---
title: "BCLXL blockade as strategy to overcome PARP inhibitor resistance in ovarian cancer"
id: "pubmed-42764286"
canonical_url: "https://medichelpline.com/clinical-feed/pubmed-42764286"
content_type: "clinical_feed_article"
specialty: "Oncology"
source_name: "PubMed / NCBI"
source_url: "https://pubmed.ncbi.nlm.nih.gov/42764286/"
doi: "10.1038/s41392-026-02870-7"
published_at: "2026-09-21T00:00:00.000Z"
evidence_level: "Journal Article"
license: "CC-BY-NC-4.0 / Informational Use"
---
# BCLXL blockade as strategy to overcome PARP inhibitor resistance in ovarian cancer
## Provenance & Clinical Metadata
- **Canonical URL:** https://medichelpline.com/clinical-feed/pubmed-42764286
- **Specialty:** [Oncology](https://medichelpline.com/clinical-feed/oncology.md)
- **Primary Source:** PubMed / NCBI
- **Source URL:** [Original Journal Publication](https://pubmed.ncbi.nlm.nih.gov/42764286/)
- **DOI:** [10.1038/s41392-026-02870-7](https://doi.org/10.1038%2Fs41392-026-02870-7)
- **Published At:** 2026-09-21T00:00:00.000Z
- **Evidence Rating:** Journal Article
## Executive GIST (TL;DR)
- Article title: “BCLXL blockade rewires cell fate to overcome PARP inhibitor resistance in ovarian cancer.” The manuscript is published in Signal Transduct Target Ther (2026 Sep 21). - Primary keywords from the title: **BCLXL**, **PARP inhibitor**, **ovarian cancer**. These denote the molecular target, the therapeutic class, and the disease context reported. - Authorship: multi‑author team from Mayo Clinic (departments of Oncology; Molecular Pharmacology and Experimental Therapeutics; Quantitative Health Sciences; Laboratory Medicine and Pathology). Two authors contributed equally. - Publication identifiers: PMID 42764286; DOI 10.1038/s41392-026-02870-7. - Article metadata available on PubMed includes full author list, affiliations, journal, issue/volume, DOI, and publication date. - The PubMed entry indicates the paper was assigned to volume 11, article 393. - The PubMed page displayed navigation links (Title & authors; Abstract; Conflict of interest statement; References; MeSH terms; Substances) but the source text provided does not include the abstract, results, methods, or conclusions. - Because the provided source content contains only bibliographic and site navigation material, experimental details, key findings, study design, outcomes, and numerical results were not reported in this source and therefore are not restated here. - Contact information: corresponding author email is listed in the PubMed record (Kaufmann.Scott@Mayo.edu). - Practical note for clinicians and researchers: consult the full article (publisher site or PubMed full text link) for methods, data, and clinical or translational implications, because the present source lacks the abstract and body text necessary to evaluate the study’s evidence and reproducibility.
## Clinical Analysis & Structured Key Points
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](https://pubmed.ncbi.nlm.nih.gov/42764286/#abstract) * [ Conflict of interest statement ](https://pubmed.ncbi.nlm.nih.gov/42764286/#conflict-of-interest) * [ References ](https://pubmed.ncbi.nlm.nih.gov/42764286/#references) * [ MeSH terms ](https://pubmed.ncbi.nlm.nih.gov/42764286/#mesh-terms) * [ Substances ](https://pubmed.ncbi.nlm.nih.gov/42764286/#substances) Title & authors Abstract Conflict of interest statement References MeSH terms Substances Signal Transduct Target Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduct+Target+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Signal+Transduct+Target+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42764286/) . 2026 Sep 21;11(1):393. doi: 10.1038/s41392-026-02870-7. # BCLXL blockade rewires cell fate to overcome PARP inhibitor resistance in ovarian cancer [Annapoorna Venkatachalam](https://pubmed.ncbi.nlm.nih.gov/?term=Venkatachalam+A&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Annabella R Strathman](https://pubmed.ncbi.nlm.nih.gov/?term=Strathman+AR&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Xianon Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+X&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Cristina Correia](https://pubmed.ncbi.nlm.nih.gov/?term=Correia+C&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [X Wei Meng](https://pubmed.ncbi.nlm.nih.gov/?term=Meng+XW&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Cordelia D McGehee](https://pubmed.ncbi.nlm.nih.gov/?term=McGehee+CD&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Emily A Balczewski](https://pubmed.ncbi.nlm.nih.gov/?term=Balczewski+EA&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Laura N Duffield](https://pubmed.ncbi.nlm.nih.gov/?term=Duffield+LN&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Olivia K Rossman](https://pubmed.ncbi.nlm.nih.gov/?term=Rossman+OK&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Clara Wong](https://pubmed.ncbi.nlm.nih.gov/?term=Wong+C&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Haiming Dai](https://pubmed.ncbi.nlm.nih.gov/?term=Dai+H&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Rachel M Hurley](https://pubmed.ncbi.nlm.nih.gov/?term=Hurley+RM&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Jill M Wagner](https://pubmed.ncbi.nlm.nih.gov/?term=Wagner+JM&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Saloni Singh](https://pubmed.ncbi.nlm.nih.gov/?term=Singh+S&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Karen S Flatten](https://pubmed.ncbi.nlm.nih.gov/?term=Flatten+KS&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Kevin L Peterson](https://pubmed.ncbi.nlm.nih.gov/?term=Peterson+KL&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Paula A Schneider](https://pubmed.ncbi.nlm.nih.gov/?term=Schneider+PA&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Silvana B De Lorenzo](https://pubmed.ncbi.nlm.nih.gov/?term=De+Lorenzo+SB&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Melissa C Larson](https://pubmed.ncbi.nlm.nih.gov/?term=Larson+MC&cauthor_id=42764286)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-3 "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA."), [Ann L Oberg](https://pubmed.ncbi.nlm.nih.gov/?term=Oberg+AL&cauthor_id=42764286)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-3 "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA."), [Andrea E Wahner Hendrickson](https://pubmed.ncbi.nlm.nih.gov/?term=Wahner+Hendrickson+AE&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Xinyan Wu](https://pubmed.ncbi.nlm.nih.gov/?term=Wu+X&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-4 "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA."), [Akhilesh Pandey](https://pubmed.ncbi.nlm.nih.gov/?term=Pandey+A&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.")[ 4 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-4 "Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA."), [Hu Li](https://pubmed.ncbi.nlm.nih.gov/?term=Li+H&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [S John Weroha](https://pubmed.ncbi.nlm.nih.gov/?term=Weroha+SJ&cauthor_id=42764286)[#](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-equal-contrib-explanation "Contributed equally")[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Scott H Kaufmann](https://pubmed.ncbi.nlm.nih.gov/?term=Kaufmann+SH&cauthor_id=42764286)[#](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-equal-contrib-explanation "Contributed equally")[ 5 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-5 "Department of Oncology, Mayo Clinic, Rochester, MN, USA. Kaufmann.Scott@Mayo.edu.")[ 6 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#full-view-affiliation-6 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Kaufmann.Scott@Mayo.edu.") Affiliations Expand ### Affiliations * 1 Department of Oncology, Mayo Clinic, Rochester, MN, USA. * 2 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. * 3 Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. * 4 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA. * 5 Department of Oncology, Mayo Clinic, Rochester, MN, USA. Kaufmann.Scott@Mayo.edu. * 6 Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA. Kaufmann.Scott@Mayo.edu. # Contributed equally. * PMID: **42764286** * DOI: [ 10.1038/s41392-026-02870-7 ](https://doi.org/10.1038/s41392-026-02870-7) Item in Clipboard # BCLXL blockade rewires cell fate to overcome PARP inhibitor resistance in ovarian cancer Annapoorna Venkatachalam et al. Signal Transduct Target Ther. 2026. Show details Display options Display options Format Abstract PubMed PMID Signal Transduct Target Ther Actions * [ Search in PubMed ](https://pubmed.ncbi.nlm.nih.gov/?term=%22Signal+Transduct+Target+Ther%22%5Bjour%5D&sort=date&sort_order=desc) * [ Search in NLM Catalog ](https://www.ncbi.nlm.nih.gov/nlmcatalog?term=%22Signal+Transduct+Target+Ther%22%5BTitle+Abbreviation%5D) * [ Add to Search ](https://pubmed.ncbi.nlm.nih.gov/42764286/) . 2026 Sep 21;11(1):393. doi: 10.1038/s41392-026-02870-7. ### Authors [Annapoorna Venkatachalam](https://pubmed.ncbi.nlm.nih.gov/?term=Venkatachalam+A&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Annabella R Strathman](https://pubmed.ncbi.nlm.nih.gov/?term=Strathman+AR&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Xianon Hou](https://pubmed.ncbi.nlm.nih.gov/?term=Hou+X&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Cristina Correia](https://pubmed.ncbi.nlm.nih.gov/?term=Correia+C&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [X Wei Meng](https://pubmed.ncbi.nlm.nih.gov/?term=Meng+XW&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Cordelia D McGehee](https://pubmed.ncbi.nlm.nih.gov/?term=McGehee+CD&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Emily A Balczewski](https://pubmed.ncbi.nlm.nih.gov/?term=Balczewski+EA&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Laura N Duffield](https://pubmed.ncbi.nlm.nih.gov/?term=Duffield+LN&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Olivia K Rossman](https://pubmed.ncbi.nlm.nih.gov/?term=Rossman+OK&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Clara Wong](https://pubmed.ncbi.nlm.nih.gov/?term=Wong+C&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Haiming Dai](https://pubmed.ncbi.nlm.nih.gov/?term=Dai+H&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA.")[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Rachel M Hurley](https://pubmed.ncbi.nlm.nih.gov/?term=Hurley+RM&cauthor_id=42764286)[ 2 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-2 "Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA."), [Jill M Wagner](https://pubmed.ncbi.nlm.nih.gov/?term=Wagner+JM&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Saloni Singh](https://pubmed.ncbi.nlm.nih.gov/?term=Singh+S&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Karen S Flatten](https://pubmed.ncbi.nlm.nih.gov/?term=Flatten+KS&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Kevin L Peterson](https://pubmed.ncbi.nlm.nih.gov/?term=Peterson+KL&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Paula A Schneider](https://pubmed.ncbi.nlm.nih.gov/?term=Schneider+PA&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Silvana B De Lorenzo](https://pubmed.ncbi.nlm.nih.gov/?term=De+Lorenzo+SB&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Melissa C Larson](https://pubmed.ncbi.nlm.nih.gov/?term=Larson+MC&cauthor_id=42764286)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-3 "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA."), [Ann L Oberg](https://pubmed.ncbi.nlm.nih.gov/?term=Oberg+AL&cauthor_id=42764286)[ 3 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-3 "Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA."), [Andrea E Wahner Hendrickson](https://pubmed.ncbi.nlm.nih.gov/?term=Wahner+Hendrickson+AE&cauthor_id=42764286)[ 1 ](https://pubmed.ncbi.nlm.nih.gov/42764286/#short-view-affiliation-1 "Department of Oncology, Mayo Clinic, Rochester, MN, USA."), [Xinyan Wu](https://pubmed.ncbi.nlm.nih.gov/
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