---
title: "Aptamer‑conjugated, oleuropein‑loaded PLGA nanoparticles increase apoptosis in breast cancer cells"
id: "pubmed-42743749"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42743749"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42743749/"
doi: "10.1016/j.bbrc.2026.154583"
published_at: "2026-10-22T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Aptamer‑conjugated, oleuropein‑loaded PLGA nanoparticles increase apoptosis in breast cancer cells
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42743749
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42743749/)
- **DOI:** [10.1016/j.bbrc.2026.154583](https://doi.org/10.1016%2Fj.bbrc.2026.154583)
- **Published At:** 2026-10-22T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The PubMed record (PMID 42743749) reports a 2026 Biochem Biophys Res Commun article titled “Aptamer conjugated and oleuropein loaded PLGA nanoparticles increase the apoptosis of breast cancer cells.” - The article lists multiple Indian research institutions among author affiliations; the corresponding authors and full author list are provided in the source record. - The source entry includes the DOI 10.1016/j.bbrc.2026.154583 and an electronic publication date of 2026 Sep 12 with issue citation 2026 Oct 22:836:154583. - The article title states that **oleuropein** loaded into **PLGA nanoparticles** and conjugated to an aptamer increased apoptosis in **breast cancer** cells, as reported by the authors. - The PubMed record does not include the study abstract or experimental details in the visible snippet; the source did not report cell lines used, dosing, nanoparticle characterization, quantitative apoptosis data, statistical analysis, or in vivo experiments in the accessible text. - Key methodological and outcome elements—sample size, controls, assays used to measure apoptosis, and any safety or toxicity findings—are not available from the source content provided. - The record provides full author names and affiliations; contact email addresses for two authors appear in the source metadata. - Important unanswered questions from the source include reproducibility, comparative efficacy versus free oleuropein, aptamer specificity, nanoparticle size and loading efficiency, and translational readiness; these items were not reported in the accessible PubMed entry.
## Clinical Analysis & Structured Key Points
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Epub 2026 Sep 12. # Aptamer conjugated and oleuropein loaded PLGA nanoparticles increase the apoptosis of breast cancer cells [Prakriti Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+P&cauthor_id=42743749)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-1 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India. Electronic address: prakriti.sh10@gmail.com."), [Sonia Devi](https://pubmed.ncbi.nlm.nih.gov/?term=Devi+S&cauthor_id=42743749)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-2 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research \(AcSIR\), Ghaziabad, 201002, India."), [Sushmita Negi](https://pubmed.ncbi.nlm.nih.gov/?term=Negi+S&cauthor_id=42743749)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-2 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research \(AcSIR\), Ghaziabad, 201002, India."), [Akhil Khajuria](https://pubmed.ncbi.nlm.nih.gov/?term=Khajuria+A&cauthor_id=42743749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-3 "University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India."), [Jatinder Kaur](https://pubmed.ncbi.nlm.nih.gov/?term=Kaur+J&cauthor_id=42743749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-3 "University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India."), [Kanwaljit Rana](https://pubmed.ncbi.nlm.nih.gov/?term=Rana+K&cauthor_id=42743749)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-4 "International Centre for Genetic Engineering and Biotechnology, New Delhi, India."), [Hema Kumari Alajangi](https://pubmed.ncbi.nlm.nih.gov/?term=Alajangi+HK&cauthor_id=42743749)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-5 "Department of Biophysics, Panjab University, Chandigarh, 160014, India."), [Reetesh Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+R&cauthor_id=42743749)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-6 "Department of Biotechnology, Galgotias Multi-Disciplinary Research & Development Cell \(G-MRDC\)\), Galgotias University, Greater Noida, UP, 201308, India."), [Ujjawal Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+U&cauthor_id=42743749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-7 "Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, Punjab, India."), [Geeta Rai](https://pubmed.ncbi.nlm.nih.gov/?term=Rai+G&cauthor_id=42743749)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-8 "Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India."), [Alka Rao](https://pubmed.ncbi.nlm.nih.gov/?term=Rao+A&cauthor_id=42743749)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-9 "CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India."), [Ravi Pratap Barnwal](https://pubmed.ncbi.nlm.nih.gov/?term=Barnwal+RP&cauthor_id=42743749)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-5 "Department of Biophysics, Panjab University, Chandigarh, 160014, India."), [Gurpal Singh](https://pubmed.ncbi.nlm.nih.gov/?term=Singh+G&cauthor_id=42743749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-3 "University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India."), [Nikunj Tandel](https://pubmed.ncbi.nlm.nih.gov/?term=Tandel+N&cauthor_id=42743749)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-10 "Department of Biotechnology, VNSGU, Surat, Gujarat, 395007, India. Electronic address: nikunj.tandel@nirmauni.ac.in."), [Rajeev K Tyagi](https://pubmed.ncbi.nlm.nih.gov/?term=Tyagi+RK&cauthor_id=42743749)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#full-view-affiliation-11 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research \(AcSIR\), Ghaziabad, 201002, India. Electronic address: rajeev.gru@gmail.com.") Affiliations Expand ### Affiliations * 1 Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India. Electronic address: prakriti.sh10@gmail.com. * 2 Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. * 3 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. * 4 International Centre for Genetic Engineering and Biotechnology, New Delhi, India. * 5 Department of Biophysics, Panjab University, Chandigarh, 160014, India. * 6 Department of Biotechnology, Galgotias Multi-Disciplinary Research & Development Cell (G-MRDC)), Galgotias University, Greater Noida, UP, 201308, India. * 7 Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, Punjab, India. * 8 Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India. * 9 CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India. * 10 Department of Biotechnology, VNSGU, Surat, Gujarat, 395007, India. Electronic address: nikunj.tandel@nirmauni.ac.in. * 11 Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. Electronic address: rajeev.gru@gmail.com. * PMID: **42743749** * DOI: [ 10.1016/j.bbrc.2026.154583 ](https://doi.org/10.1016/j.bbrc.2026.154583) Item in Clipboard # Aptamer conjugated and oleuropein loaded PLGA nanoparticles increase the apoptosis of breast cancer cells Prakriti Sharma et al. Biochem Biophys Res Commun. 2026. Show details Display options Display options Format Abstract PubMed PMID Biochem Biophys Res Commun Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Biochem+Biophys+Res+Commun%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Biochem+Biophys+Res+Commun%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743749/) . 2026 Oct 22:836:154583. doi: 10.1016/j.bbrc.2026.154583. Epub 2026 Sep 12. ### Authors [Prakriti Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+P&cauthor_id=42743749)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-1 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India. Electronic address: prakriti.sh10@gmail.com."), [Sonia Devi](https://pubmed.ncbi.nlm.nih.gov/?term=Devi+S&cauthor_id=42743749)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-2 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research \(AcSIR\), Ghaziabad, 201002, India."), [Sushmita Negi](https://pubmed.ncbi.nlm.nih.gov/?term=Negi+S&cauthor_id=42743749)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-2 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research \(AcSIR\), Ghaziabad, 201002, India."), [Akhil Khajuria](https://pubmed.ncbi.nlm.nih.gov/?term=Khajuria+A&cauthor_id=42743749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-3 "University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India."), [Jatinder Kaur](https://pubmed.ncbi.nlm.nih.gov/?term=Kaur+J&cauthor_id=42743749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-3 "University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India."), [Kanwaljit Rana](https://pubmed.ncbi.nlm.nih.gov/?term=Rana+K&cauthor_id=42743749)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-4 "International Centre for Genetic Engineering and Biotechnology, New Delhi, India."), [Hema Kumari Alajangi](https://pubmed.ncbi.nlm.nih.gov/?term=Alajangi+HK&cauthor_id=42743749)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-5 "Department of Biophysics, Panjab University, Chandigarh, 160014, India."), [Reetesh Kumar](https://pubmed.ncbi.nlm.nih.gov/?term=Kumar+R&cauthor_id=42743749)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-6 "Department of Biotechnology, Galgotias Multi-Disciplinary Research & Development Cell \(G-MRDC\)\), Galgotias University, Greater Noida, UP, 201308, India."), [Ujjawal Sharma](https://pubmed.ncbi.nlm.nih.gov/?term=Sharma+U&cauthor_id=42743749)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-7 "Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, Punjab, India."), [Geeta Rai](https://pubmed.ncbi.nlm.nih.gov/?term=Rai+G&cauthor_id=42743749)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-8 "Department of Molecular and Human Genetics, Institute of Science, Banaras Hindu University, Varanasi, 221005, India."), [Alka Rao](https://pubmed.ncbi.nlm.nih.gov/?term=Rao+A&cauthor_id=42743749)[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-9 "CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India."), [Ravi Pratap Barnwal](https://pubmed.ncbi.nlm.nih.gov/?term=Barnwal+RP&cauthor_id=42743749)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-5 "Department of Biophysics, Panjab University, Chandigarh, 160014, India."), [Gurpal Singh](https://pubmed.ncbi.nlm.nih.gov/?term=Singh+G&cauthor_id=42743749)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-3 "University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India."), [Nikunj Tandel](https://pubmed.ncbi.nlm.nih.gov/?term=Tandel+N&cauthor_id=42743749)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-10 "Department of Biotechnology, VNSGU, Surat, Gujarat, 395007, India. Electronic address: nikunj.tandel@nirmauni.ac.in."), [Rajeev K Tyagi](https://pubmed.ncbi.nlm.nih.gov/?term=Tyagi+RK&cauthor_id=42743749)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42743749/#short-view-affiliation-11 "Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology \(IMTECH\), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research \(AcSIR\), Ghaziabad, 201002, India. Electronic address: rajeev.gru@gmail.com.") ### Affiliations * 1 Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India. Electronic address: prakriti.sh10@gmail.com. * 2 Division of Cell Biology and Immunology, Biomedical Parasitology and Translational-immunology Lab, CSIR-Institute of Microbial Technology (IMTECH), Sec-39A, Chandigarh, 160036, India; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India. * 3 University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, 160014, India. * 4 International Centre for Genetic Engineering and Biotechnology, New Delhi, India. * 5 Department of Biophysics, Panjab University, Chandigarh, 160014, India. * 6 Department of Biotechnology, Galgotias Multi-Disciplinary Research & Development Cell (G-MRDC)), Galgotias University, Greater Noida, UP, 201308, India. * 7 Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, Punjab, India.
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