---
title: "B-cell Acute Lymphoblastic Leukemia with Rothia mucilaginosa Sepsis and Suppurative Meningitis"
id: "pubmed-42742023"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42742023"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42742023/"
doi: "10.3760/cma.j.cn112140-20260403-00267"
published_at: "2026-10-02T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# B-cell Acute Lymphoblastic Leukemia with Rothia mucilaginosa Sepsis and Suppurative Meningitis
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42742023
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42742023/)
- **DOI:** [10.3760/cma.j.cn112140-20260403-00267](https://doi.org/10.3760%2Fcma.j.cn112140-20260403-00267)
- **Published At:** 2026-10-02T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Case report of a female infant (1 year 7 months) diagnosed with **B-cell acute lymphoblastic leukemia** with a detected **PAX5** gene alteration and no IKZF1 gene deletion. - After induction chemotherapy the patient developed severe bone marrow suppression. - The clinical course was complicated by bloodstream infection with **Rothia mucilaginosa**, resulting in **sepsis** and **suppurative meningitis**. - The infection progressed to refractory septic shock, cerebral herniation, and multi-organ failure, and the patient died. - The report originates from Pediatric Intensive Care Unit and Emergency Department teams at Beijing Children's Hospital, Capital Medical University. - The article is a Chinese-language case report published in Zhonghua Er Ke Za Zhi (2026) with PMID 42742023 and DOI 10.3760/cma.j.cn112140-20260403-00267. - Authors declared no conflicts of interest. - The PubMed entry lists MeSH terms including Fatal Outcome, Gram-Positive Bacterial Infections complications, Infant, and PAX5 Transcription Factor genetics. - Full-text access is linked through the Chinese Medical Association Publishing House; the abstract supplies the main clinical sequence but detailed management, microbiology, antimicrobial therapy, and timelines were not reported in the PubMed abstract.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42742023/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42742023%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42742023/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42742023/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42742023/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/a447896c-976f-490b-b86b-2668b65114a8/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42742023/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42742023/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42742023%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42742023%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42742023/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42742023/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42742023/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42742023/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Full text links [![Chinese Medical Association Publishing House Ltd. full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.medjournals.cn-CMAPH-Linkout-logo.png) Chinese Medical Association Publishing House Ltd. ](https://www.yiigle.com/LinkIn.do?linkin_type=pubmed&DOI=10.3760/cma.j.cn112140-20260403-00267 "See full text options at Chinese Medical Association Publishing House Ltd.") [ Full text links ](https://pubmed.ncbi.nlm.nih.gov/42742023/) ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42742023/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42742023/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42742023/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42742023/#conflict-of-interest) * [Similar articles](https://pubmed.ncbi.nlm.nih.gov/42742023/#similar) * [ Publication types ](https://pubmed.ncbi.nlm.nih.gov/42742023/#publication-types) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42742023/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42742023/#substances) * [ LinkOut - more resources ](https://pubmed.ncbi.nlm.nih.gov/42742023/#linkout) Title & authors Abstract Conflict of interest statement Similar articles Publication types MeSH terms Substances LinkOut - more resources Case Reports Zhonghua Er Ke Za Zhi Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhonghua+Er+Ke+Za+Zhi%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhonghua+Er+Ke+Za+Zhi%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) . 2026 Oct 2;64(10):1190-1191. doi: 10.3760/cma.j.cn112140-20260403-00267. # [A case of B-cell acute lymphoblastic leukemia complicated with Rothia mucilaginosa infection] [Article in Chinese] [Y J Fu](https://pubmed.ncbi.nlm.nih.gov/?term=Fu+YJ&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#full-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [Y X Qiao](https://pubmed.ncbi.nlm.nih.gov/?term=Qiao+YX&cauthor_id=42742023)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#full-view-affiliation-2 "Department of Emergency, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [S Y Qian](https://pubmed.ncbi.nlm.nih.gov/?term=Qian+SY&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#full-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [Q Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Q&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#full-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [L J Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+LJ&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#full-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.") Affiliations Expand ### Affiliations * 1 Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. * 2 Department of Emergency, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. * PMID: **42742023** * DOI: [ 10.3760/cma.j.cn112140-20260403-00267 ](https://doi.org/10.3760/cma.j.cn112140-20260403-00267) Item in Clipboard Case Reports # [A case of B-cell acute lymphoblastic leukemia complicated with Rothia mucilaginosa infection] [Article in Chinese] Y J Fu et al. Zhonghua Er Ke Za Zhi. 2026. Show details Display options Display options Format Abstract PubMed PMID Zhonghua Er Ke Za Zhi Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Zhonghua+Er+Ke+Za+Zhi%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Zhonghua+Er+Ke+Za+Zhi%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) . 2026 Oct 2;64(10):1190-1191. doi: 10.3760/cma.j.cn112140-20260403-00267. ### Authors [Y J Fu](https://pubmed.ncbi.nlm.nih.gov/?term=Fu+YJ&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#short-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [Y X Qiao](https://pubmed.ncbi.nlm.nih.gov/?term=Qiao+YX&cauthor_id=42742023)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#short-view-affiliation-2 "Department of Emergency, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [S Y Qian](https://pubmed.ncbi.nlm.nih.gov/?term=Qian+SY&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#short-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [Q Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+Q&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#short-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China."), [L J Wang](https://pubmed.ncbi.nlm.nih.gov/?term=Wang+LJ&cauthor_id=42742023)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42742023/#short-view-affiliation-1 "Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China.") ### Affiliations * 1 Pediatric Intensive Care Unit, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. * 2 Department of Emergency, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100045, China. * PMID: **42742023** * DOI: [ 10.3760/cma.j.cn112140-20260403-00267 ](https://doi.org/10.3760/cma.j.cn112140-20260403-00267) Item in Clipboard Full text links Cite Display options Display options Format Abstract PubMed PMID ## Abstract 患儿，女，1岁7月龄，诊断为急性B淋巴细胞白血病伴PAX5基因改变（无IKZF1基因缺失），诱导化疗后出现严重骨髓抑制，并发黏液罗氏菌脓毒症及化脓性脑膜炎，最终因难治性脓毒性休克、脑疝及多脏器功能衰竭死亡。. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement 所有作者声明无利益冲突 ## Similar articles * [ PAX5-ESRRB is a recurrent fusion gene in B-cell precursor pediatric acute lymphoblastic leukemia. ](https://pubmed.ncbi.nlm.nih.gov/26494837/) Marincevic-Zuniga Y, Zachariadis V, Cavelier L, Castor A, Barbany G, Forestier E, Fogelstrand L, Heyman M, Abrahamsson J, Lönnerholm G, Nordgren A, Syvänen AC, Nordlund J.Marincevic-Zuniga Y, et al.Haematologica. 2016 Jan;101(1):e20-3. doi: 10.3324/haematol.2015.132332. Epub 2015 Oct 22.Haematologica. 2016.PMID: 26494837Free PMC article.No abstract available. * [ Germline PAX5 mutation predisposes to familial B-cell precursor acute lymphoblastic leukemia. ](https://pubmed.ncbi.nlm.nih.gov/33036026/) Duployez N, Jamrog LA, Fregona V, Hamelle C, Fenwarth L, Lejeune S, Helevaut N, Geffroy S, Caillault A, Marceau-Renaut A, Poulain S, Roche-Lestienne C, Largeaud L, Prade N, Dufrechou S, Hébrard S, Berthon C, Nelken B, Fernandes J, Villenet C, Figeac M, Gerby B, Delabesse E, Preudhomme C, Broccardo C.Duployez N, et al.Blood. 2021 Mar 11;137(10):1424-1428. doi: 10.1182/blood.2020005756.Blood. 2021.PMID: 33036026No abstract available. * [ Expression profiling of transcription factors in B- or T-acute lymphoblastic leukemia/lymphoma and burkitt lymphoma: usefulness of PAX5 immunostaining as pan-Pre-B-cell marker. ](https://pubmed.ncbi.nlm.nih.gov/20023257/) Nasr MR, Rosenthal N, Syrbu S.Nasr MR, et al.Am J Clin Pathol. 2010 Jan;133(1):41-8. doi: 10.1309/AJCPYP00JNUFWCCY.Am J Clin Pathol. 2010.PMID: 20023257 * [ PAX5 fusion genes in acute lymphoblastic leukemia: A literature review. ](https://pubmed.ncbi.nlm.nih.gov/37335685/) Fouad FM, Eid JI.Fouad FM, et al.Medicine (Baltimore). 2023 May 19;102(20):e33836. doi: 10.1097/MD.0000000000033836.Medicine (Baltimore). 2023.PMID: 37335685Free PMC article.Review. * [ PAX5-AUTS2 fusion resulting from t(7;9)(q11.2;p13.2) can now be classified as recurrent in B cell acute lymphoblastic leukemia. ](https://pubmed.ncbi.nlm.nih.gov/20723977/) Coyaud E, Struski S, Dastugue N, Brousset P, Broccardo C, Bradtke J.Coyaud E, et al.Leuk Res. 2010 Dec;34(12):e323-5. doi: 10.1016/j.leukres.2010.07.035. Epub 2010 Aug 17.Leuk Res. 2010.PMID: 20723977Review.No abstract available. [ See all similar articles ](https://pubmed.ncbi.nlm.nih.gov/?linkname=pubmed_pubmed&from_uid=42742023) ## Publication types * Case Reports Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Case+Reports%22%5Bpt%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Case+Reports) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) ## MeSH terms * Fatal Outcome Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Fatal+Outcome%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Fatal+Outcome) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * Gram-Positive Bacterial Infections* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gram-Positive+Bacterial+Infections%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Gram-Positive+Bacterial+Infections) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * Humans Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Humans%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Humans) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * Infant Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Infant%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Infant) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * PAX5 Transcription Factor / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PAX5+Transcription+Factor%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=PAX5+Transcription+Factor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * Precursor B-Cell Lymphoblastic Leukemia-Lymphoma* / complications Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Precursor+B-Cell+Lymphoblastic+Leukemia-Lymphoma%2Fcomplications%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Precursor+B-Cell+Lymphoblastic+Leukemia-Lymphoma) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) ## Substances * PAX5 Transcription Factor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PAX5+Transcription+Factor%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22PAX5+Transcription+Factor%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) * PAX5 protein, human Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PAX5+protein%2C+human%22%5Bnm%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=%22PAX5+protein%2C+human%22) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42742023/) ## LinkOut - more resources * ### Full Text Sources * [ Chinese Medical Association Publishing House Ltd. ](https://www.yiigle.com/LinkIn.do?linkin_type=pubmed&DOI=10.3760/cma.j.cn112140-20260403-00267) **Full text links** [x] [![Chinese Medical Association Publishing House Ltd. full text link](https://cdn.ncbi.nlm.nih.gov/corehtml/query/egifs/https:--www.medjournals.cn-CMAPH-Linkout-logo.png) Chinese Medical Association Publishing House Ltd. ](https://www.yiigle.com/LinkIn.do?linkin_type=pubmed&DOI=10.3760/cma.j.cn112140-20260403-00267 "See full text options at Chinese Medical Association Publishing House Ltd.") [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM **Send To** * [Clipboard](https://pubmed.ncbi.nlm.nih.gov/42742023/) * [Email](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42742023%2F%23open-email-panel) * [Save](https://pubmed.ncbi.nlm.nih.gov/42742023/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42742023%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42742023%2F%23open-collections-panel) * [Citation Manager](https://pubmed.ncbi.nlm.nih.gov/42742023/) [x] NCBI Literature Resources [MeSH](https://www.ncbi.nlm.nih.gov/mesh/) [PMC](https://www.ncbi.nlm.nih.gov/pmc/) [Bookshelf](https://www.ncbi.nlm.nih.gov/books) [Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited. Follow NCBI [ Twitter ](https://twitter.com/ncbi) [ Facebook ](https://www.facebook.com/ncbi.nlm) [ LinkedIn ](https://www.linkedin.com/company/ncbinlm) [ GitHub ](https://github.com/ncbi) [ ](https://ncbiinsights.ncbi.nlm.nih.gov/) [Connect with NLM](https://www.nlm.nih.gov/socialmedia/index.html) * [ Twitter ](https://twitter.com/NLM_NIH) * [ SM-Facebook ](https://www.facebook.com/nationallibraryofmedicine) * [ SM-Youtube ](https://www.youtube.com/user/NLMNIH) National Library of Medicine [8600 Rockville Pike Bethesda, MD 20894](https://www.google.com/maps/place/8600+Rockville+Pike,+Bethesda,+MD+20894/@38.9959508,-77.101021,17z/data=!3m1!4b1!4m5!3m4!1s0x89b7c95e25765ddb:0x19156f88b27635b8!8m2!3d38.9959508!4d-77.0988323) [Web Policies](https://www.nlm.nih.gov/web_policies.html) [FOIA](https:/
## Related Clinical Research

- [Desire for Future Children and Interest in Fertility Consultation Among AYA Cancer Patients](https://medichelpline.com/clinical-feed/pubmed-42834237.md) (DOI: 10.1007/s00520-026-11313-6)
- [Childbirth Rates Among Female Cancer Survivors in Taiwan: Nationwide Population Study](https://medichelpline.com/clinical-feed/plos-one-0-rates-of-childbirth-in-female-cancer-survivors-a-population-based-study-in.md)
- [One-month physicochemical stability of idarubicin diluted in polyolefin (Freeflex) infusion bags](https://medichelpline.com/clinical-feed/plos-one-21-one-month-physicochemical-stability-study-of-idarubicin-prepared-in-polyolefin.md)
- [PIP4K2A depletion reduces AKT signaling and increases chemotherapy sensitivity in T‑cell lymphobla](https://medichelpline.com/clinical-feed/pubmed-42570494.md) (DOI: 10.1016/j.bbrc.2026.154404)
- [Inferring tumor kinetics from single routine H&E biopsies to run virtual radiotherapy trials](https://medichelpline.com/clinical-feed/medrxiv-9-effective-tumor-kinetics-inferred-from-single-routine-h-e-biopsies-enable.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.