---
title: "Azacitidine–Venetoclax versus Induction Chemotherapy in Acute Myeloid Leukemia — NEJM Clinical Tri"
id: "pubmed-42685316"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42685316"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42685316/"
doi: "10.1056/NEJMoa2602804"
published_at: "2026-09-03T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Azacitidine–Venetoclax versus Induction Chemotherapy in Acute Myeloid Leukemia — NEJM Clinical Tri
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42685316
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42685316/)
- **DOI:** [10.1056/NEJMoa2602804](https://doi.org/10.1056%2FNEJMoa2602804)
- **Published At:** 2026-09-03T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- This entry is a Clinical Trial report titled **Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia**, published in the New England Journal of Medicine on 3 September 2026 (Vol. 395, pp. 845–858). The PubMed ID is **42685316** and the DOI is **10.1056/NEJMoa2602804**. - The study is credited to a multi-institutional author group led by Amir T. Fathi and includes senior investigators from Mass General Brigham/Massachusetts General Hospital, University of Pennsylvania, Dana-Farber Cancer Institute, UC Davis, City of Hope, Stanford, Yale, Ohio State, Beth Israel Deaconess, and additional centers. - The trial compares treatment strategies for **acute myeloid leukemia**: the combination regimen **azacitidine-venetoclax** versus conventional **induction chemotherapy**. - The PubMed listing identifies the manuscript as a Clinical Trial in NEJM but the excerpted PubMed page text provided here does not include the abstract, primary efficacy or safety outcomes, numerical results, sample size, randomization schema, eligibility criteria, follow-up duration, or statistical findings. - Affiliations for the authors span multiple U.S. academic cancer centers; the contributor list and institutions are fully enumerated on the PubMed page. - Because the source content available here is limited to bibliographic and author information, specific trial methods, endpoints, and conclusions were not reported in the excerpt and must be retrieved from the full NEJM publication for clinical interpretation. - The PubMed entry provides DOI and PMID identifiers to locate the full article and indicates the report appeared in a peer-reviewed, high-impact journal, signaling relevance for practice and guideline committees pending review of full data.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42685316/#abstract) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42685316/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42685316/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42685316/#substances) * [ Associated data ](https://pubmed.ncbi.nlm.nih.gov/42685316/#supplemental-data) Title & authors Abstract Publication types MeSH terms Substances Associated data Clinical Trial N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42685316/) . 2026 Sep 3;395(9):845-858. doi: 10.1056/NEJMoa2602804. # Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia [Amir T Fathi](https://pubmed.ncbi.nlm.nih.gov/?term=Fathi+AT&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Alexander E Perl](https://pubmed.ncbi.nlm.nih.gov/?term=Perl+AE&cauthor_id=42685316)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-2 "Perelman School of Medicine, University of Pennsylvania, Philadelphia."), [Geoffrey G Fell](https://pubmed.ncbi.nlm.nih.gov/?term=Fell+GG&cauthor_id=42685316)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-3 "Dana-Farber Cancer Institute, Boston."), [Brian A Jonas](https://pubmed.ncbi.nlm.nih.gov/?term=Jonas+BA&cauthor_id=42685316)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-4 "University of California, Davis, School of Medicine, Sacramento."), [Brittany K Ragon](https://pubmed.ncbi.nlm.nih.gov/?term=Ragon+BK&cauthor_id=42685316)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-5 "Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC."), [Alice S Mims](https://pubmed.ncbi.nlm.nih.gov/?term=Mims+AS&cauthor_id=42685316)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-6 "Ohio State University Comprehensive Cancer Center, Columbus."), [Uma Borate](https://pubmed.ncbi.nlm.nih.gov/?term=Borate+U&cauthor_id=42685316)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-6 "Ohio State University Comprehensive Cancer Center, Columbus."), [Gabriel N Mannis](https://pubmed.ncbi.nlm.nih.gov/?term=Mannis+GN&cauthor_id=42685316)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-7 "Stanford Cancer Institute, Stanford University, Stanford, CA."), [Karen Quillen](https://pubmed.ncbi.nlm.nih.gov/?term=Quillen+K&cauthor_id=42685316)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-8 "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston."), [Maximilian Stahl](https://pubmed.ncbi.nlm.nih.gov/?term=Stahl+M&cauthor_id=42685316)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-3 "Dana-Farber Cancer Institute, Boston.")[ 9 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-9 "Yale University School of Medicine, New Haven, CT."), [Brandon J Aubrey](https://pubmed.ncbi.nlm.nih.gov/?term=Aubrey+BJ&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Paul Koller](https://pubmed.ncbi.nlm.nih.gov/?term=Koller+P&cauthor_id=42685316)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-10 "City of Hope National Medical Center, Duarte, CA."), [Andrew S Artz](https://pubmed.ncbi.nlm.nih.gov/?term=Artz+AS&cauthor_id=42685316)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-10 "City of Hope National Medical Center, Duarte, CA."), [Monzr M Al Malki](https://pubmed.ncbi.nlm.nih.gov/?term=Al+Malki+MM&cauthor_id=42685316)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-10 "City of Hope National Medical Center, Duarte, CA."), [Anthony S Stein](https://pubmed.ncbi.nlm.nih.gov/?term=Stein+AS&cauthor_id=42685316)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-10 "City of Hope National Medical Center, Duarte, CA."), [Guido Marcucci](https://pubmed.ncbi.nlm.nih.gov/?term=Marcucci+G&cauthor_id=42685316)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-10 "City of Hope National Medical Center, Duarte, CA."), [Mary Linton B Peters](https://pubmed.ncbi.nlm.nih.gov/?term=Peters+MLB&cauthor_id=42685316)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-8 "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston."), [Timothy A Graubert](https://pubmed.ncbi.nlm.nih.gov/?term=Graubert+TA&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Peter Westervelt](https://pubmed.ncbi.nlm.nih.gov/?term=Westervelt+P&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Philip C Amrein](https://pubmed.ncbi.nlm.nih.gov/?term=Amrein+PC&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Hanno R Hock](https://pubmed.ncbi.nlm.nih.gov/?term=Hock+HR&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Andrew M Brunner](https://pubmed.ncbi.nlm.nih.gov/?term=Brunner+AM&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Gabriela Hobbs](https://pubmed.ncbi.nlm.nih.gov/?term=Hobbs+G&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Rupa Narayan](https://pubmed.ncbi.nlm.nih.gov/?term=Narayan+R&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Michelle H Lee](https://pubmed.ncbi.nlm.nih.gov/?term=Lee+MH&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Peter G Miller](https://pubmed.ncbi.nlm.nih.gov/?term=Miller+PG&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Alyssa L Watson](https://pubmed.ncbi.nlm.nih.gov/?term=Watson+AL&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Richard Hao](https://pubmed.ncbi.nlm.nih.gov/?term=Hao+R&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Abigail C Marola](https://pubmed.ncbi.nlm.nih.gov/?term=Marola+AC&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Jennifer Lombardi-Story](https://pubmed.ncbi.nlm.nih.gov/?term=Lombardi-Story+J&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Shilton Dhaver](https://pubmed.ncbi.nlm.nih.gov/?term=Dhaver+S&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Michael R Grunwald](https://pubmed.ncbi.nlm.nih.gov/?term=Grunwald+MR&cauthor_id=42685316)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-5 "Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC."), [Yi-Bin Chen](https://pubmed.ncbi.nlm.nih.gov/?term=Chen+YB&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Matthew J Weinstock](https://pubmed.ncbi.nlm.nih.gov/?term=Weinstock+MJ&cauthor_id=42685316)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-8 "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston."), [Andrew H Matthews](https://pubmed.ncbi.nlm.nih.gov/?term=Matthews+AH&cauthor_id=42685316)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-2 "Perelman School of Medicine, University of Pennsylvania, Philadelphia."), [Ian McGovern](https://pubmed.ncbi.nlm.nih.gov/?term=McGovern+I&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Brent L Wood](https://pubmed.ncbi.nlm.nih.gov/?term=Wood+BL&cauthor_id=42685316)[ 11 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-11 "Children's Hospital Los Angeles, Los Angeles."), [Christopher S Hourigan](https://pubmed.ncbi.nlm.nih.gov/?term=Hourigan+CS&cauthor_id=42685316)[ 12 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-12 "Fralin Biomedical Research Institute \(FBRI\), Virginia Tech FBRI Cancer Research Center, Washington, DC."), [Donna S Neuberg](https://pubmed.ncbi.nlm.nih.gov/?term=Neuberg+DS&cauthor_id=42685316)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-3 "Dana-Farber Cancer Institute, Boston."), [Areej El-Jawahri](https://pubmed.ncbi.nlm.nih.gov/?term=El-Jawahri+A&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Ibrahim Aldoss](https://pubmed.ncbi.nlm.nih.gov/?term=Aldoss+I&cauthor_id=42685316)[ 10 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#full-view-affiliation-10 "City of Hope National Medical Center, Duarte, CA.") Affiliations Expand ### Affiliations * 1 Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston. * 2 Perelman School of Medicine, University of Pennsylvania, Philadelphia. * 3 Dana-Farber Cancer Institute, Boston. * 4 University of California, Davis, School of Medicine, Sacramento. * 5 Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC. * 6 Ohio State University Comprehensive Cancer Center, Columbus. * 7 Stanford Cancer Institute, Stanford University, Stanford, CA. * 8 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston. * 9 Yale University School of Medicine, New Haven, CT. * 10 City of Hope National Medical Center, Duarte, CA. * 11 Children's Hospital Los Angeles, Los Angeles. * 12 Fralin Biomedical Research Institute (FBRI), Virginia Tech FBRI Cancer Research Center, Washington, DC. * PMID: **42685316** * DOI: [ 10.1056/NEJMoa2602804 ](https://doi.org/10.1056/nejmoa2602804) Item in Clipboard Clinical Trial # Azacitidine-Venetoclax or Induction Chemotherapy for Acute Myeloid Leukemia Amir T Fathi et al. N Engl J Med. 2026. Show details Display options Display options Format Abstract PubMed PMID N Engl J Med Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22N+Engl+J+Med%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22N+Engl+J+Med%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42685316/) . 2026 Sep 3;395(9):845-858. doi: 10.1056/NEJMoa2602804. ### Authors [Amir T Fathi](https://pubmed.ncbi.nlm.nih.gov/?term=Fathi+AT&cauthor_id=42685316)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-1 "Mass General Brigham Cancer Institute at Massachusetts General Hospital, Harvard Medical School, Boston."), [Alexander E Perl](https://pubmed.ncbi.nlm.nih.gov/?term=Perl+AE&cauthor_id=42685316)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-2 "Perelman School of Medicine, University of Pennsylvania, Philadelphia."), [Geoffrey G Fell](https://pubmed.ncbi.nlm.nih.gov/?term=Fell+GG&cauthor_id=42685316)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-3 "Dana-Farber Cancer Institute, Boston."), [Brian A Jonas](https://pubmed.ncbi.nlm.nih.gov/?term=Jonas+BA&cauthor_id=42685316)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-4 "University of California, Davis, School of Medicine, Sacramento."), [Brittany K Ragon](https://pubmed.ncbi.nlm.nih.gov/?term=Ragon+BK&cauthor_id=42685316)[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-5 "Atrium Health Levine Cancer Institute, Wake Forest University School of Medicine, Charlotte, NC."), [Alice S Mims](https://pubmed.ncbi.nlm.nih.gov/?term=Mims+AS&cauthor_id=42685316)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-6 "Ohio State University Comprehensive Cancer Center, Columbus."), [Uma Borate](https://pubmed.ncbi.nlm.nih.gov/?term=Borate+U&cauthor_id=42685316)[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-6 "Ohio State University Comprehensive Cancer Center, Columbus."), [Gabriel N Mannis](https://pubmed.ncbi.nlm.nih.gov/?term=Mannis+GN&cauthor_id=42685316)[ 7 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-7 "Stanford Cancer Institute, Stanford University, Stanford, CA."), [Karen Quillen](https://pubmed.ncbi.nlm.nih.gov/?term=Quillen+K&cauthor_id=42685316)[ 8 ](https://pubmed.ncbi.nlm.nih.gov/42685316/#short-view-affiliation-8 "Beth Israel Deaconess Medical Center, Harvard Medical School, Boston."), [Maximilian Stahl](https://pubmed.ncbi.nlm.nih.go
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