---
title: "Alcohol cessation alters hepatic metabolic signaling in cancer cachexia"
id: "pubmed-42341415"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42341415"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42341415/"
doi: "10.1016/j.bbrc.2026.154176"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Alcohol cessation alters hepatic metabolic signaling in cancer cachexia
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42341415
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42341415/)
- **DOI:** [10.1016/j.bbrc.2026.154176](https://doi.org/10.1016%2Fj.bbrc.2026.154176)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The liver is central to macronutrient metabolism and is affected by both **alcohol** and cancer; this study evaluated how prior alcohol use and its cessation influence hepatic gene and protein signaling during distal-site cancer-induced cachexia. - Male CD2F1 mice were assigned to six groups: Control no cancer, Control-Cancer, prior alcohol (PE), PE-cancer, EtOH (current alcohol), and EtOH-cancer. Alcohol provided 20% kcal from ethanol in a liquid diet for 6 weeks; PE groups were weaned off alcohol before tumor implantation. - C26 colon carcinoma cells were implanted to induce cachexia; livers were collected two weeks after implantation for RNA, cDNA, RT-PCR and Western blot analyses to assess genes for lipid metabolism and mitochondrial proteins. - Cancer reduced total body weight and epididymal adipose tissue weight, increased liver weight, and produced a greater percent weight loss. Alcohol alone also increased liver weight and reduced fat mass. - Alcohol cessation (PE) attenuated body weight loss in mice with cancer compared with mice that continued alcohol consumption during cancer, indicating some protective effect on whole-body weight loss. - Cancer upregulated hepatic genes associated with **lipid uptake** and **cholesterol synthesis**, while genes for **de novo lipogenesis** and **lipolysis** were suppressed in the liver of tumor-bearing mice. - Distal-site cancer decreased hepatic mitochondrial respiratory chain protein content and reduced levels of mitophagy-related proteins **DRP-1** and **BNIP3**. Alcohol exposure also lowered DRP-1 and BNIP3 content independent of cancer. - In non-cancer mice, alcohol cessation led to lower expression of genes for **cholesterol synthesis** and higher protein levels of vATP5A (complex V) of the mitochondrial respiratory chain. - Overall, cessation of alcohol attenuated cancer-associated body weight loss but had limited effects on cancer-induced changes in hepatic mitochondrial proteins and genes controlling hepatic lipid balance. - The study used murine C26 tumor cachexia model and molecular assays (RT-PCR, Western blot); details such as sample sizes, statistical values, and full quantitative results were not reported in the abstract and therefore are not available from the source provided.
## Clinical Analysis & Structured Key Points
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Epub 2026 Jun 19. # Impact of alcohol cessation on hepatic metabolic signaling during cancer cachexia [Abigail L Tice](https://pubmed.ncbi.nlm.nih.gov/?term=Tice+AL&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Robert D Murphy](https://pubmed.ncbi.nlm.nih.gov/?term=Murphy+RD&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Joseph A Laudato](https://pubmed.ncbi.nlm.nih.gov/?term=Laudato+JA&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Avery R Tangen](https://pubmed.ncbi.nlm.nih.gov/?term=Tangen+AR&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Mariana J Lima](https://pubmed.ncbi.nlm.nih.gov/?term=Lima+MJ&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Bradley S Gordon](https://pubmed.ncbi.nlm.nih.gov/?term=Gordon+BS&cauthor_id=42341415)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-2 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA."), [Jennifer L Steiner](https://pubmed.ncbi.nlm.nih.gov/?term=Steiner+JL&cauthor_id=42341415)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#full-view-affiliation-3 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA. Electronic address: Jsteiner2@fsu.edu.") Affiliations Expand ### Affiliations * 1 Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA. * 2 Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA. * 3 Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA. Electronic address: Jsteiner2@fsu.edu. * PMID: **42341415** * DOI: [ 10.1016/j.bbrc.2026.154176 ](https://doi.org/10.1016/j.bbrc.2026.154176) Item in Clipboard # Impact of alcohol cessation on hepatic metabolic signaling during cancer cachexia Abigail L Tice et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) . 2026 Sep 3:829:154176. doi: 10.1016/j.bbrc.2026.154176. Epub 2026 Jun 19. ### Authors [Abigail L Tice](https://pubmed.ncbi.nlm.nih.gov/?term=Tice+AL&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Robert D Murphy](https://pubmed.ncbi.nlm.nih.gov/?term=Murphy+RD&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Joseph A Laudato](https://pubmed.ncbi.nlm.nih.gov/?term=Laudato+JA&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Avery R Tangen](https://pubmed.ncbi.nlm.nih.gov/?term=Tangen+AR&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Mariana J Lima](https://pubmed.ncbi.nlm.nih.gov/?term=Lima+MJ&cauthor_id=42341415)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-1 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA."), [Bradley S Gordon](https://pubmed.ncbi.nlm.nih.gov/?term=Gordon+BS&cauthor_id=42341415)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-2 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA."), [Jennifer L Steiner](https://pubmed.ncbi.nlm.nih.gov/?term=Steiner+JL&cauthor_id=42341415)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42341415/#short-view-affiliation-3 "Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA. Electronic address: Jsteiner2@fsu.edu.") ### Affiliations * 1 Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA. * 2 Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA. * 3 Department of Health, Nutrition, and Food Sciences, Florida State University, Tallahassee, FL, 32306, USA; Institute of Sports Sciences and Medicine, Florida State University, Tallahassee, FL, 32306, USA. Electronic address: Jsteiner2@fsu.edu. * PMID: **42341415** * DOI: [ 10.1016/j.bbrc.2026.154176 ](https://doi.org/10.1016/j.bbrc.2026.154176) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract The liver is central to macronutrient metabolism, with cancer and alcohol both impacting its function. The objective was to investigate the effects of alcohol use and its cessation, on hepatic gene expression for lipid metabolism and mitochondrial proteins during cachexia inducing distal site cancer. **Methods:** Male CD2F1 mice were randomized to Control no cancer, Control-Cancer, prior alcohol (PE), PE-cancer, EtOH, or EtOH-cancer groups. Mice consumed control or alcohol (20% kcals from ethanol) liquid diet for 6 weeks, after which PE groups were weaned off alcohol. C26 colon carcinoma cells were implanted and 2 weeks later, livers were collected for RNA, cDNA, RT-PCR and Western blotting. **Results:** Cancer lowered body weight and epidydimal adipose tissue weight, led to higher liver weight and greater percent weight loss. Alcohol also increased liver weight and reduced fat mass, while cessation attenuated body weight loss with cancer. Cancer increased genes related to lipid uptake and cholesterol synthesis, while genes for de novo lipogenesis and lipolysis were suppressed in the liver. Distal site cancer led to decrements in hepatic mitochondrial respiratory chain protein content and the mitophagy related proteins, DRP-1 and BNIP3. Alcohol also lowered DRP-1 and BNIP3 content. In non-cancer mice, the cessation of alcohol led to lower expression of cholesterol synthesis genes and higher levels of vATP5A (complex V) of the mitochondrial respiratory chain. **Conclusion:** Cessation of alcohol attenuates body weight loss due to cancer but has fewer effects on mitochondrial proteins, and genes regulating lipid balance in the liver. **Keywords:** Cancer; Ethanol; Fat; Liver; Mitochondria. Copyright © 2026 Elsevier Inc. All rights reserved. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement Declaration of competing interest This statement certifies that the work contained herein has not been published previously, is not under consideration for publication elsewhere, that all authors approve the work, and that it will not be published elsewhere. ## Similar articles * [ Response of male and female mice to chronic alcohol use before and during cancer. ](https://pubmed.ncbi.nlm.nih.gov/41692215/) Laudato JA, Tice AL, Bridges BO, Lima M, Rossetti ML, Egan A, Gordon BS, Steiner JL.Laudato JA, et al.Alcohol. 2026 May;132:13-23. doi: 10.1016/j.alcohol.2026.02.003. Epub 2026 Feb 13.Alcohol. 2026.PMID: 41692215 * [ Effects of antrosterol from Antrodia camphorata submerged whole broth on lipid homeostasis, antioxidation, alcohol clearance, and anti-inflammation in livers of chronic-alcohol fed mice. ](https://pubmed.ncbi.nlm.nih.gov/28274894/) Chang YY, Liu YC, Kuo YH, Lin YL, Wu YS, Chen JW, Chen YC.Chang YY, et al.J Ethnopharmacol. 2017 Apr 18;202:200-207. doi: 10.1016/j.jep.2017.03.003. Epub 2017 Mar 6.J Ethnopharmacol. 2017.PMID: 28274894 * [ Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia. ](https://pubmed.ncbi.nlm.nih.gov/32146873/) Khamoui AV, Tokmina-Roszyk D, Rossiter HB, Fields GB, Visavadiya NP.Khamoui AV, et al.Physiol Genomics. 2020 May 1;52(5):203-216. doi: 10.1152/physiolgenomics.00124.2019. Epub 2020 Mar 9.Physiol Genomics. 2020.PMID: 32146873Free PMC article. * [ Involvement of adiponectin-SIRT1-AMPK signaling in the protective action of rosiglitazone against alcoholic fatty liver in mice. ](https://pubmed.ncbi.nlm.nih.gov/20007851/) Shen Z, Liang X, Rogers CQ, Rideout D, You M.Shen Z, et al.Am J Physiol Gastrointest Liver Physiol. 2010 Mar;298(3):G364-74. doi: 10.1152/ajpgi.00456.2009. Epub 2009 Dec 10.Am J Physiol Gastrointest Liver Physiol. 2010.PMID: 20007851Free PMC article. * [ Amelioration of Cancer Cachexia by _Dalbergia odorifera_ Extract Through AKT Signaling Pathway Regulation. ](https://pubmed.ncbi.nlm.nih.gov/39519503/) Ho PT, Park E, Luong QXT, Hakim MD, Hoang PT, Vo TTB, Kawalin K, Kang H, Lee TK, Lee S.Ho PT, et al.Nutrients. 2024 Oct 28;16(21):3671. doi: 10.3390/nu16213671.Nutrients. 2024.PMID: 39519503Free PMC article. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42341415) ## MeSH terms * Alcohol Drinking* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Alcohol+Drinking%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Alcohol+Drinking) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Cachexia* / etiology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cachexia%2Fetiology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cachexia) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Cachexia* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cachexia%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cachexia) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Cachexia* / pathology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cachexia%2Fpathology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cachexia) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Colonic Neoplasms* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colonic+Neoplasms%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colonic+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42341415/) * Colonic Neoplasms* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Colonic+Neoplasms%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Colonic+Neoplasms) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.g
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