---
title: "A CAR T cell–amplified suppressive B cell circuit in AML — preprint report"
id: "biorxiv-22-a-car-t-cell-amplified-suppressive-b-cell-circuit-in-aml"
canonical_url: "https://medichelpline.com/clinical-feed/biorxiv-22-a-car-t-cell-amplified-suppressive-b-cell-circuit-in-aml"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "bioRxiv (Biomedical Preprints)"
source_url: "https://www.biorxiv.org/content/10.64898/2026.10.12.758644v1?rss=1"
published_at: "2026-10-18T12:00:00.000Z"
evidence_level: "Verified Feed"
license: "CC-BY-NC-4.0 / Informational Use"
---
# A CAR T cell–amplified suppressive B cell circuit in AML — preprint report
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/biorxiv-22-a-car-t-cell-amplified-suppressive-b-cell-circuit-in-aml
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** bioRxiv (Biomedical Preprints)
- **Source URL:** [Original Journal Publication](https://www.biorxiv.org/content/10.64898/2026.10.12.758644v1?rss=1)
- **Published At:** 2026-10-18T12:00:00.000Z
- **Evidence Rating:** Verified Feed
## Executive GIST (TL;DR)
- The source is a bioRxiv preprint titled “A CAR T cell-amplified suppressive B cell circuit in AML.” - Authors are listed in full on the preprint page; the lead and corresponding author is Adrian Gottschlich, with multiple coauthors from LMU Munich and other institutions. - The DOI and preprint notice are provided on the page; the posting is explicitly not peer reviewed. - The JINA-provided source snippet contains authorship, affiliations, DOI, and preprint status but does not include the manuscript’s abstract, methods, results, figures, numerical endpoints, or conclusions. - The source text available here does not report trial design, patient cohort details, experimental methods, dosing or construct specifications, statistical results, or defined clinical endpoints. - Because the JINA extract lacks the body of the manuscript, specific clinical findings, measured outcomes, and safety signals cannot be summarized from this content. - The critical unanswered items from the provided source include: experimental system (in vitro, in vivo, patient samples), whether clinical data are presented, how the authors define the “suppressive B cell circuit,” and any therapeutic or translational implications. - Users should consult the full preprint at the bioRxiv link for experimental detail, or await peer-reviewed publication for validated results.
## Clinical Analysis & Structured Key Points
A CAR T cell-amplified suppressive B cell circuit in AML | bioRxiv Skip to main content New Results A CAR T cell-amplified suppressive B cell circuit in AML View ORCID Profile Adrian Gottschlich , View ORCID Profile Vladyslav Kavaka , View ORCID Profile Thomas Alexander Janert , View ORCID Profile Veronika Igl , View ORCID Profile Emanuele Carlini , View ORCID Profile Lisa Rohrbacher , View ORCID Profile Wendy den Hartog , Jakob Harwood , View ORCID Profile Marcel P. Trefny , Selin Sogukcelik , Philipp Penovici , View ORCID Profile Bernhard Ransmayr , View ORCID Profile Christian Rausch , View ORCID Profile Franziska Brauneck , View ORCID Profile Stephanie Frenz-Wiessner , Isabel Goek , Gerulf Haenel , View ORCID Profile Cristina Zucchinetti , View ORCID Profile Arman Oner , View ORCID Profile Paula Sophie Zwicker , Ruth Gruenmeier , View ORCID Profile Simon Delahais , Philipp Maximilian Schnell , Sayantan Nandi , View ORCID Profile Moritz Thomas , View ORCID Profile Ruben Brabenec , View ORCID Profile Daria Briukhovetska , View ORCID Profile Stefanos Michaelides , Rasmus David Mueller , View ORCID Profile Lilli Ye Ballheimer , View ORCID Profile Christina Angeliki Tsiverioti , View ORCID Profile Gordon Victor Hoffmann , View ORCID Profile Sophia Stock , View ORCID Profile Ignazio Piseddu , Philipp Jie Mueller , Moritz Kruppa , View ORCID Profile Walter Fiedler , View ORCID Profile Michael Rade , View ORCID Profile Markus Kreuz , Niklas Kehl , View ORCID Profile Anand S. Bhagwat , Johannes Tobias Thiel , Dominik Steiner , Henrik Lauer , Adrien Daigeler , View ORCID Profile Christoph Klein , View ORCID Profile Carsten Marr , View ORCID Profile Stefan Endres , View ORCID Profile Kristin Reiche , View ORCID Profile Mirco Friedrich , View ORCID Profile Christine Bollwein , View ORCID Profile Stephan Ledderose , View ORCID Profile Martina Rudelius , View ORCID Profile Tobias Herold , View ORCID Profile Karsten Spiekermann , View ORCID Profile Maximilian Merz , View ORCID Profile Thorsten Mempel , View ORCID Profile Saar Gill , View ORCID Profile Marion Subklewe , View ORCID Profile Michael von Bergwelt-Baildon , View ORCID Profile Sebastian Kobold doi: https://doi.org/10.64898/2026.10.12.758644 Adrian Gottschlich 1 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, German; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Adrian Gottschlich For correspondence: adrian.gottschlich{at}med.uni-muenchen.de Vladyslav Kavaka 2 Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, Eberhard Karl University Tuebingen, Tuebingen, Germany; Institute of Clinical Neuroimmunology, LMU University Hospital, LMU Munich, Munich, Germany; Biomedical Center; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Vladyslav Kavaka Thomas Alexander Janert 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Thomas Alexander Janert Veronika Igl 4 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Department of Internal Medicine 3 - Rheumatology and Immunology, Friedrich-Alexander-Universitaet Erlangen-Nuernberg and U; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Veronika Igl Emanuele Carlini 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Emanuele Carlini Lisa Rohrbacher 5 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Lisa Rohrbacher Wendy den Hartog 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Wendy den Hartog Jakob Harwood 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Marcel P. Trefny 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Marcel P. Trefny Selin Sogukcelik 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Philipp Penovici 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Bernhard Ransmayr 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Bernhard Ransmayr Christian Rausch 6 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, M; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Christian Rausch Franziska Brauneck 7 Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Mildred Scheel Cancer Career Center, University Cancer Cente; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Franziska Brauneck Stephanie Frenz-Wiessner 8 Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany; German Center for Child and Adolescent Health, Partner Site Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Stephanie Frenz-Wiessner Isabel Goek 9 Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Gerulf Haenel 5 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Cristina Zucchinetti 5 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Laboratory for Translational Cancer Immunology, Gene Center, LMU Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Cristina Zucchinetti Arman Oner 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Arman Oner Paula Sophie Zwicker 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Paula Sophie Zwicker Ruth Gruenmeier 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Simon Delahais 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Simon Delahais Philipp Maximilian Schnell 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Sayantan Nandi 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Moritz Thomas 10 Computational Health Center & Helmholtz AI, Helmholtz Munich, Neuherberg, Germany; School of Life Sciences Weihenstephan, Technical University of Munich, Freising, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Moritz Thomas Ruben Brabenec 11 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Computational Health Center & Helmholtz AI, Helmholtz Munich, Neuherberg, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Ruben Brabenec Daria Briukhovetska 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Daria Briukhovetska Stefanos Michaelides 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Stefanos Michaelides Rasmus David Mueller 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Lilli Ye Ballheimer 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Lilli Ye Ballheimer Christina Angeliki Tsiverioti 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Christina Angeliki Tsiverioti Gordon Victor Hoffmann 3 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Gordon Victor Hoffmann Sophia Stock 1 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, German; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Sophia Stock Ignazio Piseddu 12 Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Ignazio Piseddu Philipp Jie Mueller 13 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Mass General Brigham, Boston, MA, United; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Moritz Kruppa 14 Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Walter Fiedler 14 Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald University Cancer Center, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Walter Fiedler Michael Rade 15 Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Michael Rade Markus Kreuz 15 Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Markus Kreuz Niklas Kehl 16 German Cancer Research Center (DKFZ), JRG Hematology and Immune Engineering, Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Department of Hematology, Oncology and Rheumato; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Anand S. Bhagwat 17 Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA, USA; Center for Cellular Immunotherapies, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Anand S. Bhagwat Johannes Tobias Thiel 18 Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, Eberhard Karl University Tuebingen, Tuebingen, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Dominik Steiner 18 Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, Eberhard Karl University Tuebingen, Tuebingen, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Henrik Lauer 18 Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, Eberhard Karl University Tuebingen, Tuebingen, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Adrien Daigeler 18 Department of Hand, Plastic, Reconstructive and Burn Surgery, BG Unfallklinik Tuebingen, Eberhard Karl University Tuebingen, Tuebingen, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site Christoph Klein 19 Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany; German Center for Child and Adolescent Health, Partner Site Munich, Munich, Germany; Gene Center, LMU Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Christoph Klein Carsten Marr 6 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, M; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Carsten Marr Stefan Endres 20 Institute of Clinical Pharmacology, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hos; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Stefan Endres Kristin Reiche 21 German Cancer Research Center (DKFZ), JRG Hematology and Immune Engineering, Heidelberg, Germany; Institute for Clinical Immunology, University Hospital of Leipzig, Leipzig, Germany; Center for Scalable Data Analytics and Artificial Intelligence (ScaDS.AI; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Kristin Reiche Mirco Friedrich 16 German Cancer Research Center (DKFZ), JRG Hematology and Immune Engineering, Heidelberg, Germany; Heidelberg Institute for Stem Cell Technology and Experimental Medicine (HI-STEM gGmbH), Heidelberg, Germany; Department of Hematology, Oncology and Rheumato; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Mirco Friedrich Christine Bollwein 22 Institute of Pathology, Technical University of Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Christine Bollwein Stephan Ledderose 23 Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Stephan Ledderose Martina Rudelius 23 Institute of Pathology, Faculty of Medicine, Ludwig-Maximilians-University Munich, Munich, Germany; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Martina Rudelius Tobias Herold 24 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; Department of Hematology, Oncology, and Stem-Cell Transplantation, Munich Hospital Bogenhausen, Munich Municipal Hospital Group, M; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Tobias Herold Karsten Spiekermann 6 Department of Medicine III, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitaet Muenchen, Munich, Germany; German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, M; Find this author on Google Scholar Find this author on PubMed Search for this author on this site ORCID record for Karsten Spiekermann Maximilian Merz 25 Department of Hematology, Hemostaseology and Cellular Therapy, University Hospital Leipzig, Leipzig, Germany; Myeloma and Cellular Therapy Service, Memorial Sloan Kettering Cancer Center; Find this author on Google Scholar Find this author on PubMed Search for this autho
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