---
title: "Archetype Analysis Links Premalignant Heterogeneity to Divergent Invasive Features in Lung Adenoca"
id: "pubmed-42089783"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42089783"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42089783/"
doi: "10.1158/1541-7786.MCR-25-1093"
published_at: "2026-09-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Archetype Analysis Links Premalignant Heterogeneity to Divergent Invasive Features in Lung Adenoca
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42089783
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42089783/)
- **DOI:** [10.1158/1541-7786.MCR-25-1093](https://doi.org/10.1158%2F1541-7786.MCR-25-1093)
- **Published At:** 2026-09-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This PubMed entry describes a study titled “Archetype Analysis of Lung Adenocarcinoma Premalignancy Links Heterogeneity in Premalignant Lesions to Diverging Features of Invasive Disease” published in Mol Cancer Res (2026 Sep 2;24(9):737-753). - The article appears to apply an **archetype analysis** approach to examine premalignant states in **lung adenocarcinoma** and to relate heterogeneity in those lesions to differing characteristics of invasive disease, as implied by the title. - Full bibliographic identifiers are provided: PMID 42089783, PMCID PMC13455826, DOI 10.1158/1541-7786.MCR-25-1093. The full text is available on PubMed Central. - Authors and affiliations are listed in the citation; lead and contributing investigators represent Boston University, UCLA, Vanderbilt University Medical Center, and other institutions. - The PubMed entry includes article meta-data (journal, date, DOI, identifiers) and links to full text, but the supplied excerpt does not include the abstract, methods, results, or specific conclusions. - Because the provided source excerpt does not contain the study’s detailed methods, sample size, data, outcomes, or specific conclusions, those details are not reported here and must be obtained from the full-text article (PMCID link) for clinical interpretation. - Clinicians and researchers interested in the study should consult the PMC full text for complete methods, results, figures, and discussion to assess validity and clinical relevance.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42089783/#mesh-terms) * [Related information](https://pubmed.ncbi.nlm.nih.gov/42089783/#related-links) * [ Grants and funding ](https://pubmed.ncbi.nlm.nih.gov/42089783/#grants) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42089783/#linkout) Title & authors Abstract Conflict of interest statement Figures Update of Similar articles References MeSH terms Related information Grants and funding LinkOut - more resources Mol Cancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mol+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Cancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42089783/) . 2026 Sep 2;24(9):737-753. doi: 10.1158/1541-7786.MCR-25-1093. # Archetype Analysis of Lung Adenocarcinoma Premalignancy Links Heterogeneity in Premalignant Lesions to Diverging Features of Invasive Disease [Kelley E Anderson](https://pubmed.ncbi.nlm.nih.gov/?term=Anderson+KE&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Linh M Tran](https://pubmed.ncbi.nlm.nih.gov/?term=Tran+LM&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Kostyantyn Krysan](https://pubmed.ncbi.nlm.nih.gov/?term=Krysan+K&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Yohana Kefella](https://pubmed.ncbi.nlm.nih.gov/?term=Kefella+Y&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Lingge Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+L&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Gregory A Fishbein](https://pubmed.ncbi.nlm.nih.gov/?term=Fishbein+GA&cauthor_id=42089783)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-3 "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Erika F Rodriguez](https://pubmed.ncbi.nlm.nih.gov/?term=Rodriguez+EF&cauthor_id=42089783)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-3 "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Maryam Shabihkhani](https://pubmed.ncbi.nlm.nih.gov/?term=Shabihkhani+M&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Daniel P Stefanko](https://pubmed.ncbi.nlm.nih.gov/?term=Stefanko+DP&cauthor_id=42089783)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-3 "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Emily Green](https://pubmed.ncbi.nlm.nih.gov/?term=Green+E&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Gang Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+G&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Hanqiao Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Sherry Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Erin Kane](https://pubmed.ncbi.nlm.nih.gov/?term=Kane+E&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Mitra Mehrad](https://pubmed.ncbi.nlm.nih.gov/?term=Mehrad+M&cauthor_id=42089783)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-4 "Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee."), [Avrum E Spira](https://pubmed.ncbi.nlm.nih.gov/?term=Spira+AE&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Steven M Dubinett](https://pubmed.ncbi.nlm.nih.gov/?term=Dubinett+SM&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Eric J Burks](https://pubmed.ncbi.nlm.nih.gov/?term=Burks+EJ&cauthor_id=42089783)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-5 "Department of Pathology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Sarah A Mazzilli](https://pubmed.ncbi.nlm.nih.gov/?term=Mazzilli+SA&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Marc E Lenburg](https://pubmed.ncbi.nlm.nih.gov/?term=Lenburg+ME&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Jennifer E Beane](https://pubmed.ncbi.nlm.nih.gov/?term=Beane+JE&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#full-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts.") Affiliations Expand ### Affiliations * 1 Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts. * 2 Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. * 3 Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California. * 4 Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee. * 5 Department of Pathology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts. * PMID: **42089783** * PMCID: [ PMC13455826 ](https://pmc.ncbi.nlm.nih.gov/articles/PMC13455826/) * DOI: [ 10.1158/1541-7786.MCR-25-1093 ](https://doi.org/10.1158/1541-7786.mcr-25-1093) Item in Clipboard # Archetype Analysis of Lung Adenocarcinoma Premalignancy Links Heterogeneity in Premalignant Lesions to Diverging Features of Invasive Disease Kelley E Anderson et al. Mol Cancer Res. 2026. Show details Display options Display options Format Abstract PubMed PMID Mol Cancer Res Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Mol+Cancer+Res%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Mol+Cancer+Res%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42089783/) . 2026 Sep 2;24(9):737-753. doi: 10.1158/1541-7786.MCR-25-1093. ### Authors [Kelley E Anderson](https://pubmed.ncbi.nlm.nih.gov/?term=Anderson+KE&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Linh M Tran](https://pubmed.ncbi.nlm.nih.gov/?term=Tran+LM&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Kostyantyn Krysan](https://pubmed.ncbi.nlm.nih.gov/?term=Krysan+K&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Yohana Kefella](https://pubmed.ncbi.nlm.nih.gov/?term=Kefella+Y&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Lingge Yu](https://pubmed.ncbi.nlm.nih.gov/?term=Yu+L&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Gregory A Fishbein](https://pubmed.ncbi.nlm.nih.gov/?term=Fishbein+GA&cauthor_id=42089783)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-3 "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Erika F Rodriguez](https://pubmed.ncbi.nlm.nih.gov/?term=Rodriguez+EF&cauthor_id=42089783)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-3 "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Maryam Shabihkhani](https://pubmed.ncbi.nlm.nih.gov/?term=Shabihkhani+M&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Daniel P Stefanko](https://pubmed.ncbi.nlm.nih.gov/?term=Stefanko+DP&cauthor_id=42089783)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-3 "Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Emily Green](https://pubmed.ncbi.nlm.nih.gov/?term=Green+E&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Gang Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+G&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Hanqiao Liu](https://pubmed.ncbi.nlm.nih.gov/?term=Liu+H&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Sherry Zhang](https://pubmed.ncbi.nlm.nih.gov/?term=Zhang+S&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Erin Kane](https://pubmed.ncbi.nlm.nih.gov/?term=Kane+E&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Mitra Mehrad](https://pubmed.ncbi.nlm.nih.gov/?term=Mehrad+M&cauthor_id=42089783)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-4 "Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee."), [Avrum E Spira](https://pubmed.ncbi.nlm.nih.gov/?term=Spira+AE&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Steven M Dubinett](https://pubmed.ncbi.nlm.nih.gov/?term=Dubinett+SM&cauthor_id=42089783)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-2 "Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California."), [Eric J Burks](https://pubmed.ncbi.nlm.nih.gov/?term=Burks+EJ&cauthor_id=42089783)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-5 "Department of Pathology, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Sarah A Mazzilli](https://pubmed.ncbi.nlm.nih.gov/?term=Mazzilli+SA&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Marc E Lenburg](https://pubmed.ncbi.nlm.nih.gov/?term=Lenburg+ME&cauthor_id=42089783)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42089783/#short-view-affiliation-1 "Section of Computational Biomedicine, Boston University Chobanian and Avedisian School of Medicine, Boston, Massachusetts."), [Jennifer E Beane](https://pubmed.
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