmed.ncbi.nlm.nih.gov/?term=Sartor+O&cauthor_id=42561994)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-2 "LCMC Health, New Orleans, LA, USA."), [Josep M Piulats](https://pubmed.ncbi.nlm.nih.gov/?term=Piulats+JM&cauthor_id=42561994)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-3 "Institut Català d'Oncologia, Institut d'Investigació Biomèdica de Bellvitge, Barcelona, Spain."), [Fred Saad](https://pubmed.ncbi.nlm.nih.gov/?term=Saad+F&cauthor_id=42561994)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-4 "The University of Montreal Hospital Center, Montreal, QC, Canada."), [Karim Fizazi](https://pubmed.ncbi.nlm.nih.gov/?term=Fizazi+K&cauthor_id=42561994)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-5 "Centre Oscar Lambret, University of Paris-Saclay, Lille, France."), [Alison Reid](https://pubmed.ncbi.nlm.nih.gov/?term=Reid+A&cauthor_id=42561994)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-6 "The Royal Marsden NHS Foundation Trust, London, UK."), [Himisha Beltran](https://pubmed.ncbi.nlm.nih.gov/?term=Beltran+H&cauthor_id=42561994)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-7 "Division of Medical Oncology, Dana Farber Cancer Institute, Boston, MA, USA."), [Gero Kramer](https://pubmed.ncbi.nlm.nih.gov/?term=Kramer+G&cauthor_id=42561994)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-8 "Department of Urology, Medical University of Vienna, Vienna, Austria."), [Hakim Mahammedi](https://pubmed.ncbi.nlm.nih.gov/?term=Mahammedi+H&cauthor_id=42561994)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-9 "Centre Jean Perrin and INSERM U1240 IMost Université Clermont Auvergne, Clermont-Ferrand, France."), [Matthias Eiber](https://pubmed.ncbi.nlm.nih.gov/?term=Eiber+M&cauthor_id=42561994)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-10 "School of Medicine and Health, Technical University of Munich, TUM University Hospital, Munich, Germany."), [Shilpa Gupta](https://pubmed.ncbi.nlm.nih.gov/?term=Gupta+S&cauthor_id=42561994)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-11 "Taussig Cancer Institute, Cleveland Clinic Foundation, Cleveland, OH, USA."), [Daniel Castellano](https://pubmed.ncbi.nlm.nih.gov/?term=Castellano+D&cauthor_id=42561994)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-12 "Hospital Universitario 12 de Octubre, Madrid, Spain."), [Ralph Hauke](https://pubmed.ncbi.nlm.nih.gov/?term=Hauke+R&cauthor_id=42561994)[ 13 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-13 "Nebraska Cancer Specialists, Omaha, NE, USA."), [Hyun Kim](https://pubmed.ncbi.nlm.nih.gov/?term=Kim+H&cauthor_id=42561994)[ 14 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-14 "Washington University School of Medicine, St. Louis, MO, USA."), [Cheol Kwak](https://pubmed.ncbi.nlm.nih.gov/?term=Kwak+C&cauthor_id=42561994)[ 15 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-15 "Seoul National University Hospital, Seoul, South Korea."), [See Tong Pang](https://pubmed.ncbi.nlm.nih.gov/?term=Pang+ST&cauthor_id=42561994)[ 16 ](https://pubmed.ncbi.nlm.nih.gov/42561994/#short-view-affiliation-16 "Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang
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