---
title: "Bacterial RNA Lowers MHC-I on Tumor Cells via TLR8, Enhancing NK Response and Slowing Tumor Growth"
id: "pubmed-42743356"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42743356"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42743356/"
doi: "10.1371/journal.pone.0357999"
published_at: "2026-09-15T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# Bacterial RNA Lowers MHC-I on Tumor Cells via TLR8, Enhancing NK Response and Slowing Tumor Growth
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42743356
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42743356/)
- **DOI:** [10.1371/journal.pone.0357999](https://doi.org/10.1371%2Fjournal.pone.0357999)
- **Published At:** 2026-09-15T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- The authors investigated whether **bacterial RNA (bacRNA)** modulates MHC class I (MHC-I) expression in tumor cells to enhance natural killer (NK) responses against solid tumors. - Prior work from the group showed that Brucella abortus RNA downregulated IFN-γ–induced **MHC-I** on human monocytes/macrophages through a **TLR8**-dependent mechanism; other bacterial RNAs can produce similar effects. - Tumor cell lines tested included human glioblastoma (U251, LN-229), colorectal adenocarcinoma (HT-29), breast cancer (MCF-7), and murine melanoma (B16-OVA). Cells were stimulated with bacRNA in the presence of IFN-γ. - Exposure to bacRNA reduced IFN-γ–induced surface **MHC-I** expression across all tumor cell lines examined. - A synthetic human **TLR8** agonist (ORN06/LyoVec) reproduced the MHC-I–reducing effect, implicating **TLR8** as the mediating receptor. - The bacRNA-mediated decrease in **MHC-I** correlated with increased **NK** cell cytotoxicity against the tumor cells in vitro. - In vivo, treatment with bacRNA or the ORN06 agonist led to greater immune cell infiltration and activation within tumors compared with untreated controls. - In a B16 melanoma model, bacRNA treatment delayed tumor growth. - The authors propose that deliberate **MHC-I** downregulation by bacterial RNA or synthetic **hTLR8** agonists could be developed as a therapeutic strategy to promote anti-tumor immune responses. - The study reported no competing interests by the authors.
## Clinical Analysis & Structured Key Points
Clipboard, Search History, and several other advanced features are temporarily unavailable. [ Skip to main page content ](https://pubmed.ncbi.nlm.nih.gov/42743356/#article-details) ![U.S. flag](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/favicons/favicon-57.png) An official website of the United States government Here's how you know ![Dot gov](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-dot-gov.svg) **The .gov means it’s official.** Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site. ![Https](https://cdn.ncbi.nlm.nih.gov/coreutils/uswds/img/icon-https.svg) **The site is secure.** The **https://** ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. [ ![NIH NLM Logo](https://cdn.ncbi.nlm.nih.gov/coreutils/nwds/img/logos/AgencyLogo.svg) ](https://www.ncbi.nlm.nih.gov/) [Log in](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42743356%2F) Show account info Close #### Account Logged in as: **username** * [Dashboard](https://www.ncbi.nlm.nih.gov/myncbi/) * [Publications](https://www.ncbi.nlm.nih.gov/myncbi/collections/bibliography/) * [Account settings](https://www.ncbi.nlm.nih.gov/account/settings/) * [Log out](https://www.ncbi.nlm.nih.gov/account/signout/?back_url=https%3A//pubmed.ncbi.nlm.nih.gov/42743356/) [Access keys](https://www.ncbi.nlm.nih.gov/guide/browsers/#ncbi_accesskeys) [NCBI Homepage](https://www.ncbi.nlm.nih.gov) [MyNCBI Homepage](https://pubmed.ncbi.nlm.nih.gov/myncbi/) [Main Content](https://pubmed.ncbi.nlm.nih.gov/42743356/#maincontent) [Main Navigation](https://pubmed.ncbi.nlm.nih.gov/42743356/) [ ![pubmed logo](https://cdn.ncbi.nlm.nih.gov/pubmed/c24ab723-7c80-48cd-9c68-022ded852586/core/images/pubmed-logo-blue.svg) ](https://pubmed.ncbi.nlm.nih.gov/) [ ](https://pubmed.ncbi.nlm.nih.gov/42743356/ "Show search bar") Search: [](https://pubmed.ncbi.nlm.nih.gov/42743356/ "Clear search input")Search [Advanced](https://pubmed.ncbi.nlm.nih.gov/advanced/) [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/clipboard/) [ User Guide ](https://pubmed.ncbi.nlm.nih.gov/help/) Save Email Send to * [ Clipboard ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * [My Bibliography](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42743356%2F%23open-bibliography-panel) * [Collections](https://account.ncbi.nlm.nih.gov/?back_url=https%3A%2F%2Fpubmed.ncbi.nlm.nih.gov%2F42743356%2F%23open-collections-panel) * [Citation manager](https://pubmed.ncbi.nlm.nih.gov/42743356/) Display options Display options Format Abstract PubMed PMID ## Save citation to file Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel ## Email citation Email address has not been verified. Go to [ My NCBI account settings ](https://account.ncbi.nlm.nih.gov/settings/) to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel ### Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42743356/) Add Cancel ### Add to My Bibliography * My Bibliography Unable to load your delegates due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42743356/) Add Cancel ## Your saved search Name of saved search: Search terms: [Test search terms](https://pubmed.ncbi.nlm.nih.gov/42743356/) Would you like email updates of new search results? Saved Search Alert Radio Buttons * Yes * No Email: ([change](https://www.ncbi.nlm.nih.gov/account/settings/)) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel ## Create a file for external citation management software Create file Cancel ## Your RSS Feed Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy ### Actions Cite Collections Add to Collections * Create a new collection * Add to an existing collection Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error [Please try again](https://pubmed.ncbi.nlm.nih.gov/42743356/) Add Cancel Permalink Permalink Copy Display options Display options Format Abstract PubMed PMID ### Page navigation * [ Title & authors ](https://pubmed.ncbi.nlm.nih.gov/42743356/#heading) * [ Abstract ](https://pubmed.ncbi.nlm.nih.gov/42743356/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42743356/#conflict-of-interest) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42743356/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42743356/#substances) Title & authors Abstract Conflict of interest statement MeSH terms Substances PLoS One Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PLoS+One%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22PLoS+One%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) . 2026 Sep 15;21(9):e0357999. doi: 10.1371/journal.pone.0357999. eCollection 2026. # Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth [Agustina Serafino](https://pubmed.ncbi.nlm.nih.gov/?term=Serafino+A&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Mónica Vermeulen](https://pubmed.ncbi.nlm.nih.gov/?term=Vermeulen+M&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Yasmín A Bertinat](https://pubmed.ncbi.nlm.nih.gov/?term=Bertinat+YA&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Federico Birnberg-Weiss](https://pubmed.ncbi.nlm.nih.gov/?term=Birnberg-Weiss+F&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Joselyn E Castro](https://pubmed.ncbi.nlm.nih.gov/?term=Castro+JE&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [María Belén Bordignon](https://pubmed.ncbi.nlm.nih.gov/?term=Bordignon+MB&cauthor_id=42743356)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-2 "Centro de Investigaciones Oncológicas-Fundación Cáncer F.U.C.A, Buenos Aires, Argentina."), [Ayelén I Pesce Viglietti](https://pubmed.ncbi.nlm.nih.gov/?term=Pesce+Viglietti+AI&cauthor_id=42743356)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-2 "Centro de Investigaciones Oncológicas-Fundación Cáncer F.U.C.A, Buenos Aires, Argentina."), [Jorgelina Bueno](https://pubmed.ncbi.nlm.nih.gov/?term=Bueno+J&cauthor_id=42743356)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-3 "Instituto de Biociencias, Biotecnología y Biología traslacional. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, Buenos Aires, Argentina."), [M Ayelén Milillo](https://pubmed.ncbi.nlm.nih.gov/?term=Milillo+MA&cauthor_id=42743356)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-4 "Universidad Nacional de Río Negro. Instituto de Estudios en Ciencia, Tecnología, Cultura y Desarrollo. Consejo Nacional de Investigaciones Científicas y Técnicas, Río Negro, Argentina."), [Paula Barrionuevo](https://pubmed.ncbi.nlm.nih.gov/?term=Barrionuevo+P&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#full-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina.") Affiliations Expand ### Affiliations * 1 Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires, Argentina. * 2 Centro de Investigaciones Oncológicas-Fundación Cáncer F.U.C.A, Buenos Aires, Argentina. * 3 Instituto de Biociencias, Biotecnología y Biología traslacional. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, Buenos Aires, Argentina. * 4 Universidad Nacional de Río Negro. Instituto de Estudios en Ciencia, Tecnología, Cultura y Desarrollo. Consejo Nacional de Investigaciones Científicas y Técnicas, Río Negro, Argentina. * PMID: **42743356** * DOI: [ 10.1371/journal.pone.0357999 ](https://doi.org/10.1371/journal.pone.0357999) Item in Clipboard # Bacterial RNA downregulates MHC-I in tumor cell lines, promoting NK response and delaying tumor growth Agustina Serafino et al. PLoS One. 2026. Show details Display options Display options Format Abstract PubMed PMID PLoS One Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22PLoS+One%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22PLoS+One%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) . 2026 Sep 15;21(9):e0357999. doi: 10.1371/journal.pone.0357999. eCollection 2026. ### Authors [Agustina Serafino](https://pubmed.ncbi.nlm.nih.gov/?term=Serafino+A&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Mónica Vermeulen](https://pubmed.ncbi.nlm.nih.gov/?term=Vermeulen+M&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Yasmín A Bertinat](https://pubmed.ncbi.nlm.nih.gov/?term=Bertinat+YA&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Federico Birnberg-Weiss](https://pubmed.ncbi.nlm.nih.gov/?term=Birnberg-Weiss+F&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [Joselyn E Castro](https://pubmed.ncbi.nlm.nih.gov/?term=Castro+JE&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina."), [María Belén Bordignon](https://pubmed.ncbi.nlm.nih.gov/?term=Bordignon+MB&cauthor_id=42743356)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-2 "Centro de Investigaciones Oncológicas-Fundación Cáncer F.U.C.A, Buenos Aires, Argentina."), [Ayelén I Pesce Viglietti](https://pubmed.ncbi.nlm.nih.gov/?term=Pesce+Viglietti+AI&cauthor_id=42743356)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-2 "Centro de Investigaciones Oncológicas-Fundación Cáncer F.U.C.A, Buenos Aires, Argentina."), [Jorgelina Bueno](https://pubmed.ncbi.nlm.nih.gov/?term=Bueno+J&cauthor_id=42743356)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-3 "Instituto de Biociencias, Biotecnología y Biología traslacional. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, Buenos Aires, Argentina."), [M Ayelén Milillo](https://pubmed.ncbi.nlm.nih.gov/?term=Milillo+MA&cauthor_id=42743356)[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-4 "Universidad Nacional de Río Negro. Instituto de Estudios en Ciencia, Tecnología, Cultura y Desarrollo. Consejo Nacional de Investigaciones Científicas y Técnicas, Río Negro, Argentina."), [Paula Barrionuevo](https://pubmed.ncbi.nlm.nih.gov/?term=Barrionuevo+P&cauthor_id=42743356)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42743356/#short-view-affiliation-1 "Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas \(CONICET\), Academia Nacional de Medicina, Buenos Aires, Argentina.") ### Affiliations * 1 Instituto de Medicina Experimental-Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Academia Nacional de Medicina, Buenos Aires, Argentina. * 2 Centro de Investigaciones Oncológicas-Fundación Cáncer F.U.C.A, Buenos Aires, Argentina. * 3 Instituto de Biociencias, Biotecnología y Biología traslacional. Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires, Buenos Aires, Argentina. * 4 Universidad Nacional de Río Negro. Instituto de Estudios en Ciencia, Tecnología, Cultura y Desarrollo. Consejo Nacional de Investigaciones Científicas y Técnicas, Río Negro, Argentina. * PMID: **42743356** * DOI: [ 10.1371/journal.pone.0357999 ](https://doi.org/10.1371/journal.pone.0357999) Item in Clipboard Cite Display options Display options Format Abstract PubMed PMID ## Abstract Immunotherapy has introduced a new era in cancer treatment. The clinical goal of cancer immunotherapy is to prime the host immune system to provide passive or active immunity against malignant tumors. We have previously demonstrated that Brucella abortus (Ba) RNA downregulates IFN-γ-induced MHC-I surface expression in human monocytes/macrophages via a TLR8-dependent mechanism. Other bacterial RNAs can mimic this phenomenon. The presence and activity of NK cells in tumors have been correlated with better patient survival, supporting the evidence that these cells are essential in the immune response against tumors. So, we postulated that bacterial RNA (bacRNA) can be used to modulate MHC-I expression in tumors to enhance the NK cell response. Hence, the aim of this study was to investigate the immunomodulatory role of bacRNA in solid tumors. We first stimulated human glioblastomas U251 and LN-229, colorectal adenocarcinoma HT-29, breast cancer MCF-7, and murine melanoma B16-OVA cells with bacRNA in the presence of IFN-γ. Our experiments demonstrated that bacRNA diminished IFN-γ-induced MHC-I surface expression in all tumor cell lines. Moreover, the hTLR8 agonist ORN06/LyoVec mimicked the effect of bacRNA, indicating that MHC-I reduction would be mediated by TLR8. In addition, the decrease in MHC-I mediated by bacRNA correlated with increased NK cytotoxicity. Finally, treatment with either bacRNA or the ORN06 agonist resulted in greater immune cell infiltration and activation within the tumor compared to untreated mice. Furthermore, bacRNA delayed tumor growth in the B16 melanoma model. Overall, our established model of MHC-I downregulation (either by bacRNA or synthetic hTLR8 agonists) could be used as a therapeutic strategy to promote anti-tumor responses. Copyright: © 2026 Serafino et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. [PubMed Disclaimer](https://pubmed.ncbi.nlm.nih.gov/disclaimer/) ## Conflict of interest statement The authors have declared that no competing interests exist. ## MeSH terms * Animals Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Animals%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Animals) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Brucella abortus / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Brucella+abortus%2Fgenetics%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Brucella+abortus) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Cell Line, Tumor Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Cell+Line%2C+Tumor%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Cell+Line%2C+Tumor) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Down-Regulation Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Down-Regulation%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Down-Regulation) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Female Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Female%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Female) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Gene Expression Regulation, Neoplastic Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Gene+Expression+Regulation%2C+Neoplastic%22%5BMeSH%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Gene+Expression+Regulation%2C+Neoplastic) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Histocompatibility Antigens Class I* / genetics Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Histocompatibility+Antigens+Class+I%2Fgenetics%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Histocompatibility+Antigens+Class+I) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Histocompatibility Antigens Class I* / immunology Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Histocompatibility+Antigens+Class+I%2Fimmunology%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Histocompatibility+Antigens+Class+I) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Histocompatibility Antigens Class I* / metabolism Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Histocompatibility+Antigens+Class+I%2Fmetabolism%22%5BMAJR%5D&sort=date&sort_order=desc) * [ Search in MeSH ](https://www.ncbi.nlm.nih.gov/mesh?term=Histocompatibility+Antigens+Class+I) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42743356/) * Humans Actions * [ Search in PubMed ](https
## Related Clinical Research

- [Targeting VISTA for Skin Cancer Immunotherapy: Source Article Not Available](https://medichelpline.com/clinical-feed/frontiers-in-immunology-17-targeting-vista-as-a-novel-immunotherapy-for-skin-cancer.md)
- [PD-L1 PET/CT with 89Zr-atezolizumab to assess tumour saturation during atezolizumab therapy](https://medichelpline.com/clinical-feed/british-journal-of-cancer-0-programmed-death-ligand-1-pd-l1-pet-ct-imaging-to-evaluate-tumour-saturation.md)
- [Fluorinated Nanohybrid Micelles with Lutetium-177 and Gold for Potentiated Internal Radiotherapy](https://medichelpline.com/clinical-feed/pubmed-42476272.md) (DOI: 10.1016/j.ijpharm.2026.127219)
- [Cold atmospheric plasma causes selective oxidative toxicity in prostate cancer cells](https://medichelpline.com/clinical-feed/pubmed-42259195.md) (DOI: 10.1016/j.bbrc.2026.154110)
- [Personalized mRNA vaccine plus pembrolizumab lowers melanoma recurrence in phase 3 trial](https://medichelpline.com/clinical-feed/medical-news-today-0-novel-mrna-vaccine-plus-immunotherapy-reduces-melanoma-relapse-in-phase-3-trial.md)

## Navigation
- [← Back to Oncology Feed](https://medichelpline.com/clinical-feed/oncology.md)
- [← All Clinical Specialties](https://medichelpline.com/clinical-feed.md)
## Medical & Regulatory Disclaimer

> [!CAUTION]
> MedicHelpline content is structured for research, educational, and professional discovery purposes. It does not constitute individual medical advice, clinical diagnosis, or treatment recommendations.
> Always verify dosing, contraindications, and regulatory alerts against official product labeling and primary regulatory sources before clinical decision-making.